CLN3 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CLN3 protein

Gene product:

CLN3 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HC54_LEIBR

TriTrypDb:

LbrM.22.0010 , LBRM2903_220005200

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	13
GO:0016020	membrane	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HC54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC54

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006885	regulation of pH	8	1
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0030004	obsolete cellular monovalent inorganic cation homeostasis	6	1
GO:0030641	regulation of cellular pH	7	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051453	regulation of intracellular pH	8	1
GO:0055067	obsolete monovalent inorganic cation homeostasis	7	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0098771	inorganic ion homeostasis	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.548
CLV_C14_Caspase3-7	314	318	PF00656	0.513
CLV_MEL_PAP_1	113	119	PF00089	0.269
CLV_NRD_NRD_1	12	14	PF00675	0.562
CLV_NRD_NRD_1	338	340	PF00675	0.320
CLV_NRD_NRD_1	521	523	PF00675	0.354
CLV_NRD_NRD_1	590	592	PF00675	0.376
CLV_PCSK_FUR_1	38	42	PF00082	0.389
CLV_PCSK_KEX2_1	250	252	PF00082	0.223
CLV_PCSK_KEX2_1	338	340	PF00082	0.241
CLV_PCSK_KEX2_1	40	42	PF00082	0.391
CLV_PCSK_KEX2_1	484	486	PF00082	0.326
CLV_PCSK_KEX2_1	51	53	PF00082	0.308
CLV_PCSK_KEX2_1	590	592	PF00082	0.284
CLV_PCSK_KEX2_1	89	91	PF00082	0.351
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.223
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.384
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.326
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.265
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.351
DEG_APCC_DBOX_1	410	418	PF00400	0.412
DEG_Nend_UBRbox_2	1	3	PF02207	0.553
DOC_CKS1_1	139	144	PF01111	0.266
DOC_CKS1_1	219	224	PF01111	0.396
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.320
DOC_MAPK_gen_1	250	256	PF00069	0.423
DOC_MAPK_gen_1	38	46	PF00069	0.519
DOC_MAPK_gen_1	450	458	PF00069	0.293
DOC_MAPK_gen_1	590	597	PF00069	0.480
DOC_MAPK_MEF2A_6	411	419	PF00069	0.430
DOC_MAPK_MEF2A_6	450	458	PF00069	0.269
DOC_MAPK_MEF2A_6	56	63	PF00069	0.469
DOC_PP1_RVXF_1	294	301	PF00149	0.512
DOC_PP2B_LxvP_1	374	377	PF13499	0.320
DOC_PP4_FxxP_1	139	142	PF00568	0.330
DOC_USP7_MATH_1	187	191	PF00917	0.356
DOC_USP7_MATH_1	448	452	PF00917	0.232
DOC_USP7_MATH_1	515	519	PF00917	0.616
DOC_USP7_MATH_1	78	82	PF00917	0.313
DOC_WW_Pin1_4	138	143	PF00397	0.266
DOC_WW_Pin1_4	218	223	PF00397	0.397
DOC_WW_Pin1_4	234	239	PF00397	0.238
DOC_WW_Pin1_4	25	30	PF00397	0.653
DOC_WW_Pin1_4	300	305	PF00397	0.498
DOC_WW_Pin1_4	309	314	PF00397	0.513
DOC_WW_Pin1_4	329	334	PF00397	0.493
DOC_WW_Pin1_4	444	449	PF00397	0.151
LIG_14-3-3_CanoR_1	116	120	PF00244	0.445
LIG_14-3-3_CanoR_1	122	128	PF00244	0.259
LIG_14-3-3_CanoR_1	296	301	PF00244	0.512
LIG_14-3-3_CanoR_1	411	415	PF00244	0.412
LIG_14-3-3_CanoR_1	485	489	PF00244	0.518
LIG_14-3-3_CanoR_1	522	528	PF00244	0.573
LIG_14-3-3_CanoR_1	56	60	PF00244	0.447
LIG_Actin_WH2_2	607	624	PF00022	0.399
LIG_BRCT_BRCA1_1	199	203	PF00533	0.274
LIG_deltaCOP1_diTrp_1	383	391	PF00928	0.264
LIG_EH1_1	286	294	PF00400	0.423
LIG_EH1_1	402	410	PF00400	0.164
LIG_eIF4E_1	403	409	PF01652	0.278
LIG_eIF4E_1	86	92	PF01652	0.269
LIG_FHA_1	214	220	PF00498	0.295
LIG_FHA_1	601	607	PF00498	0.313
LIG_FHA_2	533	539	PF00498	0.500
LIG_FHA_2	567	573	PF00498	0.636
LIG_FHA_2	6	12	PF00498	0.604
LIG_FHA_2	608	614	PF00498	0.399
LIG_GBD_Chelix_1	153	161	PF00786	0.330
LIG_IRF3_LxIS_1	70	77	PF10401	0.286
LIG_LIR_Apic_2	138	142	PF02991	0.330
LIG_LIR_Apic_2	379	384	PF02991	0.326
LIG_LIR_Gen_1	150	160	PF02991	0.301
LIG_LIR_Gen_1	457	466	PF02991	0.312
LIG_LIR_Gen_1	474	483	PF02991	0.163
LIG_LIR_Gen_1	58	67	PF02991	0.330
LIG_LIR_Gen_1	96	105	PF02991	0.258
LIG_LIR_Nem_3	200	206	PF02991	0.250
LIG_LIR_Nem_3	354	360	PF02991	0.340
LIG_LIR_Nem_3	457	461	PF02991	0.348
LIG_LIR_Nem_3	474	478	PF02991	0.177
LIG_LIR_Nem_3	58	63	PF02991	0.311
LIG_LIR_Nem_3	96	100	PF02991	0.258
LIG_MAD2	325	333	PF02301	0.351
LIG_NRBOX	127	133	PF00104	0.413
LIG_PCNA_PIPBox_1	43	52	PF02747	0.446
LIG_PCNA_yPIPBox_3	334	342	PF02747	0.544
LIG_PCNA_yPIPBox_3	490	502	PF02747	0.536
LIG_Pex14_1	340	344	PF04695	0.351
LIG_Pex14_1	386	390	PF04695	0.320
LIG_Pex14_1	62	66	PF04695	0.330
LIG_Pex14_1	97	101	PF04695	0.298
LIG_Pex14_2	101	105	PF04695	0.372
LIG_Pex14_2	135	139	PF04695	0.401
LIG_Pex14_2	356	360	PF04695	0.251
LIG_Pex14_2	66	70	PF04695	0.335
LIG_PTB_Apo_2	350	357	PF02174	0.438
LIG_PTB_Apo_2	474	481	PF02174	0.263
LIG_PTB_Apo_2	54	61	PF02174	0.525
LIG_PTB_Apo_2	66	73	PF02174	0.195
LIG_PTB_Phospho_1	474	480	PF10480	0.278
LIG_PTB_Phospho_1	66	72	PF10480	0.259
LIG_SH2_CRK	601	605	PF00017	0.275
LIG_SH2_CRK	72	76	PF00017	0.263
LIG_SH2_GRB2like	475	478	PF00017	0.250
LIG_SH2_NCK_1	601	605	PF00017	0.259
LIG_SH2_PTP2	421	424	PF00017	0.298
LIG_SH2_PTP2	475	478	PF00017	0.250
LIG_SH2_SRC	475	478	PF00017	0.250
LIG_SH2_STAP1	287	291	PF00017	0.492
LIG_SH2_STAP1	370	374	PF00017	0.263
LIG_SH2_STAT3	370	373	PF00017	0.250
LIG_SH2_STAT5	366	369	PF00017	0.263
LIG_SH2_STAT5	381	384	PF00017	0.212
LIG_SH2_STAT5	396	399	PF00017	0.401
LIG_SH2_STAT5	421	424	PF00017	0.298
LIG_SH2_STAT5	444	447	PF00017	0.320
LIG_SH2_STAT5	475	478	PF00017	0.280
LIG_SH2_STAT5	480	483	PF00017	0.447
LIG_SH2_STAT5	501	504	PF00017	0.627
LIG_SH2_STAT5	549	552	PF00017	0.557
LIG_SH2_STAT5	72	75	PF00017	0.277
LIG_SH3_3	216	222	PF00018	0.330
LIG_SH3_3	303	309	PF00018	0.489
LIG_SH3_3	414	420	PF00018	0.520
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.469
LIG_SUMO_SIM_anti_2	610	617	PF11976	0.270
LIG_SUMO_SIM_par_1	158	164	PF11976	0.438
LIG_SUMO_SIM_par_1	278	285	PF11976	0.463
LIG_SUMO_SIM_par_1	90	96	PF11976	0.362
LIG_TRAF2_1	312	315	PF00917	0.410
LIG_TRAF2_1	8	11	PF00917	0.755
LIG_TYR_ITIM	419	424	PF00017	0.447
LIG_TYR_ITIM	478	483	PF00017	0.434
LIG_WRC_WIRS_1	136	141	PF05994	0.278
LIG_WRC_WIRS_1	149	154	PF05994	0.221
LIG_WRC_WIRS_1	173	178	PF05994	0.517
MOD_CDC14_SPxK_1	237	240	PF00782	0.469
MOD_CDC14_SPxK_1	447	450	PF00782	0.151
MOD_CDK_SPxK_1	234	240	PF00069	0.330
MOD_CDK_SPxK_1	444	450	PF00069	0.151
MOD_CDK_SPxxK_3	138	145	PF00069	0.183
MOD_CK1_1	138	144	PF00069	0.386
MOD_CK1_1	189	195	PF00069	0.270
MOD_CK1_1	28	34	PF00069	0.599
MOD_CK1_1	410	416	PF00069	0.436
MOD_CK1_1	518	524	PF00069	0.557
MOD_CK1_1	532	538	PF00069	0.600
MOD_CK2_1	164	170	PF00069	0.267
MOD_CK2_1	279	285	PF00069	0.456
MOD_CK2_1	28	34	PF00069	0.692
MOD_CK2_1	309	315	PF00069	0.472
MOD_CK2_1	5	11	PF00069	0.751
MOD_CK2_1	566	572	PF00069	0.609
MOD_CK2_1	78	84	PF00069	0.320
MOD_Cter_Amidation	248	251	PF01082	0.223
MOD_GlcNHglycan	189	192	PF01048	0.250
MOD_GlcNHglycan	194	197	PF01048	0.250
MOD_GlcNHglycan	207	210	PF01048	0.412
MOD_GlcNHglycan	21	24	PF01048	0.474
MOD_GlcNHglycan	247	250	PF01048	0.244
MOD_GlcNHglycan	30	33	PF01048	0.444
MOD_GlcNHglycan	508	512	PF01048	0.391
MOD_GlcNHglycan	531	534	PF01048	0.389
MOD_GlcNHglycan	76	79	PF01048	0.281
MOD_GSK3_1	164	171	PF00069	0.288
MOD_GSK3_1	205	212	PF00069	0.258
MOD_GSK3_1	21	28	PF00069	0.682
MOD_GSK3_1	213	220	PF00069	0.247
MOD_GSK3_1	275	282	PF00069	0.383
MOD_GSK3_1	296	303	PF00069	0.497
MOD_GSK3_1	392	399	PF00069	0.158
MOD_GSK3_1	444	451	PF00069	0.330
MOD_GSK3_1	600	607	PF00069	0.278
MOD_GSK3_1	74	81	PF00069	0.364
MOD_N-GLC_1	147	152	PF02516	0.550
MOD_N-GLC_1	19	24	PF02516	0.415
MOD_NEK2_1	112	117	PF00069	0.333
MOD_NEK2_1	126	131	PF00069	0.241
MOD_NEK2_1	135	140	PF00069	0.202
MOD_NEK2_1	161	166	PF00069	0.320
MOD_NEK2_1	204	209	PF00069	0.258
MOD_NEK2_1	21	26	PF00069	0.627
MOD_NEK2_1	217	222	PF00069	0.240
MOD_NEK2_1	242	247	PF00069	0.530
MOD_NEK2_1	351	356	PF00069	0.539
MOD_NEK2_1	483	488	PF00069	0.458
MOD_NEK2_1	50	55	PF00069	0.571
MOD_NEK2_1	600	605	PF00069	0.283
MOD_NEK2_1	614	619	PF00069	0.310
MOD_NEK2_1	621	626	PF00069	0.334
MOD_NEK2_1	74	79	PF00069	0.270
MOD_PIKK_1	209	215	PF00454	0.293
MOD_PIKK_1	298	304	PF00454	0.351
MOD_PIKK_1	396	402	PF00454	0.159
MOD_PKA_1	484	490	PF00069	0.469
MOD_PKA_2	115	121	PF00069	0.435
MOD_PKA_2	410	416	PF00069	0.412
MOD_PKA_2	484	490	PF00069	0.482
MOD_PKA_2	521	527	PF00069	0.572
MOD_PKA_2	55	61	PF00069	0.488
MOD_Plk_1	147	153	PF00069	0.350
MOD_Plk_2-3	279	285	PF00069	0.456
MOD_Plk_4	127	133	PF00069	0.288
MOD_Plk_4	148	154	PF00069	0.177
MOD_Plk_4	168	174	PF00069	0.302
MOD_Plk_4	180	186	PF00069	0.424
MOD_Plk_4	197	203	PF00069	0.148
MOD_Plk_4	213	219	PF00069	0.208
MOD_Plk_4	351	357	PF00069	0.486
MOD_Plk_4	392	398	PF00069	0.224
MOD_Plk_4	410	416	PF00069	0.340
MOD_Plk_4	454	460	PF00069	0.291
MOD_Plk_4	471	477	PF00069	0.151
MOD_Plk_4	484	490	PF00069	0.412
MOD_Plk_4	55	61	PF00069	0.495
MOD_Plk_4	607	613	PF00069	0.269
MOD_Plk_4	616	622	PF00069	0.425
MOD_ProDKin_1	138	144	PF00069	0.266
MOD_ProDKin_1	218	224	PF00069	0.397
MOD_ProDKin_1	234	240	PF00069	0.238
MOD_ProDKin_1	25	31	PF00069	0.648
MOD_ProDKin_1	300	306	PF00069	0.498
MOD_ProDKin_1	309	315	PF00069	0.513
MOD_ProDKin_1	329	335	PF00069	0.493
MOD_ProDKin_1	444	450	PF00069	0.151
MOD_SUMO_rev_2	282	292	PF00179	0.423
MOD_SUMO_rev_2	571	579	PF00179	0.510
TRG_DiLeu_BaEn_4	314	320	PF01217	0.469
TRG_ENDOCYTIC_2	421	424	PF00928	0.298
TRG_ENDOCYTIC_2	475	478	PF00928	0.271
TRG_ENDOCYTIC_2	480	483	PF00928	0.422
TRG_ENDOCYTIC_2	601	604	PF00928	0.259
TRG_ENDOCYTIC_2	72	75	PF00928	0.262
TRG_ER_diArg_1	337	339	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	581	585	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N3	Leptomonas seymouri	42%	86%
A0A0S4IMH8	Bodo saltans	40%	100%
A0A1X0NL65	Trypanosomatidae	38%	100%
A0A1X0NM99	Trypanosomatidae	42%	100%
A0A3Q8IBB0	Leishmania donovani	78%	98%
A0A3R7MV96	Trypanosoma rangeli	40%	100%
A4HT21	Leishmania infantum	78%	98%
C9ZTE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q29611	Canis lupus familiaris	23%	100%
Q4HX89	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	25%	100%
Q4QBZ3	Leishmania major	79%	100%
Q54F25	Dictyostelium discoideum	31%	100%
Q7SC45	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	100%
V5DU41	Trypanosoma cruzi	42%	100%