WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box and WD40 domain containing protein

Species:

Leishmania braziliensis

UniProt:

A4HCB8_LEIBR

TriTrypDb:

LbrM.22.0880 , LBRM2903_220014500

Length:

683

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0032991	protein-containing complex	1	3
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	3
GO:0005840	ribosome	5	2

Expansion

Sequence features

A4HCB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCB8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.630
CLV_C14_Caspase3-7	296	300	PF00656	0.680
CLV_NRD_NRD_1	103	105	PF00675	0.500
CLV_NRD_NRD_1	240	242	PF00675	0.592
CLV_NRD_NRD_1	257	259	PF00675	0.293
CLV_NRD_NRD_1	606	608	PF00675	0.429
CLV_NRD_NRD_1	622	624	PF00675	0.256
CLV_PCSK_KEX2_1	103	105	PF00082	0.327
CLV_PCSK_KEX2_1	240	242	PF00082	0.592
CLV_PCSK_KEX2_1	257	259	PF00082	0.541
CLV_PCSK_KEX2_1	608	610	PF00082	0.536
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.563
CLV_PCSK_SKI1_1	138	142	PF00082	0.500
CLV_PCSK_SKI1_1	174	178	PF00082	0.512
CLV_PCSK_SKI1_1	209	213	PF00082	0.288
CLV_PCSK_SKI1_1	240	244	PF00082	0.589
CLV_PCSK_SKI1_1	246	250	PF00082	0.577
CLV_PCSK_SKI1_1	86	90	PF00082	0.585
DEG_APCC_DBOX_1	137	145	PF00400	0.514
DEG_APCC_DBOX_1	173	181	PF00400	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.774
DOC_CYCLIN_yClb1_LxF_4	500	505	PF00134	0.506
DOC_MAPK_DCC_7	352	361	PF00069	0.554
DOC_MAPK_FxFP_2	612	615	PF00069	0.568
DOC_MAPK_gen_1	103	113	PF00069	0.602
DOC_MAPK_gen_1	352	359	PF00069	0.510
DOC_MAPK_HePTP_8	349	361	PF00069	0.629
DOC_MAPK_MEF2A_6	169	177	PF00069	0.547
DOC_MAPK_MEF2A_6	192	200	PF00069	0.531
DOC_MAPK_MEF2A_6	268	275	PF00069	0.543
DOC_MAPK_MEF2A_6	352	361	PF00069	0.491
DOC_MAPK_MEF2A_6	633	640	PF00069	0.490
DOC_PP1_RVXF_1	500	506	PF00149	0.504
DOC_PP4_FxxP_1	50	53	PF00568	0.785
DOC_PP4_FxxP_1	612	615	PF00568	0.568
DOC_PP4_MxPP_1	458	461	PF00568	0.554
DOC_USP7_MATH_1	14	18	PF00917	0.757
DOC_USP7_MATH_1	332	336	PF00917	0.687
DOC_USP7_MATH_1	384	388	PF00917	0.583
DOC_USP7_MATH_1	400	404	PF00917	0.589
DOC_USP7_MATH_1	431	435	PF00917	0.524
DOC_USP7_MATH_1	488	492	PF00917	0.616
DOC_USP7_MATH_1	670	674	PF00917	0.339
DOC_USP7_MATH_1	73	77	PF00917	0.445
DOC_WW_Pin1_4	27	32	PF00397	0.635
DOC_WW_Pin1_4	300	305	PF00397	0.443
DOC_WW_Pin1_4	336	341	PF00397	0.562
DOC_WW_Pin1_4	402	407	PF00397	0.529
DOC_WW_Pin1_4	555	560	PF00397	0.568
LIG_14-3-3_CanoR_1	119	129	PF00244	0.450
LIG_14-3-3_CanoR_1	336	340	PF00244	0.574
LIG_14-3-3_CanoR_1	348	352	PF00244	0.403
LIG_14-3-3_CanoR_1	502	506	PF00244	0.462
LIG_14-3-3_CanoR_1	633	639	PF00244	0.490
LIG_BRCT_BRCA1_1	109	113	PF00533	0.343
LIG_EH1_1	169	177	PF00400	0.547
LIG_FHA_1	163	169	PF00498	0.514
LIG_FHA_1	212	218	PF00498	0.527
LIG_FHA_1	556	562	PF00498	0.513
LIG_FHA_1	565	571	PF00498	0.541
LIG_FHA_1	586	592	PF00498	0.505
LIG_FHA_1	630	636	PF00498	0.513
LIG_FHA_1	654	660	PF00498	0.575
LIG_FHA_2	42	48	PF00498	0.688
LIG_FHA_2	441	447	PF00498	0.459
LIG_FHA_2	52	58	PF00498	0.661
LIG_FHA_2	527	533	PF00498	0.557
LIG_GBD_Chelix_1	171	179	PF00786	0.495
LIG_LIR_Apic_2	327	332	PF02991	0.582
LIG_LIR_Apic_2	47	53	PF02991	0.784
LIG_LIR_Apic_2	647	653	PF02991	0.343
LIG_LIR_Gen_1	191	201	PF02991	0.499
LIG_LIR_Gen_1	286	293	PF02991	0.607
LIG_LIR_Gen_1	374	385	PF02991	0.443
LIG_LIR_Gen_1	504	513	PF02991	0.514
LIG_LIR_Gen_1	581	592	PF02991	0.488
LIG_LIR_Nem_3	153	157	PF02991	0.552
LIG_LIR_Nem_3	191	196	PF02991	0.506
LIG_LIR_Nem_3	286	291	PF02991	0.611
LIG_LIR_Nem_3	374	380	PF02991	0.458
LIG_LIR_Nem_3	504	508	PF02991	0.483
LIG_LIR_Nem_3	533	539	PF02991	0.482
LIG_LIR_Nem_3	581	587	PF02991	0.494
LIG_LYPXL_L_2	613	622	PF13949	0.295
LIG_PDZ_Class_1	678	683	PF00595	0.577
LIG_PTB_Apo_2	662	669	PF02174	0.424
LIG_SH2_CRK	109	113	PF00017	0.493
LIG_SH2_CRK	288	292	PF00017	0.621
LIG_SH2_CRK	584	588	PF00017	0.478
LIG_SH2_GRB2like	150	153	PF00017	0.565
LIG_SH2_NCK_1	109	113	PF00017	0.343
LIG_SH2_NCK_1	584	588	PF00017	0.478
LIG_SH2_PTP2	193	196	PF00017	0.521
LIG_SH2_PTP2	536	539	PF00017	0.475
LIG_SH2_STAP1	109	113	PF00017	0.493
LIG_SH2_STAT5	193	196	PF00017	0.528
LIG_SH2_STAT5	288	291	PF00017	0.629
LIG_SH2_STAT5	310	313	PF00017	0.444
LIG_SH2_STAT5	377	380	PF00017	0.426
LIG_SH2_STAT5	394	397	PF00017	0.602
LIG_SH2_STAT5	524	527	PF00017	0.420
LIG_SH2_STAT5	536	539	PF00017	0.414
LIG_SH3_3	337	343	PF00018	0.729
LIG_SH3_3	354	360	PF00018	0.554
LIG_SH3_3	454	460	PF00018	0.586
LIG_SUMO_SIM_anti_2	504	510	PF11976	0.520
LIG_SUMO_SIM_anti_2	526	535	PF11976	0.530
LIG_SUMO_SIM_anti_2	618	623	PF11976	0.367
LIG_SUMO_SIM_par_1	438	443	PF11976	0.492
LIG_SUMO_SIM_par_1	474	481	PF11976	0.474
LIG_SUMO_SIM_par_1	636	642	PF11976	0.456
LIG_TRAF2_1	54	57	PF00917	0.677
LIG_TYR_ITIM	582	587	PF00017	0.296
LIG_TYR_ITSM	284	291	PF00017	0.603
LIG_UBA3_1	1	7	PF00899	0.527
LIG_UBA3_1	80	89	PF00899	0.591
MOD_CDK_SPK_2	336	341	PF00069	0.491
MOD_CDK_SPxxK_3	27	34	PF00069	0.617
MOD_CK1_1	17	23	PF00069	0.543
MOD_CK1_1	300	306	PF00069	0.449
MOD_CK1_1	335	341	PF00069	0.529
MOD_CK1_1	408	414	PF00069	0.736
MOD_CK1_1	481	487	PF00069	0.568
MOD_CK1_1	491	497	PF00069	0.650
MOD_CK1_1	578	584	PF00069	0.514
MOD_CK2_1	41	47	PF00069	0.725
MOD_CK2_1	440	446	PF00069	0.440
MOD_CK2_1	51	57	PF00069	0.631
MOD_CK2_1	526	532	PF00069	0.547
MOD_CK2_1	84	90	PF00069	0.459
MOD_GlcNHglycan	16	19	PF01048	0.469
MOD_GlcNHglycan	2	5	PF01048	0.536
MOD_GlcNHglycan	321	325	PF01048	0.492
MOD_GlcNHglycan	407	410	PF01048	0.727
MOD_GlcNHglycan	417	420	PF01048	0.645
MOD_GlcNHglycan	480	483	PF01048	0.512
MOD_GlcNHglycan	497	500	PF01048	0.584
MOD_GlcNHglycan	539	542	PF01048	0.422
MOD_GSK3_1	283	290	PF00069	0.525
MOD_GSK3_1	293	300	PF00069	0.463
MOD_GSK3_1	316	323	PF00069	0.511
MOD_GSK3_1	331	338	PF00069	0.547
MOD_GSK3_1	401	408	PF00069	0.757
MOD_GSK3_1	415	422	PF00069	0.611
MOD_GSK3_1	48	55	PF00069	0.694
MOD_GSK3_1	488	495	PF00069	0.682
MOD_GSK3_1	551	558	PF00069	0.550
MOD_GSK3_1	560	567	PF00069	0.497
MOD_GSK3_1	571	578	PF00069	0.435
MOD_GSK3_1	84	91	PF00069	0.542
MOD_N-GLC_1	495	500	PF02516	0.694
MOD_N-GLC_1	509	514	PF02516	0.380
MOD_NEK2_1	162	167	PF00069	0.411
MOD_NEK2_1	179	184	PF00069	0.250
MOD_NEK2_1	236	241	PF00069	0.544
MOD_NEK2_1	271	276	PF00069	0.321
MOD_NEK2_1	293	298	PF00069	0.614
MOD_NEK2_1	344	349	PF00069	0.545
MOD_NEK2_1	471	476	PF00069	0.516
MOD_NEK2_1	509	514	PF00069	0.610
MOD_NEK2_1	531	536	PF00069	0.598
MOD_NEK2_2	204	209	PF00069	0.505
MOD_PIKK_1	127	133	PF00454	0.609
MOD_PIKK_1	293	299	PF00454	0.604
MOD_PIKK_1	384	390	PF00454	0.512
MOD_PIKK_1	52	58	PF00454	0.729
MOD_PKA_2	335	341	PF00069	0.578
MOD_PKA_2	347	353	PF00069	0.403
MOD_PKA_2	471	477	PF00069	0.494
MOD_PKA_2	501	507	PF00069	0.494
MOD_PKA_2	670	676	PF00069	0.300
MOD_Plk_1	271	277	PF00069	0.502
MOD_Plk_1	445	451	PF00069	0.550
MOD_Plk_1	531	537	PF00069	0.571
MOD_Plk_1	572	578	PF00069	0.507
MOD_Plk_1	617	623	PF00069	0.538
MOD_Plk_1	73	79	PF00069	0.443
MOD_Plk_4	107	113	PF00069	0.536
MOD_Plk_4	283	289	PF00069	0.494
MOD_Plk_4	324	330	PF00069	0.511
MOD_Plk_4	471	477	PF00069	0.489
MOD_Plk_4	488	494	PF00069	0.428
MOD_Plk_4	501	507	PF00069	0.483
MOD_Plk_4	509	515	PF00069	0.526
MOD_Plk_4	526	532	PF00069	0.312
MOD_Plk_4	617	623	PF00069	0.538
MOD_Plk_4	73	79	PF00069	0.443
MOD_ProDKin_1	27	33	PF00069	0.636
MOD_ProDKin_1	300	306	PF00069	0.435
MOD_ProDKin_1	336	342	PF00069	0.561
MOD_ProDKin_1	402	408	PF00069	0.531
MOD_ProDKin_1	555	561	PF00069	0.560
TRG_DiLeu_BaLyEn_6	654	659	PF01217	0.560
TRG_ENDOCYTIC_2	109	112	PF00928	0.547
TRG_ENDOCYTIC_2	193	196	PF00928	0.521
TRG_ENDOCYTIC_2	288	291	PF00928	0.628
TRG_ENDOCYTIC_2	310	313	PF00928	0.526
TRG_ENDOCYTIC_2	377	380	PF00928	0.404
TRG_ENDOCYTIC_2	536	539	PF00928	0.456
TRG_ENDOCYTIC_2	584	587	PF00928	0.485
TRG_ENDOCYTIC_2	592	595	PF00928	0.475
TRG_ER_diArg_1	240	242	PF00400	0.609
TRG_ER_diArg_1	252	255	PF00400	0.384
TRG_ER_diArg_1	257	259	PF00400	0.293
TRG_ER_diArg_1	351	354	PF00400	0.575
TRG_ER_diArg_1	552	555	PF00400	0.590
TRG_ER_diArg_1	606	609	PF00400	0.360
TRG_ER_FFAT_2	522	529	PF00635	0.505
TRG_NLS_Bipartite_1	607	627	PF00514	0.303
TRG_NLS_MonoExtN_4	606	611	PF00514	0.315
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E7	Leptomonas seymouri	44%	69%
A0A3S7WX75	Leishmania donovani	74%	97%
A4HZX1	Leishmania infantum	74%	97%
C9ZSK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AVT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	96%
Q4QBP9	Leishmania major	75%	100%
V5DMK2	Trypanosoma cruzi	27%	100%