Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HC79_LEIBR

TriTrypDb:

LbrM.22.0280 , LBRM2903_220008000

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HC79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.410
CLV_NRD_NRD_1	253	255	PF00675	0.719
CLV_NRD_NRD_1	263	265	PF00675	0.588
CLV_NRD_NRD_1	368	370	PF00675	0.726
CLV_NRD_NRD_1	391	393	PF00675	0.533
CLV_NRD_NRD_1	65	67	PF00675	0.413
CLV_PCSK_FUR_1	63	67	PF00082	0.447
CLV_PCSK_KEX2_1	196	198	PF00082	0.410
CLV_PCSK_KEX2_1	263	265	PF00082	0.643
CLV_PCSK_KEX2_1	368	370	PF00082	0.742
CLV_PCSK_KEX2_1	391	393	PF00082	0.530
CLV_PCSK_KEX2_1	63	65	PF00082	0.426
CLV_PCSK_PC7_1	59	65	PF00082	0.409
CLV_PCSK_SKI1_1	160	164	PF00082	0.379
CLV_PCSK_SKI1_1	202	206	PF00082	0.469
CLV_PCSK_SKI1_1	65	69	PF00082	0.391
DEG_COP1_1	336	346	PF00400	0.648
DEG_SPOP_SBC_1	356	360	PF00917	0.723
DOC_CKS1_1	216	221	PF01111	0.629
DOC_CKS1_1	305	310	PF01111	0.498
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.512
DOC_MAPK_gen_1	254	262	PF00069	0.467
DOC_MAPK_gen_1	368	378	PF00069	0.733
DOC_MAPK_MEF2A_6	107	114	PF00069	0.319
DOC_MAPK_MEF2A_6	167	175	PF00069	0.224
DOC_MAPK_MEF2A_6	202	211	PF00069	0.397
DOC_MAPK_MEF2A_6	54	62	PF00069	0.409
DOC_PP1_RVXF_1	152	159	PF00149	0.449
DOC_PP1_RVXF_1	57	63	PF00149	0.426
DOC_PP4_FxxP_1	204	207	PF00568	0.415
DOC_PP4_FxxP_1	216	219	PF00568	0.606
DOC_PP4_FxxP_1	73	76	PF00568	0.411
DOC_USP7_MATH_1	232	236	PF00917	0.510
DOC_USP7_MATH_1	356	360	PF00917	0.644
DOC_USP7_MATH_1	390	394	PF00917	0.611
DOC_WW_Pin1_4	115	120	PF00397	0.443
DOC_WW_Pin1_4	17	22	PF00397	0.647
DOC_WW_Pin1_4	215	220	PF00397	0.600
DOC_WW_Pin1_4	246	251	PF00397	0.676
DOC_WW_Pin1_4	292	297	PF00397	0.364
DOC_WW_Pin1_4	304	309	PF00397	0.317
LIG_14-3-3_CanoR_1	154	159	PF00244	0.487
LIG_14-3-3_CanoR_1	160	165	PF00244	0.376
LIG_14-3-3_CanoR_1	196	205	PF00244	0.506
LIG_14-3-3_CanoR_1	213	219	PF00244	0.577
LIG_14-3-3_CanoR_1	332	338	PF00244	0.573
LIG_14-3-3_CanoR_1	391	397	PF00244	0.539
LIG_BRCT_BRCA1_1	293	297	PF00533	0.413
LIG_BRCT_BRCA1_1	92	96	PF00533	0.388
LIG_FHA_1	178	184	PF00498	0.399
LIG_FHA_1	404	410	PF00498	0.372
LIG_FHA_1	6	12	PF00498	0.663
LIG_FHA_2	362	368	PF00498	0.735
LIG_GBD_Chelix_1	285	293	PF00786	0.512
LIG_Integrin_RGD_1	239	241	PF01839	0.452
LIG_LIR_Apic_2	302	308	PF02991	0.402
LIG_LIR_Gen_1	294	305	PF02991	0.444
LIG_LIR_Gen_1	322	331	PF02991	0.487
LIG_LIR_Gen_1	406	415	PF02991	0.531
LIG_LIR_Nem_3	13	19	PF02991	0.715
LIG_LIR_Nem_3	185	191	PF02991	0.343
LIG_LIR_Nem_3	199	204	PF02991	0.426
LIG_LIR_Nem_3	294	300	PF02991	0.413
LIG_LIR_Nem_3	322	327	PF02991	0.446
LIG_LIR_Nem_3	406	410	PF02991	0.495
LIG_LIR_Nem_3	74	80	PF02991	0.424
LIG_PCNA_yPIPBox_3	78	87	PF02747	0.284
LIG_Pex14_1	201	205	PF04695	0.548
LIG_Pex14_2	175	179	PF04695	0.456
LIG_Pex14_2	73	77	PF04695	0.414
LIG_REV1ctd_RIR_1	172	180	PF16727	0.339
LIG_SH2_CRK	305	309	PF00017	0.402
LIG_SH2_CRK	324	328	PF00017	0.450
LIG_SH2_CRK	86	90	PF00017	0.374
LIG_SH2_PTP2	316	319	PF00017	0.510
LIG_SH2_PTP2	57	60	PF00017	0.390
LIG_SH2_STAP1	324	328	PF00017	0.461
LIG_SH2_STAT3	447	450	PF00017	0.550
LIG_SH2_STAT5	299	302	PF00017	0.405
LIG_SH2_STAT5	316	319	PF00017	0.445
LIG_SH2_STAT5	324	327	PF00017	0.411
LIG_SH2_STAT5	329	332	PF00017	0.333
LIG_SH2_STAT5	337	340	PF00017	0.468
LIG_SH2_STAT5	447	450	PF00017	0.515
LIG_SH2_STAT5	57	60	PF00017	0.375
LIG_SH2_STAT5	94	97	PF00017	0.477
LIG_SH3_3	109	115	PF00018	0.448
LIG_SH3_3	218	224	PF00018	0.603
LIG_SH3_3	244	250	PF00018	0.466
LIG_SxIP_EBH_1	230	239	PF03271	0.449
LIG_TYR_ITIM	314	319	PF00017	0.484
LIG_TYR_ITIM	84	89	PF00017	0.528
LIG_WRC_WIRS_1	320	325	PF05994	0.421
MOD_CDC14_SPxK_1	20	23	PF00782	0.459
MOD_CDK_SPxK_1	17	23	PF00069	0.460
MOD_CK1_1	129	135	PF00069	0.358
MOD_CK1_1	17	23	PF00069	0.698
MOD_CK1_1	217	223	PF00069	0.649
MOD_CK1_1	233	239	PF00069	0.504
MOD_CK1_1	291	297	PF00069	0.376
MOD_CK1_1	322	328	PF00069	0.462
MOD_CK1_1	358	364	PF00069	0.680
MOD_CK1_1	395	401	PF00069	0.552
MOD_CK1_1	5	11	PF00069	0.670
MOD_CK2_1	361	367	PF00069	0.752
MOD_CK2_1	7	13	PF00069	0.733
MOD_GlcNHglycan	106	110	PF01048	0.510
MOD_GlcNHglycan	128	131	PF01048	0.339
MOD_GlcNHglycan	16	19	PF01048	0.607
MOD_GlcNHglycan	198	201	PF01048	0.571
MOD_GlcNHglycan	232	235	PF01048	0.565
MOD_GlcNHglycan	241	245	PF01048	0.538
MOD_GlcNHglycan	3	7	PF01048	0.682
MOD_GlcNHglycan	33	36	PF01048	0.566
MOD_GlcNHglycan	353	356	PF01048	0.672
MOD_GlcNHglycan	40	43	PF01048	0.364
MOD_GSK3_1	1	8	PF00069	0.665
MOD_GSK3_1	154	161	PF00069	0.434
MOD_GSK3_1	242	249	PF00069	0.646
MOD_GSK3_1	288	295	PF00069	0.321
MOD_GSK3_1	315	322	PF00069	0.334
MOD_GSK3_1	351	358	PF00069	0.664
MOD_GSK3_1	382	389	PF00069	0.652
MOD_LATS_1	333	339	PF00433	0.555
MOD_N-GLC_1	14	19	PF02516	0.462
MOD_NEK2_1	1	6	PF00069	0.666
MOD_NEK2_1	158	163	PF00069	0.387
MOD_NEK2_1	31	36	PF00069	0.438
MOD_NEK2_1	319	324	PF00069	0.392
MOD_NEK2_1	327	332	PF00069	0.387
MOD_NEK2_1	441	446	PF00069	0.487
MOD_NEK2_1	7	12	PF00069	0.637
MOD_NEK2_2	429	434	PF00069	0.421
MOD_NEK2_2	97	102	PF00069	0.414
MOD_PIKK_1	322	328	PF00454	0.505
MOD_PKA_1	196	202	PF00069	0.476
MOD_PKA_2	183	189	PF00069	0.360
MOD_PKA_2	196	202	PF00069	0.364
MOD_PKA_2	390	396	PF00069	0.612
MOD_Plk_1	2	8	PF00069	0.463
MOD_Plk_1	382	388	PF00069	0.415
MOD_Plk_4	120	126	PF00069	0.449
MOD_Plk_4	154	160	PF00069	0.379
MOD_Plk_4	178	184	PF00069	0.399
MOD_Plk_4	288	294	PF00069	0.399
MOD_Plk_4	319	325	PF00069	0.435
MOD_Plk_4	441	447	PF00069	0.415
MOD_Plk_4	90	96	PF00069	0.374
MOD_ProDKin_1	115	121	PF00069	0.439
MOD_ProDKin_1	17	23	PF00069	0.647
MOD_ProDKin_1	215	221	PF00069	0.600
MOD_ProDKin_1	246	252	PF00069	0.678
MOD_ProDKin_1	292	298	PF00069	0.367
MOD_ProDKin_1	304	310	PF00069	0.326
TRG_DiLeu_BaEn_2	167	173	PF01217	0.223
TRG_ENDOCYTIC_2	316	319	PF00928	0.445
TRG_ENDOCYTIC_2	324	327	PF00928	0.396
TRG_ENDOCYTIC_2	57	60	PF00928	0.364
TRG_ENDOCYTIC_2	86	89	PF00928	0.374
TRG_ER_diArg_1	262	264	PF00400	0.645
TRG_ER_diArg_1	368	370	PF00400	0.717
TRG_ER_diArg_1	62	65	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I563	Leptomonas seymouri	58%	100%
A0A0S4JRQ8	Bodo saltans	41%	100%
A0A1X0NUU2	Trypanosomatidae	45%	100%
A0A3Q8IC61	Leishmania donovani	76%	99%
A0A3R7L681	Trypanosoma rangeli	45%	100%
A4HZQ7	Leishmania infantum	76%	99%
C9ZSF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AVL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4QBW6	Leishmania major	76%	100%
V5BK78	Trypanosoma cruzi	46%	100%