TsaA-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family UPF0066, putative

Species:

Leishmania braziliensis

UniProt:

A4HCA4_LEIBR

TriTrypDb:

LbrM.22.0530 , LBRM2903_220010800

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	465	469	PF00656	0.479
CLV_NRD_NRD_1	108	110	PF00675	0.505
CLV_NRD_NRD_1	114	116	PF00675	0.496
CLV_NRD_NRD_1	317	319	PF00675	0.551
CLV_NRD_NRD_1	46	48	PF00675	0.500
CLV_PCSK_KEX2_1	116	118	PF00082	0.551
CLV_PCSK_KEX2_1	127	129	PF00082	0.486
CLV_PCSK_KEX2_1	48	50	PF00082	0.574
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.443
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.444
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.574
CLV_PCSK_SKI1_1	121	125	PF00082	0.511
CLV_PCSK_SKI1_1	401	405	PF00082	0.304
CLV_PCSK_SKI1_1	481	485	PF00082	0.480
CLV_PCSK_SKI1_1	66	70	PF00082	0.392
CLV_Separin_Metazoa	315	319	PF03568	0.473
DEG_Nend_UBRbox_3	1	3	PF02207	0.518
DOC_MAPK_gen_1	191	200	PF00069	0.481
DOC_MAPK_gen_1	205	215	PF00069	0.357
DOC_MAPK_gen_1	47	54	PF00069	0.556
DOC_MAPK_gen_1	86	93	PF00069	0.441
DOC_MAPK_MEF2A_6	193	202	PF00069	0.479
DOC_MAPK_RevD_3	36	49	PF00069	0.519
DOC_PP2B_LxvP_1	91	94	PF13499	0.452
DOC_PP4_FxxP_1	304	307	PF00568	0.447
DOC_USP7_MATH_1	19	23	PF00917	0.612
DOC_USP7_MATH_1	307	311	PF00917	0.497
DOC_USP7_UBL2_3	127	131	PF12436	0.594
DOC_USP7_UBL2_3	474	478	PF12436	0.544
DOC_WW_Pin1_4	15	20	PF00397	0.537
DOC_WW_Pin1_4	233	238	PF00397	0.476
DOC_WW_Pin1_4	32	37	PF00397	0.511
DOC_WW_Pin1_4	326	331	PF00397	0.511
DOC_WW_Pin1_4	333	338	PF00397	0.567
DOC_WW_Pin1_4	343	348	PF00397	0.635
DOC_WW_Pin1_4	405	410	PF00397	0.304
DOC_WW_Pin1_4	438	443	PF00397	0.304
DOC_WW_Pin1_4	6	11	PF00397	0.610
LIG_14-3-3_CanoR_1	161	170	PF00244	0.525
LIG_14-3-3_CanoR_1	193	200	PF00244	0.486
LIG_14-3-3_CanoR_1	205	215	PF00244	0.376
LIG_14-3-3_CanoR_1	232	236	PF00244	0.550
LIG_14-3-3_CanoR_1	488	492	PF00244	0.568
LIG_BIR_III_2	331	335	PF00653	0.538
LIG_BIR_III_2	454	458	PF00653	0.371
LIG_BIR_III_4	468	472	PF00653	0.461
LIG_deltaCOP1_diTrp_1	294	304	PF00928	0.359
LIG_deltaCOP1_diTrp_1	397	404	PF00928	0.304
LIG_EH1_1	56	64	PF00400	0.395
LIG_FHA_1	11	17	PF00498	0.542
LIG_FHA_1	151	157	PF00498	0.525
LIG_FHA_1	193	199	PF00498	0.534
LIG_FHA_1	208	214	PF00498	0.349
LIG_FHA_1	219	225	PF00498	0.420
LIG_FHA_1	272	278	PF00498	0.426
LIG_FHA_1	35	41	PF00498	0.649
LIG_FHA_1	368	374	PF00498	0.453
LIG_FHA_1	388	394	PF00498	0.284
LIG_FHA_1	439	445	PF00498	0.352
LIG_FHA_2	136	142	PF00498	0.686
LIG_FHA_2	192	198	PF00498	0.408
LIG_FHA_2	279	285	PF00498	0.461
LIG_HCF-1_HBM_1	476	479	PF13415	0.495
LIG_LIR_Apic_2	303	307	PF02991	0.440
LIG_LIR_Apic_2	61	67	PF02991	0.361
LIG_LIR_Gen_1	294	305	PF02991	0.407
LIG_LIR_Nem_3	294	300	PF02991	0.384
LIG_LIR_Nem_3	397	403	PF02991	0.304
LIG_NBox_RRM_1	220	230	PF00076	0.448
LIG_Pex14_1	400	404	PF04695	0.304
LIG_Pex14_2	293	297	PF04695	0.353
LIG_Pex14_2	300	304	PF04695	0.378
LIG_REV1ctd_RIR_1	186	195	PF16727	0.405
LIG_REV1ctd_RIR_1	373	383	PF16727	0.474
LIG_SH2_NCK_1	216	220	PF00017	0.380
LIG_SH2_STAP1	216	220	PF00017	0.380
LIG_SH2_STAP1	243	247	PF00017	0.424
LIG_SH2_STAP1	479	483	PF00017	0.455
LIG_SH2_STAT3	479	482	PF00017	0.515
LIG_SH2_STAT5	187	190	PF00017	0.404
LIG_SH2_STAT5	449	452	PF00017	0.304
LIG_SH2_STAT5	56	59	PF00017	0.432
LIG_SH3_3	129	135	PF00018	0.505
LIG_SH3_3	13	19	PF00018	0.562
LIG_SH3_3	259	265	PF00018	0.497
LIG_SH3_3	33	39	PF00018	0.486
LIG_SH3_3	331	337	PF00018	0.545
LIG_SH3_3	406	412	PF00018	0.304
LIG_SH3_3	445	451	PF00018	0.304
LIG_SH3_3	68	74	PF00018	0.375
LIG_SH3_3	90	96	PF00018	0.438
LIG_SUMO_SIM_par_1	12	18	PF11976	0.508
LIG_TRAF2_1	194	197	PF00917	0.415
LIG_TYR_ITIM	54	59	PF00017	0.377
LIG_WW_3	393	397	PF00397	0.304
MOD_CDC14_SPxK_1	236	239	PF00782	0.458
MOD_CDC14_SPxK_1	408	411	PF00782	0.304
MOD_CDK_SPK_2	343	348	PF00069	0.563
MOD_CDK_SPxK_1	233	239	PF00069	0.474
MOD_CDK_SPxK_1	405	411	PF00069	0.304
MOD_CK1_1	218	224	PF00069	0.292
MOD_CK1_1	22	28	PF00069	0.572
MOD_CK1_1	343	349	PF00069	0.603
MOD_CK1_1	371	377	PF00069	0.538
MOD_CK1_1	9	15	PF00069	0.594
MOD_CK2_1	135	141	PF00069	0.795
MOD_CK2_1	191	197	PF00069	0.413
MOD_CK2_1	278	284	PF00069	0.459
MOD_GlcNHglycan	143	146	PF01048	0.619
MOD_GlcNHglycan	181	184	PF01048	0.340
MOD_GlcNHglycan	217	220	PF01048	0.304
MOD_GlcNHglycan	24	27	PF01048	0.710
MOD_GlcNHglycan	309	312	PF01048	0.517
MOD_GlcNHglycan	340	343	PF01048	0.608
MOD_GlcNHglycan	468	472	PF01048	0.486
MOD_GSK3_1	15	22	PF00069	0.664
MOD_GSK3_1	155	162	PF00069	0.661
MOD_GSK3_1	173	180	PF00069	0.365
MOD_GSK3_1	2	9	PF00069	0.580
MOD_GSK3_1	338	345	PF00069	0.591
MOD_GSK3_1	367	374	PF00069	0.452
MOD_N-GLC_1	1	6	PF02516	0.514
MOD_N-GLC_2	358	360	PF02516	0.518
MOD_NEK2_1	1	6	PF00069	0.525
MOD_NEK2_1	206	211	PF00069	0.344
MOD_NEK2_1	215	220	PF00069	0.294
MOD_NEK2_1	300	305	PF00069	0.378
MOD_NEK2_1	368	373	PF00069	0.453
MOD_NEK2_1	467	472	PF00069	0.490
MOD_PIKK_1	218	224	PF00454	0.434
MOD_PKA_1	127	133	PF00069	0.493
MOD_PKA_2	127	133	PF00069	0.493
MOD_PKA_2	160	166	PF00069	0.524
MOD_PKA_2	192	198	PF00069	0.524
MOD_PKA_2	207	213	PF00069	0.346
MOD_PKA_2	228	234	PF00069	0.497
MOD_Plk_1	1	7	PF00069	0.513
MOD_Plk_4	2	8	PF00069	0.510
MOD_Plk_4	250	256	PF00069	0.391
MOD_Plk_4	371	377	PF00069	0.601
MOD_Plk_4	387	393	PF00069	0.288
MOD_ProDKin_1	15	21	PF00069	0.537
MOD_ProDKin_1	233	239	PF00069	0.474
MOD_ProDKin_1	32	38	PF00069	0.511
MOD_ProDKin_1	326	332	PF00069	0.515
MOD_ProDKin_1	333	339	PF00069	0.569
MOD_ProDKin_1	343	349	PF00069	0.634
MOD_ProDKin_1	405	411	PF00069	0.304
MOD_ProDKin_1	438	444	PF00069	0.304
MOD_ProDKin_1	6	12	PF00069	0.612
MOD_SUMO_for_1	347	350	PF00179	0.556
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.434
TRG_ENDOCYTIC_2	449	452	PF00928	0.278
TRG_ENDOCYTIC_2	56	59	PF00928	0.432
TRG_ER_diArg_1	277	280	PF00400	0.395
TRG_ER_diArg_1	376	379	PF00400	0.559
TRG_ER_diArg_1	49	52	PF00400	0.571
TRG_ER_diArg_1	87	90	PF00400	0.467
TRG_NLS_MonoExtC_3	46	51	PF00514	0.552
TRG_NLS_MonoExtN_4	47	52	PF00514	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB52	Leptomonas seymouri	66%	100%
A0A3S7WX66	Leishmania donovani	78%	100%
A4HZT6	Leishmania infantum	78%	100%
E9AVP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QBT8	Leishmania major	76%	99%