TFIIS N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC96_LEIBR

TriTrypDb:

LbrM.22.0450 , LBRM2903_220010000

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HC96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC96

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0016973	poly(A)+ mRNA export from nucleus	7	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.578
CLV_C14_Caspase3-7	197	201	PF00656	0.687
CLV_C14_Caspase3-7	226	230	PF00656	0.543
CLV_C14_Caspase3-7	401	405	PF00656	0.503
CLV_C14_Caspase3-7	65	69	PF00656	0.557
CLV_NRD_NRD_1	169	171	PF00675	0.589
CLV_NRD_NRD_1	187	189	PF00675	0.646
CLV_NRD_NRD_1	259	261	PF00675	0.645
CLV_NRD_NRD_1	396	398	PF00675	0.555
CLV_NRD_NRD_1	431	433	PF00675	0.482
CLV_PCSK_KEX2_1	132	134	PF00082	0.458
CLV_PCSK_KEX2_1	169	171	PF00082	0.565
CLV_PCSK_KEX2_1	187	189	PF00082	0.584
CLV_PCSK_KEX2_1	396	398	PF00082	0.595
CLV_PCSK_KEX2_1	96	98	PF00082	0.518
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.457
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.552
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.493
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.518
CLV_PCSK_SKI1_1	129	133	PF00082	0.493
CLV_PCSK_SKI1_1	173	177	PF00082	0.556
CLV_PCSK_SKI1_1	252	256	PF00082	0.607
CLV_PCSK_SKI1_1	303	307	PF00082	0.446
DEG_APCC_DBOX_1	302	310	PF00400	0.431
DEG_Nend_UBRbox_2	1	3	PF02207	0.708
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.615
DOC_MAPK_gen_1	96	104	PF00069	0.514
DOC_MAPK_MEF2A_6	350	358	PF00069	0.348
DOC_PP4_FxxP_1	464	467	PF00568	0.608
DOC_USP7_MATH_1	180	184	PF00917	0.670
DOC_USP7_MATH_1	74	78	PF00917	0.805
DOC_USP7_UBL2_3	128	132	PF12436	0.429
DOC_USP7_UBL2_3	136	140	PF12436	0.412
DOC_USP7_UBL2_3	143	147	PF12436	0.384
DOC_USP7_UBL2_3	153	157	PF12436	0.503
DOC_USP7_UBL2_3	161	165	PF12436	0.576
DOC_USP7_UBL2_3	169	173	PF12436	0.499
DOC_USP7_UBL2_3	252	256	PF12436	0.564
DOC_USP7_UBL2_3	435	439	PF12436	0.655
DOC_WW_Pin1_4	445	450	PF00397	0.627
LIG_14-3-3_CanoR_1	260	270	PF00244	0.515
LIG_14-3-3_CanoR_1	350	358	PF00244	0.424
LIG_Actin_WH2_2	231	246	PF00022	0.575
LIG_BRCT_BRCA1_1	456	460	PF00533	0.553
LIG_eIF4E_1	318	324	PF01652	0.427
LIG_FHA_1	210	216	PF00498	0.471
LIG_FHA_1	349	355	PF00498	0.425
LIG_FHA_1	367	373	PF00498	0.714
LIG_FHA_2	17	23	PF00498	0.551
LIG_FHA_2	350	356	PF00498	0.494
LIG_FHA_2	453	459	PF00498	0.478
LIG_FHA_2	78	84	PF00498	0.534
LIG_GBD_Chelix_1	270	278	PF00786	0.485
LIG_Integrin_RGD_1	194	196	PF01839	0.530
LIG_LIR_Apic_2	463	467	PF02991	0.588
LIG_LIR_Gen_1	414	420	PF02991	0.512
LIG_LIR_Gen_1	448	454	PF02991	0.630
LIG_LIR_Nem_3	217	222	PF02991	0.707
LIG_LIR_Nem_3	331	337	PF02991	0.411
LIG_LIR_Nem_3	373	378	PF02991	0.503
LIG_LIR_Nem_3	414	419	PF02991	0.511
LIG_LIR_Nem_3	448	453	PF02991	0.634
LIG_LIR_Nem_3	473	478	PF02991	0.528
LIG_NRP_CendR_1	507	508	PF00754	0.689
LIG_Pex14_2	460	464	PF04695	0.568
LIG_SH2_CRK	475	479	PF00017	0.631
LIG_SH2_STAT5	498	501	PF00017	0.595
LIG_SH3_1	466	472	PF00018	0.523
LIG_SH3_3	355	361	PF00018	0.449
LIG_SH3_3	443	449	PF00018	0.502
LIG_SH3_3	466	472	PF00018	0.498
LIG_SH3_3	477	483	PF00018	0.514
LIG_SUMO_SIM_anti_2	351	359	PF11976	0.381
LIG_SUMO_SIM_par_1	121	127	PF11976	0.561
LIG_SUMO_SIM_par_1	30	37	PF11976	0.504
LIG_TRFH_1	219	223	PF08558	0.446
LIG_TYR_ITSM	471	478	PF00017	0.576
LIG_UBA3_1	122	129	PF00899	0.492
LIG_WRC_WIRS_1	413	418	PF05994	0.508
MOD_CK1_1	121	127	PF00069	0.555
MOD_CK1_1	183	189	PF00069	0.741
MOD_CK1_1	290	296	PF00069	0.666
MOD_CK1_1	421	427	PF00069	0.701
MOD_CK1_1	49	55	PF00069	0.722
MOD_CK1_1	77	83	PF00069	0.763
MOD_CK2_1	108	114	PF00069	0.744
MOD_CK2_1	16	22	PF00069	0.661
MOD_CK2_1	161	167	PF00069	0.690
MOD_CK2_1	239	245	PF00069	0.638
MOD_CK2_1	260	266	PF00069	0.578
MOD_CK2_1	445	451	PF00069	0.536
MOD_CK2_1	452	458	PF00069	0.463
MOD_Cter_Amidation	134	137	PF01082	0.547
MOD_GlcNHglycan	110	113	PF01048	0.680
MOD_GlcNHglycan	25	28	PF01048	0.693
MOD_GlcNHglycan	263	266	PF01048	0.583
MOD_GlcNHglycan	289	292	PF01048	0.480
MOD_GlcNHglycan	420	423	PF01048	0.495
MOD_GlcNHglycan	48	51	PF01048	0.709
MOD_GlcNHglycan	491	494	PF01048	0.624
MOD_GlcNHglycan	60	63	PF01048	0.485
MOD_GlcNHglycan	76	79	PF01048	0.779
MOD_GSK3_1	161	168	PF00069	0.559
MOD_GSK3_1	239	246	PF00069	0.442
MOD_GSK3_1	287	294	PF00069	0.459
MOD_GSK3_1	362	369	PF00069	0.594
MOD_GSK3_1	414	421	PF00069	0.513
MOD_GSK3_1	489	496	PF00069	0.505
MOD_N-GLC_1	489	494	PF02516	0.633
MOD_NEK2_1	243	248	PF00069	0.625
MOD_NEK2_1	349	354	PF00069	0.418
MOD_NEK2_1	362	367	PF00069	0.529
MOD_NEK2_1	412	417	PF00069	0.490
MOD_NEK2_1	460	465	PF00069	0.606
MOD_PIKK_1	34	40	PF00454	0.527
MOD_PKA_1	161	167	PF00069	0.562
MOD_PKA_1	188	194	PF00069	0.711
MOD_PKA_1	260	266	PF00069	0.509
MOD_PKA_2	180	186	PF00069	0.576
MOD_PKA_2	243	249	PF00069	0.481
MOD_PKA_2	259	265	PF00069	0.590
MOD_PKA_2	291	297	PF00069	0.571
MOD_PKA_2	349	355	PF00069	0.356
MOD_PKA_2	431	437	PF00069	0.572
MOD_Plk_1	118	124	PF00069	0.416
MOD_Plk_1	21	27	PF00069	0.484
MOD_Plk_1	3	9	PF00069	0.666
MOD_Plk_1	330	336	PF00069	0.322
MOD_Plk_1	370	376	PF00069	0.620
MOD_Plk_1	399	405	PF00069	0.520
MOD_Plk_2-3	500	506	PF00069	0.449
MOD_Plk_4	118	124	PF00069	0.476
MOD_Plk_4	3	9	PF00069	0.683
MOD_Plk_4	330	336	PF00069	0.327
MOD_ProDKin_1	445	451	PF00069	0.627
MOD_SUMO_rev_2	121	131	PF00179	0.503
MOD_SUMO_rev_2	172	180	PF00179	0.559
MOD_SUMO_rev_2	242	248	PF00179	0.386
MOD_SUMO_rev_2	425	434	PF00179	0.667
TRG_DiLeu_BaEn_3	2	8	PF01217	0.705
TRG_DiLeu_BaEn_4	3	9	PF01217	0.705
TRG_ENDOCYTIC_2	475	478	PF00928	0.537
TRG_ER_diArg_1	395	397	PF00400	0.574
TRG_ER_diArg_1	506	508	PF00400	0.635
TRG_NLS_Bipartite_1	143	164	PF00514	0.507
TRG_NLS_Bipartite_1	169	191	PF00514	0.527
TRG_NLS_MonoExtN_4	157	164	PF00514	0.540
TRG_NLS_MonoExtN_4	184	191	PF00514	0.615
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB7	Leptomonas seymouri	59%	100%
A0A3Q8IAL9	Leishmania donovani	76%	98%
A0A422N2J9	Trypanosoma rangeli	34%	100%
A4HZS8	Leishmania infantum	76%	98%
C9ZRL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AVN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%
Q4QBU6	Leishmania major	75%	98%
V5BLH2	Trypanosoma cruzi	33%	100%