Dynamin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynamin family, putative

Species:

Leishmania braziliensis

UniProt:

A4HC94_LEIBR

TriTrypDb:

LbrM.22.0430 , LBRM2903_220009800

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HC94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC94

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	324	330	PF00089	0.276
CLV_NRD_NRD_1	306	308	PF00675	0.285
CLV_NRD_NRD_1	338	340	PF00675	0.236
CLV_NRD_NRD_1	396	398	PF00675	0.315
CLV_NRD_NRD_1	472	474	PF00675	0.371
CLV_NRD_NRD_1	485	487	PF00675	0.424
CLV_PCSK_FUR_1	422	426	PF00082	0.209
CLV_PCSK_KEX2_1	306	308	PF00082	0.285
CLV_PCSK_KEX2_1	338	340	PF00082	0.316
CLV_PCSK_KEX2_1	396	398	PF00082	0.258
CLV_PCSK_KEX2_1	424	426	PF00082	0.224
CLV_PCSK_KEX2_1	472	474	PF00082	0.362
CLV_PCSK_KEX2_1	484	486	PF00082	0.416
CLV_PCSK_KEX2_1	89	91	PF00082	0.304
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.224
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.457
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.304
CLV_PCSK_PC7_1	392	398	PF00082	0.200
CLV_PCSK_SKI1_1	208	212	PF00082	0.238
CLV_PCSK_SKI1_1	216	220	PF00082	0.204
CLV_PCSK_SKI1_1	246	250	PF00082	0.316
CLV_PCSK_SKI1_1	320	324	PF00082	0.234
CLV_PCSK_SKI1_1	339	343	PF00082	0.200
CLV_PCSK_SKI1_1	39	43	PF00082	0.222
CLV_PCSK_SKI1_1	396	400	PF00082	0.252
CLV_PCSK_SKI1_1	408	412	PF00082	0.417
CLV_PCSK_SKI1_1	413	417	PF00082	0.386
CLV_Separin_Metazoa	430	434	PF03568	0.558
DEG_APCC_DBOX_1	427	435	PF00400	0.476
DEG_SCF_FBW7_1	41	46	PF00400	0.430
DEG_SPOP_SBC_1	256	260	PF00917	0.488
DOC_CKS1_1	144	149	PF01111	0.411
DOC_CKS1_1	150	155	PF01111	0.406
DOC_CKS1_1	40	45	PF01111	0.426
DOC_CYCLIN_RxL_1	390	403	PF00134	0.406
DOC_MAPK_gen_1	424	434	PF00069	0.541
DOC_MAPK_JIP1_4	428	434	PF00069	0.499
DOC_MAPK_MEF2A_6	45	53	PF00069	0.438
DOC_PP4_FxxP_1	40	43	PF00568	0.490
DOC_USP7_MATH_1	132	136	PF00917	0.424
DOC_USP7_MATH_1	181	185	PF00917	0.467
DOC_USP7_MATH_1	360	364	PF00917	0.575
DOC_USP7_MATH_1	43	47	PF00917	0.469
DOC_USP7_MATH_1	435	439	PF00917	0.521
DOC_USP7_MATH_1	448	452	PF00917	0.436
DOC_USP7_UBL2_3	413	417	PF12436	0.554
DOC_WW_Pin1_4	143	148	PF00397	0.407
DOC_WW_Pin1_4	149	154	PF00397	0.411
DOC_WW_Pin1_4	258	263	PF00397	0.519
DOC_WW_Pin1_4	39	44	PF00397	0.468
DOC_WW_Pin1_4	45	50	PF00397	0.438
DOC_WW_Pin1_4	7	12	PF00397	0.487
LIG_14-3-3_CanoR_1	255	263	PF00244	0.475
LIG_14-3-3_CanoR_1	27	31	PF00244	0.421
LIG_14-3-3_CanoR_1	397	406	PF00244	0.538
LIG_14-3-3_CanoR_1	4	11	PF00244	0.517
LIG_14-3-3_CanoR_1	408	415	PF00244	0.430
LIG_14-3-3_CanoR_1	422	428	PF00244	0.585
LIG_14-3-3_CanoR_1	472	482	PF00244	0.543
LIG_Actin_WH2_2	12	29	PF00022	0.462
LIG_APCC_ABBA_1	31	36	PF00400	0.412
LIG_BIR_III_4	96	100	PF00653	0.445
LIG_Clathr_ClatBox_1	188	192	PF01394	0.411
LIG_CtBP_PxDLS_1	138	142	PF00389	0.504
LIG_FHA_1	200	206	PF00498	0.400
LIG_FHA_1	279	285	PF00498	0.634
LIG_FHA_1	365	371	PF00498	0.255
LIG_FHA_1	414	420	PF00498	0.533
LIG_FHA_1	46	52	PF00498	0.466
LIG_FHA_2	196	202	PF00498	0.400
LIG_FHA_2	209	215	PF00498	0.406
LIG_FHA_2	311	317	PF00498	0.455
LIG_LIR_Apic_2	28	33	PF02991	0.579
LIG_LIR_Gen_1	107	118	PF02991	0.426
LIG_LIR_Gen_1	168	176	PF02991	0.434
LIG_LIR_Gen_1	225	234	PF02991	0.518
LIG_LIR_Gen_1	32	41	PF02991	0.428
LIG_LIR_Nem_3	107	113	PF02991	0.505
LIG_LIR_Nem_3	168	174	PF02991	0.434
LIG_LIR_Nem_3	214	220	PF02991	0.424
LIG_LIR_Nem_3	225	230	PF02991	0.509
LIG_LIR_Nem_3	32	37	PF02991	0.433
LIG_LIR_Nem_3	82	88	PF02991	0.400
LIG_LYPXL_SIV_4	33	41	PF13949	0.490
LIG_Pex14_2	116	120	PF04695	0.402
LIG_Pex14_2	40	44	PF04695	0.417
LIG_PTB_Apo_2	102	109	PF02174	0.504
LIG_PTB_Phospho_1	102	108	PF10480	0.504
LIG_Rb_pABgroove_1	185	193	PF01858	0.442
LIG_REV1ctd_RIR_1	480	490	PF16727	0.548
LIG_SH2_CRK	110	114	PF00017	0.504
LIG_SH2_CRK	171	175	PF00017	0.411
LIG_SH2_CRK	237	241	PF00017	0.446
LIG_SH2_CRK	344	348	PF00017	0.380
LIG_SH2_CRK	38	42	PF00017	0.463
LIG_SH2_NCK_1	34	38	PF00017	0.423
LIG_SH2_SRC	30	33	PF00017	0.449
LIG_SH2_SRC	34	37	PF00017	0.452
LIG_SH2_STAP1	171	175	PF00017	0.411
LIG_SH2_STAP1	213	217	PF00017	0.445
LIG_SH2_STAP1	34	38	PF00017	0.423
LIG_SH2_STAT3	108	111	PF00017	0.411
LIG_SH2_STAT5	257	260	PF00017	0.476
LIG_SH2_STAT5	30	33	PF00017	0.482
LIG_SH2_STAT5	336	339	PF00017	0.491
LIG_SH2_STAT5	344	347	PF00017	0.304
LIG_SH2_STAT5	67	70	PF00017	0.424
LIG_SH3_3	100	106	PF00018	0.424
LIG_SH3_3	141	147	PF00018	0.411
LIG_SH3_3	190	196	PF00018	0.419
LIG_SH3_3	349	355	PF00018	0.201
LIG_SUMO_SIM_anti_2	184	192	PF11976	0.406
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.389
LIG_SUMO_SIM_par_1	140	146	PF11976	0.504
LIG_SUMO_SIM_par_1	201	207	PF11976	0.431
LIG_TRAF2_1	437	440	PF00917	0.436
MOD_CDK_SPxK_1	258	264	PF00069	0.525
MOD_CDK_SPxK_1	39	45	PF00069	0.429
MOD_CDK_SPxxK_3	258	265	PF00069	0.537
MOD_CK1_1	101	107	PF00069	0.467
MOD_CK1_1	119	125	PF00069	0.467
MOD_CK1_1	267	273	PF00069	0.616
MOD_CK1_1	276	282	PF00069	0.568
MOD_CK1_1	362	368	PF00069	0.336
MOD_CK1_1	5	11	PF00069	0.521
MOD_CK1_1	59	65	PF00069	0.556
MOD_CK2_1	154	160	PF00069	0.420
MOD_CK2_1	195	201	PF00069	0.412
MOD_CK2_1	208	214	PF00069	0.469
MOD_CK2_1	26	32	PF00069	0.518
MOD_CK2_1	310	316	PF00069	0.453
MOD_CK2_1	66	72	PF00069	0.513
MOD_GlcNHglycan	157	160	PF01048	0.309
MOD_GlcNHglycan	163	166	PF01048	0.290
MOD_GlcNHglycan	266	269	PF01048	0.530
MOD_GlcNHglycan	278	281	PF01048	0.428
MOD_GlcNHglycan	316	320	PF01048	0.377
MOD_GlcNHglycan	380	383	PF01048	0.305
MOD_GlcNHglycan	443	446	PF01048	0.334
MOD_GlcNHglycan	452	455	PF01048	0.315
MOD_GlcNHglycan	58	61	PF01048	0.213
MOD_GlcNHglycan	68	71	PF01048	0.214
MOD_GSK3_1	127	134	PF00069	0.426
MOD_GSK3_1	155	162	PF00069	0.508
MOD_GSK3_1	195	202	PF00069	0.400
MOD_GSK3_1	2	9	PF00069	0.576
MOD_GSK3_1	204	211	PF00069	0.416
MOD_GSK3_1	22	29	PF00069	0.385
MOD_GSK3_1	272	279	PF00069	0.635
MOD_GSK3_1	360	367	PF00069	0.448
MOD_GSK3_1	39	46	PF00069	0.441
MOD_GSK3_1	55	62	PF00069	0.398
MOD_LATS_1	123	129	PF00433	0.504
MOD_N-GLC_1	242	247	PF02516	0.270
MOD_N-GLC_1	55	60	PF02516	0.234
MOD_NEK2_1	116	121	PF00069	0.523
MOD_NEK2_1	174	179	PF00069	0.400
MOD_NEK2_1	206	211	PF00069	0.414
MOD_NEK2_1	26	31	PF00069	0.375
MOD_NEK2_1	378	383	PF00069	0.188
MOD_NEK2_1	384	389	PF00069	0.268
MOD_NEK2_1	44	49	PF00069	0.476
MOD_NEK2_1	6	11	PF00069	0.588
MOD_NEK2_2	423	428	PF00069	0.525
MOD_PIKK_1	132	138	PF00454	0.444
MOD_PIKK_1	435	441	PF00454	0.540
MOD_PKA_1	264	270	PF00069	0.520
MOD_PKA_1	473	479	PF00069	0.485
MOD_PKA_1	89	95	PF00069	0.496
MOD_PKA_2	26	32	PF00069	0.433
MOD_PKA_2	326	332	PF00069	0.566
MOD_PKA_2	89	95	PF00069	0.454
MOD_Plk_4	26	32	PF00069	0.406
MOD_Plk_4	366	372	PF00069	0.328
MOD_Plk_4	60	66	PF00069	0.455
MOD_Plk_4	98	104	PF00069	0.504
MOD_ProDKin_1	143	149	PF00069	0.407
MOD_ProDKin_1	258	264	PF00069	0.530
MOD_ProDKin_1	39	45	PF00069	0.475
MOD_ProDKin_1	7	13	PF00069	0.479
MOD_SUMO_rev_2	209	218	PF00179	0.400
TRG_DiLeu_BaEn_2	213	219	PF01217	0.445
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.471
TRG_ENDOCYTIC_2	110	113	PF00928	0.504
TRG_ENDOCYTIC_2	171	174	PF00928	0.400
TRG_ENDOCYTIC_2	237	240	PF00928	0.447
TRG_ENDOCYTIC_2	34	37	PF00928	0.440
TRG_ENDOCYTIC_2	344	347	PF00928	0.346
TRG_ENDOCYTIC_2	38	41	PF00928	0.426
TRG_ER_diArg_1	305	307	PF00400	0.515
TRG_ER_diArg_1	337	339	PF00400	0.514
TRG_ER_diArg_1	396	398	PF00400	0.403
TRG_ER_diArg_1	471	473	PF00400	0.476
TRG_NLS_Bipartite_1	472	488	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.214

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K7	Leptomonas seymouri	29%	83%
A0A0N0P9A4	Leptomonas seymouri	27%	89%
A0A0N1I0N6	Leptomonas seymouri	65%	77%
A0A0S4IRJ8	Bodo saltans	48%	96%
A0A1X0NTG9	Trypanosomatidae	48%	78%
A0A1X0P6D7	Trypanosomatidae	27%	90%
A0A3R7N865	Trypanosoma rangeli	46%	81%
A0A3S7WX57	Leishmania donovani	89%	100%
A4HZS6	Leishmania infantum	89%	100%
B3LF48	Arabidopsis thaliana	30%	90%
C9ZRK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	82%
E9AVN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QBU8	Leishmania major	87%	100%
V5DMH3	Trypanosoma cruzi	51%	98%