Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCA0_LEIBR

TriTrypDb:

LbrM.22.0490 , LBRM2903_220010400

Length:

901

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.650
CLV_C14_Caspase3-7	256	260	PF00656	0.349
CLV_C14_Caspase3-7	384	388	PF00656	0.365
CLV_C14_Caspase3-7	737	741	PF00656	0.496
CLV_C14_Caspase3-7	818	822	PF00656	0.694
CLV_NRD_NRD_1	129	131	PF00675	0.684
CLV_NRD_NRD_1	196	198	PF00675	0.437
CLV_NRD_NRD_1	285	287	PF00675	0.567
CLV_NRD_NRD_1	41	43	PF00675	0.537
CLV_NRD_NRD_1	47	49	PF00675	0.481
CLV_NRD_NRD_1	626	628	PF00675	0.526
CLV_NRD_NRD_1	660	662	PF00675	0.539
CLV_NRD_NRD_1	678	680	PF00675	0.474
CLV_NRD_NRD_1	785	787	PF00675	0.600
CLV_NRD_NRD_1	801	803	PF00675	0.474
CLV_NRD_NRD_1	810	812	PF00675	0.533
CLV_NRD_NRD_1	881	883	PF00675	0.711
CLV_PCSK_KEX2_1	129	131	PF00082	0.684
CLV_PCSK_KEX2_1	196	198	PF00082	0.438
CLV_PCSK_KEX2_1	275	277	PF00082	0.600
CLV_PCSK_KEX2_1	285	287	PF00082	0.540
CLV_PCSK_KEX2_1	47	49	PF00082	0.495
CLV_PCSK_KEX2_1	660	662	PF00082	0.539
CLV_PCSK_KEX2_1	678	680	PF00082	0.474
CLV_PCSK_KEX2_1	785	787	PF00082	0.605
CLV_PCSK_KEX2_1	801	803	PF00082	0.481
CLV_PCSK_KEX2_1	810	812	PF00082	0.535
CLV_PCSK_KEX2_1	881	883	PF00082	0.669
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.547
CLV_PCSK_PC7_1	271	277	PF00082	0.535
CLV_PCSK_PC7_1	806	812	PF00082	0.613
CLV_PCSK_SKI1_1	323	327	PF00082	0.491
CLV_PCSK_SKI1_1	371	375	PF00082	0.427
CLV_PCSK_SKI1_1	450	454	PF00082	0.335
CLV_PCSK_SKI1_1	458	462	PF00082	0.402
CLV_PCSK_SKI1_1	463	467	PF00082	0.457
CLV_PCSK_SKI1_1	48	52	PF00082	0.477
CLV_PCSK_SKI1_1	539	543	PF00082	0.650
CLV_Separin_Metazoa	663	667	PF03568	0.485
CLV_Separin_Metazoa	675	679	PF03568	0.615
DEG_APCC_KENBOX_2	888	892	PF00400	0.683
DOC_CYCLIN_RxL_1	368	376	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	461	467	PF00134	0.485
DOC_MAPK_gen_1	448	455	PF00069	0.424
DOC_MAPK_gen_1	47	53	PF00069	0.453
DOC_MAPK_gen_1	801	807	PF00069	0.632
DOC_MAPK_MEF2A_6	506	514	PF00069	0.358
DOC_PP2B_LxvP_1	211	214	PF13499	0.493
DOC_PP2B_LxvP_1	49	52	PF13499	0.439
DOC_PP2B_LxvP_1	671	674	PF13499	0.470
DOC_PP2B_PxIxI_1	1	7	PF00149	0.554
DOC_PP4_FxxP_1	17	20	PF00568	0.574
DOC_USP7_MATH_1	25	29	PF00917	0.534
DOC_USP7_MATH_1	350	354	PF00917	0.633
DOC_USP7_MATH_1	52	56	PF00917	0.569
DOC_USP7_MATH_1	631	635	PF00917	0.485
DOC_USP7_UBL2_3	322	326	PF12436	0.490
DOC_USP7_UBL2_3	894	898	PF12436	0.689
DOC_WW_Pin1_4	109	114	PF00397	0.647
DOC_WW_Pin1_4	284	289	PF00397	0.537
DOC_WW_Pin1_4	303	308	PF00397	0.693
DOC_WW_Pin1_4	315	320	PF00397	0.562
DOC_WW_Pin1_4	426	431	PF00397	0.466
DOC_WW_Pin1_4	534	539	PF00397	0.684
DOC_WW_Pin1_4	615	620	PF00397	0.418
DOC_WW_Pin1_4	72	77	PF00397	0.540
DOC_WW_Pin1_4	764	769	PF00397	0.755
LIG_14-3-3_CanoR_1	129	138	PF00244	0.588
LIG_14-3-3_CanoR_1	197	205	PF00244	0.481
LIG_14-3-3_CanoR_1	276	281	PF00244	0.618
LIG_14-3-3_CanoR_1	299	307	PF00244	0.651
LIG_14-3-3_CanoR_1	351	359	PF00244	0.635
LIG_14-3-3_CanoR_1	463	468	PF00244	0.420
LIG_14-3-3_CanoR_1	709	718	PF00244	0.545
LIG_14-3-3_CanoR_1	785	792	PF00244	0.603
LIG_14-3-3_CanoR_1	856	860	PF00244	0.579
LIG_14-3-3_CanoR_1	881	887	PF00244	0.624
LIG_14-3-3_CanoR_1	99	106	PF00244	0.730
LIG_BRCT_BRCA1_1	857	861	PF00533	0.497
LIG_Clathr_ClatBox_1	149	153	PF01394	0.313
LIG_FHA_1	134	140	PF00498	0.502
LIG_FHA_1	188	194	PF00498	0.493
LIG_FHA_1	208	214	PF00498	0.439
LIG_FHA_1	316	322	PF00498	0.673
LIG_FHA_1	464	470	PF00498	0.481
LIG_FHA_1	509	515	PF00498	0.304
LIG_FHA_1	589	595	PF00498	0.422
LIG_FHA_1	649	655	PF00498	0.390
LIG_FHA_1	751	757	PF00498	0.637
LIG_FHA_2	236	242	PF00498	0.634
LIG_FHA_2	290	296	PF00498	0.624
LIG_FHA_2	334	340	PF00498	0.664
LIG_FHA_2	382	388	PF00498	0.381
LIG_FHA_2	470	476	PF00498	0.508
LIG_FHA_2	489	495	PF00498	0.670
LIG_FHA_2	554	560	PF00498	0.520
LIG_GBD_Chelix_1	574	582	PF00786	0.370
LIG_IBAR_NPY_1	873	875	PF08397	0.663
LIG_Integrin_RGD_1	271	273	PF01839	0.528
LIG_LIR_Apic_2	15	20	PF02991	0.536
LIG_LIR_Gen_1	169	178	PF02991	0.357
LIG_LIR_Gen_1	230	237	PF02991	0.530
LIG_LIR_Gen_1	454	464	PF02991	0.461
LIG_LIR_Gen_1	609	620	PF02991	0.496
LIG_LIR_Gen_1	689	700	PF02991	0.624
LIG_LIR_Gen_1	77	87	PF02991	0.379
LIG_LIR_Gen_1	803	812	PF02991	0.635
LIG_LIR_Nem_3	169	174	PF02991	0.357
LIG_LIR_Nem_3	177	181	PF02991	0.378
LIG_LIR_Nem_3	226	232	PF02991	0.496
LIG_LIR_Nem_3	454	459	PF02991	0.489
LIG_LIR_Nem_3	609	615	PF02991	0.481
LIG_LIR_Nem_3	689	695	PF02991	0.582
LIG_LIR_Nem_3	77	82	PF02991	0.500
LIG_LIR_Nem_3	803	807	PF02991	0.651
LIG_LIR_Nem_3	809	815	PF02991	0.672
LIG_LIR_Nem_3	838	843	PF02991	0.585
LIG_MYND_1	669	673	PF01753	0.532
LIG_NRBOX	438	444	PF00104	0.407
LIG_NRBOX	577	583	PF00104	0.379
LIG_PCNA_yPIPBox_3	74	87	PF02747	0.445
LIG_PDZ_Class_1	896	901	PF00595	0.579
LIG_Pex14_1	397	401	PF04695	0.487
LIG_Pex14_2	456	460	PF04695	0.474
LIG_PTB_Apo_2	63	70	PF02174	0.505
LIG_PTB_Phospho_1	63	69	PF10480	0.505
LIG_REV1ctd_RIR_1	840	849	PF16727	0.681
LIG_SH2_CRK	69	73	PF00017	0.496
LIG_SH2_GRB2like	468	471	PF00017	0.317
LIG_SH2_PTP2	804	807	PF00017	0.606
LIG_SH2_SRC	468	471	PF00017	0.317
LIG_SH2_STAP1	13	17	PF00017	0.473
LIG_SH2_STAP1	229	233	PF00017	0.544
LIG_SH2_STAP1	40	44	PF00017	0.607
LIG_SH2_STAP1	561	565	PF00017	0.351
LIG_SH2_STAP1	649	653	PF00017	0.479
LIG_SH2_STAP1	93	97	PF00017	0.607
LIG_SH2_STAT3	13	16	PF00017	0.474
LIG_SH2_STAT3	561	564	PF00017	0.367
LIG_SH2_STAT5	178	181	PF00017	0.427
LIG_SH2_STAT5	232	235	PF00017	0.524
LIG_SH2_STAT5	468	471	PF00017	0.454
LIG_SH2_STAT5	632	635	PF00017	0.574
LIG_SH2_STAT5	804	807	PF00017	0.584
LIG_SH3_1	532	538	PF00018	0.459
LIG_SH3_3	532	538	PF00018	0.459
LIG_SH3_CIN85_PxpxPR_1	346	351	PF14604	0.552
LIG_SUMO_SIM_anti_2	579	587	PF11976	0.476
LIG_SUMO_SIM_par_1	147	153	PF11976	0.328
LIG_SUMO_SIM_par_1	579	587	PF11976	0.484
LIG_SUMO_SIM_par_1	757	763	PF11976	0.494
LIG_TRFH_1	652	656	PF08558	0.304
LIG_UBA3_1	758	762	PF00899	0.673
LIG_WRC_WIRS_1	188	193	PF05994	0.468
LIG_WRC_WIRS_1	649	654	PF05994	0.282
LIG_WW_1	725	728	PF00397	0.474
MOD_CDK_SPK_2	109	114	PF00069	0.488
MOD_CDK_SPK_2	303	308	PF00069	0.648
MOD_CDK_SPK_2	315	320	PF00069	0.700
MOD_CDK_SPK_2	534	539	PF00069	0.477
MOD_CDK_SPxxK_3	315	322	PF00069	0.551
MOD_CK1_1	107	113	PF00069	0.485
MOD_CK1_1	12	18	PF00069	0.540
MOD_CK1_1	132	138	PF00069	0.628
MOD_CK1_1	166	172	PF00069	0.496
MOD_CK1_1	201	207	PF00069	0.425
MOD_CK1_1	245	251	PF00069	0.507
MOD_CK1_1	334	340	PF00069	0.760
MOD_CK1_1	381	387	PF00069	0.509
MOD_CK1_1	471	477	PF00069	0.552
MOD_CK1_1	537	543	PF00069	0.792
MOD_CK1_1	711	717	PF00069	0.600
MOD_CK1_1	741	747	PF00069	0.680
MOD_CK1_1	763	769	PF00069	0.746
MOD_CK1_1	770	776	PF00069	0.524
MOD_CK1_1	788	794	PF00069	0.748
MOD_CK2_1	105	111	PF00069	0.483
MOD_CK2_1	131	137	PF00069	0.660
MOD_CK2_1	250	256	PF00069	0.721
MOD_CK2_1	488	494	PF00069	0.738
MOD_CK2_1	553	559	PF00069	0.628
MOD_CK2_1	679	685	PF00069	0.597
MOD_CK2_1	89	95	PF00069	0.673
MOD_Cter_Amidation	783	786	PF01082	0.690
MOD_GlcNHglycan	184	187	PF01048	0.555
MOD_GlcNHglycan	201	204	PF01048	0.410
MOD_GlcNHglycan	245	248	PF01048	0.509
MOD_GlcNHglycan	333	336	PF01048	0.699
MOD_GlcNHglycan	338	342	PF01048	0.820
MOD_GlcNHglycan	352	355	PF01048	0.689
MOD_GlcNHglycan	416	419	PF01048	0.554
MOD_GlcNHglycan	479	482	PF01048	0.681
MOD_GlcNHglycan	565	568	PF01048	0.480
MOD_GlcNHglycan	622	625	PF01048	0.480
MOD_GlcNHglycan	657	660	PF01048	0.546
MOD_GlcNHglycan	681	684	PF01048	0.484
MOD_GlcNHglycan	710	713	PF01048	0.636
MOD_GlcNHglycan	736	739	PF01048	0.715
MOD_GlcNHglycan	769	772	PF01048	0.735
MOD_GlcNHglycan	787	790	PF01048	0.641
MOD_GlcNHglycan	837	840	PF01048	0.586
MOD_GlcNHglycan	898	901	PF01048	0.602
MOD_GlcNHglycan	99	102	PF01048	0.614
MOD_GSK3_1	105	112	PF00069	0.683
MOD_GSK3_1	125	132	PF00069	0.421
MOD_GSK3_1	166	173	PF00069	0.438
MOD_GSK3_1	21	28	PF00069	0.461
MOD_GSK3_1	242	249	PF00069	0.614
MOD_GSK3_1	303	310	PF00069	0.657
MOD_GSK3_1	333	340	PF00069	0.657
MOD_GSK3_1	350	357	PF00069	0.650
MOD_GSK3_1	379	386	PF00069	0.584
MOD_GSK3_1	471	478	PF00069	0.548
MOD_GSK3_1	533	540	PF00069	0.631
MOD_GSK3_1	734	741	PF00069	0.604
MOD_GSK3_1	750	757	PF00069	0.576
MOD_GSK3_1	760	767	PF00069	0.530
MOD_GSK3_1	784	791	PF00069	0.601
MOD_GSK3_1	855	862	PF00069	0.496
MOD_GSK3_1	95	102	PF00069	0.648
MOD_N-GLC_1	166	171	PF02516	0.501
MOD_N-GLC_1	235	240	PF02516	0.435
MOD_N-GLC_1	303	308	PF02516	0.617
MOD_N-GLC_1	469	474	PF02516	0.403
MOD_N-GLC_1	702	707	PF02516	0.623
MOD_N-GLC_1	748	753	PF02516	0.648
MOD_N-GLC_1	777	782	PF02516	0.537
MOD_N-GLC_1	854	859	PF02516	0.521
MOD_N-GLC_1	882	887	PF02516	0.649
MOD_N-GLC_2	425	427	PF02516	0.453
MOD_NEK2_1	131	136	PF00069	0.482
MOD_NEK2_1	170	175	PF00069	0.373
MOD_NEK2_1	198	203	PF00069	0.491
MOD_NEK2_1	228	233	PF00069	0.545
MOD_NEK2_1	242	247	PF00069	0.665
MOD_NEK2_1	373	378	PF00069	0.287
MOD_NEK2_1	442	447	PF00069	0.464
MOD_NEK2_1	469	474	PF00069	0.586
MOD_NEK2_1	479	484	PF00069	0.498
MOD_NEK2_1	514	519	PF00069	0.395
MOD_NEK2_1	563	568	PF00069	0.492
MOD_NEK2_1	620	625	PF00069	0.380
MOD_NEK2_1	720	725	PF00069	0.498
MOD_NEK2_1	777	782	PF00069	0.595
MOD_NEK2_1	815	820	PF00069	0.673
MOD_NEK2_2	187	192	PF00069	0.463
MOD_OFUCOSY	126	133	PF10250	0.475
MOD_PIKK_1	12	18	PF00454	0.493
MOD_PIKK_1	622	628	PF00454	0.574
MOD_PIKK_1	739	745	PF00454	0.496
MOD_PKA_1	129	135	PF00069	0.509
MOD_PKA_1	785	791	PF00069	0.637
MOD_PKA_1	881	887	PF00069	0.643
MOD_PKA_2	129	135	PF00069	0.509
MOD_PKA_2	198	204	PF00069	0.519
MOD_PKA_2	298	304	PF00069	0.720
MOD_PKA_2	307	313	PF00069	0.702
MOD_PKA_2	350	356	PF00069	0.673
MOD_PKA_2	378	384	PF00069	0.585
MOD_PKA_2	708	714	PF00069	0.535
MOD_PKA_2	784	790	PF00069	0.580
MOD_PKA_2	855	861	PF00069	0.582
MOD_PKA_2	881	887	PF00069	0.643
MOD_PKB_1	197	205	PF00069	0.511
MOD_Plk_1	166	172	PF00069	0.496
MOD_Plk_1	469	475	PF00069	0.621
MOD_Plk_1	702	708	PF00069	0.684
MOD_Plk_1	720	726	PF00069	0.617
MOD_Plk_1	882	888	PF00069	0.663
MOD_Plk_4	170	176	PF00069	0.386
MOD_Plk_4	207	213	PF00069	0.397
MOD_Plk_4	228	234	PF00069	0.554
MOD_Plk_4	310	316	PF00069	0.584
MOD_Plk_4	451	457	PF00069	0.508
MOD_Plk_4	463	469	PF00069	0.436
MOD_Plk_4	570	576	PF00069	0.475
MOD_Plk_4	754	760	PF00069	0.701
MOD_ProDKin_1	109	115	PF00069	0.645
MOD_ProDKin_1	284	290	PF00069	0.540
MOD_ProDKin_1	303	309	PF00069	0.692
MOD_ProDKin_1	315	321	PF00069	0.561
MOD_ProDKin_1	426	432	PF00069	0.455
MOD_ProDKin_1	534	540	PF00069	0.688
MOD_ProDKin_1	615	621	PF00069	0.415
MOD_ProDKin_1	72	78	PF00069	0.536
MOD_ProDKin_1	764	770	PF00069	0.757
MOD_SUMO_for_1	640	643	PF00179	0.404
MOD_SUMO_rev_2	757	763	PF00179	0.494
TRG_DiLeu_BaEn_1	438	443	PF01217	0.372
TRG_DiLeu_BaEn_3	143	149	PF01217	0.416
TRG_DiLeu_BaEn_4	223	229	PF01217	0.485
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.501
TRG_DiLeu_BaLyEn_6	573	578	PF01217	0.422
TRG_ENDOCYTIC_2	178	181	PF00928	0.383
TRG_ENDOCYTIC_2	232	235	PF00928	0.566
TRG_ENDOCYTIC_2	649	652	PF00928	0.478
TRG_ENDOCYTIC_2	69	72	PF00928	0.492
TRG_ENDOCYTIC_2	692	695	PF00928	0.452
TRG_ENDOCYTIC_2	804	807	PF00928	0.652
TRG_ER_diArg_1	129	131	PF00400	0.677
TRG_ER_diArg_1	196	198	PF00400	0.510
TRG_ER_diArg_1	252	255	PF00400	0.589
TRG_ER_diArg_1	47	49	PF00400	0.438
TRG_ER_diArg_1	677	679	PF00400	0.609
TRG_ER_diArg_1	800	802	PF00400	0.611
TRG_ER_diArg_1	810	812	PF00400	0.591
TRG_ER_diArg_1	880	882	PF00400	0.664
TRG_NES_CRM1_1	579	592	PF08389	0.468
TRG_Pf-PMV_PEXEL_1	576	580	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJM2	Leptomonas seymouri	49%	100%
A0A1X0NTP3	Trypanosomatidae	29%	100%
A0A3S7WX34	Leishmania donovani	72%	100%
A0A422N2K2	Trypanosoma rangeli	30%	100%
A4HZT2	Leishmania infantum	72%	100%
C9ZRL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AVN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QBU2	Leishmania major	72%	99%