Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HC86_LEIBR

TriTrypDb:

LbrM.22.0350 , LBRM2903_220008700

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.549
CLV_C14_Caspase3-7	69	73	PF00656	0.516
CLV_NRD_NRD_1	165	167	PF00675	0.699
CLV_PCSK_SKI1_1	12	16	PF00082	0.498
CLV_PCSK_SKI1_1	144	148	PF00082	0.508
CLV_PCSK_SKI1_1	196	200	PF00082	0.595
CLV_PCSK_SKI1_1	55	59	PF00082	0.478
DEG_APCC_DBOX_1	54	62	PF00400	0.481
DEG_Nend_UBRbox_3	1	3	PF02207	0.510
DEG_SCF_TRCP1_1	72	78	PF00400	0.517
DEG_SPOP_SBC_1	276	280	PF00917	0.520
DOC_CYCLIN_RxL_1	52	60	PF00134	0.466
DOC_MAPK_JIP1_4	55	61	PF00069	0.379
DOC_PP1_RVXF_1	240	246	PF00149	0.480
DOC_PP4_FxxP_1	62	65	PF00568	0.524
DOC_USP7_MATH_1	110	114	PF00917	0.661
DOC_USP7_MATH_1	182	186	PF00917	0.586
DOC_USP7_MATH_1	189	193	PF00917	0.536
DOC_USP7_MATH_1	277	281	PF00917	0.526
DOC_USP7_MATH_1	63	67	PF00917	0.610
DOC_USP7_MATH_1	88	92	PF00917	0.452
DOC_USP7_MATH_1	99	103	PF00917	0.630
DOC_WW_Pin1_4	167	172	PF00397	0.728
DOC_WW_Pin1_4	221	226	PF00397	0.547
LIG_14-3-3_CanoR_1	196	206	PF00244	0.468
LIG_14-3-3_CanoR_1	251	255	PF00244	0.480
LIG_BRCT_BRCA1_1	18	22	PF00533	0.485
LIG_CSL_BTD_1	96	99	PF09270	0.483
LIG_FHA_1	171	177	PF00498	0.629
LIG_FHA_1	230	236	PF00498	0.509
LIG_FHA_1	49	55	PF00498	0.373
LIG_FHA_1	9	15	PF00498	0.508
LIG_FHA_2	123	129	PF00498	0.444
LIG_FHA_2	267	273	PF00498	0.629
LIG_FHA_2	279	285	PF00498	0.531
LIG_FHA_2	85	91	PF00498	0.382
LIG_LIR_Apic_2	118	124	PF02991	0.563
LIG_LIR_Apic_2	60	65	PF02991	0.508
LIG_LIR_Gen_1	290	299	PF02991	0.462
LIG_LIR_Gen_1	87	96	PF02991	0.413
LIG_LIR_Nem_3	212	218	PF02991	0.435
LIG_LIR_Nem_3	290	295	PF02991	0.444
LIG_LIR_Nem_3	87	92	PF02991	0.406
LIG_NRBOX	22	28	PF00104	0.592
LIG_NRBOX	259	265	PF00104	0.487
LIG_SH2_CRK	121	125	PF00017	0.390
LIG_SH2_NCK_1	89	93	PF00017	0.420
LIG_SH2_STAT5	48	51	PF00017	0.368
LIG_SH3_3	93	99	PF00018	0.492
LIG_SUMO_SIM_par_1	173	181	PF11976	0.544
LIG_SUMO_SIM_par_1	55	60	PF11976	0.452
LIG_TYR_ITSM	85	92	PF00017	0.375
LIG_WRC_WIRS_1	215	220	PF05994	0.389
MOD_CK1_1	102	108	PF00069	0.641
MOD_CK1_1	180	186	PF00069	0.622
MOD_CK1_1	197	203	PF00069	0.470
MOD_CK1_1	66	72	PF00069	0.648
MOD_CK1_1	73	79	PF00069	0.577
MOD_CK2_1	122	128	PF00069	0.464
MOD_CK2_1	178	184	PF00069	0.544
MOD_CK2_1	221	227	PF00069	0.460
MOD_CK2_1	250	256	PF00069	0.458
MOD_CK2_1	64	70	PF00069	0.528
MOD_CK2_1	84	90	PF00069	0.330
MOD_Cter_Amidation	164	167	PF01082	0.647
MOD_GlcNHglycan	106	109	PF01048	0.751
MOD_GlcNHglycan	180	183	PF01048	0.572
MOD_GlcNHglycan	187	190	PF01048	0.626
MOD_GlcNHglycan	72	75	PF01048	0.625
MOD_GSK3_1	102	109	PF00069	0.609
MOD_GSK3_1	170	177	PF00069	0.641
MOD_GSK3_1	178	185	PF00069	0.647
MOD_GSK3_1	267	274	PF00069	0.482
MOD_GSK3_1	66	73	PF00069	0.587
MOD_GSK3_1	80	87	PF00069	0.385
MOD_LATS_1	194	200	PF00433	0.506
MOD_N-GLC_1	156	161	PF02516	0.532
MOD_NEK2_1	16	21	PF00069	0.515
MOD_NEK2_1	176	181	PF00069	0.551
MOD_NEK2_1	57	62	PF00069	0.474
MOD_NEK2_1	80	85	PF00069	0.543
MOD_PIKK_1	16	22	PF00454	0.453
MOD_PIKK_1	80	86	PF00454	0.451
MOD_PKA_2	250	256	PF00069	0.441
MOD_Plk_4	116	122	PF00069	0.511
MOD_Plk_4	18	24	PF00069	0.694
MOD_Plk_4	57	63	PF00069	0.387
MOD_ProDKin_1	167	173	PF00069	0.729
MOD_ProDKin_1	221	227	PF00069	0.553
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.395
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.450
TRG_ENDOCYTIC_2	208	211	PF00928	0.501
TRG_ENDOCYTIC_2	215	218	PF00928	0.399
TRG_ENDOCYTIC_2	89	92	PF00928	0.520
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB35	Leptomonas seymouri	38%	100%
A0A3S7WWY3	Leishmania donovani	62%	100%
A4HZR5	Leishmania infantum	63%	100%
E9AVM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QBV8	Leishmania major	61%	97%