CLN3 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CLN3 protein

Gene product:

CLN3 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HC54_LEIBR

TriTrypDb:

LbrM.22.0010 , LBRM2903_220005200

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	13
GO:0016020	membrane	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13

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Expansion

Sequence features

A4HC54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC54

Function

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Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006885	regulation of pH	8	1
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0030004	obsolete cellular monovalent inorganic cation homeostasis	6	1
GO:0030641	regulation of cellular pH	7	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.548
CLV_C14_Caspase3-7	314	318	PF00656	0.513
CLV_MEL_PAP_1	113	119	PF00089	0.269
CLV_NRD_NRD_1	12	14	PF00675	0.562
CLV_NRD_NRD_1	338	340	PF00675	0.320
CLV_NRD_NRD_1	521	523	PF00675	0.354
CLV_NRD_NRD_1	590	592	PF00675	0.376
CLV_PCSK_FUR_1	38	42	PF00082	0.389
CLV_PCSK_KEX2_1	250	252	PF00082	0.223
CLV_PCSK_KEX2_1	338	340	PF00082	0.241

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N3	Leptomonas seymouri	42%	86%
A0A0S4IMH8	Bodo saltans	40%	100%
A0A1X0NL65	Trypanosomatidae	38%	100%
A0A1X0NM99	Trypanosomatidae	42%	100%
A0A3Q8IBB0	Leishmania donovani	78%	98%
A0A3R7MV96	Trypanosoma rangeli	40%	100%
A4HT21	Leishmania infantum	78%	98%
C9ZTE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q29611	Canis lupus familiaris	23%	100%

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