Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC65_LEIBR

TriTrypDb:

LbrM.22.0120 , LBRM2903_220006500

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.531
CLV_C14_Caspase3-7	211	215	PF00656	0.514
CLV_NRD_NRD_1	103	105	PF00675	0.327
CLV_NRD_NRD_1	198	200	PF00675	0.480
CLV_NRD_NRD_1	30	32	PF00675	0.552
CLV_NRD_NRD_1	84	86	PF00675	0.447
CLV_NRD_NRD_1	92	94	PF00675	0.408
CLV_PCSK_FUR_1	90	94	PF00082	0.554
CLV_PCSK_KEX2_1	103	105	PF00082	0.394
CLV_PCSK_KEX2_1	84	86	PF00082	0.414
CLV_PCSK_KEX2_1	90	92	PF00082	0.422
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.424
CLV_PCSK_SKI1_1	14	18	PF00082	0.481
CLV_PCSK_SKI1_1	200	204	PF00082	0.520
DEG_APCC_DBOX_1	30	38	PF00400	0.417
DEG_Nend_UBRbox_2	1	3	PF02207	0.584
DOC_USP7_MATH_1	240	244	PF00917	0.565
LIG_14-3-3_CanoR_1	125	130	PF00244	0.530
LIG_14-3-3_CanoR_1	31	35	PF00244	0.551
LIG_14-3-3_CanoR_1	56	66	PF00244	0.547
LIG_14-3-3_CterR_2	239	244	PF00244	0.505
LIG_Actin_WH2_2	2	19	PF00022	0.447
LIG_FHA_1	5	11	PF00498	0.499
LIG_FHA_1	78	84	PF00498	0.406
LIG_FHA_2	205	211	PF00498	0.567
LIG_FHA_2	232	238	PF00498	0.522
LIG_LIR_Gen_1	214	223	PF02991	0.589
LIG_LIR_Nem_3	214	219	PF02991	0.586
LIG_PDZ_Class_2	239	244	PF00595	0.485
LIG_TRAF2_1	208	211	PF00917	0.579
LIG_WRC_WIRS_1	126	131	PF05994	0.492
MOD_CK1_1	4	10	PF00069	0.505
MOD_CK2_1	129	135	PF00069	0.527
MOD_CK2_1	16	22	PF00069	0.543
MOD_CK2_1	204	210	PF00069	0.446
MOD_CK2_1	231	237	PF00069	0.476
MOD_CK2_1	57	63	PF00069	0.521
MOD_GlcNHglycan	196	199	PF01048	0.506
MOD_GlcNHglycan	59	62	PF01048	0.543
MOD_GSK3_1	125	132	PF00069	0.529
MOD_GSK3_1	18	25	PF00069	0.535
MOD_GSK3_1	26	33	PF00069	0.545
MOD_GSK3_1	51	58	PF00069	0.515
MOD_N-GLC_1	56	61	PF02516	0.518
MOD_NEK2_1	1	6	PF00069	0.484
MOD_NEK2_1	16	21	PF00069	0.426
MOD_NEK2_1	99	104	PF00069	0.526
MOD_PIKK_1	1	7	PF00454	0.395
MOD_PIKK_1	77	83	PF00454	0.595
MOD_PKA_2	124	130	PF00069	0.476
MOD_PKA_2	30	36	PF00069	0.476
MOD_PKA_2	55	61	PF00069	0.541
MOD_PKB_1	123	131	PF00069	0.547
MOD_PKB_1	75	83	PF00069	0.313
MOD_Plk_1	1	7	PF00069	0.588
MOD_Plk_1	221	227	PF00069	0.501
MOD_Plk_2-3	22	28	PF00069	0.467
MOD_SUMO_rev_2	113	120	PF00179	0.484
MOD_SUMO_rev_2	177	182	PF00179	0.434
MOD_SUMO_rev_2	205	215	PF00179	0.535
TRG_DiLeu_BaEn_1	95	100	PF01217	0.608
TRG_ER_diArg_1	75	78	PF00400	0.434
TRG_ER_diArg_1	83	85	PF00400	0.442
TRG_ER_diArg_1	90	93	PF00400	0.447
TRG_NES_CRM1_1	26	40	PF08389	0.319
TRG_NLS_Bipartite_1	85	107	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6U5	Leptomonas seymouri	74%	100%
A0A0S4JJT7	Bodo saltans	29%	98%
A0A1X0NT26	Trypanosomatidae	51%	100%
A0A3Q8IFD0	Leishmania donovani	86%	100%
A0A3R7M6L3	Trypanosoma rangeli	50%	100%
C9ZSC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
E9AVJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QBY2	Leishmania major	87%	100%
V5AVS9	Trypanosoma cruzi	50%	80%