LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

3'a2rel-related protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
3'a2rel-related protein
Gene product:
3'a2rel-related protein
Species:
Leishmania braziliensis
UniProt:
A4HCB1_LEIBR
TriTrypDb:
LbrM.24.0460 * , LBRM2903_240009700 *
Length:
454

Annotations

LeishMANIAdb annotations

A very special family of kinetoplastid proteins, carrying multiply amyloid-like segments on their disordered extracellular domain, alongside with RGD motifs. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 4, no: 6
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4HCB1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCB1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 366 370 PF00656 0.784
CLV_NRD_NRD_1 1 3 PF00675 0.781
CLV_NRD_NRD_1 160 162 PF00675 0.439
CLV_NRD_NRD_1 165 167 PF00675 0.456
CLV_NRD_NRD_1 44 46 PF00675 0.674
CLV_NRD_NRD_1 450 452 PF00675 0.458
CLV_NRD_NRD_1 75 77 PF00675 0.373
CLV_PCSK_FUR_1 163 167 PF00082 0.448
CLV_PCSK_KEX2_1 1 3 PF00082 0.781
CLV_PCSK_KEX2_1 162 164 PF00082 0.453
CLV_PCSK_KEX2_1 165 167 PF00082 0.465
CLV_PCSK_KEX2_1 44 46 PF00082 0.674
CLV_PCSK_KEX2_1 450 452 PF00082 0.458
CLV_PCSK_KEX2_1 49 51 PF00082 0.591
CLV_PCSK_KEX2_1 75 77 PF00082 0.373
CLV_PCSK_PC1ET2_1 162 164 PF00082 0.431
CLV_PCSK_PC1ET2_1 49 51 PF00082 0.536
CLV_PCSK_PC7_1 161 167 PF00082 0.434
CLV_PCSK_PC7_1 446 452 PF00082 0.452
CLV_PCSK_PC7_1 45 51 PF00082 0.552
CLV_PCSK_SKI1_1 289 293 PF00082 0.455
CLV_PCSK_SKI1_1 50 54 PF00082 0.571
DEG_APCC_DBOX_1 49 57 PF00400 0.371
DEG_Nend_UBRbox_1 1 3 PF02207 0.402
DOC_CDC14_PxL_1 271 279 PF14671 0.625
DOC_CYCLIN_RxL_1 78 91 PF00134 0.716
DOC_CYCLIN_yCln2_LP_2 59 65 PF00134 0.443
DOC_MAPK_gen_1 159 169 PF00069 0.629
DOC_MAPK_gen_1 49 56 PF00069 0.285
DOC_MAPK_gen_1 80 88 PF00069 0.640
DOC_MAPK_RevD_3 31 45 PF00069 0.411
DOC_PP2B_LxvP_1 241 244 PF13499 0.628
DOC_PP2B_LxvP_1 309 312 PF13499 0.664
DOC_PP2B_LxvP_1 33 36 PF13499 0.417
DOC_PP2B_LxvP_1 377 380 PF13499 0.785
DOC_PP2B_LxvP_1 59 62 PF13499 0.443
DOC_PP2B_PxIxI_1 61 67 PF00149 0.251
DOC_USP7_MATH_1 12 16 PF00917 0.441
DOC_USP7_MATH_1 126 130 PF00917 0.650
DOC_USP7_MATH_1 200 204 PF00917 0.672
DOC_USP7_MATH_1 230 234 PF00917 0.776
DOC_USP7_MATH_1 251 255 PF00917 0.733
DOC_USP7_MATH_1 257 261 PF00917 0.672
DOC_USP7_MATH_1 265 269 PF00917 0.667
DOC_USP7_MATH_1 278 282 PF00917 0.618
DOC_USP7_MATH_1 3 7 PF00917 0.508
DOC_USP7_MATH_1 318 322 PF00917 0.773
DOC_USP7_MATH_1 449 453 PF00917 0.655
DOC_WW_Pin1_4 174 179 PF00397 0.653
DOC_WW_Pin1_4 425 430 PF00397 0.663
DOC_WW_Pin1_4 43 48 PF00397 0.396
LIG_14-3-3_CanoR_1 181 190 PF00244 0.639
LIG_14-3-3_CanoR_1 4 10 PF00244 0.446
LIG_14-3-3_CanoR_1 450 454 PF00244 0.679
LIG_BRCT_BRCA1_1 280 284 PF00533 0.600
LIG_BRCT_BRCA1_1 5 9 PF00533 0.430
LIG_CtBP_PxDLS_1 30 34 PF00389 0.411
LIG_FHA_1 177 183 PF00498 0.646
LIG_FHA_1 237 243 PF00498 0.768
LIG_FHA_1 285 291 PF00498 0.651
LIG_FHA_1 317 323 PF00498 0.715
LIG_FHA_1 46 52 PF00498 0.349
LIG_FHA_2 221 227 PF00498 0.640
LIG_Integrin_RGD_1 364 366 PF01839 0.587
LIG_LIR_Gen_1 110 118 PF02991 0.659
LIG_LIR_Gen_1 338 348 PF02991 0.663
LIG_LIR_Gen_1 403 412 PF02991 0.656
LIG_LIR_Nem_3 110 114 PF02991 0.654
LIG_LIR_Nem_3 145 151 PF02991 0.610
LIG_LIR_Nem_3 192 197 PF02991 0.647
LIG_LIR_Nem_3 338 344 PF02991 0.671
LIG_LIR_Nem_3 403 409 PF02991 0.658
LIG_MLH1_MIPbox_1 280 284 PF16413 0.600
LIG_NRP_CendR_1 451 454 PF00754 0.458
LIG_SH2_GRB2like 283 286 PF00017 0.651
LIG_SH2_SRC 437 440 PF00017 0.700
LIG_SH2_STAP1 237 241 PF00017 0.625
LIG_SH2_STAT5 283 286 PF00017 0.651
LIG_SH2_STAT5 437 440 PF00017 0.700
LIG_SH3_3 270 276 PF00018 0.620
LIG_SH3_3 368 374 PF00018 0.666
LIG_SUMO_SIM_anti_2 15 23 PF11976 0.532
LIG_SUMO_SIM_anti_2 268 275 PF11976 0.630
LIG_SUMO_SIM_par_1 15 23 PF11976 0.467
LIG_SUMO_SIM_par_1 307 313 PF11976 0.662
LIG_TRAF2_1 208 211 PF00917 0.771
MOD_CDC14_SPxK_1 46 49 PF00782 0.354
MOD_CDK_SPxK_1 43 49 PF00069 0.374
MOD_CDK_SPxxK_3 174 181 PF00069 0.622
MOD_CDK_SPxxK_3 43 50 PF00069 0.375
MOD_CK1_1 134 140 PF00069 0.614
MOD_CK1_1 220 226 PF00069 0.644
MOD_CK1_1 269 275 PF00069 0.782
MOD_CK1_1 367 373 PF00069 0.774
MOD_CK1_1 433 439 PF00069 0.711
MOD_CK1_1 7 13 PF00069 0.497
MOD_CK2_1 204 210 PF00069 0.821
MOD_CK2_1 339 345 PF00069 0.593
MOD_GlcNHglycan 10 13 PF01048 0.706
MOD_GlcNHglycan 133 136 PF01048 0.462
MOD_GlcNHglycan 14 17 PF01048 0.650
MOD_GlcNHglycan 186 189 PF01048 0.524
MOD_GlcNHglycan 196 200 PF01048 0.491
MOD_GlcNHglycan 219 222 PF01048 0.602
MOD_GlcNHglycan 232 235 PF01048 0.579
MOD_GlcNHglycan 268 271 PF01048 0.479
MOD_GlcNHglycan 300 303 PF01048 0.502
MOD_GlcNHglycan 341 344 PF01048 0.472
MOD_GlcNHglycan 366 369 PF01048 0.618
MOD_GlcNHglycan 433 436 PF01048 0.534
MOD_GlcNHglycan 442 445 PF01048 0.486
MOD_GSK3_1 131 138 PF00069 0.610
MOD_GSK3_1 200 207 PF00069 0.801
MOD_GSK3_1 265 272 PF00069 0.713
MOD_GSK3_1 3 10 PF00069 0.522
MOD_GSK3_1 325 332 PF00069 0.755
MOD_GSK3_1 335 342 PF00069 0.671
MOD_LATS_1 362 368 PF00433 0.666
MOD_N-GLC_1 126 131 PF02516 0.441
MOD_N-GLC_1 183 188 PF02516 0.437
MOD_N-GLC_1 284 289 PF02516 0.443
MOD_N-GLC_1 298 303 PF02516 0.433
MOD_N-GLC_1 88 93 PF02516 0.465
MOD_NEK2_1 131 136 PF00069 0.606
MOD_NEK2_1 190 195 PF00069 0.630
MOD_NEK2_1 284 289 PF00069 0.648
MOD_NEK2_1 337 342 PF00069 0.616
MOD_NEK2_1 348 353 PF00069 0.572
MOD_NEK2_1 88 93 PF00069 0.671
MOD_NEK2_2 126 131 PF00069 0.609
MOD_NEK2_2 449 454 PF00069 0.656
MOD_PIKK_1 278 284 PF00454 0.605
MOD_PIKK_1 316 322 PF00454 0.733
MOD_PKA_2 278 284 PF00069 0.616
MOD_PKA_2 3 9 PF00069 0.394
MOD_PKA_2 74 80 PF00069 0.662
MOD_PKB_1 2 10 PF00069 0.395
MOD_Plk_1 126 132 PF00069 0.609
MOD_Plk_1 20 26 PF00069 0.444
MOD_Plk_2-3 110 116 PF00069 0.596
MOD_Plk_4 237 243 PF00069 0.761
MOD_Plk_4 433 439 PF00069 0.673
MOD_ProDKin_1 174 180 PF00069 0.657
MOD_ProDKin_1 425 431 PF00069 0.664
MOD_ProDKin_1 43 49 PF00069 0.392
MOD_SUMO_for_1 297 300 PF00179 0.625
TRG_ENDOCYTIC_2 341 344 PF00928 0.594
TRG_ER_diArg_1 1 4 PF00400 0.510
TRG_ER_diArg_1 121 124 PF00400 0.622
TRG_ER_diArg_1 163 166 PF00400 0.662
TRG_ER_diArg_1 449 451 PF00400 0.656
TRG_ER_diArg_1 75 78 PF00400 0.579
TRG_ER_diArg_1 79 82 PF00400 0.612
TRG_NLS_MonoExtC_3 160 165 PF00514 0.631
TRG_NLS_MonoExtN_4 159 166 PF00514 0.633

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVL8 Leptomonas seymouri 41% 93%
A0A3Q8ILH2 Leishmania donovani 63% 74%
A0A3S7WX43 Leishmania donovani 63% 74%
A4HDA2 Leishmania braziliensis 99% 73%
E9AGZ2 Leishmania infantum 62% 74%
E9AGZ3 Leishmania infantum 63% 74%
E9AVQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 76%
Q4QBR2 Leishmania major 63% 100%
Q4QBS8 Leishmania major 63% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS