Tubulin beta chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Tubulin beta chain

Gene product:

beta tubulin

Species:

Leishmania braziliensis

UniProt:

A4HC48_LEIBR

TriTrypDb:

LbrM.21.2150 , LBRM2903_330014300

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 20

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005874	microtubule	6	24
GO:0099080	supramolecular complex	2	24
GO:0099081	supramolecular polymer	3	24
GO:0099512	supramolecular fiber	4	24
GO:0099513	polymeric cytoskeletal fiber	5	24
GO:0110165	cellular anatomical entity	1	24

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Expansion

Sequence features

A4HC48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC48

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	3
GO:0000278	mitotic cell cycle	3	3
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	3
GO:0007017	microtubule-based process	2	24
GO:0007049	cell cycle	2	3
GO:0009987	cellular process	1	24
GO:0016043	cellular component organization	3	3
GO:0071840	cellular component organization or biogenesis	2	3

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	24
GO:0003824	catalytic activity	1	24
GO:0003924	GTPase activity	7	24
GO:0005198	structural molecule activity	1	24
GO:0005200	structural constituent of cytoskeleton	2	24
GO:0005488	binding	1	24
GO:0005525	GTP binding	5	24
GO:0016462	pyrophosphatase activity	5	24
GO:0016787	hydrolase activity	2	24
GO:0016817	hydrolase activity, acting on acid anhydrides	3	24

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.538
CLV_NRD_NRD_1	120	122	PF00675	0.382
CLV_NRD_NRD_1	250	252	PF00675	0.496
CLV_NRD_NRD_1	379	381	PF00675	0.359
CLV_NRD_NRD_1	390	392	PF00675	0.543
CLV_PCSK_KEX2_1	379	381	PF00082	0.359
CLV_PCSK_KEX2_1	390	392	PF00082	0.543
CLV_PCSK_SKI1_1	213	217	PF00082	0.490
CLV_PCSK_SKI1_1	309	313	PF00082	0.359
CLV_PCSK_SKI1_1	359	363	PF00082	0.359

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P449	Leptomonas seymouri	31%	94%
A0A0N0P7H2	Leptomonas seymouri	35%	99%
A0A0N1HR67	Leptomonas seymouri	39%	98%
A0A0S4J7M4	Bodo saltans	34%	98%
A0A0S4KPM6	Bodo saltans	29%	93%
A0A1X0NLP3	Trypanosomatidae	35%	99%
A0A1X0NXK9	Trypanosomatidae	96%	100%
A0A1X0NXS7	Trypanosomatidae	29%	90%
A0A381MCS3	Leishmania infantum	39%	98%
A0A381MS01	Leishmania infantum	98%	100%

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