BAG domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC67_LEIBR

TriTrypDb:

LbrM.22.0140 , LBRM2903_220006700

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC67

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0051087	protein-folding chaperone binding	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.759
CLV_C14_Caspase3-7	192	196	PF00656	0.584
CLV_NRD_NRD_1	127	129	PF00675	0.782
CLV_NRD_NRD_1	144	146	PF00675	0.634
CLV_NRD_NRD_1	294	296	PF00675	0.768
CLV_NRD_NRD_1	404	406	PF00675	0.419
CLV_NRD_NRD_1	432	434	PF00675	0.346
CLV_PCSK_FUR_1	430	434	PF00082	0.339
CLV_PCSK_KEX2_1	160	162	PF00082	0.773
CLV_PCSK_KEX2_1	293	295	PF00082	0.759
CLV_PCSK_KEX2_1	432	434	PF00082	0.339
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.786
CLV_PCSK_SKI1_1	175	179	PF00082	0.633
CLV_PCSK_SKI1_1	37	41	PF00082	0.583
CLV_PCSK_SKI1_1	414	418	PF00082	0.346
CLV_PCSK_SKI1_1	438	442	PF00082	0.346
CLV_Separin_Metazoa	411	415	PF03568	0.546
DEG_SCF_TRCP1_1	358	363	PF00400	0.349
DEG_SPOP_SBC_1	177	181	PF00917	0.573
DOC_CKS1_1	207	212	PF01111	0.548
DOC_CYCLIN_RxL_1	411	420	PF00134	0.546
DOC_MAPK_gen_1	128	135	PF00069	0.550
DOC_MAPK_gen_1	16	25	PF00069	0.541
DOC_MAPK_gen_1	293	300	PF00069	0.689
DOC_MAPK_MEF2A_6	19	27	PF00069	0.530
DOC_MAPK_MEF2A_6	293	300	PF00069	0.684
DOC_MAPK_MEF2A_6	446	453	PF00069	0.537
DOC_PP1_RVXF_1	412	418	PF00149	0.546
DOC_PP2B_LxvP_1	25	28	PF13499	0.503
DOC_PP4_FxxP_1	197	200	PF00568	0.574
DOC_PP4_FxxP_1	204	207	PF00568	0.530
DOC_USP7_MATH_1	120	124	PF00917	0.781
DOC_USP7_MATH_1	205	209	PF00917	0.763
DOC_USP7_MATH_1	244	248	PF00917	0.728
DOC_USP7_MATH_1	253	257	PF00917	0.668
DOC_USP7_MATH_1	272	276	PF00917	0.625
DOC_USP7_MATH_1	314	318	PF00917	0.443
DOC_USP7_MATH_1	69	73	PF00917	0.496
DOC_USP7_UBL2_3	167	171	PF12436	0.811
DOC_USP7_UBL2_3	346	350	PF12436	0.390
DOC_USP7_UBL2_3	434	438	PF12436	0.546
DOC_WW_Pin1_4	145	150	PF00397	0.702
DOC_WW_Pin1_4	206	211	PF00397	0.654
DOC_WW_Pin1_4	221	226	PF00397	0.825
DOC_WW_Pin1_4	238	243	PF00397	0.653
DOC_WW_Pin1_4	263	268	PF00397	0.795
DOC_WW_Pin1_4	333	338	PF00397	0.461
DOC_WW_Pin1_4	395	400	PF00397	0.513
DOC_WW_Pin1_4	86	91	PF00397	0.616
LIG_14-3-3_CanoR_1	128	134	PF00244	0.707
LIG_14-3-3_CanoR_1	169	178	PF00244	0.657
LIG_14-3-3_CanoR_1	184	191	PF00244	0.629
LIG_Clathr_ClatBox_1	382	386	PF01394	0.424
LIG_EH1_1	318	326	PF00400	0.339
LIG_eIF4E_1	68	74	PF01652	0.494
LIG_FHA_1	130	136	PF00498	0.560
LIG_FHA_1	20	26	PF00498	0.577
LIG_FHA_1	249	255	PF00498	0.567
LIG_FHA_1	28	34	PF00498	0.576
LIG_FHA_1	36	42	PF00498	0.320
LIG_FHA_1	375	381	PF00498	0.371
LIG_FHA_1	387	393	PF00498	0.344
LIG_FHA_1	417	423	PF00498	0.546
LIG_FHA_1	48	54	PF00498	0.506
LIG_FHA_2	120	126	PF00498	0.764
LIG_FHA_2	150	156	PF00498	0.563
LIG_FHA_2	16	22	PF00498	0.660
LIG_FHA_2	178	184	PF00498	0.577
LIG_FHA_2	190	196	PF00498	0.530
LIG_FHA_2	318	324	PF00498	0.391
LIG_FHA_2	379	385	PF00498	0.463
LIG_GBD_Chelix_1	32	40	PF00786	0.570
LIG_LIR_Apic_2	195	200	PF02991	0.642
LIG_LIR_Apic_2	201	207	PF02991	0.654
LIG_LIR_Nem_3	67	73	PF02991	0.550
LIG_MYND_1	214	218	PF01753	0.577
LIG_MYND_1	333	337	PF01753	0.646
LIG_SH2_CRK	54	58	PF00017	0.593
LIG_SH2_GRB2like	374	377	PF00017	0.340
LIG_SH2_STAP1	409	413	PF00017	0.546
LIG_SH2_STAT5	64	67	PF00017	0.601
LIG_SH3_3	106	112	PF00018	0.563
LIG_SH3_3	204	210	PF00018	0.702
LIG_SH3_3	212	218	PF00018	0.703
LIG_SH3_3	308	314	PF00018	0.363
LIG_SH3_3	87	93	PF00018	0.809
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.539
LIG_SUMO_SIM_anti_2	377	384	PF11976	0.555
LIG_SUMO_SIM_par_1	381	386	PF11976	0.465
LIG_TYR_ITIM	52	57	PF00017	0.628
LIG_WRC_WIRS_1	36	41	PF05994	0.575
MOD_CDK_SPK_2	86	91	PF00069	0.583
MOD_CK1_1	118	124	PF00069	0.672
MOD_CK1_1	173	179	PF00069	0.738
MOD_CK1_1	189	195	PF00069	0.608
MOD_CK1_1	198	204	PF00069	0.569
MOD_CK1_1	208	214	PF00069	0.635
MOD_CK1_1	234	240	PF00069	0.744
MOD_CK1_1	256	262	PF00069	0.683
MOD_CK1_1	268	274	PF00069	0.803
MOD_CK1_1	317	323	PF00069	0.572
MOD_CK1_1	398	404	PF00069	0.619
MOD_CK2_1	145	151	PF00069	0.812
MOD_CK2_1	15	21	PF00069	0.533
MOD_CK2_1	177	183	PF00069	0.717
MOD_CK2_1	372	378	PF00069	0.476
MOD_GlcNHglycan	122	125	PF01048	0.674
MOD_GlcNHglycan	172	175	PF01048	0.706
MOD_GlcNHglycan	197	200	PF01048	0.591
MOD_GlcNHglycan	228	231	PF01048	0.767
MOD_GlcNHglycan	233	236	PF01048	0.772
MOD_GlcNHglycan	255	258	PF01048	0.711
MOD_GlcNHglycan	270	273	PF01048	0.665
MOD_GlcNHglycan	274	277	PF01048	0.797
MOD_GlcNHglycan	358	361	PF01048	0.353
MOD_GlcNHglycan	393	396	PF01048	0.358
MOD_GSK3_1	107	114	PF00069	0.745
MOD_GSK3_1	115	122	PF00069	0.659
MOD_GSK3_1	145	152	PF00069	0.587
MOD_GSK3_1	15	22	PF00069	0.599
MOD_GSK3_1	173	180	PF00069	0.761
MOD_GSK3_1	233	240	PF00069	0.688
MOD_GSK3_1	244	251	PF00069	0.760
MOD_GSK3_1	252	259	PF00069	0.819
MOD_GSK3_1	268	275	PF00069	0.787
MOD_GSK3_1	279	286	PF00069	0.689
MOD_GSK3_1	356	363	PF00069	0.406
MOD_GSK3_1	374	381	PF00069	0.424
MOD_GSK3_1	391	398	PF00069	0.298
MOD_GSK3_1	56	63	PF00069	0.564
MOD_N-GLC_1	129	134	PF02516	0.612
MOD_N-GLC_1	263	268	PF02516	0.782
MOD_NEK2_1	170	175	PF00069	0.748
MOD_NEK2_1	356	361	PF00069	0.343
MOD_PIKK_1	244	250	PF00454	0.816
MOD_PIKK_1	257	263	PF00454	0.645
MOD_PIKK_1	288	294	PF00454	0.762
MOD_PIKK_1	78	84	PF00454	0.632
MOD_PKA_1	160	166	PF00069	0.810
MOD_PKA_2	15	21	PF00069	0.552
MOD_PKA_2	160	166	PF00069	0.726
MOD_PKA_2	189	195	PF00069	0.607
MOD_PKB_1	184	192	PF00069	0.577
MOD_Plk_1	129	135	PF00069	0.578
MOD_Plk_1	161	167	PF00069	0.557
MOD_Plk_1	317	323	PF00069	0.495
MOD_Plk_1	60	66	PF00069	0.602
MOD_Plk_2-3	378	384	PF00069	0.468
MOD_Plk_4	161	167	PF00069	0.674
MOD_Plk_4	60	66	PF00069	0.504
MOD_Plk_4	69	75	PF00069	0.441
MOD_ProDKin_1	145	151	PF00069	0.703
MOD_ProDKin_1	206	212	PF00069	0.651
MOD_ProDKin_1	221	227	PF00069	0.824
MOD_ProDKin_1	238	244	PF00069	0.649
MOD_ProDKin_1	263	269	PF00069	0.787
MOD_ProDKin_1	333	339	PF00069	0.453
MOD_ProDKin_1	395	401	PF00069	0.513
MOD_ProDKin_1	86	92	PF00069	0.616
MOD_SUMO_rev_2	445	454	PF00179	0.725
TRG_DiLeu_BaEn_1	378	383	PF01217	0.565
TRG_DiLeu_BaEn_2	34	40	PF01217	0.573
TRG_DiLeu_BaEn_3	410	416	PF01217	0.546
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.609
TRG_ENDOCYTIC_2	409	412	PF00928	0.546
TRG_ENDOCYTIC_2	54	57	PF00928	0.556
TRG_ER_diArg_1	293	295	PF00400	0.781
TRG_ER_diArg_1	429	432	PF00400	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IB32	Leishmania donovani	69%	100%
A4HZP2	Leishmania infantum	69%	100%
C9ZSD2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AVJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QBY1	Leishmania major	69%	100%