Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger domain-like protein

Species:

Leishmania braziliensis

UniProt:

A4HC51_LEIBR

TriTrypDb:

LbrM.21.2180 , LBRM2903_210021900

Length:

596

Annotations

LeishMANIAdb annotations

Palmitoyltransferase. Leishmaniids have +2 extra TM segments at the N-terminus while all other Kinetoplastids typically only have the 4 core ones.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A4HC51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC51

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016417	S-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	8
GO:0019707	protein-cysteine S-acyltransferase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.302
CLV_NRD_NRD_1	251	253	PF00675	0.428
CLV_NRD_NRD_1	267	269	PF00675	0.410
CLV_NRD_NRD_1	323	325	PF00675	0.233
CLV_NRD_NRD_1	330	332	PF00675	0.233
CLV_NRD_NRD_1	398	400	PF00675	0.437
CLV_NRD_NRD_1	405	407	PF00675	0.429
CLV_NRD_NRD_1	480	482	PF00675	0.380
CLV_NRD_NRD_1	527	529	PF00675	0.386
CLV_PCSK_KEX2_1	13	15	PF00082	0.304
CLV_PCSK_KEX2_1	251	253	PF00082	0.428
CLV_PCSK_KEX2_1	267	269	PF00082	0.410
CLV_PCSK_KEX2_1	323	325	PF00082	0.233
CLV_PCSK_KEX2_1	330	332	PF00082	0.233
CLV_PCSK_KEX2_1	405	407	PF00082	0.438
CLV_PCSK_KEX2_1	480	482	PF00082	0.398
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.321
CLV_PCSK_SKI1_1	330	334	PF00082	0.304
CLV_PCSK_SKI1_1	367	371	PF00082	0.218
CLV_PCSK_SKI1_1	463	467	PF00082	0.233
CLV_PCSK_SKI1_1	528	532	PF00082	0.420
CLV_PCSK_SKI1_1	8	12	PF00082	0.304
CLV_Separin_Metazoa	5	9	PF03568	0.453
DEG_APCC_DBOX_1	13	21	PF00400	0.518
DEG_APCC_DBOX_1	193	201	PF00400	0.615
DEG_APCC_DBOX_1	366	374	PF00400	0.418
DEG_Nend_UBRbox_2	1	3	PF02207	0.531
DOC_CKS1_1	67	72	PF01111	0.291
DOC_CYCLIN_RxL_1	497	506	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	259	265	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	424	430	PF00134	0.233
DOC_MAPK_gen_1	147	157	PF00069	0.609
DOC_MAPK_MEF2A_6	233	241	PF00069	0.610
DOC_MAPK_MEF2A_6	38	47	PF00069	0.200
DOC_MAPK_MEF2A_6	556	563	PF00069	0.487
DOC_MAPK_RevD_3	237	252	PF00069	0.632
DOC_PP1_RVXF_1	498	505	PF00149	0.490
DOC_PP2B_LxvP_1	319	322	PF13499	0.551
DOC_PP2B_LxvP_1	332	335	PF13499	0.433
DOC_PP2B_LxvP_1	424	427	PF13499	0.233
DOC_PP4_FxxP_1	157	160	PF00568	0.612
DOC_PP4_FxxP_1	169	172	PF00568	0.646
DOC_USP7_MATH_1	204	208	PF00917	0.661
DOC_USP7_MATH_1	284	288	PF00917	0.648
DOC_USP7_MATH_1	530	534	PF00917	0.546
DOC_WW_Pin1_4	168	173	PF00397	0.658
DOC_WW_Pin1_4	189	194	PF00397	0.655
DOC_WW_Pin1_4	408	413	PF00397	0.233
DOC_WW_Pin1_4	506	511	PF00397	0.514
DOC_WW_Pin1_4	66	71	PF00397	0.291
LIG_14-3-3_CanoR_1	28	34	PF00244	0.490
LIG_14-3-3_CanoR_1	406	412	PF00244	0.205
LIG_14-3-3_CanoR_1	483	492	PF00244	0.530
LIG_14-3-3_CanoR_1	528	533	PF00244	0.579
LIG_14-3-3_CanoR_1	545	554	PF00244	0.501
LIG_Actin_WH2_2	298	316	PF00022	0.540
LIG_AP2alpha_1	504	508	PF02296	0.478
LIG_AP2alpha_2	513	515	PF02296	0.488
LIG_BRCT_BRCA1_1	486	490	PF00533	0.592
LIG_Clathr_ClatBox_1	296	300	PF01394	0.582
LIG_CtBP_PxDLS_1	262	266	PF00389	0.579
LIG_eIF4E_1	459	465	PF01652	0.252
LIG_FHA_1	180	186	PF00498	0.618
LIG_FHA_1	236	242	PF00498	0.662
LIG_FHA_1	244	250	PF00498	0.632
LIG_FHA_1	434	440	PF00498	0.243
LIG_FHA_1	441	447	PF00498	0.239
LIG_FHA_1	467	473	PF00498	0.445
LIG_FHA_1	51	57	PF00498	0.212
LIG_FHA_2	293	299	PF00498	0.583
LIG_FHA_2	468	474	PF00498	0.433
LIG_IBAR_NPY_1	494	496	PF08397	0.485
LIG_KLC1_Yacidic_2	473	478	PF13176	0.474
LIG_LIR_Apic_2	109	115	PF02991	0.618
LIG_LIR_Apic_2	154	160	PF02991	0.604
LIG_LIR_Apic_2	489	495	PF02991	0.533
LIG_LIR_Gen_1	2	11	PF02991	0.460
LIG_LIR_Gen_1	455	465	PF02991	0.252
LIG_LIR_Gen_1	513	522	PF02991	0.492
LIG_LIR_Gen_1	53	60	PF02991	0.368
LIG_LIR_Nem_3	2	7	PF02991	0.466
LIG_LIR_Nem_3	214	219	PF02991	0.792
LIG_LIR_Nem_3	384	389	PF02991	0.475
LIG_LIR_Nem_3	455	460	PF02991	0.481
LIG_LIR_Nem_3	53	57	PF02991	0.368
LIG_LIR_Nem_3	564	569	PF02991	0.520
LIG_LIR_Nem_3	72	78	PF02991	0.188
LIG_LIR_Nem_3	86	90	PF02991	0.252
LIG_LYPXL_SIV_4	427	435	PF13949	0.245
LIG_NRBOX	292	298	PF00104	0.585
LIG_PDZ_Class_2	591	596	PF00595	0.551
LIG_Pex14_1	562	566	PF04695	0.494
LIG_Pex14_2	29	33	PF04695	0.573
LIG_Pex14_2	504	508	PF04695	0.478
LIG_SH2_CRK	389	393	PF00017	0.269
LIG_SH2_CRK	492	496	PF00017	0.519
LIG_SH2_CRK	75	79	PF00017	0.200
LIG_SH2_GRB2like	459	462	PF00017	0.252
LIG_SH2_GRB2like	90	93	PF00017	0.269
LIG_SH2_STAT3	309	312	PF00017	0.549
LIG_SH2_STAT3	459	462	PF00017	0.200
LIG_SH2_STAT5	16	19	PF00017	0.522
LIG_SH2_STAT5	325	328	PF00017	0.448
LIG_SH2_STAT5	368	371	PF00017	0.351
LIG_SH2_STAT5	391	394	PF00017	0.249
LIG_SH2_STAT5	459	462	PF00017	0.252
LIG_SH2_STAT5	476	479	PF00017	0.526
LIG_SH2_STAT5	90	93	PF00017	0.435
LIG_SH3_3	190	196	PF00018	0.656
LIG_SH3_3	206	212	PF00018	0.660
LIG_SH3_3	234	240	PF00018	0.642
LIG_SH3_3	424	430	PF00018	0.233
LIG_SH3_3	529	535	PF00018	0.546
LIG_SH3_3	574	580	PF00018	0.574
LIG_SUMO_SIM_anti_2	436	443	PF11976	0.198
LIG_SUMO_SIM_anti_2	55	60	PF11976	0.201
LIG_SUMO_SIM_par_1	260	266	PF11976	0.582
LIG_SUMO_SIM_par_1	295	301	PF11976	0.578
LIG_SUMO_SIM_par_1	80	86	PF11976	0.207
LIG_TYR_ITIM	73	78	PF00017	0.269
LIG_WRC_WIRS_1	30	35	PF05994	0.529
LIG_WRC_WIRS_1	51	56	PF05994	0.269
LIG_WRC_WIRS_1	566	571	PF05994	0.530
LIG_WRC_WIRS_1	84	89	PF05994	0.252
LIG_WW_2	209	212	PF00397	0.650
MOD_CDC14_SPxK_1	171	174	PF00782	0.655
MOD_CDC14_SPxK_1	411	414	PF00782	0.233
MOD_CDC14_SPxK_1	509	512	PF00782	0.497
MOD_CDK_SPK_2	189	194	PF00069	0.628
MOD_CDK_SPxK_1	168	174	PF00069	0.654
MOD_CDK_SPxK_1	408	414	PF00069	0.233
MOD_CDK_SPxK_1	506	512	PF00069	0.474
MOD_CK1_1	128	134	PF00069	0.685
MOD_CK1_1	257	263	PF00069	0.608
MOD_CK1_1	292	298	PF00069	0.708
MOD_CK1_1	584	590	PF00069	0.552
MOD_CK2_1	284	290	PF00069	0.590
MOD_CK2_1	292	298	PF00069	0.575
MOD_CK2_1	467	473	PF00069	0.433
MOD_CMANNOS	374	377	PF00535	0.269
MOD_GlcNHglycan	229	232	PF01048	0.552
MOD_GlcNHglycan	35	38	PF01048	0.278
MOD_GlcNHglycan	586	589	PF01048	0.395
MOD_GSK3_1	127	134	PF00069	0.688
MOD_GSK3_1	179	186	PF00069	0.642
MOD_GSK3_1	235	242	PF00069	0.613
MOD_GSK3_1	257	264	PF00069	0.715
MOD_GSK3_1	29	36	PF00069	0.516
MOD_GSK3_1	377	384	PF00069	0.252
MOD_GSK3_1	440	447	PF00069	0.253
MOD_GSK3_1	484	491	PF00069	0.607
MOD_GSK3_1	561	568	PF00069	0.556
MOD_N-GLC_1	128	133	PF02516	0.451
MOD_N-GLC_1	187	192	PF02516	0.442
MOD_N-GLC_1	467	472	PF02516	0.233
MOD_N-GLC_2	358	360	PF02516	0.259
MOD_NEK2_1	183	188	PF00069	0.717
MOD_NEK2_1	20	25	PF00069	0.534
MOD_NEK2_1	29	34	PF00069	0.519
MOD_NEK2_1	381	386	PF00069	0.516
MOD_NEK2_1	434	439	PF00069	0.233
MOD_NEK2_1	444	449	PF00069	0.252
MOD_NEK2_1	452	457	PF00069	0.252
MOD_NEK2_1	466	471	PF00069	0.433
MOD_NEK2_1	94	99	PF00069	0.547
MOD_PIKK_1	239	245	PF00454	0.618
MOD_PKA_1	528	534	PF00069	0.582
MOD_PKA_2	146	152	PF00069	0.618
MOD_PKA_2	546	552	PF00069	0.506
MOD_Plk_1	153	159	PF00069	0.617
MOD_Plk_1	183	189	PF00069	0.664
MOD_Plk_1	289	295	PF00069	0.542
MOD_Plk_1	467	473	PF00069	0.435
MOD_Plk_1	488	494	PF00069	0.540
MOD_Plk_4	153	159	PF00069	0.728
MOD_Plk_4	254	260	PF00069	0.589
MOD_Plk_4	29	35	PF00069	0.486
MOD_Plk_4	292	298	PF00069	0.572
MOD_Plk_4	377	383	PF00069	0.297
MOD_Plk_4	444	450	PF00069	0.248
MOD_Plk_4	452	458	PF00069	0.239
MOD_ProDKin_1	168	174	PF00069	0.659
MOD_ProDKin_1	189	195	PF00069	0.655
MOD_ProDKin_1	408	414	PF00069	0.233
MOD_ProDKin_1	506	512	PF00069	0.521
MOD_ProDKin_1	66	72	PF00069	0.289
TRG_DiLeu_LyEn_5	589	594	PF01217	0.593
TRG_ENDOCYTIC_2	368	371	PF00928	0.252
TRG_ENDOCYTIC_2	389	392	PF00928	0.269
TRG_ENDOCYTIC_2	579	582	PF00928	0.562
TRG_ENDOCYTIC_2	75	78	PF00928	0.252
TRG_ER_diArg_1	267	270	PF00400	0.585
TRG_ER_diArg_1	322	324	PF00400	0.414
TRG_ER_diArg_1	330	332	PF00400	0.608
TRG_ER_diArg_1	404	406	PF00400	0.236
TRG_ER_diArg_1	481	484	PF00400	0.628
TRG_NLS_MonoExtN_4	480	485	PF00514	0.516
TRG_Pf-PMV_PEXEL_1	402	407	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A6	Leptomonas seymouri	43%	92%
A0A3Q8IAF5	Leishmania donovani	69%	84%
A4HZD7	Leishmania infantum	69%	100%
E9AVC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QC55	Leishmania major	67%	100%
Q4QC56	Leishmania major	67%	100%