LeishMANIAdb
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Prefoldin 5-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Prefoldin 5-like protein
Gene product:
prefoldin 5-like protein
Species:
Leishmania braziliensis
UniProt:
A4HCB2_LEIBR
TriTrypDb:
LbrM.22.0600 , LBRM2903_240009900
Length:
157

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016272 prefoldin complex 2 11
GO:0032991 protein-containing complex 1 11
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HCB2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCB2

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 11
GO:0009987 cellular process 1 11
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0051082 unfolded protein binding 3 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 18 22 PF00656 0.489
CLV_PCSK_SKI1_1 106 110 PF00082 0.344
LIG_BIR_II_1 1 5 PF00653 0.540
LIG_BRCT_BRCA1_1 72 76 PF00533 0.551
LIG_FHA_1 123 129 PF00498 0.551
LIG_FHA_1 70 76 PF00498 0.511
LIG_Integrin_isoDGR_2 36 38 PF01839 0.511
LIG_SH2_CRK 31 35 PF00017 0.426
LIG_SH2_CRK 51 55 PF00017 0.329
LIG_SH2_CRK 6 10 PF00017 0.524
LIG_SH2_STAT5 107 110 PF00017 0.454
LIG_SH2_STAT5 95 98 PF00017 0.485
LIG_SUMO_SIM_par_1 87 93 PF11976 0.455
LIG_TRAF2_1 63 66 PF00917 0.522
LIG_TYR_ITIM 49 54 PF00017 0.313
MOD_GSK3_1 77 84 PF00069 0.551
MOD_NEK2_1 71 76 PF00069 0.478
MOD_PKA_2 77 83 PF00069 0.563
MOD_Plk_1 122 128 PF00069 0.551
MOD_Plk_1 97 103 PF00069 0.539
MOD_Plk_4 122 128 PF00069 0.546
MOD_Plk_4 71 77 PF00069 0.511
TRG_ENDOCYTIC_2 31 34 PF00928 0.399
TRG_ENDOCYTIC_2 51 54 PF00928 0.397
TRG_ER_diArg_1 38 41 PF00400 0.457

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJL6 Leptomonas seymouri 80% 100%
A0A0S4IRG2 Bodo saltans 50% 100%
A0A1X0NUY3 Trypanosomatidae 42% 91%
A0A3S7WX60 Leishmania donovani 90% 100%
A0A422NDH7 Trypanosoma rangeli 41% 95%
A4HZU4 Leishmania infantum 90% 100%
C9ZSF4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 92%
E9AVP9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
O94307 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
P57742 Arabidopsis thaliana 34% 100%
Q04493 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 96%
Q21993 Caenorhabditis elegans 24% 100%
Q4QBT0 Leishmania major 89% 100%
Q54V55 Dictyostelium discoideum 25% 98%
Q5RAY0 Pongo abelii 34% 100%
Q8HYI9 Bos taurus 33% 100%
Q99471 Homo sapiens 34% 100%
Q9VCZ8 Drosophila melanogaster 28% 93%
Q9WU28 Mus musculus 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS