RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC78_LEIBR

TriTrypDb:

LbrM.22.0270 , LBRM2903_220007900

Length:

777

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.589
CLV_C14_Caspase3-7	651	655	PF00656	0.579
CLV_C14_Caspase3-7	740	744	PF00656	0.778
CLV_NRD_NRD_1	308	310	PF00675	0.559
CLV_NRD_NRD_1	4	6	PF00675	0.607
CLV_NRD_NRD_1	505	507	PF00675	0.502
CLV_NRD_NRD_1	537	539	PF00675	0.736
CLV_NRD_NRD_1	580	582	PF00675	0.704
CLV_NRD_NRD_1	589	591	PF00675	0.609
CLV_NRD_NRD_1	593	595	PF00675	0.511
CLV_NRD_NRD_1	65	67	PF00675	0.409
CLV_NRD_NRD_1	726	728	PF00675	0.751
CLV_PCSK_FUR_1	578	582	PF00082	0.688
CLV_PCSK_KEX2_1	10	12	PF00082	0.577
CLV_PCSK_KEX2_1	4	6	PF00082	0.607
CLV_PCSK_KEX2_1	505	507	PF00082	0.502
CLV_PCSK_KEX2_1	537	539	PF00082	0.725
CLV_PCSK_KEX2_1	541	543	PF00082	0.697
CLV_PCSK_KEX2_1	580	582	PF00082	0.704
CLV_PCSK_KEX2_1	589	591	PF00082	0.598
CLV_PCSK_KEX2_1	593	595	PF00082	0.484
CLV_PCSK_KEX2_1	65	67	PF00082	0.409
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.490
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.655
CLV_PCSK_PC7_1	537	543	PF00082	0.518
CLV_PCSK_PC7_1	589	595	PF00082	0.480
CLV_PCSK_SKI1_1	173	177	PF00082	0.623
CLV_PCSK_SKI1_1	246	250	PF00082	0.554
CLV_PCSK_SKI1_1	27	31	PF00082	0.445
CLV_PCSK_SKI1_1	309	313	PF00082	0.553
CLV_PCSK_SKI1_1	328	332	PF00082	0.317
CLV_PCSK_SKI1_1	538	542	PF00082	0.638
CLV_PCSK_SKI1_1	581	585	PF00082	0.644
CLV_PCSK_SKI1_1	594	598	PF00082	0.505
DOC_CKS1_1	144	149	PF01111	0.327
DOC_CKS1_1	178	183	PF01111	0.653
DOC_CKS1_1	290	295	PF01111	0.371
DOC_CKS1_1	494	499	PF01111	0.492
DOC_CKS1_1	92	97	PF01111	0.342
DOC_CYCLIN_RxL_1	24	33	PF00134	0.578
DOC_CYCLIN_RxL_1	5	19	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.569
DOC_MAPK_DCC_7	272	281	PF00069	0.557
DOC_MAPK_gen_1	198	206	PF00069	0.398
DOC_MAPK_gen_1	272	281	PF00069	0.590
DOC_MAPK_gen_1	325	335	PF00069	0.492
DOC_MAPK_gen_1	371	380	PF00069	0.480
DOC_MAPK_gen_1	633	643	PF00069	0.496
DOC_MAPK_MEF2A_6	198	206	PF00069	0.398
DOC_MAPK_MEF2A_6	275	283	PF00069	0.382
DOC_PP1_RVXF_1	244	250	PF00149	0.319
DOC_PP1_RVXF_1	9	16	PF00149	0.479
DOC_PP2B_LxvP_1	717	720	PF13499	0.754
DOC_PP4_FxxP_1	290	293	PF00568	0.407
DOC_PP4_FxxP_1	92	95	PF00568	0.344
DOC_USP7_MATH_1	193	197	PF00917	0.617
DOC_USP7_MATH_1	451	455	PF00917	0.549
DOC_USP7_MATH_1	458	462	PF00917	0.640
DOC_USP7_MATH_1	475	479	PF00917	0.455
DOC_USP7_MATH_1	507	511	PF00917	0.575
DOC_USP7_MATH_1	671	675	PF00917	0.626
DOC_USP7_MATH_1	772	776	PF00917	0.603
DOC_USP7_MATH_1	83	87	PF00917	0.511
DOC_USP7_UBL2_3	601	605	PF12436	0.477
DOC_WW_Pin1_4	126	131	PF00397	0.522
DOC_WW_Pin1_4	143	148	PF00397	0.577
DOC_WW_Pin1_4	177	182	PF00397	0.666
DOC_WW_Pin1_4	262	267	PF00397	0.581
DOC_WW_Pin1_4	289	294	PF00397	0.387
DOC_WW_Pin1_4	402	407	PF00397	0.438
DOC_WW_Pin1_4	463	468	PF00397	0.469
DOC_WW_Pin1_4	493	498	PF00397	0.473
DOC_WW_Pin1_4	520	525	PF00397	0.767
DOC_WW_Pin1_4	766	771	PF00397	0.706
DOC_WW_Pin1_4	91	96	PF00397	0.476
LIG_14-3-3_CanoR_1	192	198	PF00244	0.587
LIG_14-3-3_CanoR_1	363	367	PF00244	0.475
LIG_14-3-3_CanoR_1	4	13	PF00244	0.649
LIG_14-3-3_CanoR_1	506	515	PF00244	0.637
LIG_14-3-3_CanoR_1	571	575	PF00244	0.454
LIG_14-3-3_CanoR_1	581	591	PF00244	0.559
LIG_14-3-3_CterR_2	773	777	PF00244	0.626
LIG_Actin_WH2_2	349	365	PF00022	0.548
LIG_AP2alpha_2	732	734	PF02296	0.717
LIG_BIR_III_2	557	561	PF00653	0.601
LIG_BRCT_BRCA1_1	121	125	PF00533	0.536
LIG_BRCT_BRCA1_1	286	290	PF00533	0.407
LIG_BRCT_BRCA1_1	483	487	PF00533	0.545
LIG_BRCT_BRCA1_2	483	489	PF00533	0.331
LIG_FHA_1	127	133	PF00498	0.577
LIG_FHA_1	149	155	PF00498	0.495
LIG_FHA_1	31	37	PF00498	0.529
LIG_FHA_1	310	316	PF00498	0.518
LIG_FHA_1	402	408	PF00498	0.442
LIG_FHA_1	480	486	PF00498	0.498
LIG_FHA_1	494	500	PF00498	0.388
LIG_FHA_1	656	662	PF00498	0.577
LIG_FHA_1	724	730	PF00498	0.738
LIG_FHA_1	97	103	PF00498	0.510
LIG_FHA_2	129	135	PF00498	0.503
LIG_FHA_2	469	475	PF00498	0.606
LIG_FHA_2	633	639	PF00498	0.489
LIG_GBD_Chelix_1	566	574	PF00786	0.461
LIG_LIR_Apic_2	159	165	PF02991	0.567
LIG_LIR_Apic_2	212	217	PF02991	0.411
LIG_LIR_Apic_2	287	293	PF02991	0.398
LIG_LIR_Gen_1	428	437	PF02991	0.500
LIG_LIR_Gen_1	69	77	PF02991	0.554
LIG_LIR_Gen_1	732	742	PF02991	0.738
LIG_LIR_LC3C_4	613	617	PF02991	0.407
LIG_LIR_Nem_3	12	18	PF02991	0.546
LIG_LIR_Nem_3	19	25	PF02991	0.548
LIG_LIR_Nem_3	351	357	PF02991	0.550
LIG_LIR_Nem_3	428	433	PF02991	0.504
LIG_LIR_Nem_3	608	612	PF02991	0.469
LIG_LIR_Nem_3	69	74	PF02991	0.519
LIG_LIR_Nem_3	732	737	PF02991	0.725
LIG_MLH1_MIPbox_1	483	487	PF16413	0.545
LIG_NRBOX	25	31	PF00104	0.587
LIG_OCRL_FandH_1	595	607	PF00620	0.422
LIG_PCNA_yPIPBox_3	438	449	PF02747	0.315
LIG_Pex14_2	245	249	PF04695	0.308
LIG_PTAP_UEV_1	459	464	PF05743	0.512
LIG_PTB_Apo_2	573	580	PF02174	0.408
LIG_PTB_Apo_2	728	735	PF02174	0.730
LIG_REV1ctd_RIR_1	484	493	PF16727	0.564
LIG_REV1ctd_RIR_1	594	603	PF16727	0.437
LIG_SH2_CRK	214	218	PF00017	0.492
LIG_SH2_CRK	612	616	PF00017	0.522
LIG_SH2_PTP2	702	705	PF00017	0.603
LIG_SH2_STAP1	612	616	PF00017	0.574
LIG_SH2_STAT5	220	223	PF00017	0.437
LIG_SH2_STAT5	25	28	PF00017	0.590
LIG_SH2_STAT5	288	291	PF00017	0.554
LIG_SH2_STAT5	525	528	PF00017	0.752
LIG_SH2_STAT5	603	606	PF00017	0.483
LIG_SH2_STAT5	609	612	PF00017	0.550
LIG_SH2_STAT5	702	705	PF00017	0.492
LIG_SH3_1	621	627	PF00018	0.409
LIG_SH3_1	727	733	PF00018	0.741
LIG_SH3_3	178	184	PF00018	0.638
LIG_SH3_3	280	286	PF00018	0.592
LIG_SH3_3	457	463	PF00018	0.635
LIG_SH3_3	526	532	PF00018	0.768
LIG_SH3_3	620	626	PF00018	0.607
LIG_SH3_3	71	77	PF00018	0.516
LIG_SH3_3	727	733	PF00018	0.741
LIG_SUMO_SIM_anti_2	365	370	PF11976	0.501
LIG_SUMO_SIM_par_1	365	370	PF11976	0.468
LIG_SUMO_SIM_par_1	563	568	PF11976	0.607
LIG_TRAF2_1	500	503	PF00917	0.674
LIG_TRAF2_2	253	258	PF00917	0.594
LIG_TRAF2_2	463	468	PF00917	0.459
LIG_TYR_ITIM	352	357	PF00017	0.525
LIG_UBA3_1	485	489	PF00899	0.461
LIG_WRC_WIRS_1	476	481	PF05994	0.521
MOD_CDK_SPK_2	493	498	PF00069	0.606
MOD_CDK_SPxxK_3	402	409	PF00069	0.539
MOD_CDK_SPxxK_3	766	773	PF00069	0.547
MOD_CDK_SPxxK_3	91	98	PF00069	0.338
MOD_CK1_1	128	134	PF00069	0.514
MOD_CK1_1	398	404	PF00069	0.480
MOD_CK1_1	648	654	PF00069	0.584
MOD_CK2_1	544	550	PF00069	0.584
MOD_CK2_1	632	638	PF00069	0.374
MOD_Cter_Amidation	307	310	PF01082	0.540
MOD_GlcNHglycan	114	117	PF01048	0.556
MOD_GlcNHglycan	460	463	PF01048	0.776
MOD_GlcNHglycan	650	653	PF01048	0.636
MOD_GlcNHglycan	7	10	PF01048	0.633
MOD_GlcNHglycan	712	715	PF01048	0.711
MOD_GlcNHglycan	746	749	PF01048	0.541
MOD_GSK3_1	114	121	PF00069	0.573
MOD_GSK3_1	124	131	PF00069	0.462
MOD_GSK3_1	176	183	PF00069	0.715
MOD_GSK3_1	193	200	PF00069	0.465
MOD_GSK3_1	205	212	PF00069	0.285
MOD_GSK3_1	221	228	PF00069	0.494
MOD_GSK3_1	25	32	PF00069	0.550
MOD_GSK3_1	36	43	PF00069	0.407
MOD_GSK3_1	391	398	PF00069	0.524
MOD_GSK3_1	475	482	PF00069	0.528
MOD_GSK3_1	5	12	PF00069	0.718
MOD_GSK3_1	646	653	PF00069	0.623
MOD_GSK3_1	760	767	PF00069	0.556
MOD_N-GLC_1	228	233	PF02516	0.584
MOD_N-GLC_1	693	698	PF02516	0.660
MOD_N-GLC_2	693	695	PF02516	0.436
MOD_NEK2_1	114	119	PF00069	0.504
MOD_NEK2_1	125	130	PF00069	0.414
MOD_NEK2_1	148	153	PF00069	0.504
MOD_NEK2_1	197	202	PF00069	0.566
MOD_NEK2_1	204	209	PF00069	0.508
MOD_NEK2_1	221	226	PF00069	0.327
MOD_NEK2_1	29	34	PF00069	0.598
MOD_NEK2_1	362	367	PF00069	0.459
MOD_NEK2_1	380	385	PF00069	0.262
MOD_NEK2_1	479	484	PF00069	0.522
MOD_NEK2_1	570	575	PF00069	0.371
MOD_NEK2_1	646	651	PF00069	0.588
MOD_NEK2_2	193	198	PF00069	0.442
MOD_PIKK_1	209	215	PF00454	0.480
MOD_PIKK_1	380	386	PF00454	0.307
MOD_PIKK_1	646	652	PF00454	0.584
MOD_PIKK_1	760	766	PF00454	0.557
MOD_PKA_1	309	315	PF00069	0.550
MOD_PKA_2	191	197	PF00069	0.479
MOD_PKA_2	30	36	PF00069	0.480
MOD_PKA_2	362	368	PF00069	0.510
MOD_PKA_2	570	576	PF00069	0.431
MOD_PKA_2	632	638	PF00069	0.629
MOD_Plk_1	228	234	PF00069	0.503
MOD_Plk_1	380	386	PF00069	0.466
MOD_Plk_1	764	770	PF00069	0.551
MOD_Plk_2-3	14	20	PF00069	0.594
MOD_Plk_2-3	238	244	PF00069	0.580
MOD_Plk_2-3	468	474	PF00069	0.368
MOD_Plk_2-3	736	742	PF00069	0.667
MOD_Plk_4	205	211	PF00069	0.452
MOD_Plk_4	216	222	PF00069	0.406
MOD_Plk_4	302	308	PF00069	0.451
MOD_Plk_4	362	368	PF00069	0.510
MOD_Plk_4	40	46	PF00069	0.642
MOD_Plk_4	468	474	PF00069	0.525
MOD_Plk_4	475	481	PF00069	0.424
MOD_Plk_4	695	701	PF00069	0.598
MOD_ProDKin_1	126	132	PF00069	0.511
MOD_ProDKin_1	143	149	PF00069	0.578
MOD_ProDKin_1	177	183	PF00069	0.669
MOD_ProDKin_1	262	268	PF00069	0.577
MOD_ProDKin_1	289	295	PF00069	0.373
MOD_ProDKin_1	402	408	PF00069	0.432
MOD_ProDKin_1	463	469	PF00069	0.462
MOD_ProDKin_1	493	499	PF00069	0.479
MOD_ProDKin_1	520	526	PF00069	0.768
MOD_ProDKin_1	766	772	PF00069	0.700
MOD_ProDKin_1	91	97	PF00069	0.471
MOD_SUMO_for_1	540	543	PF00179	0.720
MOD_SUMO_rev_2	739	747	PF00179	0.785
TRG_DiLeu_BaEn_1	664	669	PF01217	0.474
TRG_DiLeu_BaEn_2	549	555	PF01217	0.507
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.505
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.557
TRG_ENDOCYTIC_2	354	357	PF00928	0.566
TRG_ENDOCYTIC_2	430	433	PF00928	0.503
TRG_ENDOCYTIC_2	445	448	PF00928	0.335
TRG_ENDOCYTIC_2	603	606	PF00928	0.429
TRG_ENDOCYTIC_2	612	615	PF00928	0.469
TRG_ER_diArg_1	170	173	PF00400	0.550
TRG_ER_diArg_1	4	6	PF00400	0.560
TRG_ER_diArg_1	505	507	PF00400	0.517
TRG_ER_diArg_1	537	539	PF00400	0.626
TRG_ER_diArg_1	579	581	PF00400	0.713
TRG_ER_diArg_1	589	591	PF00400	0.592
TRG_ER_diArg_1	592	594	PF00400	0.491
TRG_ER_diArg_1	64	66	PF00400	0.404
TRG_NES_CRM1_1	370	381	PF08389	0.536
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	272	277	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	581	586	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	659	664	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S2	Leptomonas seymouri	42%	87%
A0A1X0NUK6	Trypanosomatidae	26%	100%
A0A3Q8IC86	Leishmania donovani	73%	92%
A0A422NSI7	Trypanosoma rangeli	27%	100%
A4HZQ6	Leishmania infantum	73%	92%
C9ZSE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AVL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	92%
Q4QBW7	Leishmania major	72%	100%
V5BB53	Trypanosoma cruzi	27%	100%