DNA repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA repair protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC59_LEIBR

TriTrypDb:

LbrM.22.0070 , LBRM2903_220005900

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:0000109	nucleotide-excision repair complex	3	1
GO:0000110	nucleotide-excision repair factor 1 complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070522	ERCC4-ERCC1 complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HC59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC59

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000710	meiotic mismatch repair	4	1
GO:0006296	obsolete nucleotide-excision repair, DNA incision, 5'-to lesion	7	1
GO:0006298	mismatch repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0009314	response to radiation	3	1
GO:0009411	response to UV	5	1
GO:0009416	response to light stimulus	4	1
GO:0009628	response to abiotic stimulus	2	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0033683	obsolete nucleotide-excision repair, DNA incision	6	1
GO:0034644	cellular response to UV	6	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0070914	UV-damage excision repair	6	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071478	cellular response to radiation	4	1
GO:0071482	cellular response to light stimulus	5	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0104004	cellular response to environmental stimulus	3	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003684	damaged DNA binding	5	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.312
CLV_NRD_NRD_1	175	177	PF00675	0.546
CLV_NRD_NRD_1	24	26	PF00675	0.632
CLV_NRD_NRD_1	270	272	PF00675	0.679
CLV_NRD_NRD_1	279	281	PF00675	0.602
CLV_PCSK_FUR_1	22	26	PF00082	0.628
CLV_PCSK_KEX2_1	24	26	PF00082	0.632
CLV_PCSK_KEX2_1	269	271	PF00082	0.689
CLV_PCSK_KEX2_1	278	280	PF00082	0.608
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.478
CLV_PCSK_SKI1_1	200	204	PF00082	0.358
CLV_PCSK_SKI1_1	271	275	PF00082	0.531
DEG_SCF_FBW7_1	208	215	PF00400	0.649
DOC_CKS1_1	209	214	PF01111	0.644
DOC_MAPK_gen_1	22	31	PF00069	0.606
DOC_MAPK_MEF2A_6	22	31	PF00069	0.606
DOC_MAPK_MEF2A_6	59	68	PF00069	0.611
DOC_MAPK_MEF2A_6	74	83	PF00069	0.285
DOC_PP4_FxxP_1	209	212	PF00568	0.559
DOC_USP7_MATH_1	132	136	PF00917	0.597
DOC_USP7_MATH_1	227	231	PF00917	0.586
DOC_USP7_MATH_1	233	237	PF00917	0.637
DOC_USP7_MATH_1	238	242	PF00917	0.735
DOC_USP7_MATH_2	93	99	PF00917	0.339
DOC_WW_Pin1_4	158	163	PF00397	0.537
DOC_WW_Pin1_4	208	213	PF00397	0.638
LIG_14-3-3_CanoR_1	176	184	PF00244	0.553
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_BRCT_BRCA1_1	134	138	PF00533	0.633
LIG_FHA_1	1	7	PF00498	0.530
LIG_FHA_1	159	165	PF00498	0.494
LIG_FHA_1	16	22	PF00498	0.395
LIG_FHA_1	209	215	PF00498	0.581
LIG_FHA_1	253	259	PF00498	0.811
LIG_FHA_1	75	81	PF00498	0.550
LIG_FHA_2	132	138	PF00498	0.609
LIG_FHA_2	164	170	PF00498	0.469
LIG_LIR_Gen_1	46	57	PF02991	0.493
LIG_LIR_Gen_1	96	107	PF02991	0.492
LIG_LIR_Nem_3	189	194	PF02991	0.515
LIG_LIR_Nem_3	46	52	PF02991	0.395
LIG_LIR_Nem_3	96	102	PF02991	0.453
LIG_Pex14_2	209	213	PF04695	0.569
LIG_SH2_STAT5	124	127	PF00017	0.476
LIG_SH2_STAT5	49	52	PF00017	0.550
LIG_SUMO_SIM_par_1	111	117	PF11976	0.557
LIG_SUMO_SIM_par_1	2	10	PF11976	0.558
LIG_TYR_ITIM	47	52	PF00017	0.332
LIG_WRC_WIRS_1	220	225	PF05994	0.657
MOD_CK1_1	131	137	PF00069	0.574
MOD_CK1_1	186	192	PF00069	0.538
MOD_CK1_1	231	237	PF00069	0.749
MOD_CK1_1	241	247	PF00069	0.676
MOD_CK2_1	131	137	PF00069	0.591
MOD_CK2_1	219	225	PF00069	0.601
MOD_CK2_1	243	249	PF00069	0.690
MOD_CK2_1	85	91	PF00069	0.620
MOD_Cter_Amidation	267	270	PF01082	0.725
MOD_GlcNHglycan	130	133	PF01048	0.485
MOD_GlcNHglycan	137	141	PF01048	0.582
MOD_GlcNHglycan	18	21	PF01048	0.308
MOD_GlcNHglycan	53	56	PF01048	0.560
MOD_GSK3_1	124	131	PF00069	0.446
MOD_GSK3_1	132	139	PF00069	0.561
MOD_GSK3_1	208	215	PF00069	0.541
MOD_GSK3_1	227	234	PF00069	0.675
MOD_GSK3_1	259	266	PF00069	0.606
MOD_LATS_1	217	223	PF00433	0.474
MOD_N-GLC_1	241	246	PF02516	0.572
MOD_NEK2_1	114	119	PF00069	0.458
MOD_NEK2_1	128	133	PF00069	0.449
MOD_NEK2_1	136	141	PF00069	0.615
MOD_NEK2_1	213	218	PF00069	0.559
MOD_NEK2_1	232	237	PF00069	0.695
MOD_NEK2_1	243	248	PF00069	0.576
MOD_PIKK_1	156	162	PF00454	0.501
MOD_PIKK_1	241	247	PF00454	0.676
MOD_PIKK_1	74	80	PF00454	0.597
MOD_PKA_1	200	206	PF00069	0.349
MOD_PKA_2	175	181	PF00069	0.621
MOD_PKB_1	72	80	PF00069	0.549
MOD_Plk_1	228	234	PF00069	0.724
MOD_Plk_4	219	225	PF00069	0.694
MOD_Plk_4	43	49	PF00069	0.538
MOD_Plk_4	95	101	PF00069	0.501
MOD_ProDKin_1	158	164	PF00069	0.531
MOD_ProDKin_1	208	214	PF00069	0.642
TRG_ENDOCYTIC_2	49	52	PF00928	0.466
TRG_ER_diArg_1	143	146	PF00400	0.530
TRG_ER_diArg_1	21	24	PF00400	0.532
TRG_ER_diArg_1	270	272	PF00400	0.673
TRG_ER_diArg_1	278	280	PF00400	0.610
TRG_NES_CRM1_1	85	95	PF08389	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V1	Leptomonas seymouri	62%	100%
A0A3Q8IC77	Leishmania donovani	76%	100%
C9ZSC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AGY7	Leishmania infantum	77%	73%
E9AVJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QBY7	Leishmania major	78%	100%