Translocon-associated protein subunit alpha

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translocon-associated protein (TRAP), alpha subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HC76_LEIBR

TriTrypDb:

LbrM.22.0250 , LBRM2903_220007700

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Expansion

Sequence features

A4HC76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC76

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.412
CLV_C14_Caspase3-7	44	48	PF00656	0.429
CLV_NRD_NRD_1	256	258	PF00675	0.409
CLV_NRD_NRD_1	266	268	PF00675	0.516
CLV_NRD_NRD_1	274	276	PF00675	0.569
CLV_NRD_NRD_1	7	9	PF00675	0.636
CLV_PCSK_KEX2_1	266	268	PF00082	0.509
CLV_PCSK_KEX2_1	274	276	PF00082	0.500
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.443
CLV_PCSK_SKI1_1	122	126	PF00082	0.529

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H4	Leptomonas seymouri	61%	100%
A0A0S4JN42	Bodo saltans	32%	100%
A0A1X0NT38	Trypanosomatidae	41%	100%
A0A3R7KKR8	Trypanosoma rangeli	44%	97%
A0A3S7WWZ6	Leishmania donovani	73%	98%
A4HZQ3	Leishmania infantum	73%	98%
C9ZSE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%
Q4QBX0	Leishmania major	73%	100%
Q54R45	Dictyostelium discoideum	29%	100%

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