Transcription factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription factor-like protein

Species:

Leishmania braziliensis

UniProt:

A4HC58_LEIBR

TriTrypDb:

LbrM.22.0060 , LBRM2903_220005800

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	23
GO:0043226	organelle	2	23
GO:0043227	membrane-bounded organelle	3	23
GO:0043229	intracellular organelle	3	23
GO:0043231	intracellular membrane-bounded organelle	4	23
GO:0110165	cellular anatomical entity	1	23
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HC58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC58

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003700	DNA-binding transcription factor activity	2	23
GO:0005488	binding	1	23
GO:0008270	zinc ion binding	6	23
GO:0043167	ion binding	2	23
GO:0043169	cation binding	3	23
GO:0046872	metal ion binding	4	23
GO:0046914	transition metal ion binding	5	23
GO:0097159	organic cyclic compound binding	2	13
GO:0140110	transcription regulator activity	1	23
GO:1901363	heterocyclic compound binding	2	13
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1
GO:0000976	transcription cis-regulatory region binding	5	2
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	6	2
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	3	2
GO:0001067	transcription regulatory region nucleic acid binding	4	2
GO:0003677	DNA binding	4	2
GO:0003690	double-stranded DNA binding	5	2
GO:0043565	sequence-specific DNA binding	5	2
GO:1990837	sequence-specific double-stranded DNA binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.360
CLV_NRD_NRD_1	163	165	PF00675	0.565
CLV_NRD_NRD_1	19	21	PF00675	0.382
CLV_NRD_NRD_1	307	309	PF00675	0.499
CLV_NRD_NRD_1	310	312	PF00675	0.495
CLV_NRD_NRD_1	445	447	PF00675	0.544
CLV_NRD_NRD_1	54	56	PF00675	0.473
CLV_NRD_NRD_1	548	550	PF00675	0.500
CLV_NRD_NRD_1	571	573	PF00675	0.514
CLV_PCSK_KEX2_1	163	165	PF00082	0.524
CLV_PCSK_KEX2_1	19	21	PF00082	0.485
CLV_PCSK_KEX2_1	312	314	PF00082	0.466
CLV_PCSK_KEX2_1	445	447	PF00082	0.469
CLV_PCSK_KEX2_1	54	56	PF00082	0.438
CLV_PCSK_KEX2_1	548	550	PF00082	0.635
CLV_PCSK_KEX2_1	571	573	PF00082	0.526
CLV_PCSK_KEX2_1	747	749	PF00082	0.438
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.488
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.635
CLV_PCSK_PC1ET2_1	747	749	PF00082	0.459
CLV_PCSK_PC7_1	308	314	PF00082	0.521
CLV_PCSK_SKI1_1	164	168	PF00082	0.256
CLV_PCSK_SKI1_1	510	514	PF00082	0.350
CLV_PCSK_SKI1_1	737	741	PF00082	0.329
CLV_PCSK_SKI1_1	77	81	PF00082	0.502
DOC_CKS1_1	96	101	PF01111	0.477
DOC_MAPK_gen_1	583	593	PF00069	0.521
DOC_MAPK_gen_1	606	614	PF00069	0.543
DOC_MAPK_gen_1	696	703	PF00069	0.517
DOC_MAPK_MEF2A_6	696	703	PF00069	0.517
DOC_MAPK_NFAT4_5	696	704	PF00069	0.381
DOC_MAPK_RevD_3	557	572	PF00069	0.424
DOC_PP2B_LxvP_1	401	404	PF13499	0.398
DOC_PP4_FxxP_1	66	69	PF00568	0.356
DOC_SPAK_OSR1_1	723	727	PF12202	0.490
DOC_USP7_MATH_1	483	487	PF00917	0.347
DOC_USP7_MATH_1	653	657	PF00917	0.492
DOC_USP7_MATH_1	691	695	PF00917	0.569
DOC_USP7_MATH_1	758	762	PF00917	0.395
DOC_USP7_UBL2_3	692	696	PF12436	0.562
DOC_WW_Pin1_4	516	521	PF00397	0.550
DOC_WW_Pin1_4	95	100	PF00397	0.373
LIG_14-3-3_CanoR_1	110	118	PF00244	0.522
LIG_14-3-3_CanoR_1	260	266	PF00244	0.414
LIG_14-3-3_CanoR_1	347	356	PF00244	0.549
LIG_14-3-3_CanoR_1	445	449	PF00244	0.455
LIG_14-3-3_CanoR_1	450	456	PF00244	0.455
LIG_14-3-3_CanoR_1	529	537	PF00244	0.545
LIG_14-3-3_CterR_2	769	772	PF00244	0.440
LIG_Actin_WH2_2	208	223	PF00022	0.267
LIG_APCC_ABBA_1	642	647	PF00400	0.437
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_BIR_III_1	1	5	PF00653	0.429
LIG_BIR_III_3	1	5	PF00653	0.555
LIG_BRCT_BRCA1_1	318	322	PF00533	0.440
LIG_BRCT_BRCA1_1	583	587	PF00533	0.317
LIG_EH1_1	705	713	PF00400	0.252
LIG_FHA_1	170	176	PF00498	0.535
LIG_FHA_1	224	230	PF00498	0.534
LIG_FHA_1	262	268	PF00498	0.462
LIG_FHA_1	387	393	PF00498	0.516
LIG_FHA_1	536	542	PF00498	0.540
LIG_FHA_1	568	574	PF00498	0.431
LIG_FHA_1	629	635	PF00498	0.554
LIG_FHA_2	260	266	PF00498	0.270
LIG_FHA_2	368	374	PF00498	0.519
LIG_FHA_2	580	586	PF00498	0.613
LIG_LIR_Apic_2	143	148	PF02991	0.514
LIG_LIR_Apic_2	21	26	PF02991	0.446
LIG_LIR_Apic_2	63	69	PF02991	0.388
LIG_NRBOX	712	718	PF00104	0.341
LIG_Pex14_2	739	743	PF04695	0.493
LIG_SH2_CRK	145	149	PF00017	0.513
LIG_SH2_CRK	93	97	PF00017	0.381
LIG_SH2_NCK_1	23	27	PF00017	0.362
LIG_SH2_STAP1	589	593	PF00017	0.413
LIG_SH2_STAT5	145	148	PF00017	0.405
LIG_SH2_STAT5	194	197	PF00017	0.475
LIG_SH2_STAT5	395	398	PF00017	0.477
LIG_SH2_STAT5	527	530	PF00017	0.400
LIG_SH2_STAT5	641	644	PF00017	0.508
LIG_SH3_3	178	184	PF00018	0.487
LIG_SH3_3	234	240	PF00018	0.446
LIG_SH3_3	397	403	PF00018	0.408
LIG_SH3_3	433	439	PF00018	0.532
LIG_SH3_3	517	523	PF00018	0.516
LIG_SH3_3	556	562	PF00018	0.442
LIG_SH3_3	619	625	PF00018	0.517
LIG_SH3_3	722	728	PF00018	0.499
LIG_SH3_3	85	91	PF00018	0.340
LIG_SH3_4	692	699	PF00018	0.558
LIG_SH3_CIN85_PxpxPR_1	123	128	PF14604	0.489
LIG_SUMO_SIM_par_1	668	674	PF11976	0.526
LIG_TRAF2_1	465	468	PF00917	0.391
LIG_UBA3_1	188	197	PF00899	0.268
MOD_CK1_1	245	251	PF00069	0.516
MOD_CK1_1	620	626	PF00069	0.400
MOD_CK1_1	715	721	PF00069	0.543
MOD_CK2_1	24	30	PF00069	0.465
MOD_CK2_1	251	257	PF00069	0.550
MOD_CK2_1	579	585	PF00069	0.590
MOD_Cter_Amidation	546	549	PF01082	0.467
MOD_GlcNHglycan	377	380	PF01048	0.158
MOD_GlcNHglycan	485	488	PF01048	0.424
MOD_GlcNHglycan	600	604	PF01048	0.466
MOD_GlcNHglycan	7	13	PF01048	0.494
MOD_GlcNHglycan	703	706	PF01048	0.242
MOD_GSK3_1	183	190	PF00069	0.461
MOD_GSK3_1	202	209	PF00069	0.298
MOD_GSK3_1	238	245	PF00069	0.426
MOD_GSK3_1	251	258	PF00069	0.392
MOD_GSK3_1	312	319	PF00069	0.486
MOD_GSK3_1	347	354	PF00069	0.555
MOD_GSK3_1	386	393	PF00069	0.518
MOD_GSK3_1	575	582	PF00069	0.541
MOD_GSK3_1	60	67	PF00069	0.425
MOD_GSK3_1	653	660	PF00069	0.299
MOD_N-GLC_1	320	325	PF02516	0.546
MOD_N-GLC_1	347	352	PF02516	0.583
MOD_N-GLC_1	451	456	PF02516	0.399
MOD_N-GLC_1	617	622	PF02516	0.258
MOD_NEK2_1	211	216	PF00069	0.344
MOD_NEK2_1	528	533	PF00069	0.402
MOD_NEK2_1	579	584	PF00069	0.619
MOD_NEK2_1	587	592	PF00069	0.478
MOD_NEK2_1	634	639	PF00069	0.326
MOD_NEK2_1	659	664	PF00069	0.482
MOD_NEK2_1	701	706	PF00069	0.532
MOD_NEK2_1	712	717	PF00069	0.235
MOD_NEK2_1	756	761	PF00069	0.538
MOD_NEK2_2	216	221	PF00069	0.486
MOD_NEK2_2	285	290	PF00069	0.396
MOD_NEK2_2	37	42	PF00069	0.453
MOD_OFUCOSY	162	168	PF10250	0.430
MOD_OFUCOSY	222	227	PF10250	0.339
MOD_OFUCOSY	274	280	PF10250	0.451
MOD_OFUCOSY	328	334	PF10250	0.378
MOD_OGLYCOS	484	489	PF02709	0.424
MOD_PIKK_1	196	202	PF00454	0.367
MOD_PIKK_1	316	322	PF00454	0.421
MOD_PIKK_1	347	353	PF00454	0.410
MOD_PIKK_1	406	412	PF00454	0.519
MOD_PIKK_1	758	764	PF00454	0.552
MOD_PKA_1	312	318	PF00069	0.374
MOD_PKA_2	259	265	PF00069	0.396
MOD_PKA_2	312	318	PF00069	0.491
MOD_PKA_2	444	450	PF00069	0.497
MOD_PKA_2	528	534	PF00069	0.492
MOD_PKA_2	535	541	PF00069	0.351
MOD_PKA_2	60	66	PF00069	0.495
MOD_Plk_1	206	212	PF00069	0.341
MOD_Plk_1	451	457	PF00069	0.459
MOD_Plk_1	599	605	PF00069	0.518
MOD_Plk_1	617	623	PF00069	0.131
MOD_Plk_4	187	193	PF00069	0.488
MOD_Plk_4	206	212	PF00069	0.289
MOD_Plk_4	225	231	PF00069	0.390
MOD_Plk_4	451	457	PF00069	0.424
MOD_Plk_4	522	528	PF00069	0.424
MOD_Plk_4	587	593	PF00069	0.410
MOD_Plk_4	60	66	PF00069	0.404
MOD_Plk_4	617	623	PF00069	0.369
MOD_Plk_4	712	718	PF00069	0.496
MOD_ProDKin_1	516	522	PF00069	0.443
MOD_ProDKin_1	95	101	PF00069	0.367
TRG_DiLeu_BaEn_1	187	192	PF01217	0.511
TRG_DiLeu_BaEn_1	630	635	PF01217	0.158
TRG_ENDOCYTIC_2	589	592	PF00928	0.443
TRG_ENDOCYTIC_2	641	644	PF00928	0.312
TRG_ENDOCYTIC_2	93	96	PF00928	0.441
TRG_ER_diArg_1	108	111	PF00400	0.327
TRG_ER_diArg_1	163	165	PF00400	0.384
TRG_ER_diArg_1	18	20	PF00400	0.519
TRG_ER_diArg_1	310	313	PF00400	0.500
TRG_ER_diArg_1	444	446	PF00400	0.257
TRG_ER_diArg_1	53	55	PF00400	0.463
TRG_ER_diArg_1	571	573	PF00400	0.541
TRG_NLS_MonoExtC_3	307	312	PF00514	0.518
TRG_NLS_MonoExtN_4	306	312	PF00514	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT0	Leptomonas seymouri	66%	100%
A0A0N1I9N1	Leptomonas seymouri	35%	100%
A0A0S4INQ1	Bodo saltans	36%	100%
A0A0S4JJN5	Bodo saltans	42%	84%
A0A1X0NUI9	Trypanosomatidae	44%	96%
A0A1X0NZM6	Trypanosomatidae	36%	100%
A0A3R7M581	Trypanosoma rangeli	37%	100%
A0A3R7MD54	Trypanosoma rangeli	45%	94%
A0A3S5H7A4	Leishmania donovani	87%	100%
A0A3S7X2B6	Leishmania donovani	35%	100%
A0JMY5	Xenopus laevis	33%	84%
A4HH68	Leishmania braziliensis	35%	100%
A4I4B2	Leishmania infantum	35%	100%
A6QLA0	Bos taurus	34%	69%
B1AY10	Mus musculus	34%	69%
C9ZKS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZSC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	96%
E9ADR2	Leishmania major	36%	100%
E9AGY6	Leishmania infantum	87%	100%
E9AM18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AVJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O74853	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	72%
P40798	Drosophila melanogaster	35%	70%
P53971	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	80%
Q12986	Homo sapiens	34%	69%
Q18034	Caenorhabditis elegans	35%	69%
Q4QBY8	Leishmania major	87%	100%
Q6ZNB6	Homo sapiens	34%	85%
Q9FFK8	Arabidopsis thaliana	32%	87%
V5BFS7	Trypanosoma cruzi	44%	94%
V5BUH3	Trypanosoma cruzi	37%	100%