SEP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SEP domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HC82_LEIBR

TriTrypDb:

LbrM.22.0310 , LBRM2903_220008300

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC82

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0007033	vacuole organization	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0016043	cellular component organization	3	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0022607	cellular component assembly	4	1
GO:0030163	protein catabolic process	4	1
GO:0031468	nuclear membrane reassembly	6	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070925	organelle assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071709	membrane assembly	5	1
GO:0071763	nuclear membrane organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1905037	autophagosome organization	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.579
CLV_C14_Caspase3-7	169	173	PF00656	0.439
CLV_C14_Caspase3-7	80	84	PF00656	0.367
CLV_NRD_NRD_1	130	132	PF00675	0.643
CLV_NRD_NRD_1	179	181	PF00675	0.595
CLV_NRD_NRD_1	203	205	PF00675	0.464
CLV_NRD_NRD_1	366	368	PF00675	0.487
CLV_NRD_NRD_1	405	407	PF00675	0.545
CLV_PCSK_FUR_1	128	132	PF00082	0.396
CLV_PCSK_KEX2_1	130	132	PF00082	0.509
CLV_PCSK_KEX2_1	203	205	PF00082	0.464
CLV_PCSK_KEX2_1	366	368	PF00082	0.597
CLV_PCSK_KEX2_1	405	407	PF00082	0.545
CLV_PCSK_SKI1_1	106	110	PF00082	0.493
CLV_PCSK_SKI1_1	203	207	PF00082	0.422
CLV_PCSK_SKI1_1	70	74	PF00082	0.631
DEG_Nend_Nbox_1	1	3	PF02207	0.413
DOC_CYCLIN_yCln2_LP_2	46	52	PF00134	0.397
DOC_MAPK_gen_1	228	237	PF00069	0.454
DOC_MAPK_gen_1	363	371	PF00069	0.595
DOC_MAPK_gen_1	405	413	PF00069	0.585
DOC_MAPK_gen_1	420	428	PF00069	0.486
DOC_MAPK_gen_1	94	102	PF00069	0.533
DOC_MAPK_MEF2A_6	228	237	PF00069	0.453
DOC_MAPK_MEF2A_6	287	294	PF00069	0.369
DOC_MAPK_MEF2A_6	94	102	PF00069	0.558
DOC_PP2B_LxvP_1	309	312	PF13499	0.699
DOC_PP2B_LxvP_1	46	49	PF13499	0.392
DOC_PP2B_LxvP_1	56	59	PF13499	0.374
DOC_PP4_FxxP_1	268	271	PF00568	0.369
DOC_PP4_FxxP_1	294	297	PF00568	0.369
DOC_PP4_MxPP_1	152	155	PF00568	0.565
DOC_USP7_MATH_1	187	191	PF00917	0.731
DOC_USP7_MATH_1	229	233	PF00917	0.614
DOC_USP7_MATH_1	251	255	PF00917	0.491
DOC_USP7_MATH_1	315	319	PF00917	0.619
DOC_USP7_MATH_1	325	329	PF00917	0.537
DOC_USP7_MATH_1	332	336	PF00917	0.493
DOC_USP7_MATH_1	41	45	PF00917	0.431
DOC_WW_Pin1_4	217	222	PF00397	0.518
DOC_WW_Pin1_4	330	335	PF00397	0.678
DOC_WW_Pin1_4	6	11	PF00397	0.419
LIG_14-3-3_CanoR_1	212	222	PF00244	0.538
LIG_14-3-3_CanoR_1	231	236	PF00244	0.431
LIG_14-3-3_CanoR_1	375	379	PF00244	0.413
LIG_14-3-3_CanoR_1	406	412	PF00244	0.359
LIG_BRCT_BRCA1_1	2	6	PF00533	0.369
LIG_CaM_NSCaTE_8	114	121	PF13499	0.549
LIG_CSL_BTD_1	46	49	PF09270	0.392
LIG_CtBP_PxDLS_1	270	274	PF00389	0.560
LIG_DCNL_PONY_1	1	4	PF03556	0.394
LIG_deltaCOP1_diTrp_1	43	52	PF00928	0.407
LIG_EVH1_2	48	52	PF00568	0.387
LIG_FHA_1	281	287	PF00498	0.525
LIG_FHA_1	352	358	PF00498	0.464
LIG_FHA_2	194	200	PF00498	0.734
LIG_FHA_2	31	37	PF00498	0.430
LIG_FHA_2	360	366	PF00498	0.515
LIG_FHA_2	375	381	PF00498	0.408
LIG_LIR_Apic_2	265	271	PF02991	0.560
LIG_LIR_Apic_2	293	297	PF02991	0.512
LIG_LIR_Apic_2	43	48	PF02991	0.417
LIG_LIR_Gen_1	354	360	PF02991	0.471
LIG_LIR_Gen_1	393	403	PF02991	0.370
LIG_LIR_Nem_3	354	359	PF02991	0.471
LIG_LIR_Nem_3	393	398	PF02991	0.401
LIG_LIR_Nem_3	44	50	PF02991	0.402
LIG_LIR_Nem_3	95	100	PF02991	0.516
LIG_PCNA_yPIPBox_3	389	400	PF02747	0.504
LIG_SH2_STAT5	215	218	PF00017	0.562
LIG_SH2_STAT5	222	225	PF00017	0.574
LIG_SH2_STAT5	299	302	PF00017	0.506
LIG_SH3_3	12	18	PF00018	0.577
LIG_SH3_3	148	154	PF00018	0.601
LIG_SH3_3	245	251	PF00018	0.454
LIG_SH3_3	309	315	PF00018	0.606
LIG_SH3_3	328	334	PF00018	0.632
LIG_SUMO_SIM_anti_2	354	362	PF11976	0.429
LIG_SUMO_SIM_par_1	343	352	PF11976	0.614
LIG_SUMO_SIM_par_1	354	362	PF11976	0.496
LIG_TRAF2_1	33	36	PF00917	0.429
LIG_UBA3_1	174	181	PF00899	0.548
LIG_WW_1	296	299	PF00397	0.513
LIG_WW_3	402	406	PF00397	0.472
MOD_CDK_SPK_2	6	11	PF00069	0.419
MOD_CK1_1	272	278	PF00069	0.399
MOD_CK1_1	333	339	PF00069	0.657
MOD_CK2_1	193	199	PF00069	0.745
MOD_CK2_1	30	36	PF00069	0.431
MOD_CK2_1	359	365	PF00069	0.501
MOD_GlcNHglycan	146	149	PF01048	0.503
MOD_GlcNHglycan	168	171	PF01048	0.528
MOD_GlcNHglycan	189	192	PF01048	0.694
MOD_GlcNHglycan	23	26	PF01048	0.455
MOD_GlcNHglycan	322	325	PF01048	0.667
MOD_GSK3_1	166	173	PF00069	0.600
MOD_GSK3_1	17	24	PF00069	0.459
MOD_GSK3_1	213	220	PF00069	0.516
MOD_GSK3_1	229	236	PF00069	0.358
MOD_GSK3_1	332	339	PF00069	0.623
MOD_GSK3_1	347	354	PF00069	0.448
MOD_N-GLC_1	114	119	PF02516	0.479
MOD_N-GLC_1	166	171	PF02516	0.514
MOD_N-GLC_1	187	192	PF02516	0.730
MOD_NEK2_1	174	179	PF00069	0.418
MOD_NEK2_1	213	218	PF00069	0.524
MOD_NEK2_1	359	364	PF00069	0.529
MOD_NEK2_1	407	412	PF00069	0.564
MOD_NEK2_1	50	55	PF00069	0.533
MOD_NEK2_1	60	65	PF00069	0.603
MOD_PIKK_1	19	25	PF00454	0.459
MOD_PIKK_1	315	321	PF00454	0.569
MOD_PK_1	231	237	PF00069	0.331
MOD_PK_1	86	92	PF00069	0.559
MOD_PKA_2	374	380	PF00069	0.423
MOD_Plk_1	114	120	PF00069	0.474
MOD_Plk_1	133	139	PF00069	0.390
MOD_Plk_1	229	235	PF00069	0.447
MOD_Plk_1	280	286	PF00069	0.490
MOD_Plk_1	340	346	PF00069	0.597
MOD_Plk_1	351	357	PF00069	0.547
MOD_Plk_2-3	347	353	PF00069	0.604
MOD_Plk_2-3	374	380	PF00069	0.567
MOD_Plk_4	134	140	PF00069	0.507
MOD_Plk_4	170	176	PF00069	0.486
MOD_Plk_4	233	239	PF00069	0.224
MOD_Plk_4	352	358	PF00069	0.523
MOD_Plk_4	41	47	PF00069	0.557
MOD_ProDKin_1	217	223	PF00069	0.521
MOD_ProDKin_1	330	336	PF00069	0.674
MOD_ProDKin_1	6	12	PF00069	0.426
TRG_DiLeu_BaEn_1	393	398	PF01217	0.291
TRG_DiLeu_BaEn_2	255	261	PF01217	0.537
TRG_DiLeu_BaEn_2	351	357	PF01217	0.534
TRG_DiLeu_BaEn_2	390	396	PF01217	0.538
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.394
TRG_ENDOCYTIC_2	299	302	PF00928	0.504
TRG_ER_diArg_1	128	131	PF00400	0.614
TRG_ER_diArg_1	404	406	PF00400	0.570
TRG_ER_diArg_1	93	96	PF00400	0.550
TRG_NES_CRM1_1	281	293	PF08389	0.537
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P591	Leptomonas seymouri	65%	100%
A0A0S4JV00	Bodo saltans	33%	100%
A0A1X0NTT3	Trypanosomatidae	39%	100%
A0A3Q8IAL1	Leishmania donovani	79%	100%
A0A422NSS0	Trypanosoma rangeli	37%	100%
A4HZR0	Leishmania infantum	79%	100%
E9AVL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
O35987	Rattus norvegicus	25%	100%
Q3SZC4	Bos taurus	25%	100%
Q4QBW3	Leishmania major	78%	100%
Q5RBG3	Pongo abelii	25%	100%
Q5ZK10	Gallus gallus	24%	100%
Q9CZ44	Mus musculus	25%	100%
Q9UNZ2	Homo sapiens	25%	100%
V5AVR5	Trypanosoma cruzi	39%	100%