Rer1 family-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rer1 family-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCA2_LEIBR

TriTrypDb:

LbrM.22.0520 , LBRM2903_220010700

Length:

116

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HCA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCA2

Function

Biological processes
Term	Name	Level	Count
GO:0051179	localization	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.449
CLV_PCSK_KEX2_1	87	89	PF00082	0.624
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.624
CLV_PCSK_SKI1_1	52	56	PF00082	0.549
CLV_PCSK_SKI1_1	94	98	PF00082	0.609
DOC_MAPK_MEF2A_6	25	32	PF00069	0.650
DOC_PP1_RVXF_1	33	40	PF00149	0.650
DOC_PP1_RVXF_1	50	57	PF00149	0.252
DOC_PP1_RVXF_1	92	98	PF00149	0.806
DOC_PP4_FxxP_1	98	101	PF00568	0.804
DOC_USP7_MATH_1	77	81	PF00917	0.742
LIG_14-3-3_CanoR_1	21	25	PF00244	0.650
LIG_14-3-3_CanoR_1	52	57	PF00244	0.549
LIG_EVH1_2	110	114	PF00568	0.792
LIG_FHA_1	61	67	PF00498	0.549
LIG_LIR_Nem_3	23	27	PF02991	0.650
LIG_LIR_Nem_3	55	59	PF02991	0.549
LIG_NRBOX	69	75	PF00104	0.549
LIG_PDZ_Class_2	111	116	PF00595	0.794
LIG_SH2_SRC	27	30	PF00017	0.650
LIG_SH2_STAT5	27	30	PF00017	0.650
LIG_SH2_STAT5	49	52	PF00017	0.549
LIG_SH2_STAT5	60	63	PF00017	0.357
LIG_SH2_STAT5	72	75	PF00017	0.339
LIG_SH3_3	107	113	PF00018	0.678
LIG_SH3_3	27	33	PF00018	0.650
LIG_SH3_3	98	104	PF00018	0.798
LIG_TYR_ITIM	70	75	PF00017	0.549
LIG_WRC_WIRS_1	53	58	PF05994	0.549
MOD_Cter_Amidation	85	88	PF01082	0.624
MOD_GlcNHglycan	84	87	PF01048	0.624
MOD_GlcNHglycan	98	101	PF01048	0.428
MOD_GSK3_1	8	15	PF00069	0.777
MOD_NEK2_1	28	33	PF00069	0.650
MOD_NEK2_1	96	101	PF00069	0.806
MOD_PKA_2	20	26	PF00069	0.650
MOD_Plk_1	12	18	PF00069	0.772
MOD_Plk_1	28	34	PF00069	0.449
MOD_Plk_4	12	18	PF00069	0.772
TRG_ENDOCYTIC_2	27	30	PF00928	0.650
TRG_ENDOCYTIC_2	72	75	PF00928	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A5PJ65	BOVIN	36%	59%
O15258	HUMAN	34%	59%
O48670	ARATH	46%	61%
O48671	ARATH	41%	59%
P79003	SACPS	40%	62%
Q498C8	RAT	34%	59%
Q5R5U4	PONAB	34%	59%
Q5ZHM5	CHICK	34%	59%
Q9CQU3	MOUSE	34%	59%
Q9ZWI7	ARATH	34%	55%