G_PROTEIN_RECEP_F1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC52_LEIBR

TriTrypDb:

LbrM.21.2190 , LBRM2903_210021800

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HC52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.427
CLV_NRD_NRD_1	118	120	PF00675	0.402
CLV_NRD_NRD_1	146	148	PF00675	0.416
CLV_NRD_NRD_1	173	175	PF00675	0.418
CLV_NRD_NRD_1	181	183	PF00675	0.412
CLV_NRD_NRD_1	303	305	PF00675	0.470
CLV_NRD_NRD_1	329	331	PF00675	0.429
CLV_PCSK_FUR_1	144	148	PF00082	0.414
CLV_PCSK_KEX2_1	104	106	PF00082	0.427
CLV_PCSK_KEX2_1	118	120	PF00082	0.402
CLV_PCSK_KEX2_1	146	148	PF00082	0.452
CLV_PCSK_KEX2_1	173	175	PF00082	0.418
CLV_PCSK_KEX2_1	303	305	PF00082	0.470
CLV_PCSK_KEX2_1	329	331	PF00082	0.427
CLV_PCSK_SKI1_1	280	284	PF00082	0.424
DEG_APCC_DBOX_1	253	261	PF00400	0.662
DEG_APCC_DBOX_1	88	96	PF00400	0.540
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DEG_SPOP_SBC_1	127	131	PF00917	0.615
DEG_SPOP_SBC_1	225	229	PF00917	0.570
DOC_AGCK_PIF_1	74	79	PF00069	0.231
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.327
DOC_MAPK_gen_1	144	154	PF00069	0.615
DOC_MAPK_gen_1	179	187	PF00069	0.576
DOC_MAPK_gen_1	300	308	PF00069	0.631
DOC_MAPK_gen_1	55	64	PF00069	0.275
DOC_MAPK_HePTP_8	283	295	PF00069	0.620
DOC_MAPK_MEF2A_6	286	295	PF00069	0.620
DOC_MAPK_MEF2A_6	55	64	PF00069	0.303
DOC_MAPK_NFAT4_5	55	63	PF00069	0.256
DOC_MAPK_RevD_3	90	105	PF00069	0.608
DOC_PP1_RVXF_1	148	155	PF00149	0.632
DOC_PP1_RVXF_1	79	86	PF00149	0.545
DOC_PP2B_LxvP_1	291	294	PF13499	0.625
DOC_PP2B_LxvP_1	306	309	PF13499	0.596
DOC_PP2B_LxvP_1	62	65	PF13499	0.352
DOC_USP7_MATH_1	128	132	PF00917	0.661
DOC_USP7_MATH_1	259	263	PF00917	0.617
DOC_USP7_MATH_1	310	314	PF00917	0.711
DOC_USP7_MATH_1	46	50	PF00917	0.433
DOC_USP7_MATH_2	46	52	PF00917	0.344
DOC_USP7_UBL2_3	179	183	PF12436	0.679
DOC_WW_Pin1_4	252	257	PF00397	0.665
DOC_WW_Pin1_4	363	368	PF00397	0.686
LIG_14-3-3_CanoR_1	144	154	PF00244	0.670
LIG_14-3-3_CanoR_1	177	182	PF00244	0.582
LIG_14-3-3_CanoR_1	254	263	PF00244	0.703
LIG_14-3-3_CanoR_1	286	291	PF00244	0.644
LIG_14-3-3_CanoR_1	303	309	PF00244	0.682
LIG_14-3-3_CanoR_1	98	102	PF00244	0.566
LIG_Actin_WH2_2	218	236	PF00022	0.539
LIG_Actin_WH2_2	358	376	PF00022	0.621
LIG_Actin_WH2_2	83	100	PF00022	0.546
LIG_BRCT_BRCA1_1	150	154	PF00533	0.633
LIG_BRCT_BRCA1_1	188	192	PF00533	0.588
LIG_DCNL_PONY_1	1	4	PF03556	0.426
LIG_deltaCOP1_diTrp_1	184	192	PF00928	0.680
LIG_FHA_1	216	222	PF00498	0.574
LIG_FHA_1	226	232	PF00498	0.601
LIG_FHA_1	286	292	PF00498	0.776
LIG_FHA_1	94	100	PF00498	0.503
LIG_FHA_2	350	356	PF00498	0.631
LIG_LIR_Apic_2	78	82	PF02991	0.321
LIG_LIR_Gen_1	189	198	PF02991	0.577
LIG_LIR_LC3C_4	111	116	PF02991	0.542
LIG_LIR_Nem_3	189	195	PF02991	0.579
LIG_LIR_Nem_3	78	83	PF02991	0.321
LIG_NRBOX	57	63	PF00104	0.255
LIG_PTB_Apo_2	24	31	PF02174	0.358
LIG_PTB_Phospho_1	24	30	PF10480	0.358
LIG_RPA_C_Fungi	281	293	PF08784	0.513
LIG_SH2_CRK	80	84	PF00017	0.410
LIG_SH2_STAT5	250	253	PF00017	0.666
LIG_SH2_STAT5	59	62	PF00017	0.461
LIG_SH2_STAT5	76	79	PF00017	0.211
LIG_SH3_3	15	21	PF00018	0.312
LIG_SH3_3	32	38	PF00018	0.527
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.414
LIG_SUMO_SIM_par_1	111	117	PF11976	0.414
LIG_TRAF2_1	240	243	PF00917	0.469
MOD_CK1_1	117	123	PF00069	0.531
MOD_CK1_1	142	148	PF00069	0.536
MOD_CK1_1	226	232	PF00069	0.436
MOD_CK1_1	252	258	PF00069	0.574
MOD_CK1_1	262	268	PF00069	0.721
MOD_CK2_1	208	214	PF00069	0.458
MOD_CK2_1	349	355	PF00069	0.586
MOD_CK2_1	37	43	PF00069	0.541
MOD_GlcNHglycan	10	13	PF01048	0.312
MOD_GlcNHglycan	110	113	PF01048	0.460
MOD_GlcNHglycan	135	138	PF01048	0.663
MOD_GlcNHglycan	159	162	PF01048	0.518
MOD_GlcNHglycan	188	191	PF01048	0.482
MOD_GlcNHglycan	228	231	PF01048	0.523
MOD_GlcNHglycan	257	260	PF01048	0.614
MOD_GlcNHglycan	264	267	PF01048	0.717
MOD_GlcNHglycan	312	315	PF01048	0.648
MOD_GlcNHglycan	316	319	PF01048	0.664
MOD_GlcNHglycan	39	42	PF01048	0.534
MOD_GSK3_1	114	121	PF00069	0.469
MOD_GSK3_1	122	129	PF00069	0.576
MOD_GSK3_1	135	142	PF00069	0.574
MOD_GSK3_1	255	262	PF00069	0.649
MOD_GSK3_1	304	311	PF00069	0.632
MOD_GSK3_1	345	352	PF00069	0.525
MOD_GSK3_1	363	370	PF00069	0.522
MOD_GSK3_1	93	100	PF00069	0.418
MOD_LATS_1	175	181	PF00433	0.509
MOD_LATS_1	302	308	PF00433	0.533
MOD_N-GLC_1	215	220	PF02516	0.457
MOD_N-GLC_1	363	368	PF02516	0.529
MOD_NEK2_1	108	113	PF00069	0.441
MOD_NEK2_1	114	119	PF00069	0.538
MOD_NEK2_1	164	169	PF00069	0.576
MOD_NEK2_1	224	229	PF00069	0.389
MOD_NEK2_1	249	254	PF00069	0.557
MOD_NEK2_1	267	272	PF00069	0.567
MOD_NEK2_1	284	289	PF00069	0.468
MOD_NEK2_1	325	330	PF00069	0.542
MOD_NEK2_1	345	350	PF00069	0.517
MOD_NEK2_1	60	65	PF00069	0.387
MOD_NEK2_1	75	80	PF00069	0.250
MOD_NEK2_2	259	264	PF00069	0.513
MOD_PIKK_1	48	54	PF00454	0.513
MOD_PK_1	135	141	PF00069	0.501
MOD_PK_1	177	183	PF00069	0.514
MOD_PK_1	286	292	PF00069	0.514
MOD_PK_1	304	310	PF00069	0.531
MOD_PKA_1	118	124	PF00069	0.493
MOD_PKA_2	117	123	PF00069	0.483
MOD_PKA_2	145	151	PF00069	0.564
MOD_PKA_2	285	291	PF00069	0.527
MOD_PKA_2	349	355	PF00069	0.578
MOD_PKA_2	97	103	PF00069	0.431
MOD_Plk_1	148	154	PF00069	0.525
MOD_Plk_1	164	170	PF00069	0.382
MOD_Plk_1	331	337	PF00069	0.659
MOD_Plk_1	46	52	PF00069	0.590
MOD_Plk_4	135	141	PF00069	0.631
MOD_Plk_4	286	292	PF00069	0.514
MOD_Plk_4	349	355	PF00069	0.507
MOD_ProDKin_1	252	258	PF00069	0.577
MOD_ProDKin_1	363	369	PF00069	0.528
MOD_SUMO_rev_2	237	245	PF00179	0.473
TRG_ENDOCYTIC_2	59	62	PF00928	0.388
TRG_ENDOCYTIC_2	80	83	PF00928	0.406
TRG_ER_diArg_1	144	147	PF00400	0.531
TRG_ER_diArg_1	172	174	PF00400	0.524
TRG_ER_diArg_1	231	234	PF00400	0.441
TRG_NES_CRM1_1	91	102	PF08389	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA48	Leptomonas seymouri	50%	94%
A0A3S7WWN2	Leishmania donovani	62%	100%
A4HZD6	Leishmania infantum	62%	100%
E9AVC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4QC57	Leishmania major	64%	100%