Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCB5_LEIBR

TriTrypDb:

LbrM.22.0640 , LBRM2903_220011900

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCB5

PDB structure(s): 7ane_an

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.647
CLV_NRD_NRD_1	179	181	PF00675	0.493
CLV_NRD_NRD_1	20	22	PF00675	0.441
CLV_NRD_NRD_1	243	245	PF00675	0.451
CLV_NRD_NRD_1	5	7	PF00675	0.351
CLV_PCSK_KEX2_1	150	152	PF00082	0.647
CLV_PCSK_KEX2_1	178	180	PF00082	0.509
CLV_PCSK_KEX2_1	20	22	PF00082	0.441
CLV_PCSK_KEX2_1	5	7	PF00082	0.351
CLV_PCSK_KEX2_1	71	73	PF00082	0.392
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.392
CLV_PCSK_SKI1_1	115	119	PF00082	0.379
CLV_PCSK_SKI1_1	12	16	PF00082	0.401
CLV_PCSK_SKI1_1	89	93	PF00082	0.458
DEG_Nend_UBRbox_2	1	3	PF02207	0.382
DEG_SCF_FBW7_2	233	239	PF00400	0.423
DOC_CKS1_1	233	238	PF01111	0.429
DOC_CKS1_1	63	68	PF01111	0.337
DOC_CYCLIN_RxL_1	221	229	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.377
DOC_MAPK_gen_1	119	128	PF00069	0.272
DOC_MAPK_JIP1_4	122	128	PF00069	0.450
DOC_MAPK_MEF2A_6	119	128	PF00069	0.392
DOC_PP2B_LxvP_1	230	233	PF13499	0.365
DOC_USP7_UBL2_3	115	119	PF12436	0.336
DOC_WW_Pin1_4	232	237	PF00397	0.424
DOC_WW_Pin1_4	62	67	PF00397	0.331
DOC_WW_Pin1_4	80	85	PF00397	0.401
LIG_14-3-3_CanoR_1	195	201	PF00244	0.485
LIG_14-3-3_CanoR_1	48	52	PF00244	0.499
LIG_Actin_WH2_2	56	73	PF00022	0.376
LIG_FHA_1	221	227	PF00498	0.515
LIG_FHA_2	134	140	PF00498	0.425
LIG_FHA_2	233	239	PF00498	0.391
LIG_LIR_Apic_2	133	138	PF02991	0.460
LIG_LIR_Gen_1	225	236	PF02991	0.535
LIG_LIR_Gen_1	25	36	PF02991	0.346
LIG_LIR_Nem_3	133	137	PF02991	0.397
LIG_LIR_Nem_3	2	7	PF02991	0.349
LIG_LIR_Nem_3	225	231	PF02991	0.546
LIG_LIR_Nem_3	25	31	PF02991	0.351
LIG_PTB_Apo_2	128	135	PF02174	0.387
LIG_PTB_Apo_2	34	41	PF02174	0.342
LIG_PTB_Phospho_1	34	40	PF10480	0.341
LIG_SH2_CRK	4	8	PF00017	0.330
LIG_SH2_NCK_1	135	139	PF00017	0.448
LIG_SH2_SRC	95	98	PF00017	0.385
LIG_SH2_STAP1	40	44	PF00017	0.345
LIG_SH2_STAT3	40	43	PF00017	0.344
LIG_SH2_STAT5	135	138	PF00017	0.411
LIG_SH2_STAT5	205	208	PF00017	0.418
LIG_SH2_STAT5	234	237	PF00017	0.404
LIG_SH2_STAT5	34	37	PF00017	0.360
LIG_SH3_3	230	236	PF00018	0.451
MOD_CK1_1	259	265	PF00069	0.504
MOD_CK2_1	133	139	PF00069	0.421
MOD_NEK2_2	196	201	PF00069	0.410
MOD_PKA_2	47	53	PF00069	0.487
MOD_Plk_2-3	133	139	PF00069	0.404
MOD_Plk_2-3	152	158	PF00069	0.553
MOD_Plk_4	256	262	PF00069	0.509
MOD_Plk_4	47	53	PF00069	0.487
MOD_ProDKin_1	232	238	PF00069	0.418
MOD_ProDKin_1	62	68	PF00069	0.333
MOD_ProDKin_1	80	86	PF00069	0.399
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.359
TRG_ENDOCYTIC_2	114	117	PF00928	0.349
TRG_ENDOCYTIC_2	234	237	PF00928	0.388
TRG_ENDOCYTIC_2	4	7	PF00928	0.338
TRG_ER_diArg_1	149	151	PF00400	0.607
TRG_ER_diArg_1	177	180	PF00400	0.445
TRG_ER_diArg_1	20	22	PF00400	0.443
TRG_ER_diArg_1	213	216	PF00400	0.464
TRG_ER_diArg_1	4	6	PF00400	0.347
TRG_ER_diArg_1	72	75	PF00400	0.395
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	224	229	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB7	Leptomonas seymouri	84%	100%
A0A0S4IJG6	Bodo saltans	60%	91%
A0A1X0NT90	Trypanosomatidae	71%	97%
A0A381MHF5	Leishmania infantum	93%	98%
A0A3Q8IAP3	Leishmania donovani	93%	98%
A0A3S7WX26	Leishmania donovani	93%	98%
A0A422NDI7	Trypanosoma rangeli	75%	100%
C9ZSF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AVQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	80%
Q4QBR4	Leishmania major	93%	100%
V5DMI7	Trypanosoma cruzi	73%	88%