Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC57_LEIBR

TriTrypDb:

LbrM.22.0050 , LBRM2903_220005700

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.614
CLV_NRD_NRD_1	261	263	PF00675	0.610
CLV_NRD_NRD_1	271	273	PF00675	0.540
CLV_NRD_NRD_1	311	313	PF00675	0.431
CLV_NRD_NRD_1	336	338	PF00675	0.583
CLV_NRD_NRD_1	420	422	PF00675	0.587
CLV_PCSK_KEX2_1	216	218	PF00082	0.538
CLV_PCSK_KEX2_1	231	233	PF00082	0.576
CLV_PCSK_KEX2_1	261	263	PF00082	0.568
CLV_PCSK_KEX2_1	311	313	PF00082	0.431
CLV_PCSK_KEX2_1	336	338	PF00082	0.583
CLV_PCSK_KEX2_1	354	356	PF00082	0.602
CLV_PCSK_KEX2_1	420	422	PF00082	0.679
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.388
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.608
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.550
CLV_PCSK_SKI1_1	420	424	PF00082	0.741
CLV_PCSK_SKI1_1	434	438	PF00082	0.565
CLV_PCSK_SKI1_1	456	460	PF00082	0.554
CLV_PCSK_SKI1_1	73	77	PF00082	0.515
CLV_Separin_Metazoa	165	169	PF03568	0.430
CLV_Separin_Metazoa	253	257	PF03568	0.467
CLV_Separin_Metazoa	281	285	PF03568	0.389
DEG_APCC_DBOX_1	402	410	PF00400	0.668
DEG_SPOP_SBC_1	5	9	PF00917	0.702
DOC_MAPK_gen_1	216	223	PF00069	0.328
DOC_MAPK_MEF2A_6	216	225	PF00069	0.326
DOC_PP4_MxPP_1	1	4	PF00568	0.628
LIG_14-3-3_CanoR_1	122	131	PF00244	0.562
LIG_14-3-3_CanoR_1	171	175	PF00244	0.521
LIG_14-3-3_CanoR_1	29	34	PF00244	0.615
LIG_14-3-3_CanoR_1	38	44	PF00244	0.509
LIG_14-3-3_CanoR_1	420	428	PF00244	0.581
LIG_14-3-3_CanoR_1	456	462	PF00244	0.584
LIG_14-3-3_CanoR_1	73	83	PF00244	0.492
LIG_14-3-3_CanoR_1	94	100	PF00244	0.428
LIG_Actin_WH2_2	222	239	PF00022	0.520
LIG_Actin_WH2_2	331	348	PF00022	0.576
LIG_Actin_WH2_2	79	96	PF00022	0.541
LIG_BRCT_BRCA1_1	367	371	PF00533	0.540
LIG_CaM_IQ_9	74	90	PF13499	0.412
LIG_Clathr_ClatBox_1	111	115	PF01394	0.413
LIG_CtBP_PxDLS_1	429	434	PF00389	0.455
LIG_deltaCOP1_diTrp_1	27	33	PF00928	0.602
LIG_DLG_GKlike_1	217	225	PF00625	0.446
LIG_EH1_1	105	113	PF00400	0.459
LIG_FHA_1	151	157	PF00498	0.434
LIG_FHA_1	18	24	PF00498	0.742
LIG_FHA_1	213	219	PF00498	0.379
LIG_FHA_2	237	243	PF00498	0.400
LIG_FHA_2	302	308	PF00498	0.557
LIG_LIR_Gen_1	250	257	PF02991	0.497
LIG_LIR_Gen_1	27	36	PF02991	0.520
LIG_LIR_LC3C_4	109	113	PF02991	0.337
LIG_LIR_Nem_3	190	195	PF02991	0.460
LIG_LIR_Nem_3	250	254	PF02991	0.512
LIG_LIR_Nem_3	27	33	PF02991	0.498
LIG_LIR_Nem_3	423	428	PF02991	0.586
LIG_SH2_CRK	425	429	PF00017	0.472
LIG_SH2_SRC	68	71	PF00017	0.586
LIG_SH2_STAP1	203	207	PF00017	0.515
LIG_SH2_STAP1	251	255	PF00017	0.469
LIG_SH3_3	424	430	PF00018	0.467
LIG_SH3_3	463	469	PF00018	0.571
LIG_SUMO_SIM_anti_2	109	117	PF11976	0.424
LIG_SUMO_SIM_par_1	109	117	PF11976	0.507
LIG_TRAF2_1	11	14	PF00917	0.612
LIG_TRAF2_1	239	242	PF00917	0.479
LIG_TRAF2_1	25	28	PF00917	0.566
LIG_TRAF2_1	300	303	PF00917	0.551
LIG_TRAF2_1	460	463	PF00917	0.624
LIG_TRAF2_1	67	70	PF00917	0.551
LIG_TYR_ITSM	421	428	PF00017	0.474
MOD_CK1_1	340	346	PF00069	0.384
MOD_CK1_1	457	463	PF00069	0.591
MOD_CK2_1	187	193	PF00069	0.549
MOD_CK2_1	22	28	PF00069	0.474
MOD_CK2_1	236	242	PF00069	0.473
MOD_CK2_1	307	313	PF00069	0.424
MOD_CK2_1	457	463	PF00069	0.596
MOD_CK2_1	9	15	PF00069	0.623
MOD_GlcNHglycan	406	409	PF01048	0.662
MOD_GlcNHglycan	456	459	PF01048	0.616
MOD_GSK3_1	166	173	PF00069	0.478
MOD_GSK3_1	187	194	PF00069	0.460
MOD_GSK3_1	457	464	PF00069	0.607
MOD_GSK3_1	5	12	PF00069	0.680
MOD_GSK3_1	84	91	PF00069	0.472
MOD_LATS_1	418	424	PF00433	0.476
MOD_NEK2_1	118	123	PF00069	0.487
MOD_NEK2_1	170	175	PF00069	0.390
MOD_NEK2_1	225	230	PF00069	0.476
MOD_NEK2_1	6	11	PF00069	0.730
MOD_PIKK_1	68	74	PF00454	0.546
MOD_PIKK_1	88	94	PF00454	0.311
MOD_PK_1	440	446	PF00069	0.496
MOD_PKA_1	420	426	PF00069	0.670
MOD_PKA_2	170	176	PF00069	0.471
MOD_PKA_2	28	34	PF00069	0.637
MOD_PKA_2	340	346	PF00069	0.499
MOD_PKA_2	37	43	PF00069	0.577
MOD_PKA_2	404	410	PF00069	0.668
MOD_PKA_2	420	426	PF00069	0.670
MOD_PKA_2	93	99	PF00069	0.536
MOD_PKB_1	299	307	PF00069	0.646
MOD_PKB_1	447	455	PF00069	0.604
MOD_Plk_1	301	307	PF00069	0.595
MOD_Plk_1	88	94	PF00069	0.492
MOD_Plk_2-3	290	296	PF00069	0.364
MOD_Plk_4	301	307	PF00069	0.606
MOD_SUMO_for_1	230	233	PF00179	0.467
TRG_DiLeu_BaEn_1	250	255	PF01217	0.469
TRG_DiLeu_BaEn_4	137	143	PF01217	0.460
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.319
TRG_ENDOCYTIC_2	189	192	PF00928	0.426
TRG_ENDOCYTIC_2	251	254	PF00928	0.526
TRG_ENDOCYTIC_2	425	428	PF00928	0.471
TRG_ER_diArg_1	139	142	PF00400	0.502
TRG_ER_diArg_1	298	301	PF00400	0.554
TRG_ER_diArg_1	336	338	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	129	134	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S5	Leptomonas seymouri	65%	91%
A0A1X0NTJ5	Trypanosomatidae	31%	78%
A0A3S7WWY1	Leishmania donovani	86%	100%
A0A422N4N0	Trypanosoma rangeli	35%	75%
E9AGY5	Leishmania infantum	86%	81%
E9AVJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QBY9	Leishmania major	85%	100%
V5BK97	Trypanosoma cruzi	35%	100%