Translocon-associated protein subunit alpha

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translocon-associated protein (TRAP), alpha subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HC76_LEIBR

TriTrypDb:

LbrM.22.0250 , LBRM2903_220007700

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HC76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.412
CLV_C14_Caspase3-7	44	48	PF00656	0.429
CLV_NRD_NRD_1	256	258	PF00675	0.409
CLV_NRD_NRD_1	266	268	PF00675	0.516
CLV_NRD_NRD_1	274	276	PF00675	0.569
CLV_NRD_NRD_1	7	9	PF00675	0.636
CLV_PCSK_KEX2_1	266	268	PF00082	0.509
CLV_PCSK_KEX2_1	274	276	PF00082	0.500
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.443
CLV_PCSK_SKI1_1	122	126	PF00082	0.529
CLV_PCSK_SKI1_1	184	188	PF00082	0.472
CLV_PCSK_SKI1_1	211	215	PF00082	0.333
CLV_PCSK_SKI1_1	58	62	PF00082	0.451
CLV_PCSK_SKI1_1	8	12	PF00082	0.595
CLV_Separin_Metazoa	254	258	PF03568	0.505
DOC_CYCLIN_RxL_1	55	66	PF00134	0.325
DOC_MAPK_gen_1	8	15	PF00069	0.494
DOC_MAPK_MEF2A_6	77	84	PF00069	0.352
DOC_PP1_RVXF_1	56	62	PF00149	0.302
DOC_PP2B_LxvP_1	102	105	PF13499	0.333
DOC_USP7_MATH_1	54	58	PF00917	0.309
DOC_USP7_MATH_1	73	77	PF00917	0.178
DOC_WW_Pin1_4	268	273	PF00397	0.707
LIG_14-3-3_CanoR_1	184	190	PF00244	0.293
LIG_BIR_II_1	1	5	PF00653	0.510
LIG_BRCT_BRCA1_1	65	69	PF00533	0.324
LIG_EH1_1	95	103	PF00400	0.311
LIG_eIF4E_1	55	61	PF01652	0.352
LIG_FHA_1	161	167	PF00498	0.282
LIG_FHA_1	97	103	PF00498	0.186
LIG_FHA_2	235	241	PF00498	0.474
LIG_FHA_2	42	48	PF00498	0.427
LIG_LIR_Gen_1	14	23	PF02991	0.491
LIG_LIR_Gen_1	146	155	PF02991	0.243
LIG_LIR_Gen_1	188	196	PF02991	0.315
LIG_LIR_Nem_3	14	18	PF02991	0.463
LIG_LIR_Nem_3	146	150	PF02991	0.243
LIG_LIR_Nem_3	188	193	PF02991	0.315
LIG_LIR_Nem_3	194	199	PF02991	0.315
LIG_LIR_Nem_3	66	72	PF02991	0.320
LIG_MYND_1	140	144	PF01753	0.268
LIG_Pex14_2	11	15	PF04695	0.498
LIG_Pex14_2	165	169	PF04695	0.258
LIG_SH2_CRK	108	112	PF00017	0.225
LIG_SH2_CRK	147	151	PF00017	0.186
LIG_SH2_GRB2like	243	246	PF00017	0.533
LIG_SH2_NCK_1	239	243	PF00017	0.533
LIG_SH2_SRC	239	242	PF00017	0.510
LIG_SH2_SRC	243	246	PF00017	0.505
LIG_SH2_STAT5	134	137	PF00017	0.272
LIG_SH2_STAT5	154	157	PF00017	0.116
LIG_SH2_STAT5	164	167	PF00017	0.283
LIG_SH2_STAT5	189	192	PF00017	0.313
LIG_SH2_STAT5	243	246	PF00017	0.447
LIG_SH2_STAT5	43	46	PF00017	0.532
LIG_SH2_STAT5	55	58	PF00017	0.336
LIG_SH3_3	67	73	PF00018	0.188
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.435
LIG_TYR_ITIM	187	192	PF00017	0.315
LIG_UBA3_1	212	220	PF00899	0.522
LIG_WRC_WIRS_1	12	17	PF05994	0.531
LIG_WRC_WIRS_1	166	171	PF05994	0.320
MOD_CDC14_SPxK_1	271	274	PF00782	0.663
MOD_CDK_SPK_2	268	273	PF00069	0.731
MOD_CDK_SPxK_1	268	274	PF00069	0.713
MOD_CDK_SPxxK_3	268	275	PF00069	0.714
MOD_CK1_1	168	174	PF00069	0.210
MOD_CK1_1	219	225	PF00069	0.504
MOD_CK1_1	65	71	PF00069	0.311
MOD_GlcNHglycan	157	160	PF01048	0.426
MOD_GlcNHglycan	224	227	PF01048	0.312
MOD_GlcNHglycan	268	271	PF01048	0.570
MOD_GlcNHglycan	51	54	PF01048	0.410
MOD_GSK3_1	124	131	PF00069	0.262
MOD_GSK3_1	160	167	PF00069	0.269
MOD_GSK3_1	178	185	PF00069	0.170
MOD_GSK3_1	216	223	PF00069	0.524
MOD_GSK3_1	258	265	PF00069	0.661
MOD_LATS_1	218	224	PF00433	0.533
MOD_LATS_1	264	270	PF00433	0.738
MOD_N-GLC_1	113	118	PF02516	0.447
MOD_N-GLC_1	160	165	PF02516	0.457
MOD_N-GLC_1	169	174	PF02516	0.447
MOD_N-GLC_1	62	67	PF02516	0.533
MOD_NEK2_1	1	6	PF00069	0.551
MOD_NEK2_1	11	16	PF00069	0.498
MOD_NEK2_1	132	137	PF00069	0.208
MOD_NEK2_1	165	170	PF00069	0.260
MOD_NEK2_1	19	24	PF00069	0.528
MOD_NEK2_1	216	221	PF00069	0.555
MOD_NEK2_1	62	67	PF00069	0.315
MOD_NEK2_1	96	101	PF00069	0.196
MOD_PIKK_1	63	69	PF00454	0.333
MOD_PIKK_1	89	95	PF00454	0.333
MOD_PKA_1	257	263	PF00069	0.651
MOD_PKA_1	266	272	PF00069	0.697
MOD_PKA_2	266	272	PF00069	0.743
MOD_Plk_1	113	119	PF00069	0.258
MOD_Plk_1	160	166	PF00069	0.261
MOD_Plk_1	169	175	PF00069	0.239
MOD_Plk_1	89	95	PF00069	0.304
MOD_Plk_2-3	33	39	PF00069	0.348
MOD_Plk_4	11	17	PF00069	0.497
MOD_Plk_4	160	166	PF00069	0.267
MOD_Plk_4	169	175	PF00069	0.238
MOD_Plk_4	185	191	PF00069	0.212
MOD_ProDKin_1	268	274	PF00069	0.710
TRG_ENDOCYTIC_2	108	111	PF00928	0.197
TRG_ENDOCYTIC_2	147	150	PF00928	0.186
TRG_ENDOCYTIC_2	189	192	PF00928	0.315
TRG_ER_diLys_1	273	276	PF00400	0.687
TRG_NLS_MonoExtC_3	256	262	PF00514	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H4	Leptomonas seymouri	61%	100%
A0A0S4JN42	Bodo saltans	32%	100%
A0A1X0NT38	Trypanosomatidae	41%	100%
A0A3R7KKR8	Trypanosoma rangeli	44%	97%
A0A3S7WWZ6	Leishmania donovani	73%	98%
A4HZQ3	Leishmania infantum	73%	98%
C9ZSE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%
Q4QBX0	Leishmania major	73%	100%
Q54R45	Dictyostelium discoideum	29%	100%
V5AVS0	Trypanosoma cruzi	40%	100%