Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC62_LEIBR

TriTrypDb:

LbrM.22.0100 , LBRM2903_220006200

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.490
CLV_NRD_NRD_1	93	95	PF00675	0.552
CLV_PCSK_KEX2_1	177	179	PF00082	0.490
CLV_PCSK_KEX2_1	93	95	PF00082	0.577
DEG_Nend_UBRbox_4	1	3	PF02207	0.677
DOC_MAPK_gen_1	177	183	PF00069	0.531
DOC_MAPK_gen_1	93	101	PF00069	0.551
DOC_MAPK_RevD_3	163	178	PF00069	0.539
DOC_PP2B_LxvP_1	234	237	PF13499	0.530
DOC_PP2B_LxvP_1	240	243	PF13499	0.535
DOC_PP4_FxxP_1	167	170	PF00568	0.651
DOC_SPAK_OSR1_1	33	37	PF12202	0.626
DOC_USP7_MATH_1	8	12	PF00917	0.690
DOC_USP7_UBL2_3	137	141	PF12436	0.354
LIG_14-3-3_CanoR_1	177	182	PF00244	0.584
LIG_14-3-3_CanoR_1	211	219	PF00244	0.561
LIG_14-3-3_CanoR_1	33	39	PF00244	0.604
LIG_14-3-3_CanoR_1	41	46	PF00244	0.602
LIG_BRCT_BRCA1_1	30	34	PF00533	0.470
LIG_FHA_1	147	153	PF00498	0.636
LIG_FHA_1	158	164	PF00498	0.612
LIG_FHA_1	229	235	PF00498	0.631
LIG_FHA_1	24	30	PF00498	0.517
LIG_FHA_1	46	52	PF00498	0.462
LIG_FHA_1	74	80	PF00498	0.667
LIG_FHA_2	187	193	PF00498	0.410
LIG_FHA_2	85	91	PF00498	0.473
LIG_LIR_Gen_1	128	136	PF02991	0.483
LIG_LIR_Nem_3	128	132	PF02991	0.464
LIG_LIR_Nem_3	200	206	PF02991	0.562
LIG_SH2_STAP1	179	183	PF00017	0.553
LIG_SH2_STAP1	203	207	PF00017	0.530
LIG_SH2_STAP1	38	42	PF00017	0.606
LIG_SH2_STAT3	117	120	PF00017	0.607
LIG_SH2_STAT3	179	182	PF00017	0.621
LIG_SH2_STAT5	206	209	PF00017	0.553
LIG_SUMO_SIM_anti_2	96	103	PF11976	0.565
LIG_SUMO_SIM_par_1	46	52	PF11976	0.462
LIG_WRC_WIRS_1	198	203	PF05994	0.545
MOD_CK1_1	32	38	PF00069	0.614
MOD_CK1_1	44	50	PF00069	0.723
MOD_CK2_1	84	90	PF00069	0.482
MOD_Cter_Amidation	19	22	PF01082	0.647
MOD_GlcNHglycan	10	13	PF01048	0.475
MOD_GlcNHglycan	102	105	PF01048	0.517
MOD_GSK3_1	146	153	PF00069	0.574
MOD_GSK3_1	197	204	PF00069	0.567
MOD_GSK3_1	23	30	PF00069	0.616
MOD_GSK3_1	37	44	PF00069	0.619
MOD_GSK3_1	51	58	PF00069	0.575
MOD_LATS_1	209	215	PF00433	0.626
MOD_LATS_1	82	88	PF00433	0.425
MOD_N-GLC_1	158	163	PF02516	0.498
MOD_NEK2_1	1	6	PF00069	0.461
MOD_NEK2_1	100	105	PF00069	0.511
MOD_NEK2_1	125	130	PF00069	0.497
MOD_NEK2_1	15	20	PF00069	0.660
MOD_NEK2_1	150	155	PF00069	0.631
MOD_NEK2_1	157	162	PF00069	0.589
MOD_NEK2_1	199	204	PF00069	0.505
MOD_NEK2_1	34	39	PF00069	0.557
MOD_NEK2_1	45	50	PF00069	0.462
MOD_NEK2_2	230	235	PF00069	0.641
MOD_PIKK_1	211	217	PF00454	0.610
MOD_PK_1	177	183	PF00069	0.525
MOD_PK_1	93	99	PF00069	0.605
MOD_PKA_1	177	183	PF00069	0.584
MOD_PKA_1	93	99	PF00069	0.572
MOD_PKA_2	177	183	PF00069	0.584
MOD_PKA_2	32	38	PF00069	0.612
MOD_PKA_2	93	99	PF00069	0.534
MOD_Plk_1	158	164	PF00069	0.507
MOD_Plk_1	73	79	PF00069	0.424
MOD_Plk_2-3	146	152	PF00069	0.572
MOD_Plk_4	1	7	PF00069	0.585
MOD_Plk_4	125	131	PF00069	0.437
MOD_Plk_4	202	208	PF00069	0.552
MOD_Plk_4	230	236	PF00069	0.600
MOD_Plk_4	45	51	PF00069	0.460
MOD_Plk_4	93	99	PF00069	0.370
MOD_SUMO_for_1	80	83	PF00179	0.636
TRG_DiLeu_BaEn_2	73	79	PF01217	0.616
TRG_ER_diArg_1	176	178	PF00400	0.508
TRG_ER_diArg_1	93	95	PF00400	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN5	Leptomonas seymouri	62%	100%
A0A1X0NTR1	Trypanosomatidae	38%	82%
A0A3Q8IC30	Leishmania donovani	76%	100%
A0A3R7LNK0	Trypanosoma rangeli	33%	89%
C9ZSC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	90%
E9AGZ0	Leishmania infantum	75%	100%
E9AVJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QBY4	Leishmania major	76%	100%
V5BFS1	Trypanosoma cruzi	30%	87%