C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC66_LEIBR

TriTrypDb:

LbrM.22.0130 , LBRM2903_220006600

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC66

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.476
CLV_C14_Caspase3-7	184	188	PF00656	0.735
CLV_C14_Caspase3-7	295	299	PF00656	0.742
CLV_C14_Caspase3-7	302	306	PF00656	0.632
CLV_NRD_NRD_1	320	322	PF00675	0.709
CLV_NRD_NRD_1	325	327	PF00675	0.708
CLV_NRD_NRD_1	342	344	PF00675	0.705
CLV_PCSK_KEX2_1	152	154	PF00082	0.595
CLV_PCSK_KEX2_1	320	322	PF00082	0.707
CLV_PCSK_KEX2_1	325	327	PF00082	0.711
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.595
CLV_PCSK_PC7_1	321	327	PF00082	0.707
CLV_PCSK_SKI1_1	224	228	PF00082	0.473
CLV_PCSK_SKI1_1	71	75	PF00082	0.430
CLV_PCSK_SKI1_1	91	95	PF00082	0.189
DEG_APCC_DBOX_1	70	78	PF00400	0.419
DEG_SPOP_SBC_1	3	7	PF00917	0.749
DOC_CKS1_1	228	233	PF01111	0.574
DOC_CKS1_1	377	382	PF01111	0.765
DOC_CKS1_1	39	44	PF01111	0.551
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.537
DOC_MAPK_gen_1	15	24	PF00069	0.475
DOC_MAPK_gen_1	87	94	PF00069	0.508
DOC_MAPK_MEF2A_6	257	265	PF00069	0.495
DOC_MAPK_RevD_3	138	153	PF00069	0.507
DOC_PP2B_LxvP_1	215	218	PF13499	0.572
DOC_PP2B_LxvP_1	405	408	PF13499	0.783
DOC_PP4_FxxP_1	385	388	PF00568	0.706
DOC_USP7_MATH_1	175	179	PF00917	0.650
DOC_USP7_MATH_1	236	240	PF00917	0.489
DOC_USP7_MATH_1	3	7	PF00917	0.749
DOC_USP7_MATH_1	372	376	PF00917	0.651
DOC_USP7_MATH_1	397	401	PF00917	0.722
DOC_USP7_MATH_1	464	468	PF00917	0.733
DOC_USP7_MATH_1	85	89	PF00917	0.527
DOC_USP7_UBL2_3	13	17	PF12436	0.631
DOC_USP7_UBL2_3	87	91	PF12436	0.488
DOC_WW_Pin1_4	227	232	PF00397	0.564
DOC_WW_Pin1_4	331	336	PF00397	0.696
DOC_WW_Pin1_4	360	365	PF00397	0.655
DOC_WW_Pin1_4	376	381	PF00397	0.598
DOC_WW_Pin1_4	38	43	PF00397	0.506
DOC_WW_Pin1_4	395	400	PF00397	0.692
DOC_WW_Pin1_4	428	433	PF00397	0.697
LIG_14-3-3_CanoR_1	201	205	PF00244	0.456
LIG_14-3-3_CanoR_1	207	215	PF00244	0.488
LIG_14-3-3_CanoR_1	320	325	PF00244	0.774
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BRCT_BRCA1_1	473	477	PF00533	0.644
LIG_eIF4E_1	193	199	PF01652	0.477
LIG_eIF4E_1	237	243	PF01652	0.475
LIG_EVH1_1	407	411	PF00568	0.758
LIG_FHA_1	187	193	PF00498	0.637
LIG_FHA_1	331	337	PF00498	0.715
LIG_FHA_1	435	441	PF00498	0.714
LIG_FHA_2	230	236	PF00498	0.555
LIG_FHA_2	312	318	PF00498	0.706
LIG_FHA_2	32	38	PF00498	0.490
LIG_LIR_Gen_1	211	221	PF02991	0.580
LIG_LIR_Gen_1	389	399	PF02991	0.766
LIG_LIR_Gen_1	437	444	PF02991	0.695
LIG_LIR_Gen_1	79	85	PF02991	0.494
LIG_LIR_Nem_3	211	217	PF02991	0.433
LIG_LIR_Nem_3	250	254	PF02991	0.467
LIG_LIR_Nem_3	79	83	PF02991	0.501
LIG_Pex14_2	47	51	PF04695	0.346
LIG_SH2_CRK	80	84	PF00017	0.494
LIG_SH2_PTP2	449	452	PF00017	0.618
LIG_SH2_STAT5	214	217	PF00017	0.559
LIG_SH2_STAT5	251	254	PF00017	0.555
LIG_SH2_STAT5	449	452	PF00017	0.584
LIG_SH2_STAT5	471	474	PF00017	0.674
LIG_SH2_STAT5	76	79	PF00017	0.453
LIG_SH3_1	406	412	PF00018	0.760
LIG_SH3_3	19	25	PF00018	0.453
LIG_SH3_3	222	228	PF00018	0.459
LIG_SH3_3	381	387	PF00018	0.632
LIG_SH3_3	405	411	PF00018	0.654
LIG_SH3_3	421	427	PF00018	0.547
LIG_SH3_3	453	459	PF00018	0.677
LIG_SH3_3	463	469	PF00018	0.596
LIG_TRAF2_1	145	148	PF00917	0.578
MOD_CDK_SPxxK_3	360	367	PF00069	0.728
MOD_CDK_SPxxK_3	38	45	PF00069	0.556
MOD_CK1_1	132	138	PF00069	0.487
MOD_CK1_1	2	8	PF00069	0.679
MOD_CK1_1	203	209	PF00069	0.407
MOD_CK1_1	210	216	PF00069	0.424
MOD_CK1_1	308	314	PF00069	0.627
MOD_CK1_1	328	334	PF00069	0.429
MOD_CK1_1	348	354	PF00069	0.430
MOD_CK1_1	375	381	PF00069	0.687
MOD_CK1_1	454	460	PF00069	0.706
MOD_CK2_1	165	171	PF00069	0.677
MOD_CK2_1	216	222	PF00069	0.577
MOD_CK2_1	229	235	PF00069	0.407
MOD_CK2_1	31	37	PF00069	0.501
MOD_CK2_1	311	317	PF00069	0.719
MOD_Cter_Amidation	341	344	PF01082	0.709
MOD_GlcNHglycan	1	4	PF01048	0.763
MOD_GlcNHglycan	183	186	PF01048	0.676
MOD_GlcNHglycan	218	221	PF01048	0.516
MOD_GlcNHglycan	238	241	PF01048	0.213
MOD_GlcNHglycan	327	330	PF01048	0.723
MOD_GlcNHglycan	353	356	PF01048	0.717
MOD_GlcNHglycan	374	377	PF01048	0.734
MOD_GlcNHglycan	453	456	PF01048	0.643
MOD_GSK3_1	2	9	PF00069	0.675
MOD_GSK3_1	203	210	PF00069	0.484
MOD_GSK3_1	305	312	PF00069	0.664
MOD_GSK3_1	316	323	PF00069	0.649
MOD_GSK3_1	331	338	PF00069	0.530
MOD_GSK3_1	345	352	PF00069	0.625
MOD_GSK3_1	354	361	PF00069	0.666
MOD_GSK3_1	371	378	PF00069	0.538
MOD_GSK3_1	391	398	PF00069	0.768
MOD_LATS_1	205	211	PF00433	0.500
MOD_N-GLC_1	105	110	PF02516	0.193
MOD_N-GLC_1	132	137	PF02516	0.507
MOD_N-GLC_1	85	90	PF02516	0.515
MOD_N-GLC_1	98	103	PF02516	0.374
MOD_NEK2_1	170	175	PF00069	0.737
MOD_NEK2_1	180	185	PF00069	0.570
MOD_NEK2_1	200	205	PF00069	0.178
MOD_NEK2_1	242	247	PF00069	0.401
MOD_NEK2_1	309	314	PF00069	0.697
MOD_NEK2_1	330	335	PF00069	0.700
MOD_NEK2_1	349	354	PF00069	0.476
MOD_NEK2_1	434	439	PF00069	0.709
MOD_NEK2_1	93	98	PF00069	0.421
MOD_NEK2_2	188	193	PF00069	0.618
MOD_PIKK_1	464	470	PF00454	0.760
MOD_PIKK_1	93	99	PF00454	0.463
MOD_PK_1	320	326	PF00069	0.731
MOD_PKA_1	320	326	PF00069	0.707
MOD_PKA_2	200	206	PF00069	0.457
MOD_PKA_2	320	326	PF00069	0.707
MOD_PKA_2	358	364	PF00069	0.695
MOD_PKA_2	67	73	PF00069	0.514
MOD_Plk_1	297	303	PF00069	0.690
MOD_Plk_2-3	31	37	PF00069	0.546
MOD_Plk_4	175	181	PF00069	0.653
MOD_Plk_4	188	194	PF00069	0.533
MOD_Plk_4	210	216	PF00069	0.587
MOD_Plk_4	345	351	PF00069	0.727
MOD_Plk_4	417	423	PF00069	0.777
MOD_Plk_4	434	440	PF00069	0.680
MOD_ProDKin_1	227	233	PF00069	0.567
MOD_ProDKin_1	331	337	PF00069	0.698
MOD_ProDKin_1	360	366	PF00069	0.655
MOD_ProDKin_1	376	382	PF00069	0.598
MOD_ProDKin_1	38	44	PF00069	0.505
MOD_ProDKin_1	395	401	PF00069	0.695
MOD_ProDKin_1	428	434	PF00069	0.699
TRG_DiLeu_BaEn_2	280	286	PF01217	0.459
TRG_ENDOCYTIC_2	214	217	PF00928	0.442
TRG_ENDOCYTIC_2	251	254	PF00928	0.442
TRG_ENDOCYTIC_2	438	441	PF00928	0.620
TRG_ENDOCYTIC_2	80	83	PF00928	0.502
TRG_ER_diArg_1	324	326	PF00400	0.722
TRG_NLS_MonoExtN_4	10	16	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4X4	Leptomonas seymouri	65%	100%
A0A1X0NT27	Trypanosomatidae	38%	100%
A0A3R7M3M9	Trypanosoma rangeli	39%	100%