Carnitine palmitoyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carnitine palmitoyltransferase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HC81_LEIBR

TriTrypDb:

LbrM.22.0300 , LBRM2903_220008200

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC81

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006629	lipid metabolic process	3	7
GO:0006631	fatty acid metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0032787	monocarboxylic acid metabolic process	6	7
GO:0043436	oxoacid metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0006635	fatty acid beta-oxidation	6	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0030258	lipid modification	4	1
GO:0034440	lipid oxidation	5	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004095	carnitine O-palmitoyltransferase activity	7	8
GO:0008374	O-acyltransferase activity	5	8
GO:0016406	carnitine O-acyltransferase activity	6	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016416	O-palmitoyltransferase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.363
CLV_C14_Caspase3-7	402	406	PF00656	0.341
CLV_NRD_NRD_1	113	115	PF00675	0.427
CLV_NRD_NRD_1	391	393	PF00675	0.418
CLV_NRD_NRD_1	410	412	PF00675	0.394
CLV_NRD_NRD_1	428	430	PF00675	0.188
CLV_NRD_NRD_1	516	518	PF00675	0.427
CLV_PCSK_KEX2_1	113	115	PF00082	0.427
CLV_PCSK_KEX2_1	196	198	PF00082	0.437
CLV_PCSK_KEX2_1	391	393	PF00082	0.455
CLV_PCSK_KEX2_1	410	412	PF00082	0.370
CLV_PCSK_KEX2_1	454	456	PF00082	0.385
CLV_PCSK_KEX2_1	516	518	PF00082	0.427
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.437
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.354
CLV_PCSK_SKI1_1	137	141	PF00082	0.437
CLV_PCSK_SKI1_1	324	328	PF00082	0.406
CLV_PCSK_SKI1_1	40	44	PF00082	0.442
CLV_PCSK_SKI1_1	601	605	PF00082	0.435
CLV_PCSK_SKI1_1	626	630	PF00082	0.435
DEG_Nend_UBRbox_1	1	4	PF02207	0.544
DEG_SCF_FBW7_1	524	531	PF00400	0.244
DEG_SCF_FBW7_2	479	485	PF00400	0.447
DEG_SPOP_SBC_1	652	656	PF00917	0.538
DOC_ANK_TNKS_1	186	193	PF00023	0.452
DOC_CDC14_PxL_1	584	592	PF14671	0.410
DOC_CKS1_1	217	222	PF01111	0.427
DOC_CKS1_1	47	52	PF01111	0.529
DOC_CKS1_1	479	484	PF01111	0.205
DOC_CKS1_1	525	530	PF01111	0.246
DOC_CKS1_1	84	89	PF01111	0.365
DOC_MAPK_gen_1	135	142	PF00069	0.433
DOC_MAPK_gen_1	391	397	PF00069	0.205
DOC_MAPK_gen_1	459	469	PF00069	0.399
DOC_MAPK_MEF2A_6	60	67	PF00069	0.522
DOC_PP1_RVXF_1	254	261	PF00149	0.394
DOC_PP1_RVXF_1	437	444	PF00149	0.322
DOC_PP2B_LxvP_1	65	68	PF13499	0.310
DOC_USP7_MATH_1	120	124	PF00917	0.452
DOC_USP7_MATH_1	141	145	PF00917	0.391
DOC_USP7_MATH_1	195	199	PF00917	0.345
DOC_USP7_MATH_1	399	403	PF00917	0.427
DOC_USP7_MATH_1	422	426	PF00917	0.427
DOC_USP7_MATH_1	644	648	PF00917	0.531
DOC_USP7_MATH_1	652	656	PF00917	0.447
DOC_USP7_MATH_1	91	95	PF00917	0.427
DOC_WW_Pin1_4	216	221	PF00397	0.345
DOC_WW_Pin1_4	360	365	PF00397	0.443
DOC_WW_Pin1_4	368	373	PF00397	0.402
DOC_WW_Pin1_4	46	51	PF00397	0.522
DOC_WW_Pin1_4	478	483	PF00397	0.449
DOC_WW_Pin1_4	524	529	PF00397	0.387
DOC_WW_Pin1_4	640	645	PF00397	0.516
DOC_WW_Pin1_4	83	88	PF00397	0.333
LIG_14-3-3_CanoR_1	113	120	PF00244	0.403
LIG_14-3-3_CanoR_1	143	149	PF00244	0.457
LIG_14-3-3_CanoR_1	516	525	PF00244	0.408
LIG_14-3-3_CanoR_1	565	574	PF00244	0.446
LIG_14-3-3_CanoR_1	577	584	PF00244	0.333
LIG_14-3-3_CanoR_1	632	638	PF00244	0.537
LIG_14-3-3_CanoR_1	76	84	PF00244	0.246
LIG_Actin_WH2_2	280	297	PF00022	0.427
LIG_APCC_ABBA_1	106	111	PF00400	0.303
LIG_APCC_ABBAyCdc20_2	601	607	PF00400	0.205
LIG_BRCT_BRCA1_1	126	130	PF00533	0.427
LIG_BRCT_BRCA1_1	169	173	PF00533	0.306
LIG_BRCT_BRCA1_1	217	221	PF00533	0.403
LIG_BRCT_BRCA1_1	519	523	PF00533	0.325
LIG_BRCT_BRCA1_1	529	533	PF00533	0.294
LIG_BRCT_BRCA1_1	654	658	PF00533	0.502
LIG_BRCT_BRCA1_2	169	175	PF00533	0.391
LIG_CtBP_PxDLS_1	232	236	PF00389	0.306
LIG_eIF4E_1	124	130	PF01652	0.427
LIG_FHA_1	120	126	PF00498	0.295
LIG_FHA_1	145	151	PF00498	0.388
LIG_FHA_1	217	223	PF00498	0.325
LIG_FHA_1	323	329	PF00498	0.341
LIG_FHA_1	433	439	PF00498	0.300
LIG_FHA_1	47	53	PF00498	0.449
LIG_FHA_1	479	485	PF00498	0.384
LIG_FHA_1	529	535	PF00498	0.371
LIG_FHA_1	640	646	PF00498	0.478
LIG_FHA_1	91	97	PF00498	0.219
LIG_FHA_2	41	47	PF00498	0.578
LIG_FHA_2	655	661	PF00498	0.273
LIG_FHA_2	67	73	PF00498	0.205
LIG_Integrin_RGD_1	392	394	PF01839	0.452
LIG_LIR_Apic_2	589	594	PF02991	0.391
LIG_LIR_Gen_1	127	134	PF02991	0.345
LIG_LIR_Gen_1	236	242	PF02991	0.351
LIG_LIR_Gen_1	25	35	PF02991	0.500
LIG_LIR_Gen_1	288	298	PF02991	0.298
LIG_LIR_Gen_1	593	604	PF02991	0.311
LIG_LIR_Nem_3	170	176	PF02991	0.376
LIG_LIR_Nem_3	236	241	PF02991	0.351
LIG_LIR_Nem_3	25	31	PF02991	0.462
LIG_LIR_Nem_3	288	294	PF02991	0.298
LIG_LIR_Nem_3	593	599	PF02991	0.275
LIG_MYND_1	50	54	PF01753	0.556
LIG_Pex14_2	238	242	PF04695	0.404
LIG_Pex14_2	658	662	PF04695	0.482
LIG_PTB_Apo_2	411	418	PF02174	0.452
LIG_PTB_Phospho_1	411	417	PF10480	0.452
LIG_SH2_CRK	291	295	PF00017	0.306
LIG_SH2_GRB2like	412	415	PF00017	0.452
LIG_SH2_NCK_1	591	595	PF00017	0.205
LIG_SH2_PTP2	263	266	PF00017	0.205
LIG_SH2_STAT3	619	622	PF00017	0.303
LIG_SH2_STAT5	124	127	PF00017	0.322
LIG_SH2_STAT5	177	180	PF00017	0.300
LIG_SH2_STAT5	188	191	PF00017	0.300
LIG_SH2_STAT5	263	266	PF00017	0.262
LIG_SH2_STAT5	412	415	PF00017	0.306
LIG_SH2_STAT5	619	622	PF00017	0.447
LIG_SH2_STAT5	77	80	PF00017	0.306
LIG_SH3_1	60	66	PF00018	0.524
LIG_SH3_3	214	220	PF00018	0.452
LIG_SH3_3	226	232	PF00018	0.254
LIG_SH3_3	358	364	PF00018	0.455
LIG_SH3_3	596	602	PF00018	0.452
LIG_SH3_3	60	66	PF00018	0.524
LIG_SH3_3	638	644	PF00018	0.500
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.205
LIG_SUMO_SIM_anti_2	336	343	PF11976	0.341
LIG_SUMO_SIM_par_1	283	289	PF11976	0.408
LIG_SUMO_SIM_par_1	472	478	PF11976	0.411
LIG_SUMO_SIM_par_1	671	676	PF11976	0.321
LIG_TRAF2_1	43	46	PF00917	0.596
LIG_TRFH_1	619	623	PF08558	0.559
LIG_UBA3_1	129	135	PF00899	0.205
LIG_WRC_WIRS_1	97	102	PF05994	0.341
MOD_CDK_SPK_2	83	88	PF00069	0.247
MOD_CDK_SPxxK_3	368	375	PF00069	0.427
MOD_CK1_1	123	129	PF00069	0.302
MOD_CK1_1	144	150	PF00069	0.376
MOD_CK1_1	310	316	PF00069	0.398
MOD_CK1_1	398	404	PF00069	0.329
MOD_CK1_1	536	542	PF00069	0.427
MOD_CK1_1	597	603	PF00069	0.307
MOD_CK1_1	654	660	PF00069	0.522
MOD_CK2_1	283	289	PF00069	0.452
MOD_CK2_1	35	41	PF00069	0.583
MOD_CK2_1	654	660	PF00069	0.308
MOD_CK2_1	76	82	PF00069	0.453
MOD_GlcNHglycan	136	140	PF01048	0.381
MOD_GlcNHglycan	15	18	PF01048	0.649
MOD_GlcNHglycan	162	165	PF01048	0.465
MOD_GlcNHglycan	197	200	PF01048	0.394
MOD_GlcNHglycan	208	211	PF01048	0.313
MOD_GlcNHglycan	24	27	PF01048	0.588
MOD_GlcNHglycan	397	400	PF01048	0.421
MOD_GlcNHglycan	78	81	PF01048	0.450
MOD_GlcNHglycan	93	96	PF01048	0.367
MOD_GSK3_1	119	126	PF00069	0.306
MOD_GSK3_1	195	202	PF00069	0.403
MOD_GSK3_1	36	43	PF00069	0.551
MOD_GSK3_1	381	388	PF00069	0.345
MOD_GSK3_1	395	402	PF00069	0.285
MOD_GSK3_1	48	55	PF00069	0.313
MOD_GSK3_1	480	487	PF00069	0.315
MOD_GSK3_1	524	531	PF00069	0.311
MOD_GSK3_1	533	540	PF00069	0.274
MOD_GSK3_1	561	568	PF00069	0.452
MOD_GSK3_1	622	629	PF00069	0.507
MOD_GSK3_1	640	647	PF00069	0.371
MOD_GSK3_1	650	657	PF00069	0.531
MOD_GSK3_1	66	73	PF00069	0.322
MOD_N-GLC_1	223	228	PF02516	0.439
MOD_N-GLC_1	242	247	PF02516	0.317
MOD_N-GLC_1	91	96	PF02516	0.205
MOD_NEK2_1	160	165	PF00069	0.341
MOD_NEK2_1	206	211	PF00069	0.306
MOD_NEK2_1	22	27	PF00069	0.590
MOD_NEK2_1	233	238	PF00069	0.288
MOD_NEK2_1	241	246	PF00069	0.273
MOD_NEK2_1	273	278	PF00069	0.422
MOD_NEK2_1	385	390	PF00069	0.388
MOD_NEK2_1	533	538	PF00069	0.439
MOD_NEK2_1	628	633	PF00069	0.411
MOD_NEK2_1	70	75	PF00069	0.379
MOD_NEK2_1	90	95	PF00069	0.123
MOD_PIKK_1	233	239	PF00454	0.331
MOD_PIKK_1	541	547	PF00454	0.452
MOD_PIKK_1	566	572	PF00454	0.205
MOD_PK_1	370	376	PF00069	0.398
MOD_PK_1	383	389	PF00069	0.209
MOD_PKA_2	112	118	PF00069	0.403
MOD_PKA_2	463	469	PF00069	0.341
MOD_PKA_2	537	543	PF00069	0.421
MOD_PKA_2	576	582	PF00069	0.361
MOD_Plk_1	135	141	PF00069	0.390
MOD_Plk_1	223	229	PF00069	0.364
MOD_Plk_1	233	239	PF00069	0.301
MOD_Plk_1	242	248	PF00069	0.272
MOD_Plk_1	307	313	PF00069	0.379
MOD_Plk_1	340	346	PF00069	0.410
MOD_Plk_1	381	387	PF00069	0.333
MOD_Plk_1	399	405	PF00069	0.306
MOD_Plk_1	40	46	PF00069	0.436
MOD_Plk_1	484	490	PF00069	0.391
MOD_Plk_1	528	534	PF00069	0.452
MOD_Plk_1	611	617	PF00069	0.465
MOD_Plk_1	91	97	PF00069	0.205
MOD_Plk_2-3	463	469	PF00069	0.349
MOD_Plk_4	120	126	PF00069	0.315
MOD_Plk_4	144	150	PF00069	0.292
MOD_Plk_4	307	313	PF00069	0.462
MOD_Plk_4	340	346	PF00069	0.415
MOD_Plk_4	48	54	PF00069	0.439
MOD_Plk_4	633	639	PF00069	0.499
MOD_Plk_4	645	651	PF00069	0.620
MOD_Plk_4	96	102	PF00069	0.404
MOD_ProDKin_1	216	222	PF00069	0.345
MOD_ProDKin_1	360	366	PF00069	0.443
MOD_ProDKin_1	368	374	PF00069	0.402
MOD_ProDKin_1	46	52	PF00069	0.522
MOD_ProDKin_1	478	484	PF00069	0.449
MOD_ProDKin_1	524	530	PF00069	0.387
MOD_ProDKin_1	640	646	PF00069	0.532
MOD_ProDKin_1	83	89	PF00069	0.333
MOD_SUMO_rev_2	253	258	PF00179	0.396
TRG_DiLeu_BaEn_1	341	346	PF01217	0.439
TRG_DiLeu_BaEn_1	668	673	PF01217	0.508
TRG_DiLeu_BaEn_2	528	534	PF01217	0.452
TRG_ENDOCYTIC_2	263	266	PF00928	0.205
TRG_ENDOCYTIC_2	291	294	PF00928	0.306
TRG_ER_diArg_1	112	114	PF00400	0.427
TRG_ER_diArg_1	409	411	PF00400	0.411
TRG_ER_diArg_1	515	517	PF00400	0.344
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK11	Leptomonas seymouri	61%	100%
A0A0S4JAG1	Bodo saltans	23%	93%
A0A0S4JRH6	Bodo saltans	37%	99%
A0A0S4JRL8	Bodo saltans	24%	84%
A0A0S4KE24	Bodo saltans	21%	82%
A0A1X0NT49	Trypanosomatidae	22%	91%
A0A1X0NT60	Trypanosomatidae	38%	99%
A0A1X0NZS6	Trypanosomatidae	22%	100%
A0A1X0P523	Trypanosomatidae	22%	89%
A0A1X0P5Y2	Trypanosomatidae	25%	85%
A0A3Q8IRB8	Leishmania donovani	22%	100%
A0A3R7L2D0	Trypanosoma rangeli	23%	100%
A0A3S5IQT1	Trypanosoma rangeli	24%	90%
A0A3S7WX31	Leishmania donovani	84%	100%
A0A422NAV0	Trypanosoma rangeli	21%	92%
A0A422NSK2	Trypanosoma rangeli	35%	100%
A4HHE2	Leishmania braziliensis	22%	100%
A4HZQ9	Leishmania infantum	85%	100%
A4I4I8	Leishmania infantum	22%	100%
B2ZGJ1	Danio rerio	23%	100%
C9ZL75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZRI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A627	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	88%
E9ADY9	Leishmania major	22%	100%
E9ALU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9AVL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
F1LN46	Rattus norvegicus	24%	84%
O19094	Bos taurus	25%	100%
P07668	Drosophila melanogaster	24%	94%
P11466	Rattus norvegicus	25%	100%
P13222	Sus scrofa	25%	100%
P18886	Rattus norvegicus	30%	100%
P23786	Homo sapiens	30%	100%
P28329	Homo sapiens	25%	90%
P32198	Rattus norvegicus	24%	87%
P32738	Rattus norvegicus	25%	100%
P32756	Caenorhabditis elegans	23%	100%
P32796	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P43155	Homo sapiens	23%	100%
P47934	Mus musculus	24%	100%
P50416	Homo sapiens	23%	87%
P52825	Mus musculus	30%	100%
P52826	Columba livia	25%	100%
P80235	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	98%
P97742	Mus musculus	25%	87%
Q00614	Candida tropicalis	22%	100%
Q03059	Mus musculus	25%	100%
Q2KJB7	Bos taurus	29%	100%
Q4QBW4	Leishmania major	82%	100%
Q58DK1	Bos taurus	22%	88%
Q5U3U3	Danio rerio	29%	100%
Q60HG9	Macaca fascicularis	29%	100%
Q63704	Rattus norvegicus	23%	88%
Q68Y62	Equus caballus	23%	87%
Q6P4X5	Xenopus tropicalis	27%	100%
Q704S8	Rattus norvegicus	23%	100%
Q7ZXE1	Xenopus laevis	27%	100%
Q8BGD5	Mus musculus	23%	85%
Q8HY46	Sus scrofa	23%	88%
Q8TCG5	Homo sapiens	24%	84%
Q90YJ9	Gallus gallus	26%	100%
Q924X2	Mus musculus	22%	88%
Q92523	Homo sapiens	24%	88%
Q9DC50	Mus musculus	26%	100%
Q9UKG9	Homo sapiens	24%	100%
V5BH74	Trypanosoma cruzi	24%	100%
V5BQH8	Trypanosoma cruzi	22%	85%
V5D4R1	Trypanosoma cruzi	23%	85%
V5DBT5	Trypanosoma cruzi	38%	100%