Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HC84_LEIBR

TriTrypDb:

LbrM.22.0330 , LBRM2903_220008500

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.450
CLV_NRD_NRD_1	87	89	PF00675	0.590
CLV_PCSK_KEX2_1	87	89	PF00082	0.590
CLV_PCSK_SKI1_1	142	146	PF00082	0.359
CLV_PCSK_SKI1_1	163	167	PF00082	0.343
DEG_APCC_DBOX_1	34	42	PF00400	0.413
DEG_APCC_DBOX_1	93	101	PF00400	0.555
DEG_Nend_UBRbox_3	1	3	PF02207	0.518
DOC_CKS1_1	157	162	PF01111	0.358
DOC_MAPK_gen_1	64	72	PF00069	0.531
DOC_MAPK_MEF2A_6	66	74	PF00069	0.437
DOC_PP4_FxxP_1	157	160	PF00568	0.334
DOC_USP7_MATH_1	188	192	PF00917	0.474
DOC_USP7_MATH_1	33	37	PF00917	0.463
DOC_WW_Pin1_4	156	161	PF00397	0.363
LIG_14-3-3_CanoR_1	142	151	PF00244	0.436
LIG_14-3-3_CanoR_1	152	160	PF00244	0.387
LIG_14-3-3_CanoR_1	94	104	PF00244	0.549
LIG_BRCT_BRCA1_1	153	157	PF00533	0.356
LIG_FHA_1	157	163	PF00498	0.363
LIG_FHA_1	171	177	PF00498	0.558
LIG_FHA_2	207	213	PF00498	0.488
LIG_LIR_Apic_2	154	160	PF02991	0.334
LIG_LIR_Nem_3	139	144	PF02991	0.432
LIG_SH2_CRK	67	71	PF00017	0.431
LIG_SH2_STAP1	172	176	PF00017	0.551
LIG_SH2_STAT5	172	175	PF00017	0.544
LIG_SUMO_SIM_par_1	212	219	PF11976	0.342
LIG_TRAF2_1	90	93	PF00917	0.373
LIG_WRC_WIRS_1	20	25	PF05994	0.561
MOD_CDK_SPxxK_3	156	163	PF00069	0.367
MOD_CK1_1	191	197	PF00069	0.556
MOD_CK1_1	22	28	PF00069	0.419
MOD_CK1_1	3	9	PF00069	0.752
MOD_CK2_1	25	31	PF00069	0.411
MOD_CK2_1	87	93	PF00069	0.388
MOD_GlcNHglycan	10	13	PF01048	0.490
MOD_GlcNHglycan	2	5	PF01048	0.711
MOD_GlcNHglycan	89	92	PF01048	0.408
MOD_GSK3_1	127	134	PF00069	0.597
MOD_GSK3_1	172	179	PF00069	0.438
MOD_GSK3_1	39	46	PF00069	0.425
MOD_GSK3_1	76	83	PF00069	0.639
MOD_NEK2_1	140	145	PF00069	0.423
MOD_NEK2_1	176	181	PF00069	0.483
MOD_NEK2_1	216	221	PF00069	0.346
MOD_OFUCOSY	126	131	PF10250	0.495
MOD_PIKK_1	76	82	PF00454	0.549
MOD_PKA_1	87	93	PF00069	0.497
MOD_PKA_2	151	157	PF00069	0.542
MOD_PKA_2	87	93	PF00069	0.547
MOD_PKA_2	95	101	PF00069	0.612
MOD_Plk_1	131	137	PF00069	0.521
MOD_Plk_1	225	231	PF00069	0.399
MOD_Plk_1	25	31	PF00069	0.393
MOD_Plk_4	188	194	PF00069	0.446
MOD_Plk_4	19	25	PF00069	0.645
MOD_Plk_4	216	222	PF00069	0.324
MOD_ProDKin_1	156	162	PF00069	0.357
TRG_DiLeu_BaEn_4	92	98	PF01217	0.377
TRG_ENDOCYTIC_2	67	70	PF00928	0.432
TRG_ER_diArg_1	35	38	PF00400	0.389
TRG_ER_diArg_1	94	97	PF00400	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJI0	Leptomonas seymouri	26%	100%
A0A3Q8IE58	Leishmania donovani	59%	93%
A4HZR3	Leishmania infantum	60%	93%
E9AVL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	93%
Q4QBW0	Leishmania major	58%	100%