Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC97_LEIBR

TriTrypDb:

LbrM.22.0460 , LBRM2903_220010100

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.790
CLV_C14_Caspase3-7	600	604	PF00656	0.556
CLV_NRD_NRD_1	171	173	PF00675	0.648
CLV_NRD_NRD_1	179	181	PF00675	0.727
CLV_NRD_NRD_1	391	393	PF00675	0.550
CLV_NRD_NRD_1	504	506	PF00675	0.574
CLV_NRD_NRD_1	625	627	PF00675	0.720
CLV_PCSK_KEX2_1	171	173	PF00082	0.683
CLV_PCSK_KEX2_1	179	181	PF00082	0.793
CLV_PCSK_KEX2_1	391	393	PF00082	0.550
CLV_PCSK_KEX2_1	608	610	PF00082	0.675
CLV_PCSK_KEX2_1	625	627	PF00082	0.684
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.564
CLV_PCSK_SKI1_1	140	144	PF00082	0.477
CLV_PCSK_SKI1_1	223	227	PF00082	0.627
CLV_PCSK_SKI1_1	301	305	PF00082	0.633
CLV_PCSK_SKI1_1	391	395	PF00082	0.640
CLV_PCSK_SKI1_1	431	435	PF00082	0.525
DEG_APCC_DBOX_1	222	230	PF00400	0.623
DEG_SCF_TRCP1_1	312	317	PF00400	0.750
DEG_SPOP_SBC_1	201	205	PF00917	0.521
DEG_SPOP_SBC_1	303	307	PF00917	0.599
DEG_SPOP_SBC_1	335	339	PF00917	0.696
DEG_SPOP_SBC_1	342	346	PF00917	0.758
DEG_SPOP_SBC_1	419	423	PF00917	0.750
DOC_CKS1_1	4	9	PF01111	0.569
DOC_CYCLIN_yCln2_LP_2	32	35	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	572	578	PF00134	0.716
DOC_MAPK_gen_1	137	145	PF00069	0.339
DOC_MAPK_gen_1	391	400	PF00069	0.508
DOC_MAPK_gen_1	625	633	PF00069	0.564
DOC_MAPK_MEF2A_6	137	145	PF00069	0.339
DOC_MAPK_MEF2A_6	24	32	PF00069	0.558
DOC_MAPK_RevD_3	157	172	PF00069	0.604
DOC_PP1_RVXF_1	581	587	PF00149	0.369
DOC_PP2B_LxvP_1	32	35	PF13499	0.513
DOC_PP2B_LxvP_1	464	467	PF13499	0.467
DOC_PP2B_LxvP_1	572	575	PF13499	0.698
DOC_PP2B_LxvP_1	617	620	PF13499	0.815
DOC_SPAK_OSR1_1	156	160	PF12202	0.605
DOC_USP7_MATH_1	201	205	PF00917	0.586
DOC_USP7_MATH_1	208	212	PF00917	0.503
DOC_USP7_MATH_1	236	240	PF00917	0.530
DOC_USP7_MATH_1	253	257	PF00917	0.500
DOC_USP7_MATH_1	303	307	PF00917	0.649
DOC_USP7_MATH_1	318	322	PF00917	0.642
DOC_USP7_MATH_1	334	338	PF00917	0.686
DOC_USP7_MATH_1	419	423	PF00917	0.574
DOC_USP7_MATH_1	473	477	PF00917	0.605
DOC_USP7_MATH_1	507	511	PF00917	0.642
DOC_USP7_MATH_1	514	518	PF00917	0.633
DOC_USP7_MATH_1	561	565	PF00917	0.549
DOC_USP7_MATH_1	68	72	PF00917	0.650
DOC_USP7_UBL2_3	297	301	PF12436	0.597
DOC_WW_Pin1_4	116	121	PF00397	0.490
DOC_WW_Pin1_4	143	148	PF00397	0.351
DOC_WW_Pin1_4	270	275	PF00397	0.719
DOC_WW_Pin1_4	3	8	PF00397	0.545
DOC_WW_Pin1_4	304	309	PF00397	0.551
DOC_WW_Pin1_4	324	329	PF00397	0.620
DOC_WW_Pin1_4	343	348	PF00397	0.608
DOC_WW_Pin1_4	447	452	PF00397	0.572
DOC_WW_Pin1_4	469	474	PF00397	0.714
DOC_WW_Pin1_4	56	61	PF00397	0.600
DOC_WW_Pin1_4	634	639	PF00397	0.780
DOC_WW_Pin1_4	98	103	PF00397	0.665
LIG_14-3-3_CanoR_1	156	162	PF00244	0.385
LIG_14-3-3_CanoR_1	179	183	PF00244	0.579
LIG_14-3-3_CanoR_1	200	209	PF00244	0.704
LIG_14-3-3_CanoR_1	289	298	PF00244	0.565
LIG_14-3-3_CanoR_1	299	308	PF00244	0.523
LIG_14-3-3_CanoR_1	402	407	PF00244	0.449
LIG_14-3-3_CanoR_1	418	427	PF00244	0.464
LIG_14-3-3_CanoR_1	491	499	PF00244	0.569
LIG_14-3-3_CanoR_1	519	528	PF00244	0.755
LIG_14-3-3_CanoR_1	609	617	PF00244	0.723
LIG_14-3-3_CanoR_1	649	656	PF00244	0.652
LIG_Actin_WH2_2	123	139	PF00022	0.606
LIG_Actin_WH2_2	378	396	PF00022	0.617
LIG_BRCT_BRCA1_1	148	152	PF00533	0.537
LIG_BRCT_BRCA1_1	428	432	PF00533	0.522
LIG_Clathr_ClatBox_1	397	401	PF01394	0.363
LIG_CSL_BTD_1	545	548	PF09270	0.450
LIG_CSL_BTD_1	617	620	PF09270	0.815
LIG_deltaCOP1_diTrp_1	541	546	PF00928	0.539
LIG_EH1_1	382	390	PF00400	0.600
LIG_EVH1_2	34	38	PF00568	0.540
LIG_FHA_1	213	219	PF00498	0.415
LIG_FHA_1	249	255	PF00498	0.623
LIG_FHA_1	4	10	PF00498	0.627
LIG_FHA_1	600	606	PF00498	0.780
LIG_FHA_2	182	188	PF00498	0.677
LIG_FHA_2	236	242	PF00498	0.643
LIG_FHA_2	485	491	PF00498	0.553
LIG_IRF3_LxIS_1	141	146	PF10401	0.322
LIG_LIR_Gen_1	162	173	PF02991	0.676
LIG_LIR_Gen_1	541	549	PF02991	0.559
LIG_LIR_Nem_3	162	168	PF02991	0.636
LIG_LIR_Nem_3	251	255	PF02991	0.550
LIG_LIR_Nem_3	541	545	PF02991	0.634
LIG_LIR_Nem_3	650	656	PF02991	0.575
LIG_SH2_CRK	250	254	PF00017	0.651
LIG_SH2_NCK_1	128	132	PF00017	0.599
LIG_SH2_STAP1	128	132	PF00017	0.506
LIG_SH2_STAT5	250	253	PF00017	0.531
LIG_SH2_STAT5	384	387	PF00017	0.496
LIG_SH2_STAT5	42	45	PF00017	0.527
LIG_SH2_STAT5	539	542	PF00017	0.509
LIG_SH2_STAT5	643	646	PF00017	0.675
LIG_SH3_3	114	120	PF00018	0.411
LIG_SH3_3	268	274	PF00018	0.836
LIG_SH3_3	322	328	PF00018	0.512
LIG_SH3_3	4	10	PF00018	0.569
LIG_SH3_3	542	548	PF00018	0.667
LIG_SH3_3	57	63	PF00018	0.552
LIG_SH3_3	96	102	PF00018	0.519
LIG_SUMO_SIM_par_1	140	146	PF11976	0.369
LIG_SUMO_SIM_par_1	472	478	PF11976	0.543
LIG_SUMO_SIM_par_1	526	532	PF11976	0.699
LIG_TRAF2_1	266	269	PF00917	0.595
MOD_CDC14_SPxK_1	101	104	PF00782	0.672
MOD_CDC14_SPxK_1	450	453	PF00782	0.406
MOD_CDK_SPxK_1	447	453	PF00069	0.408
MOD_CDK_SPxK_1	98	104	PF00069	0.655
MOD_CK1_1	146	152	PF00069	0.620
MOD_CK1_1	17	23	PF00069	0.702
MOD_CK1_1	211	217	PF00069	0.655
MOD_CK1_1	273	279	PF00069	0.823
MOD_CK1_1	283	289	PF00069	0.615
MOD_CK1_1	291	297	PF00069	0.501
MOD_CK1_1	302	308	PF00069	0.534
MOD_CK1_1	338	344	PF00069	0.738
MOD_CK1_1	364	370	PF00069	0.425
MOD_CK1_1	405	411	PF00069	0.613
MOD_CK1_1	413	419	PF00069	0.708
MOD_CK1_1	421	427	PF00069	0.743
MOD_CK1_1	493	499	PF00069	0.667
MOD_CK1_1	517	523	PF00069	0.657
MOD_CK1_1	564	570	PF00069	0.649
MOD_CK1_1	621	627	PF00069	0.789
MOD_CK1_1	632	638	PF00069	0.682
MOD_CK2_1	262	268	PF00069	0.783
MOD_CK2_1	419	425	PF00069	0.768
MOD_CK2_1	484	490	PF00069	0.674
MOD_CK2_1	609	615	PF00069	0.562
MOD_Cter_Amidation	503	506	PF01082	0.735
MOD_GlcNHglycan	105	108	PF01048	0.740
MOD_GlcNHglycan	114	117	PF01048	0.604
MOD_GlcNHglycan	16	19	PF01048	0.590
MOD_GlcNHglycan	176	179	PF01048	0.667
MOD_GlcNHglycan	204	207	PF01048	0.737
MOD_GlcNHglycan	264	267	PF01048	0.731
MOD_GlcNHglycan	278	281	PF01048	0.705
MOD_GlcNHglycan	301	304	PF01048	0.654
MOD_GlcNHglycan	312	315	PF01048	0.746
MOD_GlcNHglycan	320	323	PF01048	0.601
MOD_GlcNHglycan	367	370	PF01048	0.623
MOD_GlcNHglycan	374	377	PF01048	0.562
MOD_GlcNHglycan	412	415	PF01048	0.661
MOD_GlcNHglycan	487	490	PF01048	0.731
MOD_GlcNHglycan	494	498	PF01048	0.693
MOD_GlcNHglycan	515	519	PF01048	0.727
MOD_GlcNHglycan	563	566	PF01048	0.681
MOD_GlcNHglycan	595	598	PF01048	0.573
MOD_GlcNHglycan	611	614	PF01048	0.721
MOD_GlcNHglycan	627	630	PF01048	0.657
MOD_GSK3_1	112	119	PF00069	0.666
MOD_GSK3_1	146	153	PF00069	0.521
MOD_GSK3_1	174	181	PF00069	0.779
MOD_GSK3_1	208	215	PF00069	0.507
MOD_GSK3_1	258	265	PF00069	0.636
MOD_GSK3_1	276	283	PF00069	0.657
MOD_GSK3_1	284	291	PF00069	0.741
MOD_GSK3_1	299	306	PF00069	0.621
MOD_GSK3_1	310	317	PF00069	0.667
MOD_GSK3_1	334	341	PF00069	0.689
MOD_GSK3_1	361	368	PF00069	0.400
MOD_GSK3_1	405	412	PF00069	0.641
MOD_GSK3_1	419	426	PF00069	0.756
MOD_GSK3_1	469	476	PF00069	0.538
MOD_GSK3_1	480	487	PF00069	0.499
MOD_GSK3_1	560	567	PF00069	0.668
MOD_GSK3_1	609	616	PF00069	0.672
MOD_GSK3_1	621	628	PF00069	0.718
MOD_GSK3_1	629	636	PF00069	0.740
MOD_GSK3_1	637	644	PF00069	0.445
MOD_GSK3_1	68	75	PF00069	0.594
MOD_LATS_1	607	613	PF00433	0.560
MOD_N-GLC_2	443	445	PF02516	0.578
MOD_NEK2_1	103	108	PF00069	0.709
MOD_NEK2_1	212	217	PF00069	0.486
MOD_NEK2_1	284	289	PF00069	0.544
MOD_NEK2_1	310	315	PF00069	0.778
MOD_NEK2_1	361	366	PF00069	0.458
MOD_NEK2_1	484	489	PF00069	0.546
MOD_NEK2_1	631	636	PF00069	0.790
MOD_NEK2_1	641	646	PF00069	0.490
MOD_NEK2_2	280	285	PF00069	0.548
MOD_OFUCOSY	411	417	PF10250	0.543
MOD_PIKK_1	146	152	PF00454	0.635
MOD_PIKK_1	437	443	PF00454	0.503
MOD_PIKK_1	520	526	PF00454	0.765
MOD_PIKK_1	648	654	PF00454	0.579
MOD_PK_1	402	408	PF00069	0.454
MOD_PKA_1	608	614	PF00069	0.562
MOD_PKA_1	625	631	PF00069	0.738
MOD_PKA_2	103	109	PF00069	0.774
MOD_PKA_2	14	20	PF00069	0.593
MOD_PKA_2	155	161	PF00069	0.353
MOD_PKA_2	178	184	PF00069	0.575
MOD_PKA_2	199	205	PF00069	0.604
MOD_PKA_2	288	294	PF00069	0.763
MOD_PKA_2	372	378	PF00069	0.556
MOD_PKA_2	490	496	PF00069	0.634
MOD_PKA_2	608	614	PF00069	0.816
MOD_PKA_2	621	627	PF00069	0.716
MOD_PKA_2	648	654	PF00069	0.579
MOD_Plk_2-3	182	188	PF00069	0.683
MOD_Plk_4	273	279	PF00069	0.667
MOD_Plk_4	480	486	PF00069	0.541
MOD_Plk_4	613	619	PF00069	0.566
MOD_Plk_4	95	101	PF00069	0.504
MOD_ProDKin_1	116	122	PF00069	0.481
MOD_ProDKin_1	143	149	PF00069	0.353
MOD_ProDKin_1	270	276	PF00069	0.718
MOD_ProDKin_1	3	9	PF00069	0.547
MOD_ProDKin_1	304	310	PF00069	0.550
MOD_ProDKin_1	324	330	PF00069	0.621
MOD_ProDKin_1	343	349	PF00069	0.604
MOD_ProDKin_1	447	453	PF00069	0.571
MOD_ProDKin_1	469	475	PF00069	0.713
MOD_ProDKin_1	56	62	PF00069	0.600
MOD_ProDKin_1	634	640	PF00069	0.770
MOD_ProDKin_1	98	104	PF00069	0.666
MOD_SUMO_rev_2	291	298	PF00179	0.703
TRG_ER_diArg_1	12	15	PF00400	0.637
TRG_ER_diArg_1	171	173	PF00400	0.706
TRG_ER_diArg_1	218	221	PF00400	0.507
TRG_ER_diArg_1	391	393	PF00400	0.550
TRG_ER_diArg_1	625	627	PF00400	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZL6	Leptomonas seymouri	33%	100%
A0A3Q8IFE8	Leishmania donovani	65%	100%
A4HZS9	Leishmania infantum	64%	100%
E9AVN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4QBU5	Leishmania major	65%	100%