tRNA-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative tRNA binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HC93_LEIBR

TriTrypDb:

LbrM.22.0420 , LBRM2903_220009700

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC93

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	11
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	3
GO:0004812	aminoacyl-tRNA ligase activity	4	3
GO:0016874	ligase activity	2	3
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	3
GO:0140098	catalytic activity, acting on RNA	3	3
GO:0140101	catalytic activity, acting on a tRNA	4	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.578
CLV_C14_Caspase3-7	95	99	PF00656	0.604
CLV_MEL_PAP_1	264	270	PF00089	0.394
CLV_NRD_NRD_1	215	217	PF00675	0.594
CLV_NRD_NRD_1	275	277	PF00675	0.369
CLV_NRD_NRD_1	58	60	PF00675	0.566
CLV_PCSK_KEX2_1	214	216	PF00082	0.598
CLV_PCSK_KEX2_1	275	277	PF00082	0.353
CLV_PCSK_KEX2_1	58	60	PF00082	0.625
CLV_PCSK_SKI1_1	20	24	PF00082	0.457
CLV_PCSK_SKI1_1	358	362	PF00082	0.480
CLV_PCSK_SKI1_1	67	71	PF00082	0.548
CLV_Separin_Metazoa	211	215	PF03568	0.610
DEG_COP1_1	409	418	PF00400	0.381
DEG_Nend_UBRbox_3	1	3	PF02207	0.520
DEG_ODPH_VHL_1	171	183	PF01847	0.450
DEG_SPOP_SBC_1	99	103	PF00917	0.487
DOC_ANK_TNKS_1	38	45	PF00023	0.492
DOC_MAPK_gen_1	322	329	PF00069	0.597
DOC_MAPK_gen_1	403	413	PF00069	0.362
DOC_MAPK_MEF2A_6	175	183	PF00069	0.486
DOC_MAPK_MEF2A_6	322	329	PF00069	0.450
DOC_MAPK_MEF2A_6	406	415	PF00069	0.368
DOC_MAPK_RevD_3	200	216	PF00069	0.641
DOC_PP1_RVXF_1	356	362	PF00149	0.589
DOC_PP2B_LxvP_1	23	26	PF13499	0.580
DOC_PP2B_PxIxI_1	324	330	PF00149	0.450
DOC_USP7_MATH_1	118	122	PF00917	0.592
DOC_USP7_MATH_1	173	177	PF00917	0.645
DOC_USP7_MATH_1	200	204	PF00917	0.690
DOC_USP7_MATH_1	248	252	PF00917	0.697
DOC_USP7_MATH_1	368	372	PF00917	0.580
DOC_USP7_MATH_1	99	103	PF00917	0.684
DOC_USP7_UBL2_3	219	223	PF12436	0.578
DOC_WW_Pin1_4	240	245	PF00397	0.743
DOC_WW_Pin1_4	60	65	PF00397	0.578
LIG_14-3-3_CanoR_1	133	137	PF00244	0.457
LIG_14-3-3_CanoR_1	20	26	PF00244	0.450
LIG_14-3-3_CanoR_1	39	43	PF00244	0.568
LIG_14-3-3_CanoR_1	58	64	PF00244	0.443
LIG_Actin_WH2_2	43	60	PF00022	0.527
LIG_FHA_1	292	298	PF00498	0.568
LIG_FHA_1	311	317	PF00498	0.567
LIG_FHA_2	127	133	PF00498	0.502
LIG_FHA_2	196	202	PF00498	0.755
LIG_FHA_2	361	367	PF00498	0.426
LIG_FHA_2	390	396	PF00498	0.486
LIG_FHA_2	93	99	PF00498	0.576
LIG_KLC1_Yacidic_2	281	286	PF13176	0.567
LIG_LIR_Apic_2	167	173	PF02991	0.498
LIG_LIR_Apic_2	201	207	PF02991	0.737
LIG_LIR_Gen_1	262	271	PF02991	0.478
LIG_LIR_LC3C_4	313	318	PF02991	0.612
LIG_LIR_Nem_3	158	164	PF02991	0.504
LIG_LIR_Nem_3	262	268	PF02991	0.532
LIG_LIR_Nem_3	46	50	PF02991	0.533
LIG_SH2_NCK_1	110	114	PF00017	0.619
LIG_SH2_NCK_1	142	146	PF00017	0.554
LIG_SH2_PTP2	204	207	PF00017	0.710
LIG_SH2_PTP2	265	268	PF00017	0.478
LIG_SH2_STAP1	142	146	PF00017	0.554
LIG_SH2_STAP1	365	369	PF00017	0.623
LIG_SH2_STAT5	127	130	PF00017	0.572
LIG_SH2_STAT5	170	173	PF00017	0.475
LIG_SH2_STAT5	204	207	PF00017	0.710
LIG_SH2_STAT5	265	268	PF00017	0.478
LIG_SH2_STAT5	284	287	PF00017	0.551
LIG_SH3_3	176	182	PF00018	0.490
LIG_SH3_3	190	196	PF00018	0.569
LIG_SH3_3	22	28	PF00018	0.363
LIG_SH3_3	410	416	PF00018	0.545
LIG_SUMO_SIM_anti_2	73	81	PF11976	0.579
LIG_SUMO_SIM_par_1	88	93	PF11976	0.485
LIG_TRAF2_1	207	210	PF00917	0.618
LIG_TRAF2_1	306	309	PF00917	0.597
LIG_WRC_WIRS_1	50	55	PF05994	0.331
MOD_CAAXbox	421	424	PF01239	0.570
MOD_CDK_SPxxK_3	60	67	PF00069	0.576
MOD_CK1_1	21	27	PF00069	0.543
MOD_CK1_1	243	249	PF00069	0.629
MOD_CK2_1	108	114	PF00069	0.630
MOD_CK2_1	126	132	PF00069	0.622
MOD_CK2_1	195	201	PF00069	0.660
MOD_CK2_1	205	211	PF00069	0.560
MOD_CK2_1	406	412	PF00069	0.567
MOD_GlcNHglycan	175	178	PF01048	0.618
MOD_GlcNHglycan	190	193	PF01048	0.767
MOD_GlcNHglycan	298	301	PF01048	0.337
MOD_GlcNHglycan	31	35	PF01048	0.557
MOD_GlcNHglycan	370	373	PF01048	0.525
MOD_GlcNHglycan	378	381	PF01048	0.491
MOD_GlcNHglycan	408	411	PF01048	0.646
MOD_GSK3_1	118	125	PF00069	0.611
MOD_GSK3_1	128	135	PF00069	0.413
MOD_GSK3_1	234	241	PF00069	0.746
MOD_GSK3_1	243	250	PF00069	0.771
MOD_GSK3_1	360	367	PF00069	0.496
MOD_GSK3_1	381	388	PF00069	0.582
MOD_N-GLC_1	339	344	PF02516	0.347
MOD_NEK2_1	259	264	PF00069	0.597
MOD_NEK2_1	310	315	PF00069	0.543
MOD_NEK2_1	360	365	PF00069	0.539
MOD_NEK2_1	57	62	PF00069	0.525
MOD_PIKK_1	122	128	PF00454	0.540
MOD_PIKK_1	310	316	PF00454	0.631
MOD_PIKK_1	328	334	PF00454	0.612
MOD_PKA_2	132	138	PF00069	0.461
MOD_PKA_2	38	44	PF00069	0.599
MOD_PKA_2	57	63	PF00069	0.288
MOD_Plk_1	200	206	PF00069	0.670
MOD_Plk_1	259	265	PF00069	0.578
MOD_Plk_2-3	132	138	PF00069	0.592
MOD_Plk_4	200	206	PF00069	0.767
MOD_Plk_4	260	266	PF00069	0.534
MOD_Plk_4	49	55	PF00069	0.353
MOD_Plk_4	6	12	PF00069	0.511
MOD_ProDKin_1	240	246	PF00069	0.746
MOD_ProDKin_1	60	66	PF00069	0.573
MOD_SUMO_for_1	222	225	PF00179	0.687
TRG_DiLeu_BaEn_1	74	79	PF01217	0.589
TRG_DiLeu_BaEn_2	64	70	PF01217	0.539
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.450
TRG_ENDOCYTIC_2	110	113	PF00928	0.567
TRG_ENDOCYTIC_2	265	268	PF00928	0.478
TRG_ER_diArg_1	213	216	PF00400	0.597
TRG_ER_diArg_1	274	276	PF00400	0.569
TRG_ER_diArg_1	57	59	PF00400	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P301	Leptomonas seymouri	66%	100%
A0A0S4IJF4	Bodo saltans	38%	100%
A0A1X0NUW2	Trypanosomatidae	45%	100%
A0A3R7KNR3	Trypanosoma rangeli	45%	100%
A0A3S7WX09	Leishmania donovani	77%	100%
A4HZS5	Leishmania infantum	77%	100%
C9ZRK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AVN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QBU9	Leishmania major	78%	100%
V5B5W2	Trypanosoma cruzi	34%	100%