SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC56_LEIBR

TriTrypDb:

LbrM.22.0040 , LBRM2903_220005600

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.533
CLV_NRD_NRD_1	144	146	PF00675	0.341
CLV_NRD_NRD_1	211	213	PF00675	0.334
CLV_PCSK_KEX2_1	144	146	PF00082	0.524
CLV_PCSK_KEX2_1	211	213	PF00082	0.315
DOC_CDC14_PxL_1	33	41	PF14671	0.495
DOC_MAPK_FxFP_2	244	247	PF00069	0.586
DOC_MAPK_gen_1	211	218	PF00069	0.562
DOC_MAPK_MEF2A_6	144	151	PF00069	0.469
DOC_MAPK_RevD_3	112	126	PF00069	0.316
DOC_PP1_RVXF_1	259	265	PF00149	0.509
DOC_PP4_FxxP_1	175	178	PF00568	0.482
DOC_PP4_FxxP_1	244	247	PF00568	0.586
DOC_PP4_FxxP_1	270	273	PF00568	0.503
DOC_USP7_MATH_1	160	164	PF00917	0.537
DOC_USP7_MATH_2	251	257	PF00917	0.345
DOC_WW_Pin1_4	40	45	PF00397	0.411
DOC_WW_Pin1_4	47	52	PF00397	0.399
DOC_WW_Pin1_4	90	95	PF00397	0.558
LIG_14-3-3_CanoR_1	61	66	PF00244	0.559
LIG_14-3-3_CanoR_1	71	75	PF00244	0.565
LIG_APCC_ABBA_1	196	201	PF00400	0.496
LIG_CaM_NSCaTE_8	52	59	PF13499	0.544
LIG_FHA_1	111	117	PF00498	0.363
LIG_FHA_1	201	207	PF00498	0.515
LIG_FHA_1	225	231	PF00498	0.512
LIG_FHA_1	233	239	PF00498	0.513
LIG_FHA_1	60	66	PF00498	0.520
LIG_FHA_2	24	30	PF00498	0.532
LIG_FHA_2	62	68	PF00498	0.568
LIG_LIR_Apic_2	172	178	PF02991	0.498
LIG_LIR_Apic_2	242	247	PF02991	0.586
LIG_LIR_Gen_1	226	234	PF02991	0.465
LIG_LIR_Gen_1	42	51	PF02991	0.279
LIG_LIR_Gen_1	7	12	PF02991	0.415
LIG_LIR_Gen_1	81	91	PF02991	0.403
LIG_LIR_Nem_3	226	231	PF02991	0.474
LIG_LIR_Nem_3	266	271	PF02991	0.468
LIG_LIR_Nem_3	42	48	PF02991	0.461
LIG_LIR_Nem_3	7	11	PF02991	0.510
LIG_LIR_Nem_3	81	87	PF02991	0.403
LIG_MYND_1	178	182	PF01753	0.496
LIG_PCNA_TLS_4	92	99	PF02747	0.531
LIG_Pex14_1	264	268	PF04695	0.378
LIG_PTB_Apo_2	257	264	PF02174	0.425
LIG_PTB_Phospho_1	257	263	PF10480	0.300
LIG_SH2_CRK	8	12	PF00017	0.554
LIG_SH2_GRB2like	258	261	PF00017	0.308
LIG_SH2_NCK_1	248	252	PF00017	0.338
LIG_SH2_SRC	248	251	PF00017	0.481
LIG_SH2_SRC	8	11	PF00017	0.546
LIG_SH2_STAP1	258	262	PF00017	0.522
LIG_SH2_STAP1	74	78	PF00017	0.534
LIG_SH2_STAT3	98	101	PF00017	0.581
LIG_SH2_STAT5	10	13	PF00017	0.568
LIG_SH2_STAT5	63	66	PF00017	0.468
LIG_SH2_STAT5	98	101	PF00017	0.429
LIG_SH3_3	163	169	PF00018	0.496
LIG_SH3_3	88	94	PF00018	0.543
LIG_SUMO_SIM_anti_2	31	37	PF11976	0.481
LIG_TRAF2_1	64	67	PF00917	0.535
LIG_TYR_ITIM	6	11	PF00017	0.537
LIG_UBA3_1	218	224	PF00899	0.597
MOD_CK2_1	61	67	PF00069	0.529
MOD_CK2_1	90	96	PF00069	0.554
MOD_GSK3_1	78	85	PF00069	0.357
MOD_NEK2_1	200	205	PF00069	0.531
MOD_NEK2_1	39	44	PF00069	0.331
MOD_PKA_1	211	217	PF00069	0.567
MOD_PKA_2	211	217	PF00069	0.516
MOD_PKA_2	232	238	PF00069	0.534
MOD_PKA_2	70	76	PF00069	0.546
MOD_Plk_1	242	248	PF00069	0.562
MOD_Plk_4	129	135	PF00069	0.434
MOD_Plk_4	176	182	PF00069	0.534
MOD_Plk_4	253	259	PF00069	0.546
MOD_ProDKin_1	40	46	PF00069	0.413
MOD_ProDKin_1	47	53	PF00069	0.392
MOD_ProDKin_1	90	96	PF00069	0.554
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.562
TRG_ENDOCYTIC_2	8	11	PF00928	0.508
TRG_ER_diArg_1	210	212	PF00400	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZC8	Leptomonas seymouri	64%	79%
A0A1X0NT21	Trypanosomatidae	39%	97%
A0A3R7M657	Trypanosoma rangeli	39%	97%
A0A3S7WWX4	Leishmania donovani	84%	96%
C9ZSB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AGY4	Leishmania infantum	85%	96%
E9AVI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	96%
Q4QBZ0	Leishmania major	83%	100%
V5BB74	Trypanosoma cruzi	37%	96%