Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC80_LEIBR

TriTrypDb:

LbrM.22.0290 , LBRM2903_220008100

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.289
CLV_C14_Caspase3-7	459	463	PF00656	0.334
CLV_NRD_NRD_1	122	124	PF00675	0.506
CLV_NRD_NRD_1	247	249	PF00675	0.440
CLV_NRD_NRD_1	411	413	PF00675	0.487
CLV_NRD_NRD_1	538	540	PF00675	0.782
CLV_NRD_NRD_1	556	558	PF00675	0.659
CLV_PCSK_KEX2_1	413	415	PF00082	0.438
CLV_PCSK_KEX2_1	482	484	PF00082	0.483
CLV_PCSK_KEX2_1	504	506	PF00082	0.611
CLV_PCSK_KEX2_1	529	531	PF00082	0.684
CLV_PCSK_KEX2_1	540	542	PF00082	0.738
CLV_PCSK_KEX2_1	556	558	PF00082	0.622
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.438
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.483
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.611
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.647
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.727
CLV_PCSK_PC7_1	525	531	PF00082	0.517
CLV_PCSK_SKI1_1	124	128	PF00082	0.344
CLV_PCSK_SKI1_1	181	185	PF00082	0.511
CLV_PCSK_SKI1_1	205	209	PF00082	0.432
CLV_PCSK_SKI1_1	356	360	PF00082	0.351
CLV_PCSK_SKI1_1	363	367	PF00082	0.354
CLV_PCSK_SKI1_1	473	477	PF00082	0.402
CLV_PCSK_SKI1_1	525	529	PF00082	0.514
DEG_APCC_DBOX_1	204	212	PF00400	0.451
DEG_APCC_DBOX_1	482	490	PF00400	0.557
DEG_SPOP_SBC_1	57	61	PF00917	0.494
DOC_CDC14_PxL_1	328	336	PF14671	0.398
DOC_CYCLIN_RxL_1	479	488	PF00134	0.542
DOC_MAPK_RevD_3	400	414	PF00069	0.443
DOC_PP1_RVXF_1	100	106	PF00149	0.337
DOC_PP1_RVXF_1	208	215	PF00149	0.340
DOC_PP1_RVXF_1	441	448	PF00149	0.458
DOC_USP7_MATH_1	192	196	PF00917	0.386
DOC_USP7_MATH_1	203	207	PF00917	0.350
DOC_USP7_MATH_1	452	456	PF00917	0.463
DOC_USP7_MATH_1	465	469	PF00917	0.514
DOC_USP7_MATH_1	496	500	PF00917	0.549
DOC_USP7_MATH_1	91	95	PF00917	0.565
DOC_USP7_UBL2_3	6	10	PF12436	0.710
DOC_WW_Pin1_4	136	141	PF00397	0.413
DOC_WW_Pin1_4	9	14	PF00397	0.776
DOC_WW_Pin1_4	94	99	PF00397	0.466
LIG_14-3-3_CanoR_1	123	133	PF00244	0.487
LIG_14-3-3_CanoR_1	248	258	PF00244	0.554
LIG_14-3-3_CanoR_1	265	271	PF00244	0.281
LIG_14-3-3_CanoR_1	280	287	PF00244	0.466
LIG_14-3-3_CanoR_1	305	312	PF00244	0.560
LIG_14-3-3_CanoR_1	320	330	PF00244	0.475
LIG_14-3-3_CanoR_1	412	419	PF00244	0.512
LIG_14-3-3_CanoR_1	530	537	PF00244	0.742
LIG_Actin_WH2_2	109	125	PF00022	0.475
LIG_BIR_III_2	182	186	PF00653	0.450
LIG_BRCT_BRCA1_1	200	204	PF00533	0.449
LIG_CaM_IQ_9	517	532	PF13499	0.513
LIG_Clathr_ClatBox_1	397	401	PF01394	0.445
LIG_FHA_1	125	131	PF00498	0.355
LIG_FHA_1	137	143	PF00498	0.367
LIG_FHA_1	237	243	PF00498	0.435
LIG_FHA_1	26	32	PF00498	0.653
LIG_FHA_1	280	286	PF00498	0.527
LIG_FHA_1	301	307	PF00498	0.420
LIG_FHA_1	397	403	PF00498	0.437
LIG_FHA_1	495	501	PF00498	0.598
LIG_FHA_1	95	101	PF00498	0.466
LIG_FHA_2	338	344	PF00498	0.480
LIG_FHA_2	472	478	PF00498	0.464
LIG_LIR_Apic_2	255	261	PF02991	0.497
LIG_LIR_Gen_1	160	171	PF02991	0.388
LIG_LIR_Gen_1	274	283	PF02991	0.335
LIG_LIR_Gen_1	61	71	PF02991	0.373
LIG_LIR_Nem_3	160	166	PF02991	0.421
LIG_LIR_Nem_3	201	207	PF02991	0.341
LIG_LIR_Nem_3	274	278	PF02991	0.337
LIG_LIR_Nem_3	325	331	PF02991	0.460
LIG_LIR_Nem_3	371	377	PF02991	0.351
LIG_LIR_Nem_3	440	445	PF02991	0.427
LIG_LIR_Nem_3	61	67	PF02991	0.384
LIG_LRP6_Inhibitor_1	467	473	PF00058	0.421
LIG_LYPXL_S_1	330	334	PF13949	0.333
LIG_LYPXL_S_1	373	377	PF13949	0.458
LIG_LYPXL_yS_3	331	334	PF13949	0.339
LIG_LYPXL_yS_3	374	377	PF13949	0.464
LIG_NRBOX	207	213	PF00104	0.451
LIG_NRP_CendR_1	560	561	PF00754	0.706
LIG_PCNA_yPIPBox_3	291	300	PF02747	0.478
LIG_RPA_C_Fungi	407	419	PF08784	0.417
LIG_SH2_CRK	378	382	PF00017	0.372
LIG_SH2_CRK	442	446	PF00017	0.437
LIG_SH2_CRK	64	68	PF00017	0.397
LIG_SH2_SRC	258	261	PF00017	0.494
LIG_SH2_SRC	376	379	PF00017	0.235
LIG_SH2_STAT3	81	84	PF00017	0.487
LIG_SH2_STAT5	165	168	PF00017	0.350
LIG_SH2_STAT5	300	303	PF00017	0.445
LIG_SH2_STAT5	376	379	PF00017	0.466
LIG_SH2_STAT5	81	84	PF00017	0.487
LIG_SH3_3	239	245	PF00018	0.385
LIG_SH3_3	47	53	PF00018	0.660
LIG_SUMO_SIM_anti_2	313	319	PF11976	0.325
LIG_SUMO_SIM_par_1	154	160	PF11976	0.474
LIG_SUMO_SIM_par_1	356	362	PF11976	0.500
LIG_SUMO_SIM_par_1	396	401	PF11976	0.414
LIG_SUMO_SIM_par_1	69	74	PF11976	0.367
LIG_TRFH_1	328	332	PF08558	0.352
MOD_CK1_1	195	201	PF00069	0.435
MOD_CK1_1	348	354	PF00069	0.529
MOD_CK1_1	383	389	PF00069	0.449
MOD_CK1_1	510	516	PF00069	0.766
MOD_CK1_1	548	554	PF00069	0.749
MOD_CK1_1	9	15	PF00069	0.750
MOD_CK1_1	94	100	PF00069	0.530
MOD_CK2_1	321	327	PF00069	0.403
MOD_CK2_1	471	477	PF00069	0.452
MOD_CK2_1	56	62	PF00069	0.482
MOD_Cter_Amidation	558	561	PF01082	0.657
MOD_GlcNHglycan	201	204	PF01048	0.488
MOD_GlcNHglycan	414	417	PF01048	0.510
MOD_GlcNHglycan	429	432	PF01048	0.462
MOD_GlcNHglycan	93	96	PF01048	0.301
MOD_GSK3_1	195	202	PF00069	0.358
MOD_GSK3_1	300	307	PF00069	0.388
MOD_GSK3_1	344	351	PF00069	0.553
MOD_GSK3_1	359	366	PF00069	0.404
MOD_GSK3_1	423	430	PF00069	0.491
MOD_GSK3_1	548	555	PF00069	0.766
MOD_GSK3_1	58	65	PF00069	0.510
MOD_N-GLC_1	348	353	PF02516	0.400
MOD_N-GLC_1	422	427	PF02516	0.528
MOD_NEK2_1	199	204	PF00069	0.425
MOD_NEK2_1	233	238	PF00069	0.307
MOD_NEK2_1	321	326	PF00069	0.348
MOD_NEK2_1	359	364	PF00069	0.482
MOD_NEK2_1	388	393	PF00069	0.498
MOD_NEK2_1	422	427	PF00069	0.515
MOD_NEK2_1	494	499	PF00069	0.493
MOD_PIKK_1	252	258	PF00454	0.425
MOD_PIKK_1	530	536	PF00454	0.766
MOD_PIKK_1	62	68	PF00454	0.513
MOD_PKA_1	412	418	PF00069	0.507
MOD_PKA_1	528	534	PF00069	0.757
MOD_PKA_2	236	242	PF00069	0.495
MOD_PKA_2	279	285	PF00069	0.509
MOD_PKA_2	304	310	PF00069	0.557
MOD_PKA_2	494	500	PF00069	0.400
MOD_PKA_2	529	535	PF00069	0.623
MOD_PKA_2	552	558	PF00069	0.775
MOD_PKB_1	505	513	PF00069	0.610
MOD_Plk_1	252	258	PF00069	0.448
MOD_Plk_1	348	354	PF00069	0.365
MOD_Plk_1	422	428	PF00069	0.517
MOD_Plk_4	125	131	PF00069	0.355
MOD_Plk_4	154	160	PF00069	0.455
MOD_Plk_4	380	386	PF00069	0.452
MOD_Plk_4	489	495	PF00069	0.436
MOD_ProDKin_1	136	142	PF00069	0.403
MOD_ProDKin_1	9	15	PF00069	0.774
MOD_ProDKin_1	94	100	PF00069	0.468
MOD_SUMO_rev_2	533	542	PF00179	0.675
MOD_SUMO_rev_2	544	548	PF00179	0.559
TRG_DiLeu_BaEn_1	96	101	PF01217	0.426
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.489
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.354
TRG_ENDOCYTIC_2	331	334	PF00928	0.402
TRG_ENDOCYTIC_2	374	377	PF00928	0.372
TRG_ENDOCYTIC_2	378	381	PF00928	0.360
TRG_ENDOCYTIC_2	442	445	PF00928	0.437
TRG_ENDOCYTIC_2	64	67	PF00928	0.392
TRG_NES_CRM1_1	277	290	PF08389	0.312
TRG_NES_CRM1_1	62	74	PF08389	0.379
TRG_NLS_MonoExtC_3	411	417	PF00514	0.502
TRG_NLS_MonoExtN_4	525	532	PF00514	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V0	Leptomonas seymouri	68%	95%
A0A0S4JSH7	Bodo saltans	30%	100%
A0A1X0NTF0	Trypanosomatidae	44%	99%
A0A3Q8IC40	Leishmania donovani	84%	100%
A0A3R7NVM0	Trypanosoma rangeli	41%	100%
A4HZQ8	Leishmania infantum	84%	100%
C9ZSF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AVL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QBW5	Leishmania major	84%	100%
V5BFQ6	Trypanosoma cruzi	41%	100%