EngB-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania braziliensis

UniProt:

A4HCB6_LEIBR

TriTrypDb:

LbrM.22.0650 , LBRM2903_220012000

Length:

1000

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCB6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0005488	binding	1	13
GO:0005525	GTP binding	5	13
GO:0017076	purine nucleotide binding	4	13
GO:0019001	guanyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032561	guanyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003676	nucleic acid binding	3	2
GO:0003746	translation elongation factor activity	4	2
GO:0008135	translation factor activity, RNA binding	3	2
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.541
CLV_C14_Caspase3-7	432	436	PF00656	0.458
CLV_C14_Caspase3-7	595	599	PF00656	0.728
CLV_C14_Caspase3-7	678	682	PF00656	0.682
CLV_NRD_NRD_1	110	112	PF00675	0.575
CLV_NRD_NRD_1	230	232	PF00675	0.531
CLV_NRD_NRD_1	286	288	PF00675	0.341
CLV_NRD_NRD_1	354	356	PF00675	0.297
CLV_NRD_NRD_1	418	420	PF00675	0.486
CLV_NRD_NRD_1	421	423	PF00675	0.479
CLV_NRD_NRD_1	524	526	PF00675	0.822
CLV_NRD_NRD_1	60	62	PF00675	0.838
CLV_NRD_NRD_1	621	623	PF00675	0.605
CLV_NRD_NRD_1	624	626	PF00675	0.589
CLV_NRD_NRD_1	632	634	PF00675	0.595
CLV_NRD_NRD_1	819	821	PF00675	0.658
CLV_NRD_NRD_1	826	828	PF00675	0.651
CLV_NRD_NRD_1	865	867	PF00675	0.598
CLV_NRD_NRD_1	895	897	PF00675	0.547
CLV_NRD_NRD_1	910	912	PF00675	0.560
CLV_PCSK_FUR_1	622	626	PF00082	0.623
CLV_PCSK_FUR_1	824	828	PF00082	0.716
CLV_PCSK_KEX2_1	109	111	PF00082	0.568
CLV_PCSK_KEX2_1	229	231	PF00082	0.541
CLV_PCSK_KEX2_1	354	356	PF00082	0.300
CLV_PCSK_KEX2_1	418	420	PF00082	0.454
CLV_PCSK_KEX2_1	526	528	PF00082	0.766
CLV_PCSK_KEX2_1	59	61	PF00082	0.848
CLV_PCSK_KEX2_1	621	623	PF00082	0.583
CLV_PCSK_KEX2_1	624	626	PF00082	0.571
CLV_PCSK_KEX2_1	632	634	PF00082	0.582
CLV_PCSK_KEX2_1	819	821	PF00082	0.637
CLV_PCSK_KEX2_1	826	828	PF00082	0.629
CLV_PCSK_KEX2_1	865	867	PF00082	0.595
CLV_PCSK_KEX2_1	895	897	PF00082	0.571
CLV_PCSK_KEX2_1	976	978	PF00082	0.647
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.635
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.556
CLV_PCSK_PC1ET2_1	976	978	PF00082	0.647
CLV_PCSK_SKI1_1	111	115	PF00082	0.572
CLV_PCSK_SKI1_1	152	156	PF00082	0.502
CLV_PCSK_SKI1_1	214	218	PF00082	0.794
CLV_PCSK_SKI1_1	368	372	PF00082	0.300
CLV_PCSK_SKI1_1	422	426	PF00082	0.460
CLV_PCSK_SKI1_1	459	463	PF00082	0.576
CLV_PCSK_SKI1_1	465	469	PF00082	0.576
CLV_PCSK_SKI1_1	49	53	PF00082	0.518
CLV_PCSK_SKI1_1	572	576	PF00082	0.639
CLV_PCSK_SKI1_1	811	815	PF00082	0.546
CLV_PCSK_SKI1_1	876	880	PF00082	0.667
CLV_Separin_Metazoa	440	444	PF03568	0.489
DEG_APCC_DBOX_1	110	118	PF00400	0.580
DEG_Nend_UBRbox_2	1	3	PF02207	0.545
DEG_ODPH_VHL_1	17	28	PF01847	0.560
DEG_SPOP_SBC_1	277	281	PF00917	0.500
DOC_ANK_TNKS_1	753	760	PF00023	0.749
DOC_ANK_TNKS_1	967	974	PF00023	0.693
DOC_CKS1_1	28	33	PF01111	0.705
DOC_CKS1_1	985	990	PF01111	0.657
DOC_CYCLIN_RxL_1	871	883	PF00134	0.675
DOC_CYCLIN_yCln2_LP_2	131	134	PF00134	0.611
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.704
DOC_MAPK_DCC_7	130	139	PF00069	0.639
DOC_MAPK_gen_1	569	577	PF00069	0.679
DOC_MAPK_MEF2A_6	130	139	PF00069	0.615
DOC_PP1_RVXF_1	285	292	PF00149	0.500
DOC_PP1_RVXF_1	374	381	PF00149	0.598
DOC_PP1_RVXF_1	625	632	PF00149	0.598
DOC_PP2B_LxvP_1	131	134	PF13499	0.611
DOC_PP2B_LxvP_1	204	207	PF13499	0.789
DOC_PP2B_LxvP_1	659	662	PF13499	0.534
DOC_PP4_FxxP_1	427	430	PF00568	0.446
DOC_PP4_MxPP_1	1	4	PF00568	0.547
DOC_USP7_MATH_1	11	15	PF00917	0.757
DOC_USP7_MATH_1	196	200	PF00917	0.772
DOC_USP7_MATH_1	262	266	PF00917	0.500
DOC_USP7_MATH_1	277	281	PF00917	0.500
DOC_USP7_MATH_1	43	47	PF00917	0.688
DOC_USP7_MATH_1	542	546	PF00917	0.734
DOC_USP7_MATH_1	576	580	PF00917	0.741
DOC_USP7_MATH_1	608	612	PF00917	0.792
DOC_USP7_MATH_1	733	737	PF00917	0.770
DOC_USP7_MATH_1	74	78	PF00917	0.762
DOC_USP7_MATH_1	747	751	PF00917	0.485
DOC_USP7_MATH_1	773	777	PF00917	0.751
DOC_USP7_UBL2_3	372	376	PF12436	0.572
DOC_USP7_UBL2_3	416	420	PF12436	0.468
DOC_USP7_UBL2_3	817	821	PF12436	0.549
DOC_WW_Pin1_4	192	197	PF00397	0.757
DOC_WW_Pin1_4	209	214	PF00397	0.749
DOC_WW_Pin1_4	27	32	PF00397	0.707
DOC_WW_Pin1_4	293	298	PF00397	0.475
DOC_WW_Pin1_4	638	643	PF00397	0.743
DOC_WW_Pin1_4	653	658	PF00397	0.745
DOC_WW_Pin1_4	783	788	PF00397	0.640
DOC_WW_Pin1_4	880	885	PF00397	0.482
DOC_WW_Pin1_4	945	950	PF00397	0.484
DOC_WW_Pin1_4	984	989	PF00397	0.655
LIG_14-3-3_CanoR_1	168	176	PF00244	0.756
LIG_14-3-3_CanoR_1	186	196	PF00244	0.761
LIG_14-3-3_CanoR_1	287	292	PF00244	0.500
LIG_14-3-3_CanoR_1	354	358	PF00244	0.500
LIG_14-3-3_CanoR_1	402	407	PF00244	0.434
LIG_14-3-3_CanoR_1	443	453	PF00244	0.574
LIG_14-3-3_CanoR_1	61	71	PF00244	0.717
LIG_14-3-3_CanoR_1	754	758	PF00244	0.748
LIG_14-3-3_CanoR_1	789	796	PF00244	0.774
LIG_14-3-3_CanoR_1	924	930	PF00244	0.683
LIG_APCC_ABBA_1	690	695	PF00400	0.693
LIG_APCC_Cbox_1	626	632	PF00515	0.653
LIG_BIR_III_2	654	658	PF00653	0.519
LIG_BIR_III_4	838	842	PF00653	0.692
LIG_DLG_GKlike_1	287	295	PF00625	0.500
LIG_eIF4E_1	251	257	PF01652	0.230
LIG_EVH1_2	135	139	PF00568	0.633
LIG_FHA_1	156	162	PF00498	0.713
LIG_FHA_1	284	290	PF00498	0.500
LIG_FHA_1	385	391	PF00498	0.484
LIG_FHA_1	447	453	PF00498	0.518
LIG_FHA_1	601	607	PF00498	0.636
LIG_FHA_1	63	69	PF00498	0.838
LIG_FHA_1	654	660	PF00498	0.730
LIG_FHA_1	783	789	PF00498	0.758
LIG_FHA_1	791	797	PF00498	0.583
LIG_FHA_1	960	966	PF00498	0.608
LIG_FHA_1	985	991	PF00498	0.652
LIG_FHA_2	20	26	PF00498	0.698
LIG_FHA_2	321	327	PF00498	0.500
LIG_FHA_2	369	375	PF00498	0.500
LIG_FHA_2	391	397	PF00498	0.512
LIG_FHA_2	435	441	PF00498	0.461
LIG_FHA_2	538	544	PF00498	0.761
LIG_FHA_2	65	71	PF00498	0.721
LIG_FHA_2	676	682	PF00498	0.659
LIG_FHA_2	857	863	PF00498	0.674
LIG_LIR_Apic_2	76	82	PF02991	0.652
LIG_LIR_Apic_2	982	988	PF02991	0.643
LIG_LIR_Gen_1	158	165	PF02991	0.778
LIG_LIR_Gen_1	248	257	PF02991	0.461
LIG_LIR_Gen_1	290	300	PF02991	0.500
LIG_LIR_Gen_1	323	332	PF02991	0.500
LIG_LIR_Gen_1	387	396	PF02991	0.484
LIG_LIR_Gen_1	468	475	PF02991	0.445
LIG_LIR_Gen_1	641	651	PF02991	0.738
LIG_LIR_Gen_1	797	806	PF02991	0.668
LIG_LIR_Gen_1	885	894	PF02991	0.547
LIG_LIR_Gen_1	926	936	PF02991	0.586
LIG_LIR_Nem_3	138	142	PF02991	0.608
LIG_LIR_Nem_3	158	162	PF02991	0.447
LIG_LIR_Nem_3	248	254	PF02991	0.494
LIG_LIR_Nem_3	290	295	PF02991	0.500
LIG_LIR_Nem_3	323	327	PF02991	0.518
LIG_LIR_Nem_3	347	353	PF02991	0.500
LIG_LIR_Nem_3	387	392	PF02991	0.484
LIG_LIR_Nem_3	641	647	PF02991	0.662
LIG_LIR_Nem_3	797	802	PF02991	0.595
LIG_LIR_Nem_3	885	891	PF02991	0.575
LIG_LIR_Nem_3	926	932	PF02991	0.585
LIG_MYND_1	854	858	PF01753	0.461
LIG_NRBOX	267	273	PF00104	0.500
LIG_NRBOX	457	463	PF00104	0.633
LIG_NRBOX	874	880	PF00104	0.673
LIG_SH2_CRK	159	163	PF00017	0.664
LIG_SH2_CRK	292	296	PF00017	0.500
LIG_SH2_CRK	411	415	PF00017	0.435
LIG_SH2_CRK	421	425	PF00017	0.465
LIG_SH2_CRK	644	648	PF00017	0.740
LIG_SH2_GRB2like	941	944	PF00017	0.599
LIG_SH2_NCK_1	411	415	PF00017	0.435
LIG_SH2_NCK_1	79	83	PF00017	0.540
LIG_SH2_PTP2	573	576	PF00017	0.751
LIG_SH2_SRC	251	254	PF00017	0.470
LIG_SH2_SRC	79	82	PF00017	0.545
LIG_SH2_STAT3	806	809	PF00017	0.702
LIG_SH2_STAT5	125	128	PF00017	0.615
LIG_SH2_STAT5	243	246	PF00017	0.629
LIG_SH2_STAT5	350	353	PF00017	0.500
LIG_SH2_STAT5	362	365	PF00017	0.500
LIG_SH2_STAT5	377	380	PF00017	0.432
LIG_SH2_STAT5	495	498	PF00017	0.603
LIG_SH2_STAT5	573	576	PF00017	0.676
LIG_SH2_STAT5	918	921	PF00017	0.559
LIG_SH3_1	130	136	PF00018	0.609
LIG_SH3_1	881	887	PF00018	0.648
LIG_SH3_2	784	789	PF14604	0.540
LIG_SH3_3	129	135	PF00018	0.626
LIG_SH3_3	310	316	PF00018	0.500
LIG_SH3_3	322	328	PF00018	0.500
LIG_SH3_3	65	71	PF00018	0.706
LIG_SH3_3	693	699	PF00018	0.531
LIG_SH3_3	781	787	PF00018	0.807
LIG_SH3_3	848	854	PF00018	0.708
LIG_SH3_3	881	887	PF00018	0.549
LIG_SUMO_SIM_anti_2	170	180	PF11976	0.529
LIG_SUMO_SIM_anti_2	253	258	PF11976	0.412
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.590
LIG_SUMO_SIM_par_1	90	97	PF11976	0.590
LIG_TRAF2_1	73	76	PF00917	0.560
MOD_CDC14_SPxK_1	786	789	PF00782	0.536
MOD_CDK_SPK_2	209	214	PF00069	0.524
MOD_CDK_SPK_2	984	989	PF00069	0.626
MOD_CDK_SPxK_1	783	789	PF00069	0.790
MOD_CDK_SPxxK_3	945	952	PF00069	0.493
MOD_CK1_1	195	201	PF00069	0.656
MOD_CK1_1	209	215	PF00069	0.751
MOD_CK1_1	356	362	PF00069	0.500
MOD_CK1_1	592	598	PF00069	0.607
MOD_CK1_1	736	742	PF00069	0.746
MOD_CK2_1	195	201	PF00069	0.784
MOD_CK2_1	41	47	PF00069	0.714
MOD_CK2_1	434	440	PF00069	0.464
MOD_CK2_1	537	543	PF00069	0.764
MOD_CK2_1	64	70	PF00069	0.724
MOD_CK2_1	991	997	PF00069	0.794
MOD_Cter_Amidation	619	622	PF01082	0.641
MOD_GlcNHglycan	43	46	PF01048	0.542
MOD_GlcNHglycan	431	434	PF01048	0.434
MOD_GlcNHglycan	448	452	PF01048	0.369
MOD_GlcNHglycan	505	508	PF01048	0.743
MOD_GlcNHglycan	521	524	PF01048	0.658
MOD_GlcNHglycan	528	532	PF01048	0.832
MOD_GlcNHglycan	533	536	PF01048	0.654
MOD_GlcNHglycan	539	543	PF01048	0.604
MOD_GlcNHglycan	544	547	PF01048	0.553
MOD_GlcNHglycan	561	564	PF01048	0.476
MOD_GlcNHglycan	578	581	PF01048	0.479
MOD_GlcNHglycan	670	673	PF01048	0.798
MOD_GlcNHglycan	774	778	PF01048	0.680
MOD_GlcNHglycan	814	817	PF01048	0.714
MOD_GlcNHglycan	837	842	PF01048	0.675
MOD_GlcNHglycan	843	846	PF01048	0.669
MOD_GSK3_1	192	199	PF00069	0.807
MOD_GSK3_1	278	285	PF00069	0.519
MOD_GSK3_1	287	294	PF00069	0.520
MOD_GSK3_1	390	397	PF00069	0.500
MOD_GSK3_1	398	405	PF00069	0.456
MOD_GSK3_1	515	522	PF00069	0.643
MOD_GSK3_1	527	534	PF00069	0.821
MOD_GSK3_1	538	545	PF00069	0.808
MOD_GSK3_1	588	595	PF00069	0.746
MOD_GSK3_1	636	643	PF00069	0.731
MOD_GSK3_1	7	14	PF00069	0.713
MOD_GSK3_1	758	765	PF00069	0.763
MOD_GSK3_1	790	797	PF00069	0.596
MOD_GSK3_1	837	844	PF00069	0.640
MOD_GSK3_1	93	100	PF00069	0.688
MOD_GSK3_1	980	987	PF00069	0.633
MOD_GSK3_1	991	998	PF00069	0.660
MOD_LATS_1	400	406	PF00433	0.450
MOD_N-GLC_1	283	288	PF02516	0.300
MOD_N-GLC_1	942	947	PF02516	0.593
MOD_N-GLC_1	959	964	PF02516	0.597
MOD_NEK2_1	155	160	PF00069	0.684
MOD_NEK2_1	177	182	PF00069	0.642
MOD_NEK2_1	291	296	PF00069	0.517
MOD_NEK2_1	320	325	PF00069	0.541
MOD_NEK2_1	487	492	PF00069	0.577
MOD_NEK2_1	496	501	PF00069	0.567
MOD_NEK2_1	503	508	PF00069	0.591
MOD_NEK2_1	589	594	PF00069	0.699
MOD_NEK2_1	894	899	PF00069	0.499
MOD_NEK2_1	942	947	PF00069	0.593
MOD_NEK2_1	959	964	PF00069	0.597
MOD_NEK2_2	733	738	PF00069	0.531
MOD_NEK2_2	74	79	PF00069	0.558
MOD_PIKK_1	487	493	PF00454	0.471
MOD_PIKK_1	49	55	PF00454	0.525
MOD_PIKK_1	717	723	PF00454	0.555
MOD_PIKK_1	950	956	PF00454	0.633
MOD_PK_1	394	400	PF00069	0.443
MOD_PK_1	402	408	PF00069	0.441
MOD_PKA_1	287	293	PF00069	0.541
MOD_PKA_1	465	471	PF00069	0.448
MOD_PKA_2	167	173	PF00069	0.755
MOD_PKA_2	353	359	PF00069	0.500
MOD_PKA_2	519	525	PF00069	0.721
MOD_PKA_2	725	731	PF00069	0.784
MOD_PKA_2	753	759	PF00069	0.746
MOD_PKA_2	841	847	PF00069	0.690
MOD_PKA_2	894	900	PF00069	0.605
MOD_PKA_2	923	929	PF00069	0.650
MOD_PKB_1	525	533	PF00069	0.818
MOD_PKB_1	673	681	PF00069	0.762
MOD_Plk_1	123	129	PF00069	0.617
MOD_Plk_1	609	615	PF00069	0.737
MOD_Plk_1	74	80	PF00069	0.556
MOD_Plk_1	773	779	PF00069	0.625
MOD_Plk_1	902	908	PF00069	0.704
MOD_Plk_4	157	163	PF00069	0.656
MOD_Plk_4	263	269	PF00069	0.500
MOD_Plk_4	30	36	PF00069	0.697
MOD_Plk_4	320	326	PF00069	0.500
MOD_Plk_4	356	362	PF00069	0.500
MOD_Plk_4	402	408	PF00069	0.463
MOD_Plk_4	739	745	PF00069	0.590
MOD_Plk_4	74	80	PF00069	0.556
MOD_Plk_4	753	759	PF00069	0.633
MOD_Plk_4	874	880	PF00069	0.644
MOD_Plk_4	980	986	PF00069	0.631
MOD_ProDKin_1	192	198	PF00069	0.755
MOD_ProDKin_1	209	215	PF00069	0.751
MOD_ProDKin_1	27	33	PF00069	0.706
MOD_ProDKin_1	293	299	PF00069	0.475
MOD_ProDKin_1	638	644	PF00069	0.745
MOD_ProDKin_1	653	659	PF00069	0.748
MOD_ProDKin_1	783	789	PF00069	0.640
MOD_ProDKin_1	880	886	PF00069	0.480
MOD_ProDKin_1	945	951	PF00069	0.488
MOD_ProDKin_1	984	990	PF00069	0.655
TRG_DiLeu_BaEn_1	585	590	PF01217	0.731
TRG_DiLeu_BaEn_4	144	150	PF01217	0.563
TRG_ENDOCYTIC_2	159	162	PF00928	0.659
TRG_ENDOCYTIC_2	251	254	PF00928	0.437
TRG_ENDOCYTIC_2	292	295	PF00928	0.500
TRG_ENDOCYTIC_2	350	353	PF00928	0.500
TRG_ENDOCYTIC_2	411	414	PF00928	0.415
TRG_ENDOCYTIC_2	421	424	PF00928	0.439
TRG_ENDOCYTIC_2	495	498	PF00928	0.623
TRG_ENDOCYTIC_2	644	647	PF00928	0.661
TRG_ENDOCYTIC_2	967	970	PF00928	0.598
TRG_ER_diArg_1	228	231	PF00400	0.673
TRG_ER_diArg_1	353	355	PF00400	0.500
TRG_ER_diArg_1	524	527	PF00400	0.560
TRG_ER_diArg_1	59	61	PF00400	0.701
TRG_ER_diArg_1	631	633	PF00400	0.658
TRG_ER_diArg_1	825	827	PF00400	0.674
TRG_ER_diArg_1	894	896	PF00400	0.639
TRG_NLS_MonoExtC_3	418	423	PF00514	0.445
TRG_NLS_MonoExtN_4	416	423	PF00514	0.445
TRG_Pf-PMV_PEXEL_1	443	448	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH8	Leptomonas seymouri	56%	85%
A0A3Q8IC70	Leishmania donovani	81%	100%
A0A3R7NJM0	Trypanosoma rangeli	44%	100%
A0A3S7WX68	Leishmania donovani	80%	85%
A4HZV0	Leishmania infantum	81%	100%
C9ZSF9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AVQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	88%
E9AVR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QBR5	Leishmania major	80%	100%
Q4QBS5	Leishmania major	80%	100%
V5BVT0	Trypanosoma cruzi	43%	100%