Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guide RNA associated protein, GAP2, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HCA9_LEIBR

TriTrypDb:

LbrM.22.0580 , LBRM2903_220011400

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HCA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCA9

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	2
GO:0000963	mitochondrial RNA processing	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	2
GO:0010467	gene expression	4	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0140053	mitochondrial gene expression	5	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.545
CLV_NRD_NRD_1	118	120	PF00675	0.508
CLV_NRD_NRD_1	316	318	PF00675	0.538
CLV_PCSK_KEX2_1	118	120	PF00082	0.563
CLV_PCSK_KEX2_1	329	331	PF00082	0.455
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.463
CLV_PCSK_SKI1_1	260	264	PF00082	0.450
CLV_PCSK_SKI1_1	329	333	PF00082	0.544
CLV_PCSK_SKI1_1	369	373	PF00082	0.384
CLV_PCSK_SKI1_1	70	74	PF00082	0.466
CLV_PCSK_SKI1_1	97	101	PF00082	0.522
DEG_APCC_DBOX_1	96	104	PF00400	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.450
DEG_SPOP_SBC_1	204	208	PF00917	0.588
DOC_CKS1_1	262	267	PF01111	0.393
DOC_CYCLIN_RxL_1	257	264	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.390
DOC_MAPK_gen_1	329	339	PF00069	0.414
DOC_MAPK_MEF2A_6	249	258	PF00069	0.512
DOC_MAPK_MEF2A_6	29	38	PF00069	0.438
DOC_MAPK_MEF2A_6	330	339	PF00069	0.410
DOC_MAPK_MEF2A_6	59	67	PF00069	0.577
DOC_PP1_RVXF_1	18	24	PF00149	0.450
DOC_PP1_RVXF_1	234	241	PF00149	0.420
DOC_PP2B_LxvP_1	9	12	PF13499	0.606
DOC_USP7_MATH_1	199	203	PF00917	0.514
DOC_USP7_MATH_1	273	277	PF00917	0.443
DOC_USP7_MATH_1	376	380	PF00917	0.589
DOC_USP7_MATH_1	58	62	PF00917	0.670
DOC_USP7_MATH_1	66	70	PF00917	0.543
DOC_USP7_UBL2_3	144	148	PF12436	0.459
DOC_WW_Pin1_4	261	266	PF00397	0.456
DOC_WW_Pin1_4	47	52	PF00397	0.673
LIG_14-3-3_CanoR_1	20	24	PF00244	0.712
LIG_14-3-3_CanoR_1	203	213	PF00244	0.451
LIG_14-3-3_CanoR_1	321	325	PF00244	0.588
LIG_14-3-3_CanoR_1	46	51	PF00244	0.676
LIG_14-3-3_CanoR_1	6	12	PF00244	0.577
LIG_BIR_III_4	225	229	PF00653	0.551
LIG_deltaCOP1_diTrp_1	351	359	PF00928	0.500
LIG_deltaCOP1_diTrp_1	77	83	PF00928	0.448
LIG_FHA_1	2	8	PF00498	0.617
LIG_FHA_1	225	231	PF00498	0.529
LIG_FHA_1	253	259	PF00498	0.531
LIG_FHA_1	69	75	PF00498	0.663
LIG_FHA_2	161	167	PF00498	0.502
LIG_FHA_2	293	299	PF00498	0.368
LIG_FHA_2	359	365	PF00498	0.543
LIG_FHA_2	52	58	PF00498	0.609
LIG_LIR_Gen_1	232	242	PF02991	0.377
LIG_LIR_Gen_1	287	297	PF02991	0.548
LIG_LIR_Gen_1	351	359	PF02991	0.382
LIG_LIR_Gen_1	384	394	PF02991	0.468
LIG_LIR_Nem_3	206	212	PF02991	0.477
LIG_LIR_Nem_3	232	237	PF02991	0.424
LIG_LIR_Nem_3	287	293	PF02991	0.539
LIG_LIR_Nem_3	310	316	PF02991	0.468
LIG_LIR_Nem_3	351	355	PF02991	0.402
LIG_LIR_Nem_3	384	389	PF02991	0.496
LIG_NRBOX	257	263	PF00104	0.287
LIG_SH2_CRK	234	238	PF00017	0.392
LIG_SH2_CRK	386	390	PF00017	0.426
LIG_SH2_NCK_1	386	390	PF00017	0.426
LIG_SH2_SRC	76	79	PF00017	0.392
LIG_SH2_STAP1	234	238	PF00017	0.392
LIG_SH2_STAP1	76	80	PF00017	0.547
LIG_SH2_STAT3	278	281	PF00017	0.403
LIG_SH2_STAT5	123	126	PF00017	0.464
LIG_SH2_STAT5	219	222	PF00017	0.477
LIG_SH2_STAT5	278	281	PF00017	0.431
LIG_SH2_STAT5	290	293	PF00017	0.491
LIG_SH2_STAT5	386	389	PF00017	0.577
LIG_SH3_3	207	213	PF00018	0.452
LIG_SH3_3	360	366	PF00018	0.452
LIG_SH3_3	399	405	PF00018	0.547
LIG_SUMO_SIM_anti_2	333	339	PF11976	0.528
LIG_SUMO_SIM_par_1	272	279	PF11976	0.300
LIG_SUMO_SIM_par_1	390	398	PF11976	0.582
LIG_TYR_ITIM	74	79	PF00017	0.556
LIG_TYR_ITSM	230	237	PF00017	0.369
MOD_CK1_1	22	28	PF00069	0.724
MOD_CK1_1	224	230	PF00069	0.494
MOD_CK1_1	276	282	PF00069	0.404
MOD_CK2_1	160	166	PF00069	0.588
MOD_CK2_1	192	198	PF00069	0.572
MOD_CK2_1	292	298	PF00069	0.454
MOD_CK2_1	358	364	PF00069	0.526
MOD_CMANNOS	80	83	PF00535	0.392
MOD_GlcNHglycan	15	18	PF01048	0.648
MOD_GlcNHglycan	298	301	PF01048	0.551
MOD_GlcNHglycan	378	381	PF01048	0.585
MOD_GlcNHglycan	60	63	PF01048	0.594
MOD_GSK3_1	1	8	PF00069	0.586
MOD_GSK3_1	160	167	PF00069	0.594
MOD_GSK3_1	19	26	PF00069	0.628
MOD_GSK3_1	199	206	PF00069	0.423
MOD_GSK3_1	213	220	PF00069	0.429
MOD_GSK3_1	28	35	PF00069	0.594
MOD_GSK3_1	284	291	PF00069	0.495
MOD_GSK3_1	292	299	PF00069	0.406
MOD_GSK3_1	354	361	PF00069	0.395
MOD_GSK3_1	47	54	PF00069	0.652
MOD_LATS_1	125	131	PF00433	0.426
MOD_N-GLC_1	204	209	PF02516	0.439
MOD_NEK2_1	1	6	PF00069	0.541
MOD_NEK2_1	13	18	PF00069	0.501
MOD_NEK2_1	190	195	PF00069	0.435
MOD_NEK2_1	284	289	PF00069	0.528
MOD_NEK2_1	371	376	PF00069	0.383
MOD_NEK2_1	41	46	PF00069	0.717
MOD_NEK2_1	7	12	PF00069	0.508
MOD_NEK2_2	273	278	PF00069	0.305
MOD_PIKK_1	160	166	PF00454	0.604
MOD_PKA_2	19	25	PF00069	0.737
MOD_PKA_2	232	238	PF00069	0.391
MOD_PKA_2	28	34	PF00069	0.724
MOD_PKA_2	320	326	PF00069	0.580
MOD_PKA_2	382	388	PF00069	0.505
MOD_PKA_2	5	11	PF00069	0.485
MOD_PKA_2	58	64	PF00069	0.595
MOD_Plk_1	204	210	PF00069	0.453
MOD_Plk_1	252	258	PF00069	0.522
MOD_Plk_4	164	170	PF00069	0.420
MOD_Plk_4	273	279	PF00069	0.437
MOD_Plk_4	288	294	PF00069	0.451
MOD_ProDKin_1	261	267	PF00069	0.451
MOD_ProDKin_1	47	53	PF00069	0.676
MOD_SUMO_for_1	343	346	PF00179	0.383
MOD_SUMO_for_1	74	77	PF00179	0.581
TRG_DiLeu_BaEn_1	257	262	PF01217	0.531
TRG_DiLeu_BaEn_4	77	83	PF01217	0.380
TRG_ENDOCYTIC_2	234	237	PF00928	0.397
TRG_ENDOCYTIC_2	290	293	PF00928	0.429
TRG_ENDOCYTIC_2	386	389	PF00928	0.577
TRG_ENDOCYTIC_2	76	79	PF00928	0.551
TRG_ER_diArg_1	117	119	PF00400	0.529
TRG_ER_diArg_1	372	375	PF00400	0.405
TRG_NES_CRM1_1	333	346	PF08389	0.514
TRG_NES_CRM1_1	95	108	PF08389	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK37	Leptomonas seymouri	71%	81%
A0A0N1IKX3	Leptomonas seymouri	26%	75%
A0A0S4IN88	Bodo saltans	43%	76%
A0A0S4JQR1	Bodo saltans	28%	76%
A0A1X0NRA1	Trypanosomatidae	27%	80%
A0A1X0NTQ0	Trypanosomatidae	54%	85%
A0A3Q8II17	Leishmania donovani	27%	81%
A0A3S7WX47	Leishmania donovani	88%	81%
A0A422NDT8	Trypanosoma rangeli	55%	87%
A0A422NKD3	Trypanosoma rangeli	27%	84%
A4HLY4	Leishmania braziliensis	27%	81%
A4HZU2	Leishmania infantum	88%	81%
A4I9B3	Leishmania infantum	27%	81%
C9ZJB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	83%
C9ZRN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	86%
E9AVP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	81%
E9B4B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	81%
Q4Q3R2	Leishmania major	25%	100%
Q4QBT2	Leishmania major	87%	100%
V5BAI0	Trypanosoma cruzi	26%	84%
V5BVS4	Trypanosoma cruzi	55%	86%