Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC89_LEIBR

TriTrypDb:

LbrM.22.0380 , LBRM2903_220009000

Length:

737

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	606	610	PF00656	0.457
CLV_C14_Caspase3-7	651	655	PF00656	0.536
CLV_NRD_NRD_1	128	130	PF00675	0.626
CLV_NRD_NRD_1	187	189	PF00675	0.499
CLV_NRD_NRD_1	262	264	PF00675	0.588
CLV_NRD_NRD_1	295	297	PF00675	0.747
CLV_NRD_NRD_1	418	420	PF00675	0.471
CLV_NRD_NRD_1	541	543	PF00675	0.464
CLV_NRD_NRD_1	659	661	PF00675	0.532
CLV_NRD_NRD_1	698	700	PF00675	0.430
CLV_PCSK_FUR_1	416	420	PF00082	0.621
CLV_PCSK_KEX2_1	128	130	PF00082	0.626
CLV_PCSK_KEX2_1	262	264	PF00082	0.588
CLV_PCSK_KEX2_1	295	297	PF00082	0.782
CLV_PCSK_KEX2_1	418	420	PF00082	0.471
CLV_PCSK_KEX2_1	541	543	PF00082	0.464
CLV_PCSK_KEX2_1	549	551	PF00082	0.452
CLV_PCSK_KEX2_1	659	661	PF00082	0.532
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.370
CLV_PCSK_PC7_1	258	264	PF00082	0.461
CLV_PCSK_SKI1_1	400	404	PF00082	0.340
CLV_PCSK_SKI1_1	433	437	PF00082	0.472
CLV_PCSK_SKI1_1	549	553	PF00082	0.542
CLV_PCSK_SKI1_1	560	564	PF00082	0.555
CLV_PCSK_SKI1_1	705	709	PF00082	0.597
CLV_PCSK_SKI1_1	716	720	PF00082	0.413
DEG_APCC_DBOX_1	517	525	PF00400	0.515
DEG_APCC_KENBOX_2	291	295	PF00400	0.571
DEG_SCF_FBW7_2	521	526	PF00400	0.508
DEG_SPOP_SBC_1	644	648	PF00917	0.561
DOC_CDC14_PxL_1	16	24	PF14671	0.541
DOC_CKS1_1	112	117	PF01111	0.702
DOC_CYCLIN_yClb5_NLxxxL_5	435	444	PF00134	0.346
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.556
DOC_MAPK_gen_1	128	136	PF00069	0.636
DOC_MAPK_gen_1	407	415	PF00069	0.392
DOC_MAPK_gen_1	730	736	PF00069	0.459
DOC_MAPK_HePTP_8	138	150	PF00069	0.511
DOC_MAPK_MEF2A_6	129	138	PF00069	0.595
DOC_MAPK_MEF2A_6	141	150	PF00069	0.420
DOC_MAPK_MEF2A_6	409	417	PF00069	0.376
DOC_MAPK_MEF2A_6	503	510	PF00069	0.487
DOC_MAPK_RevD_3	174	189	PF00069	0.513
DOC_PP1_RVXF_1	346	352	PF00149	0.453
DOC_PP2B_LxvP_1	134	137	PF13499	0.557
DOC_PP2B_LxvP_1	158	161	PF13499	0.591
DOC_USP7_MATH_1	218	222	PF00917	0.590
DOC_USP7_MATH_1	223	227	PF00917	0.588
DOC_USP7_MATH_1	302	306	PF00917	0.614
DOC_USP7_MATH_1	466	470	PF00917	0.650
DOC_USP7_MATH_1	638	642	PF00917	0.702
DOC_USP7_MATH_1	78	82	PF00917	0.580
DOC_USP7_MATH_1	95	99	PF00917	0.739
DOC_WW_Pin1_4	111	116	PF00397	0.671
DOC_WW_Pin1_4	283	288	PF00397	0.571
DOC_WW_Pin1_4	298	303	PF00397	0.519
DOC_WW_Pin1_4	462	467	PF00397	0.604
DOC_WW_Pin1_4	519	524	PF00397	0.509
DOC_WW_Pin1_4	56	61	PF00397	0.725
DOC_WW_Pin1_4	560	565	PF00397	0.580
DOC_WW_Pin1_4	626	631	PF00397	0.522
DOC_WW_Pin1_4	645	650	PF00397	0.560
DOC_WW_Pin1_4	96	101	PF00397	0.690
LIG_14-3-3_CanoR_1	129	135	PF00244	0.532
LIG_14-3-3_CanoR_1	151	157	PF00244	0.495
LIG_14-3-3_CanoR_1	188	193	PF00244	0.438
LIG_14-3-3_CanoR_1	295	299	PF00244	0.654
LIG_14-3-3_CanoR_1	316	321	PF00244	0.728
LIG_14-3-3_CanoR_1	366	371	PF00244	0.415
LIG_14-3-3_CanoR_1	39	46	PF00244	0.773
LIG_14-3-3_CanoR_1	49	58	PF00244	0.596
LIG_14-3-3_CanoR_1	541	551	PF00244	0.518
LIG_14-3-3_CanoR_1	75	81	PF00244	0.547
LIG_APCC_ABBAyCdc20_2	716	722	PF00400	0.493
LIG_BIR_III_4	376	380	PF00653	0.482
LIG_BRCT_BRCA1_1	654	658	PF00533	0.725
LIG_deltaCOP1_diTrp_1	609	617	PF00928	0.583
LIG_EVH1_1	16	20	PF00568	0.524
LIG_FHA_1	171	177	PF00498	0.580
LIG_FHA_1	182	188	PF00498	0.451
LIG_FHA_1	272	278	PF00498	0.713
LIG_FHA_1	312	318	PF00498	0.689
LIG_FHA_1	360	366	PF00498	0.499
LIG_FHA_1	510	516	PF00498	0.521
LIG_FHA_2	140	146	PF00498	0.368
LIG_FHA_2	210	216	PF00498	0.782
LIG_FHA_2	463	469	PF00498	0.703
LIG_FHA_2	476	482	PF00498	0.723
LIG_FHA_2	6	12	PF00498	0.634
LIG_FHA_2	604	610	PF00498	0.453
LIG_FHA_2	646	652	PF00498	0.556
LIG_LIR_Gen_1	336	343	PF02991	0.470
LIG_LIR_Gen_1	671	681	PF02991	0.467
LIG_LIR_Nem_3	126	130	PF02991	0.518
LIG_LIR_Nem_3	199	204	PF02991	0.624
LIG_LIR_Nem_3	336	341	PF02991	0.475
LIG_LIR_Nem_3	364	370	PF02991	0.656
LIG_LIR_Nem_3	671	677	PF02991	0.462
LIG_LIR_Nem_3	706	711	PF02991	0.478
LIG_Pex14_1	612	616	PF04695	0.572
LIG_PTAP_UEV_1	623	628	PF05743	0.507
LIG_SH2_CRK	201	205	PF00017	0.523
LIG_SH2_CRK	711	715	PF00017	0.431
LIG_SH2_GRB2like	597	600	PF00017	0.607
LIG_SH2_NCK_1	711	715	PF00017	0.324
LIG_SH2_PTP2	674	677	PF00017	0.458
LIG_SH2_STAP1	380	384	PF00017	0.567
LIG_SH2_STAP1	711	715	PF00017	0.506
LIG_SH2_STAT3	370	373	PF00017	0.519
LIG_SH2_STAT5	393	396	PF00017	0.421
LIG_SH2_STAT5	530	533	PF00017	0.396
LIG_SH2_STAT5	591	594	PF00017	0.466
LIG_SH2_STAT5	597	600	PF00017	0.505
LIG_SH2_STAT5	674	677	PF00017	0.458
LIG_SH3_3	106	112	PF00018	0.672
LIG_SH3_3	14	20	PF00018	0.524
LIG_SH3_3	24	30	PF00018	0.595
LIG_SH3_3	264	270	PF00018	0.641
LIG_SH3_3	444	450	PF00018	0.415
LIG_SH3_3	486	492	PF00018	0.483
LIG_SH3_3	565	571	PF00018	0.686
LIG_SH3_3	621	627	PF00018	0.491
LIG_SH3_3	672	678	PF00018	0.464
LIG_SH3_3	94	100	PF00018	0.704
LIG_SUMO_SIM_anti_2	395	406	PF11976	0.604
LIG_SUMO_SIM_par_1	164	173	PF11976	0.483
LIG_SUMO_SIM_par_1	339	344	PF11976	0.466
LIG_SUMO_SIM_par_1	395	406	PF11976	0.604
LIG_SxIP_EBH_1	69	82	PF03271	0.569
LIG_TRFH_1	370	374	PF08558	0.617
LIG_TRFH_1	674	678	PF08558	0.460
LIG_WW_2	17	20	PF00397	0.525
LIG_WW_2	573	576	PF00397	0.431
MOD_CDK_SPK_2	462	467	PF00069	0.604
MOD_CDK_SPxxK_3	626	633	PF00069	0.527
MOD_CDK_SPxxK_3	96	103	PF00069	0.564
MOD_CK1_1	221	227	PF00069	0.641
MOD_CK1_1	268	274	PF00069	0.699
MOD_CK1_1	283	289	PF00069	0.587
MOD_CK1_1	361	367	PF00069	0.706
MOD_CK1_1	396	402	PF00069	0.397
MOD_CK1_1	47	53	PF00069	0.803
MOD_CK1_1	5	11	PF00069	0.740
MOD_CK1_1	65	71	PF00069	0.558
MOD_CK1_1	86	92	PF00069	0.690
MOD_CK2_1	120	126	PF00069	0.453
MOD_CK2_1	209	215	PF00069	0.606
MOD_CK2_1	462	468	PF00069	0.692
MOD_CK2_1	475	481	PF00069	0.730
MOD_CK2_1	493	499	PF00069	0.312
MOD_CK2_1	5	11	PF00069	0.639
MOD_DYRK1A_RPxSP_1	560	564	PF00069	0.668
MOD_GlcNHglycan	270	273	PF01048	0.567
MOD_GlcNHglycan	282	285	PF01048	0.621
MOD_GlcNHglycan	343	346	PF01048	0.425
MOD_GlcNHglycan	459	462	PF01048	0.647
MOD_GlcNHglycan	53	56	PF01048	0.699
MOD_GlcNHglycan	533	536	PF01048	0.322
MOD_GlcNHglycan	64	67	PF01048	0.784
MOD_GSK3_1	177	184	PF00069	0.518
MOD_GSK3_1	193	200	PF00069	0.464
MOD_GSK3_1	218	225	PF00069	0.684
MOD_GSK3_1	276	283	PF00069	0.766
MOD_GSK3_1	294	301	PF00069	0.685
MOD_GSK3_1	311	318	PF00069	0.747
MOD_GSK3_1	35	42	PF00069	0.798
MOD_GSK3_1	392	399	PF00069	0.471
MOD_GSK3_1	451	458	PF00069	0.654
MOD_GSK3_1	462	469	PF00069	0.523
MOD_GSK3_1	47	54	PF00069	0.717
MOD_GSK3_1	531	538	PF00069	0.302
MOD_GSK3_1	56	63	PF00069	0.719
MOD_GSK3_1	622	629	PF00069	0.737
MOD_GSK3_1	638	645	PF00069	0.740
MOD_GSK3_1	76	83	PF00069	0.626
MOD_N-GLC_1	438	443	PF02516	0.368
MOD_N-GLC_1	642	647	PF02516	0.614
MOD_NEK2_1	152	157	PF00069	0.492
MOD_NEK2_1	177	182	PF00069	0.644
MOD_NEK2_1	244	249	PF00069	0.536
MOD_NEK2_1	402	407	PF00069	0.360
MOD_NEK2_1	45	50	PF00069	0.616
MOD_NEK2_1	531	536	PF00069	0.308
MOD_NEK2_1	80	85	PF00069	0.561
MOD_NEK2_2	120	125	PF00069	0.467
MOD_NEK2_2	653	658	PF00069	0.735
MOD_PIKK_1	239	245	PF00454	0.549
MOD_PIKK_1	509	515	PF00454	0.433
MOD_PIKK_1	542	548	PF00454	0.526
MOD_PIKK_1	78	84	PF00454	0.567
MOD_PK_1	188	194	PF00069	0.417
MOD_PKA_1	188	194	PF00069	0.417
MOD_PKA_2	294	300	PF00069	0.739
MOD_PKA_2	315	321	PF00069	0.733
MOD_PKA_2	466	472	PF00069	0.587
MOD_Plk_1	239	245	PF00069	0.549
MOD_Plk_1	396	402	PF00069	0.521
MOD_Plk_1	438	444	PF00069	0.447
MOD_Plk_1	5	11	PF00069	0.488
MOD_Plk_1	653	659	PF00069	0.585
MOD_Plk_4	181	187	PF00069	0.435
MOD_Plk_4	475	481	PF00069	0.656
MOD_Plk_4	493	499	PF00069	0.616
MOD_Plk_4	511	517	PF00069	0.392
MOD_Plk_4	535	541	PF00069	0.333
MOD_Plk_4	612	618	PF00069	0.461
MOD_Plk_4	653	659	PF00069	0.619
MOD_Plk_4	661	667	PF00069	0.478
MOD_Plk_4	669	675	PF00069	0.484
MOD_ProDKin_1	111	117	PF00069	0.668
MOD_ProDKin_1	283	289	PF00069	0.572
MOD_ProDKin_1	298	304	PF00069	0.519
MOD_ProDKin_1	462	468	PF00069	0.603
MOD_ProDKin_1	519	525	PF00069	0.511
MOD_ProDKin_1	56	62	PF00069	0.725
MOD_ProDKin_1	560	566	PF00069	0.588
MOD_ProDKin_1	626	632	PF00069	0.525
MOD_ProDKin_1	645	651	PF00069	0.560
MOD_ProDKin_1	96	102	PF00069	0.689
MOD_SUMO_rev_2	545	551	PF00179	0.377
MOD_SUMO_rev_2	603	613	PF00179	0.441
MOD_SUMO_rev_2	86	93	PF00179	0.560
TRG_DiLeu_BaEn_1	240	245	PF01217	0.548
TRG_DiLeu_BaEn_1	336	341	PF01217	0.358
TRG_DiLeu_BaEn_1	397	402	PF01217	0.611
TRG_DiLeu_BaEn_1	554	559	PF01217	0.641
TRG_DiLeu_BaEn_4	143	149	PF01217	0.603
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.469
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.490
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.404
TRG_DiLeu_LyEn_5	397	402	PF01217	0.358
TRG_ENDOCYTIC_2	201	204	PF00928	0.520
TRG_ENDOCYTIC_2	380	383	PF00928	0.513
TRG_ENDOCYTIC_2	530	533	PF00928	0.444
TRG_ENDOCYTIC_2	674	677	PF00928	0.458
TRG_ENDOCYTIC_2	704	707	PF00928	0.498
TRG_ENDOCYTIC_2	711	714	PF00928	0.483
TRG_ER_diArg_1	127	129	PF00400	0.632
TRG_ER_diArg_1	261	263	PF00400	0.579
TRG_ER_diArg_1	415	418	PF00400	0.481
TRG_ER_diArg_1	540	542	PF00400	0.486
TRG_ER_diArg_1	658	660	PF00400	0.549
TRG_NES_CRM1_1	165	178	PF08389	0.502
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	723	727	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U6	Leptomonas seymouri	40%	99%
A0A3Q8ILF7	Leishmania donovani	65%	100%
A4HZR8	Leishmania infantum	65%	100%
E9AVM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4QBV5	Leishmania major	63%	98%