Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HC74_LEIBR

TriTrypDb:

LbrM.22.0230 , LBRM2903_220007600

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.525
CLV_NRD_NRD_1	293	295	PF00675	0.585
CLV_NRD_NRD_1	35	37	PF00675	0.489
CLV_PCSK_KEX2_1	172	174	PF00082	0.675
CLV_PCSK_KEX2_1	35	37	PF00082	0.489
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.691
CLV_PCSK_SKI1_1	267	271	PF00082	0.494
CLV_PCSK_SKI1_1	35	39	PF00082	0.612
CLV_PCSK_SKI1_1	429	433	PF00082	0.678
DEG_Nend_Nbox_1	1	3	PF02207	0.516
DOC_ANK_TNKS_1	391	398	PF00023	0.531
DOC_CYCLIN_RxL_1	425	436	PF00134	0.664
DOC_MAPK_DCC_7	294	304	PF00069	0.512
DOC_MAPK_MEF2A_6	267	274	PF00069	0.498
DOC_MAPK_NFAT4_5	267	275	PF00069	0.498
DOC_PP1_RVXF_1	427	434	PF00149	0.677
DOC_PP4_FxxP_1	102	105	PF00568	0.473
DOC_USP7_MATH_1	111	115	PF00917	0.469
DOC_USP7_MATH_1	150	154	PF00917	0.646
DOC_USP7_MATH_1	351	355	PF00917	0.763
DOC_USP7_MATH_1	405	409	PF00917	0.607
DOC_USP7_MATH_1	96	100	PF00917	0.492
DOC_USP7_UBL2_3	425	429	PF12436	0.610
DOC_WW_Pin1_4	14	19	PF00397	0.511
DOC_WW_Pin1_4	165	170	PF00397	0.667
DOC_WW_Pin1_4	323	328	PF00397	0.691
DOC_WW_Pin1_4	409	414	PF00397	0.787
DOC_WW_Pin1_4	51	56	PF00397	0.503
DOC_WW_Pin1_4	58	63	PF00397	0.488
LIG_14-3-3_CanoR_1	205	211	PF00244	0.694
LIG_14-3-3_CanoR_1	36	42	PF00244	0.473
LIG_14-3-3_CanoR_1	403	413	PF00244	0.727
LIG_BIR_III_2	436	440	PF00653	0.689
LIG_BRCT_BRCA1_1	45	49	PF00533	0.461
LIG_BRCT_BRCA1_1	98	102	PF00533	0.569
LIG_CtBP_PxDLS_1	414	418	PF00389	0.535
LIG_FHA_1	207	213	PF00498	0.599
LIG_FHA_1	269	275	PF00498	0.665
LIG_FHA_1	330	336	PF00498	0.528
LIG_FHA_1	89	95	PF00498	0.519
LIG_FHA_2	249	255	PF00498	0.603
LIG_FHA_2	316	322	PF00498	0.611
LIG_FHA_2	85	91	PF00498	0.537
LIG_LIR_Apic_2	99	105	PF02991	0.477
LIG_LIR_Nem_3	103	107	PF02991	0.497
LIG_LIR_Nem_3	52	56	PF02991	0.604
LIG_LIR_Nem_3	89	95	PF02991	0.616
LIG_Pex14_1	104	108	PF04695	0.477
LIG_Pex14_2	49	53	PF04695	0.492
LIG_SH2_STAP1	116	120	PF00017	0.506
LIG_SH2_STAP1	41	45	PF00017	0.453
LIG_SH3_1	295	301	PF00018	0.506
LIG_SH3_3	127	133	PF00018	0.759
LIG_SH3_3	295	301	PF00018	0.606
LIG_SH3_3	307	313	PF00018	0.615
LIG_SH3_3	321	327	PF00018	0.687
LIG_SH3_3	53	59	PF00018	0.593
LIG_SH3_3	71	77	PF00018	0.557
LIG_SUMO_SIM_par_1	207	215	PF11976	0.568
LIG_SUMO_SIM_par_1	229	234	PF11976	0.507
LIG_SUMO_SIM_par_1	270	276	PF11976	0.505
LIG_SUMO_SIM_par_1	300	306	PF11976	0.515
LIG_TRAF2_1	124	127	PF00917	0.653
LIG_TRAF2_1	318	321	PF00917	0.519
LIG_TRAF2_1	87	90	PF00917	0.534
LIG_WRC_WIRS_1	50	55	PF05994	0.529
MOD_CDK_SPK_2	58	63	PF00069	0.509
MOD_CDK_SPxxK_3	165	172	PF00069	0.671
MOD_CK1_1	114	120	PF00069	0.589
MOD_CK1_1	17	23	PF00069	0.513
MOD_CK1_1	234	240	PF00069	0.659
MOD_CK1_1	248	254	PF00069	0.554
MOD_CK1_1	401	407	PF00069	0.786
MOD_CK1_1	58	64	PF00069	0.513
MOD_CK2_1	248	254	PF00069	0.532
MOD_CK2_1	270	276	PF00069	0.667
MOD_CK2_1	315	321	PF00069	0.692
MOD_CK2_1	336	342	PF00069	0.628
MOD_CK2_1	360	366	PF00069	0.609
MOD_CK2_1	37	43	PF00069	0.470
MOD_CK2_1	84	90	PF00069	0.539
MOD_GlcNHglycan	117	120	PF01048	0.624
MOD_GlcNHglycan	169	172	PF01048	0.596
MOD_GlcNHglycan	183	187	PF01048	0.501
MOD_GlcNHglycan	206	209	PF01048	0.660
MOD_GlcNHglycan	403	406	PF01048	0.556
MOD_GSK3_1	111	118	PF00069	0.458
MOD_GSK3_1	14	21	PF00069	0.513
MOD_GSK3_1	150	157	PF00069	0.806
MOD_GSK3_1	161	168	PF00069	0.620
MOD_GSK3_1	329	336	PF00069	0.528
MOD_GSK3_1	356	363	PF00069	0.617
MOD_GSK3_1	37	44	PF00069	0.467
MOD_GSK3_1	380	387	PF00069	0.642
MOD_GSK3_1	401	408	PF00069	0.752
MOD_GSK3_1	409	416	PF00069	0.721
MOD_GSK3_1	425	432	PF00069	0.519
MOD_GSK3_1	440	447	PF00069	0.700
MOD_GSK3_1	51	58	PF00069	0.504
MOD_GSK3_1	84	91	PF00069	0.538
MOD_GSK3_1	96	103	PF00069	0.461
MOD_N-GLC_1	14	19	PF02516	0.546
MOD_N-GLC_1	384	389	PF02516	0.544
MOD_NEK2_1	270	275	PF00069	0.547
MOD_NEK2_1	277	282	PF00069	0.566
MOD_NEK2_1	37	42	PF00069	0.472
MOD_NEK2_1	49	54	PF00069	0.457
MOD_NEK2_1	95	100	PF00069	0.500
MOD_PIKK_1	154	160	PF00454	0.533
MOD_PIKK_1	283	289	PF00454	0.593
MOD_PIKK_1	336	342	PF00454	0.703
MOD_PIKK_1	440	446	PF00454	0.536
MOD_PKA_2	204	210	PF00069	0.724
MOD_PKA_2	372	378	PF00069	0.544
MOD_PKA_2	405	411	PF00069	0.742
MOD_PKA_2	81	87	PF00069	0.553
MOD_Plk_1	161	167	PF00069	0.587
MOD_Plk_1	248	254	PF00069	0.675
MOD_Plk_1	88	94	PF00069	0.523
MOD_Plk_4	18	24	PF00069	0.512
MOD_Plk_4	44	50	PF00069	0.467
MOD_Plk_4	96	102	PF00069	0.609
MOD_ProDKin_1	14	20	PF00069	0.512
MOD_ProDKin_1	165	171	PF00069	0.669
MOD_ProDKin_1	323	329	PF00069	0.691
MOD_ProDKin_1	409	415	PF00069	0.789
MOD_ProDKin_1	51	57	PF00069	0.503
MOD_ProDKin_1	58	64	PF00069	0.493
MOD_SUMO_rev_2	177	184	PF00179	0.539
TRG_DiLeu_BaEn_4	265	271	PF01217	0.494
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.513
TRG_ER_diArg_1	35	37	PF00400	0.489
TRG_NLS_MonoExtC_3	171	177	PF00514	0.629
TRG_NLS_MonoExtN_4	169	176	PF00514	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7A5	Leishmania donovani	53%	100%
A4HZQ1	Leishmania infantum	53%	100%
E9AVK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4QBX2	Leishmania major	52%	100%