Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC69_LEIBR

TriTrypDb:

LbrM.22.0160 , LBRM2903_220006900

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC69

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.302
CLV_NRD_NRD_1	65	67	PF00675	0.343
CLV_PCSK_KEX2_1	65	67	PF00082	0.379
CLV_PCSK_SKI1_1	203	207	PF00082	0.410
CLV_PCSK_SKI1_1	66	70	PF00082	0.417
DEG_Kelch_Keap1_1	121	126	PF01344	0.621
DOC_CKS1_1	69	74	PF01111	0.461
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.433
DOC_MAPK_gen_1	99	107	PF00069	0.415
DOC_MAPK_MEF2A_6	99	107	PF00069	0.415
DOC_PP2B_LxvP_1	14	17	PF13499	0.346
DOC_PP2B_LxvP_1	174	177	PF13499	0.458
DOC_SPAK_OSR1_1	148	152	PF12202	0.296
DOC_USP7_MATH_1	243	247	PF00917	0.658
DOC_USP7_MATH_1	296	300	PF00917	0.738
DOC_USP7_MATH_1	334	338	PF00917	0.603
DOC_USP7_MATH_1	56	60	PF00917	0.479
DOC_WW_Pin1_4	118	123	PF00397	0.643
DOC_WW_Pin1_4	217	222	PF00397	0.622
DOC_WW_Pin1_4	68	73	PF00397	0.453
LIG_14-3-3_CanoR_1	203	208	PF00244	0.301
LIG_14-3-3_CanoR_1	294	302	PF00244	0.563
LIG_14-3-3_CanoR_1	325	333	PF00244	0.690
LIG_APCC_ABBA_1	52	57	PF00400	0.387
LIG_BIR_II_1	1	5	PF00653	0.294
LIG_FHA_1	148	154	PF00498	0.366
LIG_FHA_1	157	163	PF00498	0.328
LIG_FHA_2	130	136	PF00498	0.712
LIG_FHA_2	141	147	PF00498	0.478
LIG_FHA_2	17	23	PF00498	0.563
LIG_IBAR_NPY_1	331	333	PF08397	0.509
LIG_LIR_Gen_1	195	205	PF02991	0.270
LIG_LIR_Nem_3	195	201	PF02991	0.294
LIG_MYND_1	307	311	PF01753	0.577
LIG_SH2_NCK_1	333	337	PF00017	0.600
LIG_SH2_SRC	333	336	PF00017	0.676
LIG_SH2_STAP1	234	238	PF00017	0.476
LIG_SH2_STAT5	161	164	PF00017	0.374
LIG_SH3_3	91	97	PF00018	0.384
LIG_SUMO_SIM_par_1	90	96	PF11976	0.259
LIG_WW_3	96	100	PF00397	0.556
MOD_CK1_1	121	127	PF00069	0.704
MOD_CK1_1	237	243	PF00069	0.641
MOD_CK1_1	255	261	PF00069	0.660
MOD_CK1_1	301	307	PF00069	0.707
MOD_CK1_1	318	324	PF00069	0.703
MOD_CK2_1	120	126	PF00069	0.725
MOD_CK2_1	140	146	PF00069	0.448
MOD_CK2_1	16	22	PF00069	0.371
MOD_CK2_1	161	167	PF00069	0.529
MOD_DYRK1A_RPxSP_1	217	221	PF00069	0.451
MOD_GlcNHglycan	114	117	PF01048	0.697
MOD_GlcNHglycan	123	126	PF01048	0.734
MOD_GlcNHglycan	239	242	PF01048	0.628
MOD_GlcNHglycan	272	275	PF01048	0.520
MOD_GlcNHglycan	4	7	PF01048	0.411
MOD_GSK3_1	2	9	PF00069	0.427
MOD_GSK3_1	213	220	PF00069	0.601
MOD_GSK3_1	232	239	PF00069	0.701
MOD_GSK3_1	250	257	PF00069	0.630
MOD_GSK3_1	264	271	PF00069	0.615
MOD_GSK3_1	277	284	PF00069	0.515
MOD_N-GLC_1	127	132	PF02516	0.689
MOD_N-GLC_1	140	145	PF02516	0.526
MOD_N-GLC_1	243	248	PF02516	0.740
MOD_N-GLC_2	155	157	PF02516	0.468
MOD_N-GLC_2	194	196	PF02516	0.346
MOD_NEK2_1	127	132	PF00069	0.607
MOD_NEK2_1	215	220	PF00069	0.685
MOD_NEK2_1	227	232	PF00069	0.574
MOD_NEK2_1	264	269	PF00069	0.637
MOD_NEK2_1	277	282	PF00069	0.575
MOD_PIKK_1	250	256	PF00454	0.676
MOD_PIKK_1	268	274	PF00454	0.595
MOD_PIKK_1	281	287	PF00454	0.479
MOD_PIKK_1	315	321	PF00454	0.490
MOD_PKA_2	112	118	PF00069	0.580
MOD_PKA_2	147	153	PF00069	0.374
MOD_PKA_2	324	330	PF00069	0.709
MOD_Plk_1	194	200	PF00069	0.441
MOD_Plk_1	277	283	PF00069	0.734
MOD_Plk_1	334	340	PF00069	0.639
MOD_Plk_4	194	200	PF00069	0.433
MOD_Plk_4	264	270	PF00069	0.622
MOD_Plk_4	272	278	PF00069	0.557
MOD_Plk_4	56	62	PF00069	0.503
MOD_ProDKin_1	118	124	PF00069	0.644
MOD_ProDKin_1	217	223	PF00069	0.624
MOD_ProDKin_1	68	74	PF00069	0.446
MOD_SUMO_for_1	109	112	PF00179	0.562
MOD_SUMO_rev_2	102	111	PF00179	0.432
TRG_DiLeu_BaEn_1	28	33	PF01217	0.565
TRG_DiLeu_BaEn_3	167	173	PF01217	0.545
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.581
TRG_ER_diArg_1	64	66	PF00400	0.348
TRG_NES_CRM1_1	30	42	PF08389	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY30	Leptomonas seymouri	55%	82%
A0A1X0NUJ7	Trypanosomatidae	37%	100%
A0A3R7MUT8	Trypanosoma rangeli	36%	94%
A0A3S7WWZ1	Leishmania donovani	73%	83%
A4HZP4	Leishmania infantum	73%	83%
C9ZSD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	91%
C9ZSH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	74%
E9AVK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	83%
Q4QBX9	Leishmania major	74%	100%
Q57Y77	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	28%	74%
V5DBU7	Trypanosoma cruzi	38%	93%
V5DMJ0	Trypanosoma cruzi	27%	77%