LeishMANIAdb
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Putative heat shock protein DNAJ

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative heat shock protein DNAJ
Gene product:
heat shock protein DNAJ, putative
Species:
Leishmania braziliensis
UniProt:
A4HC61_LEIBR
TriTrypDb:
LbrM.22.0080 , LBRM2903_220006000 *
Length:
248

Annotations

LeishMANIAdb annotations

An extensive family in kinetoplastids, these chaperone proteins are likely also involved in the folding of secreted proteins as well.. This group contains both cytoplasmic and secreted (likely ER) proteins.. Localization: Cytoplasmic (by homology) / ER (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 13
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HC61
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC61

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 15
GO:0009987 cellular process 1 15
GO:0042026 protein refolding 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 15
GO:0005515 protein binding 2 15
GO:0030544 Hsp70 protein binding 4 15
GO:0031072 heat shock protein binding 3 15
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13
GO:0051082 unfolded protein binding 3 15
GO:0051087 protein-folding chaperone binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 130 134 PF00656 0.352
CLV_PCSK_SKI1_1 193 197 PF00082 0.455
DEG_APCC_DBOX_1 217 225 PF00400 0.444
DEG_Kelch_Keap1_1 207 212 PF01344 0.405
DEG_Nend_UBRbox_4 1 3 PF02207 0.151
DOC_MAPK_MEF2A_6 168 176 PF00069 0.299
DOC_PP1_RVXF_1 70 76 PF00149 0.358
DOC_PP2B_LxvP_1 196 199 PF13499 0.458
DOC_WW_Pin1_4 237 242 PF00397 0.453
LIG_14-3-3_CanoR_1 113 119 PF00244 0.313
LIG_14-3-3_CanoR_1 70 76 PF00244 0.425
LIG_FHA_1 208 214 PF00498 0.622
LIG_FHA_1 50 56 PF00498 0.452
LIG_FHA_2 102 108 PF00498 0.367
LIG_FHA_2 128 134 PF00498 0.331
LIG_FHA_2 177 183 PF00498 0.164
LIG_FHA_2 203 209 PF00498 0.598
LIG_FHA_2 215 221 PF00498 0.481
LIG_LIR_LC3C_4 136 139 PF02991 0.409
LIG_LIR_Nem_3 167 172 PF02991 0.312
LIG_Pex14_2 125 129 PF04695 0.317
LIG_SH2_STAT5 215 218 PF00017 0.481
LIG_SH3_3 175 181 PF00018 0.247
LIG_SUMO_SIM_anti_2 219 227 PF11976 0.570
LIG_SUMO_SIM_par_1 51 56 PF11976 0.349
LIG_TRAF2_1 206 209 PF00917 0.546
LIG_TRAF2_1 79 82 PF00917 0.409
MOD_CK1_1 45 51 PF00069 0.425
MOD_CK2_1 114 120 PF00069 0.275
MOD_CK2_1 202 208 PF00069 0.527
MOD_CK2_1 219 225 PF00069 0.519
MOD_GlcNHglycan 185 188 PF01048 0.393
MOD_GlcNHglycan 33 36 PF01048 0.271
MOD_GlcNHglycan 47 50 PF01048 0.206
MOD_GlcNHglycan 7 10 PF01048 0.317
MOD_GSK3_1 198 205 PF00069 0.552
MOD_GSK3_1 45 52 PF00069 0.481
MOD_N-GLC_1 237 242 PF02516 0.453
MOD_N-GLC_1 49 54 PF02516 0.269
MOD_N-GLC_2 42 44 PF02516 0.294
MOD_NEK2_1 127 132 PF00069 0.338
MOD_NEK2_1 176 181 PF00069 0.287
MOD_PKA_2 142 148 PF00069 0.411
MOD_PKA_2 202 208 PF00069 0.657
MOD_PKA_2 42 48 PF00069 0.459
MOD_PKA_2 5 11 PF00069 0.503
MOD_PKA_2 71 77 PF00069 0.444
MOD_Plk_1 176 182 PF00069 0.268
MOD_Plk_1 219 225 PF00069 0.552
MOD_Plk_1 49 55 PF00069 0.520
MOD_Plk_2-3 219 225 PF00069 0.513
MOD_Plk_4 219 225 PF00069 0.542
MOD_ProDKin_1 237 243 PF00069 0.455
TRG_ER_diArg_1 40 43 PF00400 0.507
TRG_ER_diArg_1 70 73 PF00400 0.332
TRG_NES_CRM1_1 16 29 PF08389 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0E7 Leptomonas seymouri 72% 69%
A0A0S4JDP6 Bodo saltans 33% 68%
A0A0S4JDS8 Bodo saltans 35% 67%
A0A0S4JJ93 Bodo saltans 51% 74%
A0A1X0NTD2 Trypanosomatidae 52% 78%
A0A3Q8IC51 Leishmania donovani 88% 75%
A0A422N4Q4 Trypanosoma rangeli 51% 77%
A0A422P326 Trypanosoma rangeli 31% 73%
A1K4C4 Azoarcus sp. (strain BH72) 29% 66%
A1KR91 Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18) 31% 66%
A1U613 Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8) 31% 66%
A3MA88 Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) 30% 67%
A4IX29 Francisella tularensis subsp. tularensis (strain WY96-3418) 30% 67%
A4XYF5 Pseudomonas mendocina (strain ymp) 30% 66%
A5CX57 Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA) 27% 68%
A5EYE5 Dichelobacter nodosus (strain VCS1703A) 28% 66%
A5W9A2 Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) 30% 66%
A6UEY1 Sinorhizobium medicae (strain WSM419) 31% 66%
A7I2G3 Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) 26% 69%
A7Z6W0 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) 26% 66%
A8EXP6 Rickettsia canadensis (strain McKiel) 25% 66%
A8G9K9 Serratia proteamaculans (strain 568) 31% 66%
A8GMF8 Rickettsia akari (strain Hartford) 25% 67%
A8GR21 Rickettsia rickettsii (strain Sheila Smith) 24% 66%
A9HEA1 Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) 27% 66%
A9IGC5 Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) 28% 66%
A9LZV9 Neisseria meningitidis serogroup C (strain 053442) 31% 66%
A9MR76 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 32% 66%
B0BWH0 Rickettsia rickettsii (strain Iowa) 24% 66%
B0CAZ0 Acaryochloris marina (strain MBIC 11017) 26% 66%
B0JW23 Microcystis aeruginosa (strain NIES-843 / IAM M-2473) 24% 66%
B0KIS4 Pseudomonas putida (strain GB-1) 30% 66%
B0SHT0 Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames) 24% 66%
B0SRF0 Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris) 24% 66%
B0TYF3 Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 / O#319-036) 29% 66%
B0U3J7 Xylella fastidiosa (strain M12) 29% 67%
B0UWR3 Histophilus somni (strain 2336) 27% 66%
B0VA24 Acinetobacter baumannii (strain AYE) 30% 67%
B0VQ00 Acinetobacter baumannii (strain SDF) 30% 67%
B1HUD0 Lysinibacillus sphaericus (strain C3-41) 25% 67%
B1J255 Pseudomonas putida (strain W619) 30% 66%
B2I2G6 Acinetobacter baumannii (strain ACICU) 30% 67%
B2I6F5 Xylella fastidiosa (strain M23) 29% 67%
B2IBR5 Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB 8712) 31% 67%
B3CP03 Wolbachia pipientis subsp. Culex pipiens (strain wPip) 25% 67%
B3PXH2 Rhizobium etli (strain CIAT 652) 28% 66%
B5BLH9 Salmonella paratyphi A (strain AKU_12601) 31% 66%
B7GV08 Acinetobacter baumannii (strain AB307-0294) 30% 67%
B7I2B2 Acinetobacter baumannii (strain AB0057) 30% 67%
B7KEJ8 Gloeothece citriformis (strain PCC 7424) 25% 66%
B8CXL0 Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) 26% 66%
B9KFK6 Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060) 26% 66%
C0R562 Wolbachia sp. subsp. Drosophila simulans (strain wRi) 25% 67%
C0ZB49 Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) 24% 66%
C3K274 Pseudomonas fluorescens (strain SBW25) 32% 66%
C3PMM6 Rickettsia africae (strain ESF-5) 24% 66%
C4K111 Rickettsia peacockii (strain Rustic) 24% 66%
C4L424 Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b) 28% 67%
C4Z1J3 Lachnospira eligens (strain ATCC 27750 / DSM 3376 / VPI C15-48 / C15-B4) 24% 66%
C6BYN5 Maridesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIMB 8403 / VKM B-1763) 26% 66%
C9ZJL3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 73%
C9ZSC3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 77%
E9AGY8 Leishmania infantum 87% 75%
E9AVJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 76%
O06431 Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298) 26% 67%
O25890 Helicobacter pylori (strain ATCC 700392 / 26695) 28% 67%
O67623 Aquifex aeolicus (strain VF5) 26% 68%
O69269 Lysinibacillus sphaericus 25% 67%
P28616 Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) 24% 68%
P48207 Francisella tularensis 30% 67%
P59910 Homo sapiens 28% 78%
P61440 Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) 27% 67%
P61441 Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) 27% 67%
P63968 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) 31% 66%
P63969 Neisseria meningitidis serogroup B (strain MC58) 31% 66%
P77866 Aggregatibacter actinomycetemcomitans 27% 66%
Q04VC7 Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197) 26% 67%
Q04Y48 Leptospira borgpetersenii serovar Hardjo-bovis (strain L550) 26% 67%
Q0I3V1 Haemophilus somnus (strain 129Pt) 27% 66%
Q11KJ5 Chelativorans sp. (strain BNC1) 34% 66%
Q14GX0 Francisella tularensis subsp. tularensis (strain FSC 198) 30% 66%
Q1H3B9 Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) 28% 66%
Q1IF58 Pseudomonas entomophila (strain L48) 31% 66%
Q1MN12 Rhizobium leguminosarum bv. viciae (strain 3841) 28% 66%
Q2A327 Francisella tularensis subsp. holarctica (strain LVS) 30% 67%
Q2KDW7 Rhizobium etli (strain CFN 42 / ATCC 51251) 28% 66%
Q2KWA4 Bordetella avium (strain 197N) 29% 66%
Q2NVZ0 Sodalis glossinidius (strain morsitans) 33% 66%
Q2SMM7 Hahella chejuensis (strain KCTC 2396) 29% 66%
Q316U7 Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20) 33% 66%
Q3SIN3 Thiobacillus denitrificans (strain ATCC 25259) 30% 67%
Q493S6 Blochmannia pennsylvanicus (strain BPEN) 28% 66%
Q4FVQ7 Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4) 28% 66%
Q4QBY6 Leishmania major 86% 100%
Q4UJK6 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 25% 67%
Q5F5M1 Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) 32% 66%
Q5GRK1 Wolbachia sp. subsp. Brugia malayi (strain TRS) 25% 66%
Q5HNW7 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 26% 66%
Q5NFG8 Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) 30% 66%
Q5NPS5 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) 29% 66%
Q5PDJ4 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 31% 66%
Q65H55 Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) 25% 66%
Q661A4 Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi) 26% 68%
Q6AEC0 Leifsonia xyli subsp. xyli (strain CTCB07) 25% 67%
Q6F150 Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) 23% 66%
Q6F6R1 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) 30% 67%
Q6L0S6 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) 27% 69%
Q6MNG0 Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100) 28% 67%
Q6NG14 Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) 27% 66%
Q73IV4 Wolbachia pipientis wMel 25% 67%
Q74H58 Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) 27% 66%
Q75VW3 Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) 26% 70%
Q7M9T3 Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) 29% 66%
Q7N8Y3 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 28% 67%
Q7NXI1 Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) 28% 66%
Q80Y75 Mus musculus 27% 78%
Q83MZ4 Tropheryma whipplei (strain Twist) 31% 71%
Q83NI2 Tropheryma whipplei (strain TW08/27) 31% 71%
Q87BS9 Xylella fastidiosa (strain Temecula1 / ATCC 700964) 29% 67%
Q88DU3 Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) 30% 66%
Q892R1 Clostridium tetani (strain Massachusetts / E88) 27% 66%
Q8CP18 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 26% 66%
Q8CXD3 Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831) 26% 66%
Q8DKR7 Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1) 26% 66%
Q8MPX3 Caenorhabditis elegans 28% 70%
Q92J37 Rickettsia conorii (strain ATCC VR-613 / Malish 7) 24% 66%
Q93S23 Rhizobium tropici 30% 75%
Q97BG9 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 29% 68%
Q9CMS2 Pasteurella multocida (strain Pm70) 28% 67%
Q9D832 Mus musculus 30% 74%
Q9HJ83 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 29% 68%
Q9KD71 Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 26% 67%
Q9LCQ4 Brevibacillus choshinensis 24% 66%
Q9LZK5 Arabidopsis thaliana 35% 72%
Q9PB06 Xylella fastidiosa (strain 9a5c) 31% 67%
Q9ZDY0 Rickettsia prowazekii (strain Madrid E) 24% 67%
Q9ZJQ2 Helicobacter pylori (strain J99 / ATCC 700824) 28% 67%
V5AVT4 Trypanosoma cruzi 52% 69%
V5BQX2 Trypanosoma cruzi 34% 96%
V5C2Y5 Trypanosoma cruzi 30% 72%
V5DH06 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS