Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HC95_LEIBR

TriTrypDb:

LbrM.22.0440 , LBRM2903_220009900

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC95

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004707	MAP kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	490	492	PF00675	0.618
CLV_NRD_NRD_1	9	11	PF00675	0.688
CLV_PCSK_FUR_1	7	11	PF00082	0.659
CLV_PCSK_KEX2_1	297	299	PF00082	0.502
CLV_PCSK_KEX2_1	447	449	PF00082	0.299
CLV_PCSK_KEX2_1	490	492	PF00082	0.560
CLV_PCSK_KEX2_1	77	79	PF00082	0.382
CLV_PCSK_KEX2_1	9	11	PF00082	0.688
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.502
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.299
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.382
CLV_PCSK_SKI1_1	242	246	PF00082	0.320
CLV_PCSK_SKI1_1	324	328	PF00082	0.302
CLV_PCSK_SKI1_1	345	349	PF00082	0.299
CLV_PCSK_SKI1_1	423	427	PF00082	0.299
CLV_PCSK_SKI1_1	532	536	PF00082	0.542
CLV_Separin_Metazoa	416	420	PF03568	0.299
DEG_Kelch_Keap1_1	271	276	PF01344	0.533
DEG_SPOP_SBC_1	134	138	PF00917	0.624
DOC_CDC14_PxL_1	388	396	PF14671	0.299
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.499
DOC_MAPK_gen_1	345	354	PF00069	0.299
DOC_MAPK_gen_1	387	396	PF00069	0.299
DOC_MAPK_gen_1	490	499	PF00069	0.774
DOC_MAPK_HePTP_8	384	396	PF00069	0.299
DOC_MAPK_MEF2A_6	387	396	PF00069	0.299
DOC_MAPK_MEF2A_6	493	501	PF00069	0.756
DOC_PP1_RVXF_1	322	329	PF00149	0.342
DOC_PP1_RVXF_1	330	337	PF00149	0.263
DOC_PP2B_LxvP_1	442	445	PF13499	0.362
DOC_USP7_MATH_1	134	138	PF00917	0.654
DOC_USP7_MATH_1	19	23	PF00917	0.647
DOC_USP7_MATH_1	255	259	PF00917	0.582
DOC_USP7_MATH_1	29	33	PF00917	0.587
DOC_USP7_MATH_1	5	9	PF00917	0.609
DOC_USP7_MATH_1	550	554	PF00917	0.655
DOC_USP7_UBL2_3	73	77	PF12436	0.352
DOC_WW_Pin1_4	126	131	PF00397	0.751
DOC_WW_Pin1_4	207	212	PF00397	0.501
DOC_WW_Pin1_4	257	262	PF00397	0.678
DOC_WW_Pin1_4	285	290	PF00397	0.711
DOC_WW_Pin1_4	42	47	PF00397	0.476
DOC_WW_Pin1_4	543	548	PF00397	0.583
LIG_14-3-3_CanoR_1	102	110	PF00244	0.497
LIG_14-3-3_CanoR_1	253	263	PF00244	0.526
LIG_14-3-3_CanoR_1	40	46	PF00244	0.464
LIG_14-3-3_CanoR_1	427	435	PF00244	0.299
LIG_14-3-3_CanoR_1	469	474	PF00244	0.593
LIG_14-3-3_CanoR_1	490	499	PF00244	0.652
LIG_14-3-3_CanoR_1	9	17	PF00244	0.629
LIG_Actin_WH2_2	406	421	PF00022	0.299
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_deltaCOP1_diTrp_1	406	410	PF00928	0.299
LIG_eIF4E_1	389	395	PF01652	0.299
LIG_FHA_1	356	362	PF00498	0.299
LIG_FHA_1	42	48	PF00498	0.474
LIG_FHA_2	138	144	PF00498	0.611
LIG_FHA_2	165	171	PF00498	0.389
LIG_FHA_2	428	434	PF00498	0.299
LIG_GSK3_LRP6_1	285	290	PF00069	0.503
LIG_HCF-1_HBM_1	197	200	PF13415	0.470
LIG_LIR_Apic_2	386	392	PF02991	0.337
LIG_LIR_Gen_1	221	230	PF02991	0.273
LIG_LIR_Nem_3	160	165	PF02991	0.409
LIG_LIR_Nem_3	221	226	PF02991	0.301
LIG_LIR_Nem_3	393	399	PF02991	0.318
LIG_LIR_Nem_3	409	413	PF02991	0.319
LIG_LIR_Nem_3	437	442	PF02991	0.396
LIG_LIR_Nem_3	45	51	PF02991	0.473
LIG_LIR_Nem_3	58	62	PF02991	0.400
LIG_REV1ctd_RIR_1	242	250	PF16727	0.359
LIG_SH2_CRK	48	52	PF00017	0.417
LIG_SH2_STAP1	81	85	PF00017	0.497
LIG_SH2_STAT5	162	165	PF00017	0.358
LIG_SH2_STAT5	225	228	PF00017	0.331
LIG_SH2_STAT5	232	235	PF00017	0.371
LIG_SH2_STAT5	383	386	PF00017	0.299
LIG_SH2_STAT5	53	56	PF00017	0.438
LIG_SH3_3	205	211	PF00018	0.590
LIG_SH3_3	263	269	PF00018	0.502
LIG_SH3_3	283	289	PF00018	0.629
LIG_SH3_3	44	50	PF00018	0.393
LIG_SH3_3	95	101	PF00018	0.504
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.388
LIG_SUMO_SIM_par_1	154	160	PF11976	0.352
LIG_SUMO_SIM_par_1	60	67	PF11976	0.373
LIG_TRAF2_1	375	378	PF00917	0.362
LIG_TRAF2_1	505	508	PF00917	0.620
LIG_UBA3_1	438	447	PF00899	0.299
LIG_WRC_WIRS_1	407	412	PF05994	0.299
MOD_CDK_SPK_2	285	290	PF00069	0.655
MOD_CDK_SPxxK_3	42	49	PF00069	0.421
MOD_CK1_1	117	123	PF00069	0.590
MOD_CK1_1	133	139	PF00069	0.621
MOD_CK1_1	22	28	PF00069	0.597
MOD_CK1_1	257	263	PF00069	0.610
MOD_CK1_1	306	312	PF00069	0.666
MOD_CK1_1	32	38	PF00069	0.534
MOD_CK1_1	541	547	PF00069	0.654
MOD_CK2_1	164	170	PF00069	0.358
MOD_CK2_1	270	276	PF00069	0.575
MOD_CK2_1	443	449	PF00069	0.299
MOD_CK2_1	483	489	PF00069	0.499
MOD_GlcNHglycan	119	122	PF01048	0.594
MOD_GlcNHglycan	12	15	PF01048	0.668
MOD_GlcNHglycan	132	135	PF01048	0.756
MOD_GlcNHglycan	17	20	PF01048	0.663
MOD_GlcNHglycan	202	205	PF01048	0.645
MOD_GlcNHglycan	21	24	PF01048	0.647
MOD_GlcNHglycan	214	217	PF01048	0.539
MOD_GlcNHglycan	220	223	PF01048	0.531
MOD_GlcNHglycan	257	260	PF01048	0.545
MOD_GlcNHglycan	273	276	PF01048	0.749
MOD_GlcNHglycan	309	312	PF01048	0.646
MOD_GlcNHglycan	34	37	PF01048	0.643
MOD_GlcNHglycan	367	370	PF01048	0.318
MOD_GlcNHglycan	420	423	PF01048	0.299
MOD_GlcNHglycan	478	481	PF01048	0.766
MOD_GlcNHglycan	485	488	PF01048	0.662
MOD_GlcNHglycan	514	517	PF01048	0.561
MOD_GSK3_1	106	113	PF00069	0.795
MOD_GSK3_1	120	127	PF00069	0.602
MOD_GSK3_1	128	135	PF00069	0.659
MOD_GSK3_1	15	22	PF00069	0.715
MOD_GSK3_1	161	168	PF00069	0.358
MOD_GSK3_1	189	196	PF00069	0.528
MOD_GSK3_1	214	221	PF00069	0.554
MOD_GSK3_1	249	256	PF00069	0.544
MOD_GSK3_1	257	264	PF00069	0.614
MOD_GSK3_1	267	274	PF00069	0.750
MOD_GSK3_1	298	305	PF00069	0.656
MOD_GSK3_1	31	38	PF00069	0.601
MOD_GSK3_1	379	386	PF00069	0.299
MOD_GSK3_1	550	557	PF00069	0.648
MOD_N-GLC_1	379	384	PF02516	0.325
MOD_N-GLC_1	469	474	PF02516	0.503
MOD_N-GLC_1	491	496	PF02516	0.479
MOD_NEK2_1	132	137	PF00069	0.670
MOD_NEK2_1	189	194	PF00069	0.513
MOD_NEK2_1	214	219	PF00069	0.446
MOD_NEK2_1	418	423	PF00069	0.299
MOD_NEK2_1	461	466	PF00069	0.422
MOD_OFUCOSY	296	302	PF10250	0.498
MOD_PIKK_1	538	544	PF00454	0.591
MOD_PIKK_1	550	556	PF00454	0.552
MOD_PKA_1	297	303	PF00069	0.495
MOD_PKA_2	117	123	PF00069	0.604
MOD_PKA_2	19	25	PF00069	0.647
MOD_PKA_2	297	303	PF00069	0.686
MOD_PKA_2	418	424	PF00069	0.309
MOD_PKA_2	55	61	PF00069	0.436
MOD_PKB_1	474	482	PF00069	0.489
MOD_Plk_1	379	385	PF00069	0.325
MOD_Plk_1	469	475	PF00069	0.446
MOD_Plk_4	379	385	PF00069	0.299
MOD_Plk_4	92	98	PF00069	0.419
MOD_ProDKin_1	126	132	PF00069	0.752
MOD_ProDKin_1	207	213	PF00069	0.498
MOD_ProDKin_1	257	263	PF00069	0.679
MOD_ProDKin_1	285	291	PF00069	0.714
MOD_ProDKin_1	42	48	PF00069	0.460
MOD_ProDKin_1	543	549	PF00069	0.587
TRG_DiLeu_BaEn_4	508	514	PF01217	0.517
TRG_ENDOCYTIC_2	225	228	PF00928	0.339
TRG_ENDOCYTIC_2	232	235	PF00928	0.347
TRG_ENDOCYTIC_2	48	51	PF00928	0.415
TRG_ER_diArg_1	473	476	PF00400	0.548
TRG_ER_diArg_1	490	493	PF00400	0.458
TRG_ER_diArg_1	7	10	PF00400	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU16	Leptomonas seymouri	53%	91%
A0A3Q8IC49	Leishmania donovani	77%	77%
E9AVN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	77%
Q4QBU7	Leishmania major	76%	100%