Ubiquitin-conjugating enzyme-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCA6_LEIBR

TriTrypDb:

LbrM.22.0550 , LBRM2903_220011000

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCA6

Function

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0016567	protein ubiquitination	7	1
GO:0016570	histone modification	5	1
GO:0016574	histone ubiquitination	6	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061631	ubiquitin conjugating enzyme activity	5	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.533
CLV_NRD_NRD_1	93	95	PF00675	0.350
CLV_PCSK_KEX2_1	93	95	PF00082	0.348
CLV_PCSK_SKI1_1	161	165	PF00082	0.388
CLV_PCSK_SKI1_1	219	223	PF00082	0.384
CLV_PCSK_SKI1_1	5	9	PF00082	0.748
DEG_Nend_UBRbox_3	1	3	PF02207	0.800
DOC_MAPK_MEF2A_6	165	174	PF00069	0.379
DOC_PP1_RVXF_1	157	163	PF00149	0.485
DOC_PP4_FxxP_1	155	158	PF00568	0.384
DOC_PP4_FxxP_1	57	60	PF00568	0.767
DOC_USP7_MATH_1	67	71	PF00917	0.591
DOC_WW_Pin1_4	133	138	PF00397	0.384
DOC_WW_Pin1_4	153	158	PF00397	0.156
DOC_WW_Pin1_4	56	61	PF00397	0.676
LIG_14-3-3_CanoR_1	219	228	PF00244	0.384
LIG_14-3-3_CanoR_1	71	79	PF00244	0.727
LIG_Clathr_ClatBox_1	142	146	PF01394	0.384
LIG_deltaCOP1_diTrp_1	135	143	PF00928	0.384
LIG_FHA_1	193	199	PF00498	0.217
LIG_FHA_2	108	114	PF00498	0.279
LIG_FHA_2	134	140	PF00498	0.384
LIG_FHA_2	48	54	PF00498	0.704
LIG_FHA_2	9	15	PF00498	0.535
LIG_IRF3_LxIS_1	193	199	PF10401	0.384
LIG_LIR_Apic_2	152	158	PF02991	0.384
LIG_LIR_Gen_1	59	67	PF02991	0.469
LIG_LIR_Nem_3	59	65	PF02991	0.509
LIG_LIR_Nem_3	98	102	PF02991	0.384
LIG_NRBOX	192	198	PF00104	0.485
LIG_PDZ_Class_3	255	260	PF00595	0.639
LIG_SH2_SRC	173	176	PF00017	0.384
LIG_SH2_STAP1	228	232	PF00017	0.384
LIG_SH2_STAP1	62	66	PF00017	0.475
LIG_SH2_STAT5	173	176	PF00017	0.379
LIG_SH3_2	154	159	PF14604	0.485
LIG_SH3_3	151	157	PF00018	0.384
LIG_SH3_3	38	44	PF00018	0.538
LIG_SUMO_SIM_par_1	194	202	PF11976	0.386
LIG_WRC_WIRS_1	99	104	PF05994	0.485
MOD_CDC14_SPxK_1	156	159	PF00782	0.485
MOD_CDK_SPxK_1	153	159	PF00069	0.485
MOD_CK1_1	112	118	PF00069	0.485
MOD_CK1_1	199	205	PF00069	0.320
MOD_CK1_1	70	76	PF00069	0.718
MOD_CK2_1	133	139	PF00069	0.384
MOD_CK2_1	47	53	PF00069	0.575
MOD_GlcNHglycan	130	133	PF01048	0.384
MOD_GlcNHglycan	210	213	PF01048	0.384
MOD_GlcNHglycan	225	228	PF01048	0.384
MOD_GlcNHglycan	72	75	PF01048	0.714
MOD_GSK3_1	192	199	PF00069	0.311
MOD_GSK3_1	219	226	PF00069	0.384
MOD_GSK3_1	236	243	PF00069	0.493
MOD_GSK3_1	26	33	PF00069	0.806
MOD_GSK3_1	5	12	PF00069	0.802
MOD_N-GLC_1	223	228	PF02516	0.384
MOD_N-GLC_1	9	14	PF02516	0.536
MOD_N-GLC_2	177	179	PF02516	0.384
MOD_NEK2_1	196	201	PF00069	0.320
MOD_NEK2_1	240	245	PF00069	0.524
MOD_NEK2_2	179	184	PF00069	0.384
MOD_PKA_2	67	73	PF00069	0.618
MOD_PKA_2	8	14	PF00069	0.536
MOD_Plk_1	112	118	PF00069	0.485
MOD_Plk_1	223	229	PF00069	0.384
MOD_Plk_1	236	242	PF00069	0.487
MOD_Plk_2-3	247	253	PF00069	0.743
MOD_Plk_4	192	198	PF00069	0.392
MOD_Plk_4	199	205	PF00069	0.379
MOD_ProDKin_1	133	139	PF00069	0.384
MOD_ProDKin_1	153	159	PF00069	0.156
MOD_ProDKin_1	56	62	PF00069	0.676
MOD_SUMO_rev_2	223	232	PF00179	0.384
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.384
TRG_ENDOCYTIC_2	62	65	PF00928	0.623
TRG_ENDOCYTIC_2	99	102	PF00928	0.384
TRG_ER_diArg_1	93	95	PF00400	0.345
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXA7	Leptomonas seymouri	75%	97%
A0A1X0PAA1	Trypanosomatidae	24%	100%
A0A3Q8IFB8	Leishmania donovani	31%	100%
A0A3S7WX16	Leishmania donovani	82%	100%
A0A3S7WYH9	Leishmania donovani	26%	100%
A4HDN1	Leishmania braziliensis	28%	100%
A4HK50	Leishmania braziliensis	30%	100%
A4HZT8	Leishmania infantum	82%	100%
A4I7L2	Leishmania infantum	31%	100%
E9AH78	Leishmania infantum	26%	100%
E9AVP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AX16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B2J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O60015	Pichia angusta	30%	100%
P0C8G3	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	31%	100%
P0C8G5	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	33%	100%
P33296	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q4Q5L3	Leishmania major	31%	100%
Q4QAG0	Leishmania major	27%	100%
Q4QBT6	Leishmania major	83%	100%