Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4HCA1_LEIBR

TriTrypDb:

LbrM.22.0500 , LBRM2903_220010500

Length:

893

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	2
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2

Expansion

Sequence features

A4HCA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCA1

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	16
GO:0007018	microtubule-based movement	3	16
GO:0009987	cellular process	1	16
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003774	cytoskeletal motor activity	1	16
GO:0003777	microtubule motor activity	2	16
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	16
GO:0005515	protein binding	2	16
GO:0005524	ATP binding	5	16
GO:0008017	microtubule binding	5	16
GO:0008092	cytoskeletal protein binding	3	16
GO:0015631	tubulin binding	4	16
GO:0016787	hydrolase activity	2	10
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140657	ATP-dependent activity	1	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.303
CLV_C14_Caspase3-7	755	759	PF00656	0.567
CLV_NRD_NRD_1	21	23	PF00675	0.603
CLV_NRD_NRD_1	306	308	PF00675	0.575
CLV_NRD_NRD_1	458	460	PF00675	0.470
CLV_NRD_NRD_1	794	796	PF00675	0.429
CLV_PCSK_FUR_1	430	434	PF00082	0.387
CLV_PCSK_KEX2_1	21	23	PF00082	0.464
CLV_PCSK_KEX2_1	306	308	PF00082	0.731
CLV_PCSK_KEX2_1	432	434	PF00082	0.380
CLV_PCSK_KEX2_1	458	460	PF00082	0.401
CLV_PCSK_KEX2_1	794	796	PF00082	0.428
CLV_PCSK_KEX2_1	819	821	PF00082	0.424
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.380
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.427
CLV_PCSK_SKI1_1	148	152	PF00082	0.306
CLV_PCSK_SKI1_1	315	319	PF00082	0.300
CLV_PCSK_SKI1_1	337	341	PF00082	0.270
CLV_PCSK_SKI1_1	356	360	PF00082	0.255
CLV_PCSK_SKI1_1	432	436	PF00082	0.277
CLV_PCSK_SKI1_1	458	462	PF00082	0.470
CLV_PCSK_SKI1_1	474	478	PF00082	0.423
CLV_PCSK_SKI1_1	496	500	PF00082	0.439
CLV_PCSK_SKI1_1	534	538	PF00082	0.490
CLV_PCSK_SKI1_1	710	714	PF00082	0.532
CLV_PCSK_SKI1_1	766	770	PF00082	0.466
CLV_Separin_Metazoa	145	149	PF03568	0.156
DEG_SCF_FBW7_2	411	416	PF00400	0.387
DEG_SPOP_SBC_1	176	180	PF00917	0.162
DEG_SPOP_SBC_1	308	312	PF00917	0.469
DOC_CYCLIN_RxL_1	458	468	PF00134	0.447
DOC_MAPK_gen_1	430	440	PF00069	0.386
DOC_MAPK_gen_1	447	455	PF00069	0.422
DOC_MAPK_gen_1	458	465	PF00069	0.344
DOC_MAPK_gen_1	534	542	PF00069	0.399
DOC_MAPK_gen_1	817	826	PF00069	0.471
DOC_MAPK_gen_1	827	835	PF00069	0.457
DOC_MAPK_MEF2A_6	105	114	PF00069	0.392
DOC_MAPK_MEF2A_6	241	250	PF00069	0.255
DOC_MAPK_MEF2A_6	449	457	PF00069	0.403
DOC_MAPK_MEF2A_6	7	15	PF00069	0.456
DOC_MAPK_MEF2A_6	819	828	PF00069	0.420
DOC_PP4_FxxP_1	882	885	PF00568	0.507
DOC_USP7_MATH_1	156	160	PF00917	0.387
DOC_USP7_MATH_1	174	178	PF00917	0.420
DOC_USP7_MATH_1	414	418	PF00917	0.347
DOC_USP7_MATH_1	500	504	PF00917	0.671
DOC_USP7_MATH_1	764	768	PF00917	0.527
DOC_USP7_MATH_1	785	789	PF00917	0.537
DOC_USP7_UBL2_3	318	322	PF12436	0.238
DOC_USP7_UBL2_3	858	862	PF12436	0.415
DOC_WW_Pin1_4	103	108	PF00397	0.368
DOC_WW_Pin1_4	186	191	PF00397	0.308
DOC_WW_Pin1_4	409	414	PF00397	0.318
DOC_WW_Pin1_4	496	501	PF00397	0.638
LIG_14-3-3_CanoR_1	173	183	PF00244	0.462
LIG_14-3-3_CanoR_1	228	235	PF00244	0.311
LIG_14-3-3_CanoR_1	367	375	PF00244	0.361
LIG_14-3-3_CanoR_1	422	426	PF00244	0.245
LIG_14-3-3_CanoR_1	571	575	PF00244	0.537
LIG_14-3-3_CanoR_1	622	630	PF00244	0.553
LIG_14-3-3_CanoR_1	7	12	PF00244	0.533
LIG_14-3-3_CanoR_1	705	713	PF00244	0.569
LIG_14-3-3_CanoR_1	766	772	PF00244	0.427
LIG_14-3-3_CanoR_1	820	825	PF00244	0.388
LIG_14-3-3_CanoR_1	865	873	PF00244	0.478
LIG_Actin_WH2_2	139	154	PF00022	0.215
LIG_APCC_ABBA_1	140	145	PF00400	0.307
LIG_APCC_ABBA_1	383	388	PF00400	0.273
LIG_APCC_ABBAyCdc20_2	128	134	PF00400	0.387
LIG_BIR_III_4	155	159	PF00653	0.238
LIG_CaM_IQ_9	697	712	PF13499	0.365
LIG_EH1_1	242	250	PF00400	0.177
LIG_FHA_1	180	186	PF00498	0.397
LIG_FHA_1	216	222	PF00498	0.278
LIG_FHA_1	390	396	PF00498	0.308
LIG_FHA_1	403	409	PF00498	0.301
LIG_FHA_1	410	416	PF00498	0.269
LIG_FHA_1	466	472	PF00498	0.479
LIG_FHA_1	489	495	PF00498	0.694
LIG_FHA_1	575	581	PF00498	0.510
LIG_FHA_1	58	64	PF00498	0.255
LIG_FHA_1	760	766	PF00498	0.399
LIG_FHA_1	8	14	PF00498	0.338
LIG_FHA_2	35	41	PF00498	0.240
LIG_FHA_2	361	367	PF00498	0.401
LIG_FHA_2	57	63	PF00498	0.357
LIG_FHA_2	753	759	PF00498	0.719
LIG_FHA_2	782	788	PF00498	0.411
LIG_LIR_Gen_1	133	143	PF02991	0.287
LIG_LIR_Gen_1	403	411	PF02991	0.260
LIG_LIR_Gen_1	47	58	PF02991	0.307
LIG_LIR_Gen_1	684	692	PF02991	0.450
LIG_LIR_Gen_1	95	104	PF02991	0.309
LIG_LIR_Nem_3	116	121	PF02991	0.294
LIG_LIR_Nem_3	133	139	PF02991	0.325
LIG_LIR_Nem_3	141	146	PF02991	0.319
LIG_LIR_Nem_3	196	202	PF02991	0.333
LIG_LIR_Nem_3	403	407	PF02991	0.260
LIG_LIR_Nem_3	47	53	PF02991	0.297
LIG_LIR_Nem_3	684	688	PF02991	0.452
LIG_LIR_Nem_3	729	735	PF02991	0.478
LIG_LIR_Nem_3	95	99	PF02991	0.306
LIG_NRBOX	146	152	PF00104	0.255
LIG_NRBOX	390	396	PF00104	0.306
LIG_NRBOX	730	736	PF00104	0.478
LIG_PCNA_PIPBox_1	822	831	PF02747	0.319
LIG_PCNA_yPIPBox_3	144	152	PF02747	0.350
LIG_PCNA_yPIPBox_3	817	829	PF02747	0.324
LIG_SH2_CRK	685	689	PF00017	0.584
LIG_SH2_NCK_1	222	226	PF00017	0.387
LIG_SH2_STAP1	222	226	PF00017	0.253
LIG_SH2_STAP1	481	485	PF00017	0.633
LIG_SH2_STAP1	54	58	PF00017	0.360
LIG_SH2_STAP1	64	68	PF00017	0.289
LIG_SH2_STAT3	481	484	PF00017	0.617
LIG_SH2_STAT5	222	225	PF00017	0.450
LIG_SH2_STAT5	255	258	PF00017	0.540
LIG_SH2_STAT5	470	473	PF00017	0.446
LIG_SH2_STAT5	667	670	PF00017	0.494
LIG_SH2_STAT5	730	733	PF00017	0.377
LIG_SH2_STAT5	96	99	PF00017	0.287
LIG_SH3_2	382	387	PF14604	0.268
LIG_SH3_3	379	385	PF00018	0.219
LIG_SH3_3	883	889	PF00018	0.506
LIG_SUMO_SIM_anti_2	643	649	PF11976	0.504
LIG_SUMO_SIM_par_1	188	196	PF11976	0.273
LIG_TRAF2_1	213	216	PF00917	0.336
LIG_TRAF2_1	274	277	PF00917	0.685
LIG_TRAF2_1	528	531	PF00917	0.519
LIG_TRAF2_1	632	635	PF00917	0.533
LIG_UBA3_1	848	855	PF00899	0.471
MOD_CK1_1	175	181	PF00069	0.421
MOD_CK1_1	186	192	PF00069	0.343
MOD_CK1_1	227	233	PF00069	0.309
MOD_CK1_1	239	245	PF00069	0.307
MOD_CK1_1	289	295	PF00069	0.756
MOD_CK1_1	341	347	PF00069	0.377
MOD_CK1_1	357	363	PF00069	0.287
MOD_CK1_1	370	376	PF00069	0.224
MOD_CK1_1	389	395	PF00069	0.326
MOD_CK1_1	418	424	PF00069	0.287
MOD_CK1_1	503	509	PF00069	0.652
MOD_CK1_1	556	562	PF00069	0.524
MOD_CK1_1	573	579	PF00069	0.542
MOD_CK1_1	704	710	PF00069	0.661
MOD_CK1_1	759	765	PF00069	0.586
MOD_CK1_1	767	773	PF00069	0.551
MOD_CK1_1	92	98	PF00069	0.306
MOD_CK2_1	135	141	PF00069	0.306
MOD_CK2_1	190	196	PF00069	0.273
MOD_CK2_1	210	216	PF00069	0.273
MOD_CK2_1	271	277	PF00069	0.660
MOD_CK2_1	34	40	PF00069	0.256
MOD_CK2_1	414	420	PF00069	0.360
MOD_CK2_1	56	62	PF00069	0.345
MOD_CK2_1	591	597	PF00069	0.486
MOD_CK2_1	621	627	PF00069	0.512
MOD_CK2_1	628	634	PF00069	0.545
MOD_CK2_1	781	787	PF00069	0.445
MOD_GlcNHglycan	174	177	PF01048	0.256
MOD_GlcNHglycan	185	188	PF01048	0.148
MOD_GlcNHglycan	229	232	PF01048	0.317
MOD_GlcNHglycan	294	297	PF01048	0.659
MOD_GlcNHglycan	340	343	PF01048	0.390
MOD_GlcNHglycan	396	399	PF01048	0.321
MOD_GlcNHglycan	416	420	PF01048	0.390
MOD_GlcNHglycan	502	505	PF01048	0.626
MOD_GlcNHglycan	545	548	PF01048	0.609
MOD_GlcNHglycan	554	558	PF01048	0.509
MOD_GlcNHglycan	630	633	PF01048	0.456
MOD_GlcNHglycan	735	738	PF01048	0.577
MOD_GlcNHglycan	91	94	PF01048	0.304
MOD_GSK3_1	172	179	PF00069	0.458
MOD_GSK3_1	186	193	PF00069	0.376
MOD_GSK3_1	206	213	PF00069	0.259
MOD_GSK3_1	216	223	PF00069	0.286
MOD_GSK3_1	285	292	PF00069	0.732
MOD_GSK3_1	295	302	PF00069	0.739
MOD_GSK3_1	309	316	PF00069	0.444
MOD_GSK3_1	356	363	PF00069	0.297
MOD_GSK3_1	414	421	PF00069	0.376
MOD_GSK3_1	496	503	PF00069	0.665
MOD_GSK3_1	552	559	PF00069	0.512
MOD_GSK3_1	566	573	PF00069	0.561
MOD_GSK3_1	642	649	PF00069	0.501
MOD_GSK3_1	677	684	PF00069	0.514
MOD_GSK3_1	752	759	PF00069	0.628
MOD_GSK3_1	767	774	PF00069	0.422
MOD_GSK3_1	781	788	PF00069	0.532
MOD_GSK3_1	99	106	PF00069	0.303
MOD_N-GLC_1	354	359	PF02516	0.307
MOD_N-GLC_1	608	613	PF02516	0.458
MOD_N-GLC_1	80	85	PF02516	0.318
MOD_NEK2_1	1	6	PF00069	0.559
MOD_NEK2_1	117	122	PF00069	0.250
MOD_NEK2_1	185	190	PF00069	0.317
MOD_NEK2_1	24	29	PF00069	0.368
MOD_NEK2_1	394	399	PF00069	0.268
MOD_NEK2_1	570	575	PF00069	0.531
MOD_NEK2_1	588	593	PF00069	0.534
MOD_NEK2_1	646	651	PF00069	0.470
MOD_NEK2_1	681	686	PF00069	0.587
MOD_NEK2_1	771	776	PF00069	0.406
MOD_NEK2_1	854	859	PF00069	0.481
MOD_NEK2_1	99	104	PF00069	0.274
MOD_NEK2_2	190	195	PF00069	0.387
MOD_NEK2_2	752	757	PF00069	0.518
MOD_NEK2_2	785	790	PF00069	0.405
MOD_NEK2_2	80	85	PF00069	0.352
MOD_PIKK_1	2	8	PF00454	0.453
MOD_PIKK_1	206	212	PF00454	0.260
MOD_PIKK_1	287	293	PF00454	0.731
MOD_PIKK_1	480	486	PF00454	0.594
MOD_PIKK_1	521	527	PF00454	0.312
MOD_PIKK_1	574	580	PF00454	0.573
MOD_PIKK_1	588	594	PF00454	0.610
MOD_PIKK_1	608	614	PF00454	0.342
MOD_PIKK_1	646	652	PF00454	0.489
MOD_PIKK_1	739	745	PF00454	0.576
MOD_PIKK_1	756	762	PF00454	0.451
MOD_PIKK_1	856	862	PF00454	0.579
MOD_PKA_2	172	178	PF00069	0.239
MOD_PKA_2	227	233	PF00069	0.316
MOD_PKA_2	285	291	PF00069	0.732
MOD_PKA_2	386	392	PF00069	0.307
MOD_PKA_2	421	427	PF00069	0.245
MOD_PKA_2	570	576	PF00069	0.537
MOD_PKA_2	621	627	PF00069	0.417
MOD_PKA_2	701	707	PF00069	0.563
MOD_PKA_2	756	762	PF00069	0.636
MOD_Plk_1	215	221	PF00069	0.316
MOD_Plk_1	250	256	PF00069	0.331
MOD_Plk_1	269	275	PF00069	0.669
MOD_Plk_1	33	39	PF00069	0.405
MOD_Plk_1	354	360	PF00069	0.300
MOD_Plk_1	370	376	PF00069	0.274
MOD_Plk_1	44	50	PF00069	0.330
MOD_Plk_1	642	648	PF00069	0.513
MOD_Plk_1	752	758	PF00069	0.418
MOD_Plk_2-3	258	264	PF00069	0.518
MOD_Plk_2-3	271	277	PF00069	0.611
MOD_Plk_2-3	34	40	PF00069	0.387
MOD_Plk_4	135	141	PF00069	0.306
MOD_Plk_4	216	222	PF00069	0.390
MOD_Plk_4	360	366	PF00069	0.266
MOD_Plk_4	465	471	PF00069	0.465
MOD_Plk_4	503	509	PF00069	0.568
MOD_Plk_4	513	519	PF00069	0.558
MOD_Plk_4	642	648	PF00069	0.598
MOD_Plk_4	726	732	PF00069	0.466
MOD_Plk_4	80	86	PF00069	0.321
MOD_Plk_4	820	826	PF00069	0.415
MOD_Plk_4	94	100	PF00069	0.307
MOD_ProDKin_1	103	109	PF00069	0.368
MOD_ProDKin_1	186	192	PF00069	0.308
MOD_ProDKin_1	409	415	PF00069	0.318
MOD_ProDKin_1	496	502	PF00069	0.607
MOD_SUMO_rev_2	23	30	PF00179	0.312
MOD_SUMO_rev_2	531	538	PF00179	0.538
MOD_SUMO_rev_2	604	611	PF00179	0.604
MOD_SUMO_rev_2	704	712	PF00179	0.586
MOD_SUMO_rev_2	811	818	PF00179	0.435
TRG_DiLeu_BaEn_1	625	630	PF01217	0.497
TRG_DiLeu_BaEn_1	695	700	PF01217	0.410
TRG_DiLeu_BaEn_2	197	203	PF01217	0.156
TRG_DiLeu_BaEn_4	531	537	PF01217	0.527
TRG_DiLeu_BaEn_4	635	641	PF01217	0.567
TRG_DiLeu_BaLyEn_6	654	659	PF01217	0.451
TRG_DiLeu_BaLyEn_6	730	735	PF01217	0.462
TRG_ENDOCYTIC_2	143	146	PF00928	0.287
TRG_ENDOCYTIC_2	199	202	PF00928	0.156
TRG_ENDOCYTIC_2	685	688	PF00928	0.585
TRG_ENDOCYTIC_2	96	99	PF00928	0.273
TRG_ER_diArg_1	15	18	PF00400	0.371
TRG_ER_diArg_1	20	22	PF00400	0.456
TRG_ER_diArg_1	306	308	PF00400	0.480
TRG_ER_diArg_1	437	440	PF00400	0.451
TRG_ER_diArg_1	447	450	PF00400	0.413
TRG_ER_diArg_1	457	459	PF00400	0.406
TRG_ER_diArg_1	794	796	PF00400	0.512
TRG_ER_diArg_1	879	882	PF00400	0.605
TRG_NES_CRM1_1	531	545	PF08389	0.516
TRG_NES_CRM1_1	822	837	PF08389	0.392
TRG_NLS_Bipartite_1	306	324	PF00514	0.222
TRG_NLS_MonoExtN_4	318	324	PF00514	0.238
TRG_NLS_MonoExtN_4	430	436	PF00514	0.387
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.177
TRG_Pf-PMV_PEXEL_1	603	608	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM1	Leptomonas seymouri	64%	96%
A0A0S4INA4	Bodo saltans	39%	100%
A0A1X0NDZ3	Trypanosomatidae	27%	80%
A0A1X0NUN6	Trypanosomatidae	42%	95%
A0A3Q8IBS7	Leishmania donovani	25%	100%
A0A3R7KHX7	Trypanosoma rangeli	26%	100%
A0A3R7NW09	Trypanosoma rangeli	30%	86%
A0A3S7WX05	Leishmania donovani	78%	100%
A0A422N2N4	Trypanosoma rangeli	40%	100%
A4H4I4	Leishmania braziliensis	26%	100%
A4HHY2	Leishmania braziliensis	25%	100%
A4HMM9	Leishmania braziliensis	31%	100%
A4HZT3	Leishmania infantum	78%	100%
A4I562	Leishmania infantum	25%	100%
E9AF32	Leishmania major	31%	100%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q9P2	Leishmania major	29%	84%
Q4QBU1	Leishmania major	78%	100%
Q4QJ61	Leishmania major	24%	100%
Q86ZC1	Botryotinia fuckeliana	26%	100%
Q9LPC6	Arabidopsis thaliana	27%	100%
V5B2F4	Trypanosoma cruzi	28%	85%
V5BLH7	Trypanosoma cruzi	44%	100%