N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCA5_LEIBR

TriTrypDb:

LbrM.22.0540 , LBRM2903_220010900

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCA5

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.541
CLV_NRD_NRD_1	210	212	PF00675	0.521
CLV_NRD_NRD_1	298	300	PF00675	0.276
CLV_NRD_NRD_1	367	369	PF00675	0.577
CLV_NRD_NRD_1	375	377	PF00675	0.519
CLV_NRD_NRD_1	84	86	PF00675	0.652
CLV_PCSK_KEX2_1	176	178	PF00082	0.508
CLV_PCSK_KEX2_1	210	212	PF00082	0.521
CLV_PCSK_KEX2_1	297	299	PF00082	0.276
CLV_PCSK_KEX2_1	339	341	PF00082	0.308
CLV_PCSK_KEX2_1	367	369	PF00082	0.558
CLV_PCSK_KEX2_1	375	377	PF00082	0.465
CLV_PCSK_KEX2_1	84	86	PF00082	0.614
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.511
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.308
CLV_PCSK_SKI1_1	184	188	PF00082	0.496
CLV_PCSK_SKI1_1	210	214	PF00082	0.522
CLV_PCSK_SKI1_1	347	351	PF00082	0.409
CLV_PCSK_SKI1_1	450	454	PF00082	0.641
DEG_Nend_Nbox_1	1	3	PF02207	0.367
DEG_SCF_FBW7_1	272	278	PF00400	0.524
DEG_SPOP_SBC_1	264	268	PF00917	0.542
DOC_CKS1_1	272	277	PF01111	0.689
DOC_CYCLIN_RxL_1	181	190	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.266
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.409
DOC_MAPK_gen_1	339	346	PF00069	0.405
DOC_MAPK_gen_1	347	357	PF00069	0.453
DOC_MAPK_MEF2A_6	211	220	PF00069	0.397
DOC_MAPK_MEF2A_6	283	291	PF00069	0.533
DOC_PP1_RVXF_1	337	344	PF00149	0.525
DOC_PP2B_LxvP_1	14	17	PF13499	0.255
DOC_PP2B_LxvP_1	67	70	PF13499	0.407
DOC_USP7_MATH_1	165	169	PF00917	0.517
DOC_USP7_MATH_1	191	195	PF00917	0.479
DOC_USP7_MATH_1	264	268	PF00917	0.742
DOC_USP7_MATH_1	275	279	PF00917	0.271
DOC_USP7_MATH_1	38	42	PF00917	0.448
DOC_USP7_MATH_1	404	408	PF00917	0.623
DOC_USP7_MATH_1	444	448	PF00917	0.490
DOC_USP7_UBL2_3	325	329	PF12436	0.416
DOC_WW_Pin1_4	246	251	PF00397	0.592
DOC_WW_Pin1_4	256	261	PF00397	0.673
DOC_WW_Pin1_4	268	273	PF00397	0.574
DOC_WW_Pin1_4	418	423	PF00397	0.728
LIG_14-3-3_CanoR_1	258	264	PF00244	0.676
LIG_APCC_ABBA_1	343	348	PF00400	0.334
LIG_APCC_ABBA_1	349	354	PF00400	0.404
LIG_APCC_ABBA_1	71	76	PF00400	0.420
LIG_BRCT_BRCA1_1	281	285	PF00533	0.476
LIG_EH1_1	284	292	PF00400	0.476
LIG_FHA_1	118	124	PF00498	0.490
LIG_FHA_1	233	239	PF00498	0.509
LIG_FHA_1	282	288	PF00498	0.487
LIG_FHA_1	318	324	PF00498	0.476
LIG_FHA_1	336	342	PF00498	0.492
LIG_FHA_1	384	390	PF00498	0.520
LIG_FHA_1	62	68	PF00498	0.364
LIG_FHA_2	145	151	PF00498	0.716
LIG_FHA_2	201	207	PF00498	0.412
LIG_FHA_2	361	367	PF00498	0.410
LIG_FHA_2	37	43	PF00498	0.450
LIG_FHA_2	426	432	PF00498	0.532
LIG_LIR_Apic_2	435	440	PF02991	0.669
LIG_LIR_Gen_1	64	73	PF02991	0.388
LIG_LIR_Nem_3	64	68	PF02991	0.345
LIG_MYND_1	17	21	PF01753	0.437
LIG_RPA_C_Fungi	294	306	PF08784	0.323
LIG_SH2_PTP2	217	220	PF00017	0.346
LIG_SH2_SRC	178	181	PF00017	0.597
LIG_SH2_STAP1	312	316	PF00017	0.346
LIG_SH2_STAT5	18	21	PF00017	0.440
LIG_SH2_STAT5	217	220	PF00017	0.346
LIG_SH3_1	18	24	PF00018	0.438
LIG_SH3_3	136	142	PF00018	0.751
LIG_SH3_3	18	24	PF00018	0.501
LIG_SH3_3	269	275	PF00018	0.698
LIG_SH3_3	420	426	PF00018	0.618
LIG_SUMO_SIM_anti_2	10	17	PF11976	0.424
LIG_SUMO_SIM_anti_2	286	291	PF11976	0.314
LIG_TRAF2_1	196	199	PF00917	0.475
MOD_CK1_1	122	128	PF00069	0.562
MOD_CK1_1	144	150	PF00069	0.649
MOD_CK1_1	193	199	PF00069	0.551
MOD_CK1_1	240	246	PF00069	0.530
MOD_CK1_1	256	262	PF00069	0.769
MOD_CK1_1	268	274	PF00069	0.597
MOD_CK1_1	360	366	PF00069	0.577
MOD_CK1_1	384	390	PF00069	0.632
MOD_CK2_1	164	170	PF00069	0.617
MOD_CK2_1	193	199	PF00069	0.473
MOD_CK2_1	200	206	PF00069	0.400
MOD_CK2_1	36	42	PF00069	0.437
MOD_CK2_1	360	366	PF00069	0.408
MOD_CK2_1	425	431	PF00069	0.646
MOD_GlcNHglycan	134	137	PF01048	0.493
MOD_GlcNHglycan	167	170	PF01048	0.606
MOD_GlcNHglycan	193	196	PF01048	0.571
MOD_GlcNHglycan	239	242	PF01048	0.522
MOD_GlcNHglycan	32	35	PF01048	0.329
MOD_GlcNHglycan	399	402	PF01048	0.573
MOD_GlcNHglycan	418	421	PF01048	0.690
MOD_GSK3_1	117	124	PF00069	0.621
MOD_GSK3_1	259	266	PF00069	0.642
MOD_GSK3_1	271	278	PF00069	0.570
MOD_GSK3_1	38	45	PF00069	0.446
MOD_GSK3_1	381	388	PF00069	0.608
MOD_GSK3_1	52	59	PF00069	0.409
MOD_N-GLC_1	384	389	PF02516	0.541
MOD_NEK2_1	107	112	PF00069	0.619
MOD_NEK2_1	118	123	PF00069	0.585
MOD_NEK2_1	132	137	PF00069	0.499
MOD_NEK2_1	245	250	PF00069	0.603
MOD_NEK2_1	263	268	PF00069	0.508
MOD_NEK2_1	30	35	PF00069	0.321
MOD_NEK2_1	357	362	PF00069	0.467
MOD_NEK2_1	445	450	PF00069	0.480
MOD_OFUCOSY	251	257	PF10250	0.524
MOD_OFUCOSY	374	379	PF10250	0.387
MOD_PIKK_1	178	184	PF00454	0.594
MOD_PIKK_1	193	199	PF00454	0.479
MOD_PIKK_1	450	456	PF00454	0.617
MOD_PKA_1	375	381	PF00069	0.438
MOD_PKA_1	84	90	PF00069	0.524
MOD_PKA_2	107	113	PF00069	0.501
MOD_PKA_2	374	380	PF00069	0.502
MOD_PKA_2	84	90	PF00069	0.618
MOD_Plk_1	384	390	PF00069	0.542
MOD_Plk_2-3	42	48	PF00069	0.447
MOD_Plk_4	141	147	PF00069	0.508
MOD_Plk_4	432	438	PF00069	0.595
MOD_Plk_4	52	58	PF00069	0.401
MOD_Plk_4	61	67	PF00069	0.372
MOD_ProDKin_1	246	252	PF00069	0.593
MOD_ProDKin_1	256	262	PF00069	0.673
MOD_ProDKin_1	268	274	PF00069	0.574
MOD_ProDKin_1	418	424	PF00069	0.731
TRG_DiLeu_BaEn_1	4	9	PF01217	0.436
TRG_DiLeu_LyEn_5	170	175	PF01217	0.435
TRG_ENDOCYTIC_2	217	220	PF00928	0.346
TRG_ER_diArg_1	105	108	PF00400	0.517
TRG_ER_diArg_1	209	211	PF00400	0.384
TRG_ER_diArg_1	296	299	PF00400	0.314
TRG_ER_diArg_1	84	86	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	359	364	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y0	Leptomonas seymouri	40%	100%
A0A3S7WX61	Leishmania donovani	68%	92%
A4HZT7	Leishmania infantum	68%	92%
E9AVP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	92%
Q4QBT7	Leishmania major	67%	100%