Putative peptidyl-prolyl cis-trans isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase, putative

Species:

Leishmania braziliensis

UniProt:

A4HC99_LEIBR

TriTrypDb:

LbrM.22.0480 , LBRM2903_220010300

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC99

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	9
GO:0003824	catalytic activity	1	9
GO:0016853	isomerase activity	2	9
GO:0016859	cis-trans isomerase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.269
CLV_NRD_NRD_1	148	150	PF00675	0.293
CLV_PCSK_KEX2_1	144	146	PF00082	0.284
CLV_PCSK_KEX2_1	180	182	PF00082	0.533
CLV_PCSK_KEX2_1	394	396	PF00082	0.308
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.270
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.533
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.297
CLV_PCSK_PC7_1	140	146	PF00082	0.286
CLV_PCSK_SKI1_1	353	357	PF00082	0.386
CLV_PCSK_SKI1_1	403	407	PF00082	0.221
CLV_PCSK_SKI1_1	412	416	PF00082	0.208
DEG_APCC_DBOX_1	394	402	PF00400	0.331
DEG_SCF_FBW7_1	255	261	PF00400	0.511
DOC_CKS1_1	255	260	PF01111	0.508
DOC_MAPK_gen_1	149	156	PF00069	0.337
DOC_MAPK_MEF2A_6	149	156	PF00069	0.330
DOC_MAPK_MEF2A_6	268	277	PF00069	0.632
DOC_MAPK_MEF2A_6	362	371	PF00069	0.338
DOC_MAPK_MEF2A_6	81	89	PF00069	0.399
DOC_PP4_FxxP_1	60	63	PF00568	0.333
DOC_USP7_MATH_1	155	159	PF00917	0.293
DOC_USP7_MATH_1	196	200	PF00917	0.631
DOC_USP7_MATH_1	232	236	PF00917	0.736
DOC_USP7_MATH_1	264	268	PF00917	0.700
DOC_USP7_MATH_1	291	295	PF00917	0.589
DOC_USP7_MATH_1	296	300	PF00917	0.594
DOC_USP7_MATH_1	306	310	PF00917	0.659
DOC_USP7_MATH_1	36	40	PF00917	0.415
DOC_WW_Pin1_4	241	246	PF00397	0.636
DOC_WW_Pin1_4	254	259	PF00397	0.499
DOC_WW_Pin1_4	363	368	PF00397	0.395
DOC_WW_Pin1_4	369	374	PF00397	0.388
LIG_14-3-3_CanoR_1	194	201	PF00244	0.520
LIG_Actin_WH2_2	403	420	PF00022	0.331
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_BRCT_BRCA1_1	69	73	PF00533	0.400
LIG_eIF4E_1	312	318	PF01652	0.413
LIG_FHA_1	134	140	PF00498	0.337
LIG_FHA_1	166	172	PF00498	0.472
LIG_FHA_1	224	230	PF00498	0.543
LIG_FHA_1	238	244	PF00498	0.629
LIG_FHA_1	46	52	PF00498	0.497
LIG_FHA_2	18	24	PF00498	0.561
LIG_FHA_2	373	379	PF00498	0.386
LIG_FHA_2	380	386	PF00498	0.386
LIG_Integrin_RGD_1	395	397	PF01839	0.331
LIG_LIR_Gen_1	385	391	PF02991	0.365
LIG_LIR_Nem_3	309	315	PF02991	0.551
LIG_LIR_Nem_3	385	389	PF02991	0.317
LIG_LIR_Nem_3	70	76	PF02991	0.263
LIG_LYPXL_yS_3	84	87	PF13949	0.388
LIG_SH2_CRK	312	316	PF00017	0.394
LIG_SH2_SRC	312	315	PF00017	0.433
LIG_SH2_STAP1	169	173	PF00017	0.467
LIG_SH2_STAT5	105	108	PF00017	0.337
LIG_SH2_STAT5	354	357	PF00017	0.331
LIG_SH2_STAT5	386	389	PF00017	0.386
LIG_SH2_STAT5	76	79	PF00017	0.452
LIG_SH2_STAT5	95	98	PF00017	0.287
LIG_SH3_1	145	151	PF00018	0.331
LIG_SH3_3	145	151	PF00018	0.331
LIG_SH3_3	170	176	PF00018	0.312
LIG_SH3_3	252	258	PF00018	0.776
LIG_SH3_3	26	32	PF00018	0.663
LIG_SH3_3	324	330	PF00018	0.388
LIG_SH3_3	361	367	PF00018	0.319
LIG_SH3_3	419	425	PF00018	0.274
LIG_SH3_3	66	72	PF00018	0.427
LIG_SH3_3	79	85	PF00018	0.331
LIG_SUMO_SIM_par_1	129	136	PF11976	0.328
LIG_SUMO_SIM_par_1	152	158	PF11976	0.386
LIG_TYR_ITIM	82	87	PF00017	0.401
LIG_TYR_ITSM	308	315	PF00017	0.367
LIG_UBA3_1	317	325	PF00899	0.393
LIG_WRC_WIRS_1	1	6	PF05994	0.570
MOD_CK1_1	111	117	PF00069	0.322
MOD_CK1_1	165	171	PF00069	0.464
MOD_CK1_1	199	205	PF00069	0.751
MOD_CK1_1	307	313	PF00069	0.563
MOD_CK1_1	372	378	PF00069	0.328
MOD_CK2_1	17	23	PF00069	0.664
MOD_CK2_1	296	302	PF00069	0.616
MOD_CK2_1	372	378	PF00069	0.272
MOD_CK2_1	379	385	PF00069	0.288
MOD_Cter_Amidation	142	145	PF01082	0.386
MOD_GlcNHglycan	187	192	PF01048	0.696
MOD_GlcNHglycan	198	201	PF01048	0.610
MOD_GlcNHglycan	203	206	PF01048	0.618
MOD_GlcNHglycan	214	217	PF01048	0.503
MOD_GlcNHglycan	234	237	PF01048	0.782
MOD_GlcNHglycan	269	273	PF01048	0.617
MOD_GlcNHglycan	293	296	PF01048	0.603
MOD_GlcNHglycan	306	309	PF01048	0.714
MOD_GlcNHglycan	388	392	PF01048	0.335
MOD_GlcNHglycan	421	425	PF01048	0.451
MOD_GSK3_1	195	202	PF00069	0.729
MOD_GSK3_1	219	226	PF00069	0.583
MOD_GSK3_1	227	234	PF00069	0.536
MOD_GSK3_1	237	244	PF00069	0.549
MOD_GSK3_1	254	261	PF00069	0.777
MOD_GSK3_1	264	271	PF00069	0.606
MOD_NEK2_1	133	138	PF00069	0.281
MOD_NEK2_1	162	167	PF00069	0.328
MOD_NEK2_1	201	206	PF00069	0.765
MOD_NEK2_1	379	384	PF00069	0.206
MOD_NEK2_2	189	194	PF00069	0.513
MOD_PIKK_1	425	431	PF00454	0.386
MOD_PIKK_1	67	73	PF00454	0.397
MOD_Plk_1	209	215	PF00069	0.472
MOD_Plk_1	268	274	PF00069	0.684
MOD_Plk_4	155	161	PF00069	0.404
MOD_ProDKin_1	241	247	PF00069	0.633
MOD_ProDKin_1	254	260	PF00069	0.498
MOD_ProDKin_1	363	369	PF00069	0.395
TRG_DiLeu_BaEn_2	123	129	PF01217	0.328
TRG_ENDOCYTIC_2	312	315	PF00928	0.400
TRG_ENDOCYTIC_2	386	389	PF00928	0.386
TRG_ENDOCYTIC_2	84	87	PF00928	0.488
TRG_ENDOCYTIC_2	94	97	PF00928	0.328
TRG_ER_diArg_1	415	418	PF00400	0.324
TRG_NLS_MonoCore_2	391	396	PF00514	0.331
TRG_NLS_MonoExtC_3	391	397	PF00514	0.386
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSF6	Leptomonas seymouri	60%	100%
A0A3Q8IE70	Leishmania donovani	78%	100%
A0A3R7K0E7	Trypanosoma rangeli	43%	100%
C9ZRL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AVN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QBU3	Leishmania major	78%	100%
V5BR42	Trypanosoma cruzi	44%	100%