Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HC63_LEIBR

TriTrypDb:

LbrM.22.0105

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HC63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.820
CLV_PCSK_SKI1_1	221	225	PF00082	0.449
CLV_PCSK_SKI1_1	25	29	PF00082	0.627
CLV_PCSK_SKI1_1	353	357	PF00082	0.802
CLV_PCSK_SKI1_1	381	385	PF00082	0.549
DEG_APCC_DBOX_1	184	192	PF00400	0.736
DEG_APCC_DBOX_1	380	388	PF00400	0.549
DEG_SPOP_SBC_1	142	146	PF00917	0.636
DOC_CDC14_PxL_1	120	128	PF14671	0.752
DOC_CYCLIN_yCln2_LP_2	119	122	PF00134	0.742
DOC_CYCLIN_yCln2_LP_2	128	131	PF00134	0.493
DOC_MAPK_DCC_7	4	12	PF00069	0.843
DOC_MAPK_FxFP_2	243	246	PF00069	0.683
DOC_MAPK_HePTP_8	178	190	PF00069	0.549
DOC_MAPK_MEF2A_6	181	190	PF00069	0.729
DOC_MAPK_MEF2A_6	317	324	PF00069	0.804
DOC_PP1_RVXF_1	219	225	PF00149	0.650
DOC_PP2B_LxvP_1	118	121	PF13499	0.549
DOC_PP2B_LxvP_1	128	131	PF13499	0.480
DOC_PP2B_LxvP_1	267	270	PF13499	0.769
DOC_PP4_FxxP_1	243	246	PF00568	0.683
DOC_PP4_FxxP_1	420	423	PF00568	0.726
DOC_PP4_FxxP_1	479	482	PF00568	0.830
DOC_USP7_MATH_1	172	176	PF00917	0.549
DOC_USP7_MATH_1	213	217	PF00917	0.774
DOC_USP7_MATH_1	428	432	PF00917	0.566
DOC_WW_Pin1_4	13	18	PF00397	0.721
DOC_WW_Pin1_4	209	214	PF00397	0.782
DOC_WW_Pin1_4	235	240	PF00397	0.549
DOC_WW_Pin1_4	268	273	PF00397	0.772
DOC_WW_Pin1_4	285	290	PF00397	0.603
DOC_WW_Pin1_4	3	8	PF00397	0.840
DOC_WW_Pin1_4	309	314	PF00397	0.811
DOC_WW_Pin1_4	332	337	PF00397	0.549
DOC_WW_Pin1_4	390	395	PF00397	0.773
DOC_WW_Pin1_4	407	412	PF00397	0.252
DOC_WW_Pin1_4	422	427	PF00397	0.393
DOC_WW_Pin1_4	478	483	PF00397	0.827
DOC_WW_Pin1_4	52	57	PF00397	0.798
LIG_14-3-3_CanoR_1	143	153	PF00244	0.632
LIG_14-3-3_CanoR_1	185	191	PF00244	0.780
LIG_14-3-3_CanoR_1	195	200	PF00244	0.671
LIG_14-3-3_CanoR_1	353	358	PF00244	0.601
LIG_14-3-3_CanoR_1	370	374	PF00244	0.237
LIG_14-3-3_CanoR_1	388	394	PF00244	0.548
LIG_14-3-3_CanoR_1	449	459	PF00244	0.734
LIG_14-3-3_CanoR_1	460	464	PF00244	0.647
LIG_14-3-3_CanoR_1	51	55	PF00244	0.808
LIG_Actin_RPEL_3	158	177	PF02755	0.449
LIG_Actin_WH2_2	184	202	PF00022	0.744
LIG_Actin_WH2_2	372	390	PF00022	0.549
LIG_BRCT_BRCA1_1	219	223	PF00533	0.754
LIG_BRCT_BRCA1_1	343	347	PF00533	0.549
LIG_BRCT_BRCA1_1	360	364	PF00533	0.393
LIG_BRCT_BRCA1_1	367	371	PF00533	0.498
LIG_BRCT_BRCA1_1	408	412	PF00533	0.549
LIG_BRCT_BRCA1_1	452	456	PF00533	0.780
LIG_CtBP_PxDLS_1	337	341	PF00389	0.549
LIG_EH1_1	260	268	PF00400	0.549
LIG_eIF4E_1	261	267	PF01652	0.549
LIG_EVH1_1	120	124	PF00568	0.747
LIG_EVH1_2	394	398	PF00568	0.782
LIG_FHA_1	101	107	PF00498	0.549
LIG_FHA_1	146	152	PF00498	0.633
LIG_FHA_1	153	159	PF00498	0.528
LIG_FHA_1	194	200	PF00498	0.795
LIG_FHA_1	205	211	PF00498	0.651
LIG_FHA_1	229	235	PF00498	0.549
LIG_FHA_1	271	277	PF00498	0.815
LIG_FHA_1	290	296	PF00498	0.582
LIG_FHA_1	300	306	PF00498	0.694
LIG_FHA_1	343	349	PF00498	0.549
LIG_FHA_1	352	358	PF00498	0.491
LIG_FHA_1	45	51	PF00498	0.813
LIG_FHA_1	78	84	PF00498	0.830
LIG_GBD_Chelix_1	106	114	PF00786	0.549
LIG_LIR_Apic_2	476	482	PF02991	0.823
LIG_LIR_Gen_1	216	227	PF02991	0.752
LIG_LIR_Gen_1	238	248	PF02991	0.549
LIG_LIR_Gen_1	344	355	PF02991	0.549
LIG_LIR_Gen_1	368	379	PF02991	0.449
LIG_LIR_Gen_1	453	464	PF02991	0.782
LIG_LIR_Nem_3	169	173	PF02991	0.549
LIG_LIR_Nem_3	216	222	PF02991	0.758
LIG_LIR_Nem_3	238	243	PF02991	0.549
LIG_LIR_Nem_3	344	350	PF02991	0.549
LIG_LIR_Nem_3	368	374	PF02991	0.449
LIG_LIR_Nem_3	409	415	PF02991	0.549
LIG_LIR_Nem_3	439	443	PF02991	0.549
LIG_LIR_Nem_3	453	459	PF02991	0.604
LIG_MLH1_MIPbox_1	371	375	PF16413	0.549
LIG_MLH1_MIPbox_1	409	413	PF16413	0.549
LIG_MYND_1	127	131	PF01753	0.604
LIG_MYND_1	395	399	PF01753	0.781
LIG_NRBOX	104	110	PF00104	0.549
LIG_PALB2_WD40_1	451	459	PF16756	0.733
LIG_Pex14_1	219	223	PF04695	0.754
LIG_Pex14_2	243	247	PF04695	0.549
LIG_Pex14_2	248	252	PF04695	0.462
LIG_Pex14_2	371	375	PF04695	0.549
LIG_Pex14_2	376	380	PF04695	0.462
LIG_Pex14_2	414	418	PF04695	0.549
LIG_Pex14_2	420	424	PF04695	0.624
LIG_REV1ctd_RIR_1	375	385	PF16727	0.549
LIG_SH2_CRK	184	188	PF00017	0.732
LIG_SH2_CRK	352	356	PF00017	0.606
LIG_SH2_NCK_1	58	62	PF00017	0.774
LIG_SH2_STAT5	133	136	PF00017	0.615
LIG_SH2_STAT5	209	212	PF00017	0.782
LIG_SH2_STAT5	249	252	PF00017	0.549
LIG_SH2_STAT5	261	264	PF00017	0.339
LIG_SH2_STAT5	406	409	PF00017	0.549
LIG_SH3_3	118	124	PF00018	0.745
LIG_SH3_3	290	296	PF00018	0.819
LIG_SH3_3	420	426	PF00018	0.730
LIG_SH3_3	80	86	PF00018	0.830
LIG_SUMO_SIM_anti_2	174	180	PF11976	0.549
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.549
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.549
LIG_SUMO_SIM_anti_2	354	359	PF11976	0.413
LIG_SUMO_SIM_par_1	265	271	PF11976	0.549
LIG_SUMO_SIM_par_1	354	361	PF11976	0.600
LIG_SUMO_SIM_par_1	431	439	PF11976	0.449
LIG_TRFH_1	224	228	PF08558	0.549
LIG_TRFH_1	242	246	PF08558	0.234
LIG_TYR_ITIM	350	355	PF00017	0.759
LIG_WRC_WIRS_1	167	172	PF05994	0.549
LIG_WRC_WIRS_1	437	442	PF05994	0.549
LIG_WW_1	130	133	PF00397	0.775
LIG_WW_2	121	124	PF00397	0.750
MOD_CDC14_SPxK_1	481	484	PF00782	0.809
MOD_CDK_SPK_2	13	18	PF00069	0.825
MOD_CDK_SPxK_1	478	484	PF00069	0.801
MOD_CK1_1	198	204	PF00069	0.749
MOD_CK1_1	299	305	PF00069	0.788
MOD_CK1_1	312	318	PF00069	0.556
MOD_CK1_1	363	369	PF00069	0.754
MOD_CK1_1	436	442	PF00069	0.549
MOD_CK1_1	467	473	PF00069	0.749
MOD_CK2_1	13	19	PF00069	0.823
MOD_DYRK1A_RPxSP_1	422	426	PF00069	0.738
MOD_GlcNHglycan	302	305	PF01048	0.791
MOD_GSK3_1	13	20	PF00069	0.819
MOD_GSK3_1	141	148	PF00069	0.811
MOD_GSK3_1	194	201	PF00069	0.751
MOD_GSK3_1	209	216	PF00069	0.469
MOD_GSK3_1	277	284	PF00069	0.786
MOD_GSK3_1	285	292	PF00069	0.642
MOD_GSK3_1	296	303	PF00069	0.456
MOD_GSK3_1	332	339	PF00069	0.549
MOD_GSK3_1	342	349	PF00069	0.375
MOD_GSK3_1	360	367	PF00069	0.445
MOD_GSK3_1	40	47	PF00069	0.758
MOD_GSK3_1	424	431	PF00069	0.720
MOD_GSK3_1	66	73	PF00069	0.800
MOD_LATS_1	193	199	PF00433	0.752
MOD_LATS_1	351	357	PF00433	0.765
MOD_NEK2_1	109	114	PF00069	0.549
MOD_NEK2_1	199	204	PF00069	0.748
MOD_NEK2_1	217	222	PF00069	0.385
MOD_NEK2_1	233	238	PF00069	0.269
MOD_NEK2_1	254	259	PF00069	0.549
MOD_NEK2_1	342	347	PF00069	0.549
MOD_NEK2_1	358	363	PF00069	0.487
MOD_NEK2_1	364	369	PF00069	0.646
MOD_NEK2_1	40	45	PF00069	0.754
MOD_NEK2_1	433	438	PF00069	0.549
MOD_NEK2_1	450	455	PF00069	0.435
MOD_NEK2_1	459	464	PF00069	0.579
MOD_NEK2_1	50	55	PF00069	0.600
MOD_NEK2_1	66	71	PF00069	0.522
MOD_NEK2_2	228	233	PF00069	0.549
MOD_NEK2_2	304	309	PF00069	0.770
MOD_NEK2_2	365	370	PF00069	0.749
MOD_OFUCOSY	447	454	PF10250	0.549
MOD_PIKK_1	152	158	PF00454	0.785
MOD_PIKK_1	297	303	PF00454	0.788
MOD_PIKK_1	358	364	PF00454	0.767
MOD_PKA_2	142	148	PF00069	0.811
MOD_PKA_2	194	200	PF00069	0.753
MOD_PKA_2	369	375	PF00069	0.549
MOD_PKA_2	459	465	PF00069	0.736
MOD_PKA_2	50	56	PF00069	0.773
MOD_PKB_1	23	31	PF00069	0.788
MOD_Plk_4	100	106	PF00069	0.549
MOD_Plk_4	109	115	PF00069	0.392
MOD_Plk_4	166	172	PF00069	0.549
MOD_Plk_4	186	192	PF00069	0.385
MOD_Plk_4	204	210	PF00069	0.426
MOD_Plk_4	213	219	PF00069	0.563
MOD_Plk_4	262	268	PF00069	0.549
MOD_Plk_4	318	324	PF00069	0.762
MOD_Plk_4	342	348	PF00069	0.549
MOD_Plk_4	353	359	PF00069	0.571
MOD_Plk_4	429	435	PF00069	0.706
MOD_ProDKin_1	13	19	PF00069	0.647
MOD_ProDKin_1	209	215	PF00069	0.736
MOD_ProDKin_1	235	241	PF00069	0.549
MOD_ProDKin_1	268	274	PF00069	0.773
MOD_ProDKin_1	285	291	PF00069	0.484
MOD_ProDKin_1	3	9	PF00069	0.818
MOD_ProDKin_1	309	315	PF00069	0.776
MOD_ProDKin_1	332	338	PF00069	0.549
MOD_ProDKin_1	390	396	PF00069	0.728
MOD_ProDKin_1	407	413	PF00069	0.252
MOD_ProDKin_1	422	428	PF00069	0.472
MOD_ProDKin_1	478	484	PF00069	0.801
MOD_ProDKin_1	52	58	PF00069	0.752
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.753
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.786
TRG_ENDOCYTIC_2	249	252	PF00928	0.549
TRG_ENDOCYTIC_2	352	355	PF00928	0.769