Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC50_LEIBR

TriTrypDb:

LbrM.21.2170 , LBRM2903_210018800

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.641
CLV_NRD_NRD_1	113	115	PF00675	0.452
CLV_NRD_NRD_1	258	260	PF00675	0.681
CLV_PCSK_KEX2_1	112	114	PF00082	0.476
CLV_PCSK_KEX2_1	258	260	PF00082	0.681
CLV_PCSK_SKI1_1	78	82	PF00082	0.536
CLV_Separin_Metazoa	313	317	PF03568	0.450
DEG_Nend_UBRbox_1	1	4	PF02207	0.734
DOC_ANK_TNKS_1	269	276	PF00023	0.581
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.550
DOC_MAPK_HePTP_8	18	30	PF00069	0.575
DOC_MAPK_MEF2A_6	21	30	PF00069	0.564
DOC_MAPK_MEF2A_6	47	54	PF00069	0.608
DOC_PP2B_LxvP_1	24	27	PF13499	0.556
DOC_USP7_MATH_1	98	102	PF00917	0.754
DOC_USP7_UBL2_3	84	88	PF12436	0.578
DOC_WW_Pin1_4	164	169	PF00397	0.613
DOC_WW_Pin1_4	180	185	PF00397	0.768
DOC_WW_Pin1_4	322	327	PF00397	0.544
LIG_14-3-3_CanoR_1	235	244	PF00244	0.734
LIG_14-3-3_CanoR_1	51	61	PF00244	0.513
LIG_14-3-3_CanoR_1	9	18	PF00244	0.739
LIG_CtBP_PxDLS_1	27	31	PF00389	0.657
LIG_FHA_1	11	17	PF00498	0.737
LIG_FHA_1	250	256	PF00498	0.753
LIG_FHA_2	307	313	PF00498	0.512
LIG_LIR_Nem_3	321	327	PF02991	0.703
LIG_NRBOX	145	151	PF00104	0.654
LIG_PDZ_Class_1	322	327	PF00595	0.602
LIG_SH2_PTP2	319	322	PF00017	0.428
LIG_SH2_STAT5	115	118	PF00017	0.670
LIG_SH2_STAT5	319	322	PF00017	0.458
LIG_SH2_STAT5	60	63	PF00017	0.492
LIG_SH3_3	77	83	PF00018	0.536
LIG_TYR_ITIM	322	327	PF00017	0.704
MOD_CK1_1	101	107	PF00069	0.756
MOD_CK1_1	173	179	PF00069	0.633
MOD_CK1_1	180	186	PF00069	0.636
MOD_CK1_1	3	9	PF00069	0.544
MOD_CK2_1	306	312	PF00069	0.751
MOD_GlcNHglycan	172	175	PF01048	0.663
MOD_GlcNHglycan	179	182	PF01048	0.565
MOD_GlcNHglycan	5	8	PF01048	0.499
MOD_GlcNHglycan	70	73	PF01048	0.724
MOD_GSK3_1	151	158	PF00069	0.559
MOD_GSK3_1	162	169	PF00069	0.612
MOD_GSK3_1	173	180	PF00069	0.778
MOD_NEK2_1	170	175	PF00069	0.542
MOD_NEK2_1	68	73	PF00069	0.694
MOD_PIKK_1	183	189	PF00454	0.783
MOD_PIKK_1	230	236	PF00454	0.515
MOD_Plk_1	116	122	PF00069	0.553
MOD_Plk_1	78	84	PF00069	0.764
MOD_ProDKin_1	164	170	PF00069	0.613
MOD_ProDKin_1	180	186	PF00069	0.766
TRG_DiLeu_BaEn_1	240	245	PF01217	0.518
TRG_ENDOCYTIC_2	136	139	PF00928	0.478
TRG_ENDOCYTIC_2	319	322	PF00928	0.601
TRG_ENDOCYTIC_2	324	327	PF00928	0.589
TRG_ER_diArg_1	112	114	PF00400	0.515
TRG_ER_diArg_1	258	260	PF00400	0.689
TRG_ER_diArg_1	315	318	PF00400	0.703
TRG_NES_CRM1_1	56	67	PF08389	0.383
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P3	Leptomonas seymouri	36%	100%
A0A3Q8IL55	Leishmania donovani	67%	100%
A4HZ90	Leishmania infantum	67%	100%
E9AV98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QC82	Leishmania major	67%	92%