UAA transporter family-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-galactose transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HCB7_LEIBR

TriTrypDb:

LbrM.22.0910 , LBRM2903_220014800

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HCB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCB7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0009987	cellular process	1	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0055085	transmembrane transport	2	11
GO:0006811	monoatomic ion transport	4	1
GO:0006820	monoatomic anion transport	5	1
GO:0015711	organic anion transport	5	1
GO:0015780	nucleotide-sugar transmembrane transport	3	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072334	UDP-galactose transmembrane transport	5	1
GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	4	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:1901264	carbohydrate derivative transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	1
GO:0005459	UDP-galactose transmembrane transporter activity	6	1
GO:0005460	UDP-glucose transmembrane transporter activity	6	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.459
CLV_NRD_NRD_1	134	136	PF00675	0.443
CLV_NRD_NRD_1	159	161	PF00675	0.459
CLV_NRD_NRD_1	408	410	PF00675	0.297
CLV_NRD_NRD_1	453	455	PF00675	0.301
CLV_NRD_NRD_1	489	491	PF00675	0.497
CLV_NRD_NRD_1	49	51	PF00675	0.662
CLV_PCSK_KEX2_1	104	106	PF00082	0.447
CLV_PCSK_KEX2_1	134	136	PF00082	0.445
CLV_PCSK_KEX2_1	159	161	PF00082	0.460
CLV_PCSK_KEX2_1	273	275	PF00082	0.282
CLV_PCSK_KEX2_1	453	455	PF00082	0.317
CLV_PCSK_KEX2_1	49	51	PF00082	0.651
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.282
CLV_PCSK_PC7_1	101	107	PF00082	0.282
CLV_PCSK_SKI1_1	135	139	PF00082	0.343
CLV_PCSK_SKI1_1	21	25	PF00082	0.513
CLV_PCSK_SKI1_1	475	479	PF00082	0.455
DEG_APCC_DBOX_1	134	142	PF00400	0.555
DEG_APCC_DBOX_1	284	292	PF00400	0.457
DEG_APCC_DBOX_1	474	482	PF00400	0.550
DEG_Nend_Nbox_1	1	3	PF02207	0.242
DEG_SCF_FBW7_2	495	502	PF00400	0.607
DEG_SPOP_SBC_1	485	489	PF00917	0.726
DOC_CYCLIN_yClb5_NLxxxL_5	283	292	PF00134	0.345
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.179
DOC_CYCLIN_yCln2_LP_2	348	354	PF00134	0.182
DOC_MAPK_gen_1	159	167	PF00069	0.270
DOC_MAPK_gen_1	170	180	PF00069	0.261
DOC_MAPK_gen_1	273	282	PF00069	0.534
DOC_MAPK_gen_1	409	416	PF00069	0.312
DOC_MAPK_gen_1	490	497	PF00069	0.709
DOC_MAPK_HePTP_8	167	179	PF00069	0.312
DOC_MAPK_MEF2A_6	170	179	PF00069	0.310
DOC_MAPK_MEF2A_6	276	284	PF00069	0.529
DOC_MAPK_MEF2A_6	409	418	PF00069	0.312
DOC_PP2B_LxvP_1	348	351	PF13499	0.182
DOC_PP2B_LxvP_1	59	62	PF13499	0.299
DOC_USP7_MATH_1	326	330	PF00917	0.312
DOC_USP7_MATH_1	42	46	PF00917	0.373
DOC_USP7_MATH_1	424	428	PF00917	0.359
DOC_USP7_MATH_1	483	487	PF00917	0.717
DOC_USP7_MATH_1	86	90	PF00917	0.406
DOC_WW_Pin1_4	495	500	PF00397	0.780
DOC_WW_Pin1_4	526	531	PF00397	0.749
LIG_14-3-3_CanoR_1	159	164	PF00244	0.312
LIG_14-3-3_CanoR_1	21	26	PF00244	0.324
LIG_14-3-3_CanoR_1	213	223	PF00244	0.318
LIG_14-3-3_CanoR_1	454	463	PF00244	0.501
LIG_14-3-3_CterR_2	533	538	PF00244	0.611
LIG_Actin_WH2_2	393	411	PF00022	0.331
LIG_AP2alpha_1	259	263	PF02296	0.204
LIG_APCC_ABBA_1	256	261	PF00400	0.204
LIG_BRCT_BRCA1_1	145	149	PF00533	0.457
LIG_BRCT_BRCA1_1	244	248	PF00533	0.261
LIG_Clathr_ClatBox_1	298	302	PF01394	0.312
LIG_deltaCOP1_diTrp_1	305	314	PF00928	0.339
LIG_FHA_1	199	205	PF00498	0.336
LIG_FHA_1	265	271	PF00498	0.473
LIG_FHA_1	284	290	PF00498	0.345
LIG_FHA_1	342	348	PF00498	0.299
LIG_FHA_1	391	397	PF00498	0.334
LIG_FHA_1	54	60	PF00498	0.411
LIG_FHA_1	78	84	PF00498	0.346
LIG_FHA_2	120	126	PF00498	0.590
LIG_FHA_2	128	134	PF00498	0.682
LIG_GBD_Chelix_1	83	91	PF00786	0.345
LIG_LIR_Gen_1	152	163	PF02991	0.354
LIG_LIR_Gen_1	305	314	PF02991	0.332
LIG_LIR_Gen_1	353	363	PF02991	0.313
LIG_LIR_Gen_1	427	438	PF02991	0.460
LIG_LIR_Gen_1	443	451	PF02991	0.423
LIG_LIR_Nem_3	305	311	PF02991	0.325
LIG_LIR_Nem_3	353	359	PF02991	0.291
LIG_LIR_Nem_3	360	365	PF02991	0.276
LIG_LIR_Nem_3	395	400	PF02991	0.331
LIG_LIR_Nem_3	427	433	PF02991	0.360
LIG_LIR_Nem_3	443	448	PF02991	0.404
LIG_NRBOX	296	302	PF00104	0.204
LIG_NRBOX	377	383	PF00104	0.457
LIG_PCNA_yPIPBox_3	96	106	PF02747	0.496
LIG_Pex14_1	310	314	PF04695	0.339
LIG_Pex14_2	145	149	PF04695	0.355
LIG_Pex14_2	259	263	PF04695	0.251
LIG_Pex14_2	299	303	PF04695	0.204
LIG_SH2_GRB2like	445	448	PF00017	0.500
LIG_SH2_NCK_1	479	483	PF00017	0.551
LIG_SH2_PTP2	445	448	PF00017	0.500
LIG_SH2_SRC	445	448	PF00017	0.500
LIG_SH2_STAP1	479	483	PF00017	0.551
LIG_SH2_STAT5	111	114	PF00017	0.546
LIG_SH2_STAT5	27	30	PF00017	0.371
LIG_SH2_STAT5	445	448	PF00017	0.500
LIG_SH2_STAT5	70	73	PF00017	0.427
LIG_SH3_3	524	530	PF00018	0.698
LIG_SH3_3	60	66	PF00018	0.473
LIG_SUMO_SIM_anti_2	375	380	PF11976	0.234
LIG_SUMO_SIM_par_1	162	168	PF11976	0.261
LIG_SUMO_SIM_par_1	398	403	PF11976	0.376
LIG_SUMO_SIM_par_1	493	498	PF11976	0.603
LIG_ULM_U2AF65_1	273	278	PF00076	0.534
LIG_WRC_WIRS_1	311	316	PF05994	0.339
LIG_WRC_WIRS_1	362	367	PF05994	0.182
MOD_CDK_SPxxK_3	526	533	PF00069	0.584
MOD_CK1_1	229	235	PF00069	0.331
MOD_CK1_1	242	248	PF00069	0.324
MOD_CK1_1	278	284	PF00069	0.482
MOD_CK1_1	37	43	PF00069	0.396
MOD_CK1_1	380	386	PF00069	0.403
MOD_CK1_1	486	492	PF00069	0.692
MOD_GlcNHglycan	277	280	PF01048	0.240
MOD_GlcNHglycan	330	333	PF01048	0.565
MOD_GlcNHglycan	382	385	PF01048	0.424
MOD_GlcNHglycan	88	91	PF01048	0.370
MOD_GSK3_1	189	196	PF00069	0.530
MOD_GSK3_1	226	233	PF00069	0.256
MOD_GSK3_1	239	246	PF00069	0.294
MOD_GSK3_1	283	290	PF00069	0.331
MOD_GSK3_1	29	36	PF00069	0.399
MOD_GSK3_1	357	364	PF00069	0.294
MOD_GSK3_1	392	399	PF00069	0.315
MOD_GSK3_1	410	417	PF00069	0.283
MOD_GSK3_1	481	488	PF00069	0.717
MOD_GSK3_1	493	500	PF00069	0.693
MOD_GSK3_1	75	82	PF00069	0.296
MOD_N-GLC_1	264	269	PF02516	0.273
MOD_N-GLC_2	9	11	PF02516	0.578
MOD_NEK2_1	112	117	PF00069	0.759
MOD_NEK2_1	143	148	PF00069	0.406
MOD_NEK2_1	149	154	PF00069	0.417
MOD_NEK2_1	198	203	PF00069	0.385
MOD_NEK2_1	263	268	PF00069	0.264
MOD_NEK2_1	283	288	PF00069	0.312
MOD_NEK2_1	328	333	PF00069	0.223
MOD_NEK2_1	34	39	PF00069	0.461
MOD_NEK2_1	377	382	PF00069	0.411
MOD_NEK2_1	400	405	PF00069	0.331
MOD_NEK2_1	79	84	PF00069	0.395
MOD_NEK2_2	13	18	PF00069	0.288
MOD_NEK2_2	70	75	PF00069	0.406
MOD_PIKK_1	21	27	PF00454	0.287
MOD_PIKK_1	264	270	PF00454	0.459
MOD_PIKK_1	77	83	PF00454	0.413
MOD_PK_1	410	416	PF00069	0.331
MOD_PKA_1	159	165	PF00069	0.339
MOD_PKA_2	159	165	PF00069	0.311
MOD_PKA_2	212	218	PF00069	0.293
MOD_PKA_2	275	281	PF00069	0.445
MOD_Plk_1	30	36	PF00069	0.379
MOD_Plk_1	357	363	PF00069	0.370
MOD_Plk_4	244	250	PF00069	0.275
MOD_Plk_4	278	284	PF00069	0.512
MOD_Plk_4	287	293	PF00069	0.303
MOD_Plk_4	361	367	PF00069	0.308
MOD_Plk_4	377	383	PF00069	0.318
MOD_Plk_4	403	409	PF00069	0.308
MOD_Plk_4	410	416	PF00069	0.312
MOD_Plk_4	70	76	PF00069	0.326
MOD_Plk_4	94	100	PF00069	0.530
MOD_ProDKin_1	495	501	PF00069	0.778
MOD_ProDKin_1	526	532	PF00069	0.753
MOD_SUMO_for_1	17	20	PF00179	0.281
TRG_ENDOCYTIC_2	155	158	PF00928	0.319
TRG_ENDOCYTIC_2	445	448	PF00928	0.500
TRG_ER_diArg_1	103	106	PF00400	0.642
TRG_ER_diArg_1	158	160	PF00400	0.259
TRG_ER_diArg_1	185	188	PF00400	0.562
TRG_ER_diArg_1	274	277	PF00400	0.562
TRG_ER_diLys_1	535	538	PF00400	0.779
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F6	Leptomonas seymouri	52%	100%
A0A0S4KJY1	Bodo saltans	36%	100%
A0A1X0NV21	Trypanosomatidae	38%	100%
A0A3Q8IBG5	Leishmania donovani	69%	92%
A0A422N3L8	Trypanosoma rangeli	38%	100%
A4HZX4	Leishmania infantum	69%	92%
C9ZSL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AVT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	91%
P0CP32	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CP33	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
Q4QBP6	Leishmania major	69%	100%
Q6C4X5	Yarrowia lipolytica (strain CLIB 122 / E 150)	23%	100%