Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized conserved protein (DUF2036), putative

Species:

Leishmania braziliensis

UniProt:

A4HC68_LEIBR

TriTrypDb:

LbrM.22.0150 , LBRM2903_220006800

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031390	Ctf18 RFC-like complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0000775	chromosome, centromeric region	3	1
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098687	chromosomal region	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC68

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	11
GO:0007062	sister chromatid cohesion	3	11
GO:0007064	mitotic sister chromatid cohesion	4	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	11
GO:0022402	cell cycle process	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	11
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1903047	mitotic cell cycle process	3	12
GO:0034086	maintenance of sister chromatid cohesion	3	1
GO:0034088	maintenance of mitotic sister chromatid cohesion	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.447
CLV_NRD_NRD_1	101	103	PF00675	0.276
CLV_NRD_NRD_1	13	15	PF00675	0.325
CLV_NRD_NRD_1	88	90	PF00675	0.275
CLV_PCSK_FUR_1	45	49	PF00082	0.360
CLV_PCSK_KEX2_1	101	103	PF00082	0.253
CLV_PCSK_KEX2_1	13	15	PF00082	0.325
CLV_PCSK_KEX2_1	47	49	PF00082	0.432
CLV_PCSK_KEX2_1	88	90	PF00082	0.284
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.424
CLV_PCSK_SKI1_1	372	376	PF00082	0.312
CLV_PCSK_SKI1_1	423	427	PF00082	0.362
DEG_MDM2_SWIB_1	351	359	PF02201	0.274
DEG_Nend_UBRbox_2	1	3	PF02207	0.536
DEG_SPOP_SBC_1	128	132	PF00917	0.193
DOC_CYCLIN_RxL_1	341	350	PF00134	0.193
DOC_CYCLIN_RxL_1	420	427	PF00134	0.352
DOC_CYCLIN_yCln2_LP_2	306	312	PF00134	0.193
DOC_CYCLIN_yCln2_LP_2	445	448	PF00134	0.425
DOC_MAPK_gen_1	13	21	PF00069	0.193
DOC_PP2B_LxvP_1	306	309	PF13499	0.377
DOC_PP2B_LxvP_1	445	448	PF13499	0.492
DOC_USP7_MATH_1	115	119	PF00917	0.369
DOC_USP7_MATH_1	35	39	PF00917	0.410
DOC_USP7_MATH_1	448	452	PF00917	0.441
DOC_USP7_MATH_1	49	53	PF00917	0.476
DOC_USP7_MATH_2	410	416	PF00917	0.350
DOC_WW_Pin1_4	111	116	PF00397	0.381
DOC_WW_Pin1_4	194	199	PF00397	0.378
DOC_WW_Pin1_4	211	216	PF00397	0.402
DOC_WW_Pin1_4	358	363	PF00397	0.223
DOC_WW_Pin1_4	50	55	PF00397	0.437
LIG_14-3-3_CanoR_1	105	115	PF00244	0.193
LIG_14-3-3_CanoR_1	17	22	PF00244	0.473
LIG_14-3-3_CanoR_1	200	205	PF00244	0.371
LIG_14-3-3_CanoR_1	209	215	PF00244	0.306
LIG_14-3-3_CanoR_1	48	54	PF00244	0.432
LIG_BIR_III_2	357	361	PF00653	0.350
LIG_BRCT_BRCA1_1	153	157	PF00533	0.368
LIG_BRCT_BRCA1_1	360	364	PF00533	0.346
LIG_BRCT_BRCA1_1	414	418	PF00533	0.350
LIG_BRCT_BRCA1_1	64	68	PF00533	0.381
LIG_Clathr_ClatBox_1	18	22	PF01394	0.308
LIG_CSL_BTD_1	407	410	PF09270	0.417
LIG_eIF4E_1	92	98	PF01652	0.308
LIG_FHA_1	129	135	PF00498	0.234
LIG_FHA_1	143	149	PF00498	0.393
LIG_FHA_1	245	251	PF00498	0.343
LIG_FHA_1	337	343	PF00498	0.368
LIG_FHA_1	82	88	PF00498	0.323
LIG_FHA_1	93	99	PF00498	0.279
LIG_FHA_2	176	182	PF00498	0.274
LIG_FHA_2	249	255	PF00498	0.388
LIG_FHA_2	295	301	PF00498	0.217
LIG_FHA_2	348	354	PF00498	0.247
LIG_FHA_2	378	384	PF00498	0.487
LIG_FHA_2	399	405	PF00498	0.193
LIG_LIR_Apic_2	284	290	PF02991	0.278
LIG_LIR_Apic_2	404	410	PF02991	0.437
LIG_LIR_Apic_2	460	466	PF02991	0.398
LIG_LIR_Gen_1	174	182	PF02991	0.353
LIG_LIR_Gen_1	203	211	PF02991	0.348
LIG_LIR_Gen_1	440	448	PF02991	0.420
LIG_LIR_Gen_1	449	459	PF02991	0.416
LIG_LIR_Nem_3	15	19	PF02991	0.300
LIG_LIR_Nem_3	174	179	PF02991	0.334
LIG_LIR_Nem_3	203	207	PF02991	0.280
LIG_LIR_Nem_3	273	278	PF02991	0.368
LIG_LIR_Nem_3	449	455	PF02991	0.423
LIG_LYPXL_L_2	274	283	PF13949	0.368
LIG_LYPXL_S_1	274	278	PF13949	0.308
LIG_LYPXL_yS_3	275	278	PF13949	0.308
LIG_NRBOX	217	223	PF00104	0.417
LIG_NRBOX	232	238	PF00104	0.417
LIG_PCNA_PIPBox_1	435	444	PF02747	0.217
LIG_PCNA_yPIPBox_3	429	442	PF02747	0.394
LIG_Pex14_2	351	355	PF04695	0.274
LIG_Rb_pABgroove_1	151	159	PF01858	0.417
LIG_SH2_CRK	16	20	PF00017	0.308
LIG_SH2_CRK	287	291	PF00017	0.368
LIG_SH2_CRK	463	467	PF00017	0.434
LIG_SH2_CRK	472	476	PF00017	0.375
LIG_SH2_GRB2like	144	147	PF00017	0.350
LIG_SH2_GRB2like	92	95	PF00017	0.289
LIG_SH2_PTP2	388	391	PF00017	0.350
LIG_SH2_STAP1	144	148	PF00017	0.350
LIG_SH2_STAP1	459	463	PF00017	0.286
LIG_SH2_STAP1	92	96	PF00017	0.289
LIG_SH2_STAT5	144	147	PF00017	0.427
LIG_SH2_STAT5	176	179	PF00017	0.371
LIG_SH2_STAT5	202	205	PF00017	0.289
LIG_SH2_STAT5	388	391	PF00017	0.350
LIG_SH2_STAT5	441	444	PF00017	0.362
LIG_SH2_STAT5	459	462	PF00017	0.391
LIG_SH3_1	463	469	PF00018	0.496
LIG_SH3_3	258	264	PF00018	0.193
LIG_SH3_3	463	469	PF00018	0.417
LIG_SUMO_SIM_par_1	17	23	PF11976	0.288
LIG_TRAF2_1	178	181	PF00917	0.334
LIG_TRFH_1	426	430	PF08558	0.368
LIG_TYR_ITIM	470	475	PF00017	0.367
LIG_WRC_WIRS_1	249	254	PF05994	0.278
LIG_WRC_WIRS_1	348	353	PF05994	0.368
MOD_CDC14_SPxK_1	114	117	PF00782	0.193
MOD_CDK_SPxK_1	111	117	PF00069	0.193
MOD_CDK_SPxK_1	194	200	PF00069	0.193
MOD_CK1_1	111	117	PF00069	0.391
MOD_CK1_1	175	181	PF00069	0.340
MOD_CK1_1	189	195	PF00069	0.281
MOD_CK1_1	213	219	PF00069	0.300
MOD_CK1_1	294	300	PF00069	0.320
MOD_CK1_1	393	399	PF00069	0.463
MOD_CK1_1	53	59	PF00069	0.370
MOD_CK1_1	83	89	PF00069	0.417
MOD_CK2_1	17	23	PF00069	0.348
MOD_CK2_1	175	181	PF00069	0.310
MOD_CK2_1	211	217	PF00069	0.293
MOD_CK2_1	294	300	PF00069	0.193
MOD_CK2_1	347	353	PF00069	0.303
MOD_CK2_1	377	383	PF00069	0.386
MOD_DYRK1A_RPxSP_1	50	54	PF00069	0.350
MOD_GlcNHglycan	108	111	PF01048	0.433
MOD_GlcNHglycan	122	125	PF01048	0.375
MOD_GlcNHglycan	37	40	PF01048	0.383
MOD_GlcNHglycan	395	398	PF01048	0.403
MOD_GlcNHglycan	55	58	PF01048	0.403
MOD_GSK3_1	111	118	PF00069	0.349
MOD_GSK3_1	182	189	PF00069	0.383
MOD_GSK3_1	244	251	PF00069	0.256
MOD_GSK3_1	358	365	PF00069	0.214
MOD_GSK3_1	398	405	PF00069	0.386
MOD_GSK3_1	49	56	PF00069	0.402
MOD_N-GLC_1	62	67	PF02516	0.227
MOD_N-GLC_2	167	169	PF02516	0.355
MOD_NEK2_1	127	132	PF00069	0.208
MOD_NEK2_1	156	161	PF00069	0.370
MOD_NEK2_1	172	177	PF00069	0.349
MOD_NEK2_1	221	226	PF00069	0.330
MOD_NEK2_1	377	382	PF00069	0.269
MOD_NEK2_1	97	102	PF00069	0.378
MOD_NEK2_2	248	253	PF00069	0.193
MOD_PK_1	17	23	PF00069	0.370
MOD_PKA_2	393	399	PF00069	0.193
MOD_PKA_2	457	463	PF00069	0.444
MOD_PKA_2	49	55	PF00069	0.350
MOD_Plk_1	259	265	PF00069	0.360
MOD_Plk_1	299	305	PF00069	0.350
MOD_Plk_1	448	454	PF00069	0.524
MOD_Plk_1	62	68	PF00069	0.203
MOD_Plk_4	172	178	PF00069	0.417
MOD_Plk_4	237	243	PF00069	0.209
MOD_Plk_4	248	254	PF00069	0.361
MOD_Plk_4	270	276	PF00069	0.289
MOD_Plk_4	377	383	PF00069	0.371
MOD_Plk_4	92	98	PF00069	0.323
MOD_ProDKin_1	111	117	PF00069	0.381
MOD_ProDKin_1	194	200	PF00069	0.378
MOD_ProDKin_1	211	217	PF00069	0.402
MOD_ProDKin_1	358	364	PF00069	0.223
MOD_ProDKin_1	50	56	PF00069	0.437
TRG_DiLeu_BaEn_1	217	222	PF01217	0.417
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.274
TRG_ENDOCYTIC_2	16	19	PF00928	0.372
TRG_ENDOCYTIC_2	176	179	PF00928	0.340
TRG_ENDOCYTIC_2	275	278	PF00928	0.289
TRG_ENDOCYTIC_2	388	391	PF00928	0.372
TRG_ENDOCYTIC_2	441	444	PF00928	0.356
TRG_ENDOCYTIC_2	472	475	PF00928	0.369
TRG_ER_diArg_1	101	103	PF00400	0.264
TRG_ER_diArg_1	87	89	PF00400	0.290
TRG_NES_CRM1_1	427	440	PF08389	0.457
TRG_NLS_MonoExtN_4	45	51	PF00514	0.416
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	344	349	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC72	Leptomonas seymouri	54%	98%
A0A0S4JIP1	Bodo saltans	24%	100%
A0A1X0NTK3	Trypanosomatidae	32%	97%
A0A3S7WWY5	Leishmania donovani	79%	100%
A0A422NSK5	Trypanosoma rangeli	33%	100%
A4HZP3	Leishmania infantum	79%	100%
C9ZSD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AVJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QBY0	Leishmania major	80%	100%
V5BFR5	Trypanosoma cruzi	31%	100%