Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC85_LEIBR

TriTrypDb:

LbrM.22.0340 , LBRM2903_220008600

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC85

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.621
CLV_NRD_NRD_1	106	108	PF00675	0.366
CLV_NRD_NRD_1	187	189	PF00675	0.554
CLV_NRD_NRD_1	199	201	PF00675	0.395
CLV_NRD_NRD_1	22	24	PF00675	0.466
CLV_NRD_NRD_1	229	231	PF00675	0.463
CLV_NRD_NRD_1	265	267	PF00675	0.526
CLV_NRD_NRD_1	3	5	PF00675	0.526
CLV_NRD_NRD_1	334	336	PF00675	0.694
CLV_NRD_NRD_1	98	100	PF00675	0.409
CLV_PCSK_KEX2_1	106	108	PF00082	0.385
CLV_PCSK_KEX2_1	199	201	PF00082	0.450
CLV_PCSK_KEX2_1	2	4	PF00082	0.537
CLV_PCSK_KEX2_1	22	24	PF00082	0.464
CLV_PCSK_KEX2_1	229	231	PF00082	0.463
CLV_PCSK_KEX2_1	311	313	PF00082	0.621
CLV_PCSK_KEX2_1	334	336	PF00082	0.694
CLV_PCSK_KEX2_1	98	100	PF00082	0.443
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.621
CLV_PCSK_PC7_1	307	313	PF00082	0.601
CLV_PCSK_SKI1_1	119	123	PF00082	0.594
CLV_PCSK_SKI1_1	216	220	PF00082	0.523
CLV_PCSK_SKI1_1	229	233	PF00082	0.423
DEG_APCC_DBOX_1	198	206	PF00400	0.600
DEG_Nend_UBRbox_1	1	4	PF02207	0.547
DOC_CYCLIN_RxL_1	116	125	PF00134	0.518
DOC_CYCLIN_RxL_1	185	197	PF00134	0.364
DOC_MAPK_DCC_7	347	356	PF00069	0.487
DOC_MAPK_gen_1	185	193	PF00069	0.466
DOC_MAPK_gen_1	199	205	PF00069	0.367
DOC_MAPK_MEF2A_6	347	356	PF00069	0.487
DOC_MAPK_MEF2A_6	8	15	PF00069	0.525
DOC_USP7_MATH_1	187	191	PF00917	0.373
DOC_USP7_MATH_1	253	257	PF00917	0.657
DOC_USP7_MATH_1	316	320	PF00917	0.537
DOC_USP7_MATH_1	35	39	PF00917	0.499
DOC_USP7_MATH_1	83	87	PF00917	0.508
DOC_USP7_UBL2_3	185	189	PF12436	0.380
DOC_USP7_UBL2_3	270	274	PF12436	0.690
DOC_WW_Pin1_4	14	19	PF00397	0.536
DOC_WW_Pin1_4	88	93	PF00397	0.632
LIG_14-3-3_CanoR_1	117	122	PF00244	0.386
LIG_14-3-3_CanoR_1	188	192	PF00244	0.510
LIG_14-3-3_CanoR_1	199	203	PF00244	0.446
LIG_14-3-3_CanoR_1	22	26	PF00244	0.514
LIG_14-3-3_CanoR_1	324	332	PF00244	0.677
LIG_14-3-3_CanoR_1	334	340	PF00244	0.574
LIG_14-3-3_CanoR_1	63	67	PF00244	0.619
LIG_14-3-3_CanoR_1	87	92	PF00244	0.538
LIG_14-3-3_CanoR_1	98	104	PF00244	0.483
LIG_APCC_ABBAyCdc20_2	230	236	PF00400	0.546
LIG_FHA_1	118	124	PF00498	0.546
LIG_FHA_1	304	310	PF00498	0.516
LIG_FHA_1	325	331	PF00498	0.525
LIG_FHA_2	174	180	PF00498	0.516
LIG_FHA_2	316	322	PF00498	0.474
LIG_Integrin_isoDGR_2	56	58	PF01839	0.559
LIG_LIR_Apic_2	346	352	PF02991	0.504
LIG_LIR_Gen_1	128	135	PF02991	0.366
LIG_LIR_Nem_3	217	222	PF02991	0.439
LIG_MAD2	27	35	PF02301	0.520
LIG_PDZ_Class_2	380	385	PF00595	0.537
LIG_REV1ctd_RIR_1	217	225	PF16727	0.544
LIG_SH2_NCK_1	6	10	PF00017	0.523
LIG_SH2_STAP1	373	377	PF00017	0.589
LIG_SH2_STAT3	301	304	PF00017	0.607
LIG_SH2_STAT5	248	251	PF00017	0.462
LIG_SH3_3	41	47	PF00018	0.522
LIG_SH3_3	86	92	PF00018	0.492
LIG_SUMO_SIM_par_1	119	125	PF11976	0.524
LIG_TRAF2_1	91	94	PF00917	0.607
MOD_CK1_1	14	20	PF00069	0.536
MOD_CK1_1	153	159	PF00069	0.384
MOD_CK2_1	177	183	PF00069	0.558
MOD_CK2_1	315	321	PF00069	0.440
MOD_CK2_1	88	94	PF00069	0.675
MOD_Cter_Amidation	309	312	PF01082	0.598
MOD_GlcNHglycan	373	376	PF01048	0.614
MOD_GlcNHglycan	99	102	PF01048	0.394
MOD_GSK3_1	113	120	PF00069	0.526
MOD_GSK3_1	14	21	PF00069	0.535
MOD_GSK3_1	173	180	PF00069	0.474
MOD_GSK3_1	194	201	PF00069	0.537
MOD_GSK3_1	316	323	PF00069	0.590
MOD_GSK3_1	62	69	PF00069	0.702
MOD_GSK3_1	83	90	PF00069	0.668
MOD_N-GLC_1	177	182	PF02516	0.373
MOD_N-GLC_1	51	56	PF02516	0.665
MOD_NEK2_1	150	155	PF00069	0.573
MOD_NEK2_1	173	178	PF00069	0.548
MOD_NEK2_1	66	71	PF00069	0.607
MOD_NEK2_2	194	199	PF00069	0.527
MOD_OFUCOSY	140	147	PF10250	0.338
MOD_PIKK_1	300	306	PF00454	0.423
MOD_PKA_2	153	159	PF00069	0.383
MOD_PKA_2	173	179	PF00069	0.485
MOD_PKA_2	187	193	PF00069	0.437
MOD_PKA_2	198	204	PF00069	0.550
MOD_PKA_2	21	27	PF00069	0.517
MOD_PKA_2	323	329	PF00069	0.570
MOD_PKA_2	343	349	PF00069	0.450
MOD_PKA_2	62	68	PF00069	0.796
MOD_PKA_2	97	103	PF00069	0.583
MOD_PKB_1	2	10	PF00069	0.527
MOD_Plk_1	177	183	PF00069	0.403
MOD_Plk_1	320	326	PF00069	0.465
MOD_Plk_1	75	81	PF00069	0.572
MOD_Plk_2-3	179	185	PF00069	0.377
MOD_ProDKin_1	14	20	PF00069	0.536
MOD_ProDKin_1	88	94	PF00069	0.628
MOD_SUMO_rev_2	179	187	PF00179	0.378
MOD_SUMO_rev_2	24	29	PF00179	0.514
TRG_DiLeu_LyEn_5	209	214	PF01217	0.395
TRG_ER_diArg_1	1	4	PF00400	0.547
TRG_ER_diArg_1	106	109	PF00400	0.366
TRG_ER_diArg_1	198	200	PF00400	0.602
TRG_ER_diArg_1	228	230	PF00400	0.461
TRG_ER_diArg_1	97	99	PF00400	0.419
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVH6	Leptomonas seymouri	42%	100%
A0A3S7WX10	Leishmania donovani	70%	100%
A4HZR4	Leishmania infantum	70%	100%
E9AVM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QBV9	Leishmania major	69%	100%