LeishMANIAdb
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zf-Tim10_DDP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
zf-Tim10_DDP domain-containing protein
Gene product:
Tim10/DDP family zinc finger, putative
Species:
Leishmania braziliensis
UniProt:
A4HC77_LEIBR
TriTrypDb:
LbrM.22.0260 , LBRM2903_220007800
Length:
75

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005743 mitochondrial inner membrane 5 1
GO:0016020 membrane 2 1
GO:0019866 organelle inner membrane 4 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0032991 protein-containing complex 1 1
GO:0042719 mitochondrial intermembrane space protein transporter complex 3 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0110165 cellular anatomical entity 1 1
GO:1990351 transporter complex 2 1

Expansion

Sequence features

A4HC77
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC77

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006839 mitochondrial transport 4 1
GO:0006886 intracellular protein transport 4 1
GO:0006996 organelle organization 4 1
GO:0007005 mitochondrion organization 5 1
GO:0007006 mitochondrial membrane organization 5 1
GO:0007007 inner mitochondrial membrane organization 6 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0045039 protein insertion into mitochondrial inner membrane 6 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051204 protein insertion into mitochondrial membrane 5 1
GO:0051205 protein insertion into membrane 5 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0061024 membrane organization 4 1
GO:0070585 protein localization to mitochondrion 6 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072655 establishment of protein localization to mitochondrion 5 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
GO:0090151 establishment of protein localization to mitochondrial membrane 4 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 19 21 PF00675 0.249
CLV_NRD_NRD_1 64 66 PF00675 0.656
DEG_Nend_UBRbox_3 1 3 PF02207 0.583
DOC_MAPK_gen_1 20 26 PF00069 0.249
LIG_14-3-3_CanoR_1 47 51 PF00244 0.405
LIG_EH1_1 9 17 PF00400 0.430
LIG_FHA_1 53 59 PF00498 0.430
LIG_FHA_2 36 42 PF00498 0.376
LIG_LIR_Nem_3 49 53 PF02991 0.430
LIG_SH2_STAT5 52 55 PF00017 0.368
LIG_UBA3_1 15 21 PF00899 0.249
MOD_CK2_1 35 41 PF00069 0.501
MOD_Cter_Amidation 70 73 PF01082 0.731
MOD_GSK3_1 11 18 PF00069 0.353
MOD_N-GLC_1 1 6 PF02516 0.385
MOD_N-GLC_2 25 27 PF02516 0.444
MOD_NEK2_1 1 6 PF00069 0.537
MOD_NEK2_1 15 20 PF00069 0.387
MOD_PKA_2 46 52 PF00069 0.430
MOD_Plk_1 1 7 PF00069 0.382
MOD_Plk_4 11 17 PF00069 0.386
MOD_SUMO_for_1 5 8 PF00179 0.376
MOD_SUMO_rev_2 60 67 PF00179 0.598
TRG_ER_diLys_1 72 75 PF00400 0.684
TRG_Pf-PMV_PEXEL_1 29 34 PF00026 0.341

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCN4 Leptomonas seymouri 81% 100%
A0A3S7WX00 Leishmania donovani 91% 100%
A4HZQ4 Leishmania infantum 91% 100%
C9ZSE6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 96%
E9AVL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QBW9 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS