LeishMANIAdb
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Protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase
Gene product:
protein kinase
Species:
Leishmania braziliensis
UniProt:
A4HC47_LEIBR
TriTrypDb:
LbrM.21.2140 , LBRM2903_080018300 *
Length:
842

Annotations

LeishMANIAdb annotations

A protein kinase likely belonging to the STE20 kinase family. The TM segments are a kinetoplastid innovation, but the kinase is otherwise conservative.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4HC47
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC47

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 9
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0016310 phosphorylation 5 9
GO:0019538 protein metabolic process 3 9
GO:0036211 protein modification process 4 9
GO:0043170 macromolecule metabolic process 3 9
GO:0043412 macromolecule modification 4 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0071704 organic substance metabolic process 2 9
GO:1901564 organonitrogen compound metabolic process 3 9
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003824 catalytic activity 1 9
GO:0004672 protein kinase activity 3 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0016301 kinase activity 4 9
GO:0016740 transferase activity 2 9
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 9
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 9
GO:0017076 purine nucleotide binding 4 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:0140096 catalytic activity, acting on a protein 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9
GO:0004674 protein serine/threonine kinase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 362 366 PF00656 0.561
CLV_NRD_NRD_1 118 120 PF00675 0.452
CLV_NRD_NRD_1 159 161 PF00675 0.323
CLV_NRD_NRD_1 299 301 PF00675 0.469
CLV_NRD_NRD_1 35 37 PF00675 0.384
CLV_NRD_NRD_1 384 386 PF00675 0.476
CLV_NRD_NRD_1 474 476 PF00675 0.546
CLV_NRD_NRD_1 603 605 PF00675 0.280
CLV_NRD_NRD_1 724 726 PF00675 0.278
CLV_NRD_NRD_1 73 75 PF00675 0.550
CLV_NRD_NRD_1 818 820 PF00675 0.278
CLV_PCSK_FUR_1 157 161 PF00082 0.327
CLV_PCSK_FUR_1 601 605 PF00082 0.280
CLV_PCSK_KEX2_1 118 120 PF00082 0.452
CLV_PCSK_KEX2_1 159 161 PF00082 0.323
CLV_PCSK_KEX2_1 298 300 PF00082 0.479
CLV_PCSK_KEX2_1 34 36 PF00082 0.388
CLV_PCSK_KEX2_1 384 386 PF00082 0.476
CLV_PCSK_KEX2_1 474 476 PF00082 0.546
CLV_PCSK_KEX2_1 601 603 PF00082 0.280
CLV_PCSK_KEX2_1 724 726 PF00082 0.278
CLV_PCSK_KEX2_1 73 75 PF00082 0.550
CLV_PCSK_KEX2_1 818 820 PF00082 0.329
CLV_PCSK_PC1ET2_1 298 300 PF00082 0.510
CLV_PCSK_PC1ET2_1 818 820 PF00082 0.329
CLV_PCSK_SKI1_1 191 195 PF00082 0.543
CLV_PCSK_SKI1_1 352 356 PF00082 0.459
CLV_PCSK_SKI1_1 411 415 PF00082 0.465
CLV_PCSK_SKI1_1 724 728 PF00082 0.329
CLV_PCSK_SKI1_1 73 77 PF00082 0.549
CLV_PCSK_SKI1_1 802 806 PF00082 0.263
CLV_PCSK_SKI1_1 820 824 PF00082 0.201
CLV_Separin_Metazoa 314 318 PF03568 0.694
DEG_APCC_DBOX_1 186 194 PF00400 0.607
DEG_Nend_UBRbox_1 1 4 PF02207 0.751
DEG_SPOP_SBC_1 446 450 PF00917 0.725
DOC_ANK_TNKS_1 682 689 PF00023 0.536
DOC_CDC14_PxL_1 423 431 PF14671 0.627
DOC_CDC14_PxL_1 45 53 PF14671 0.395
DOC_CKS1_1 440 445 PF01111 0.711
DOC_CKS1_1 796 801 PF01111 0.478
DOC_MAPK_gen_1 298 307 PF00069 0.669
DOC_MAPK_gen_1 602 613 PF00069 0.480
DOC_MAPK_HePTP_8 297 309 PF00069 0.640
DOC_MAPK_MEF2A_6 298 306 PF00069 0.649
DOC_MAPK_MEF2A_6 424 432 PF00069 0.560
DOC_MAPK_MEF2A_6 570 578 PF00069 0.480
DOC_MAPK_MEF2A_6 802 809 PF00069 0.523
DOC_MAPK_MEF2A_6 95 103 PF00069 0.280
DOC_PP2B_LxvP_1 46 49 PF13499 0.395
DOC_PP2B_LxvP_1 826 829 PF13499 0.478
DOC_PP4_FxxP_1 239 242 PF00568 0.750
DOC_USP7_MATH_1 196 200 PF00917 0.806
DOC_USP7_MATH_1 446 450 PF00917 0.725
DOC_USP7_MATH_1 511 515 PF00917 0.733
DOC_USP7_MATH_1 538 542 PF00917 0.728
DOC_USP7_MATH_1 835 839 PF00917 0.682
DOC_USP7_MATH_1 84 88 PF00917 0.498
DOC_USP7_UBL2_3 823 827 PF12436 0.529
DOC_WW_Pin1_4 202 207 PF00397 0.766
DOC_WW_Pin1_4 217 222 PF00397 0.640
DOC_WW_Pin1_4 238 243 PF00397 0.682
DOC_WW_Pin1_4 245 250 PF00397 0.734
DOC_WW_Pin1_4 384 389 PF00397 0.655
DOC_WW_Pin1_4 439 444 PF00397 0.656
DOC_WW_Pin1_4 447 452 PF00397 0.668
DOC_WW_Pin1_4 528 533 PF00397 0.628
DOC_WW_Pin1_4 534 539 PF00397 0.711
DOC_WW_Pin1_4 734 739 PF00397 0.478
DOC_WW_Pin1_4 795 800 PF00397 0.478
LIG_14-3-3_CanoR_1 187 191 PF00244 0.616
LIG_14-3-3_CanoR_1 278 283 PF00244 0.744
LIG_14-3-3_CanoR_1 34 40 PF00244 0.684
LIG_14-3-3_CanoR_1 352 358 PF00244 0.697
LIG_14-3-3_CanoR_1 474 480 PF00244 0.727
LIG_14-3-3_CanoR_1 575 585 PF00244 0.480
LIG_14-3-3_CanoR_1 630 640 PF00244 0.551
LIG_14-3-3_CanoR_1 669 677 PF00244 0.414
LIG_14-3-3_CanoR_1 724 734 PF00244 0.478
LIG_14-3-3_CanoR_1 73 79 PF00244 0.469
LIG_14-3-3_CanoR_1 819 826 PF00244 0.478
LIG_14-3-3_CanoR_1 95 99 PF00244 0.335
LIG_Actin_WH2_2 636 652 PF00022 0.536
LIG_AP2alpha_1 378 382 PF02296 0.661
LIG_APCC_ABBA_1 346 351 PF00400 0.614
LIG_APCC_ABBAyCdc20_2 695 701 PF00400 0.529
LIG_BIR_III_2 3 7 PF00653 0.634
LIG_BRCT_BRCA1_1 326 330 PF00533 0.663
LIG_CSL_BTD_1 246 249 PF09270 0.748
LIG_deltaCOP1_diTrp_1 755 759 PF00928 0.478
LIG_EVH1_2 532 536 PF00568 0.595
LIG_FHA_1 187 193 PF00498 0.731
LIG_FHA_1 281 287 PF00498 0.731
LIG_FHA_1 39 45 PF00498 0.618
LIG_FHA_1 476 482 PF00498 0.617
LIG_FHA_1 52 58 PF00498 0.307
LIG_FHA_1 632 638 PF00498 0.492
LIG_FHA_1 66 72 PF00498 0.394
LIG_FHA_1 729 735 PF00498 0.468
LIG_FHA_1 766 772 PF00498 0.529
LIG_FHA_2 309 315 PF00498 0.688
LIG_FHA_2 405 411 PF00498 0.648
LIG_FHA_2 474 480 PF00498 0.741
LIG_FHA_2 492 498 PF00498 0.693
LIG_FHA_2 548 554 PF00498 0.536
LIG_FHA_2 669 675 PF00498 0.414
LIG_FHA_2 744 750 PF00498 0.617
LIG_FHA_2 796 802 PF00498 0.436
LIG_FHA_2 810 816 PF00498 0.542
LIG_GBD_Chelix_1 302 310 PF00786 0.493
LIG_Integrin_RGD_1 594 596 PF01839 0.335
LIG_IRF3_LxIS_1 573 579 PF10401 0.536
LIG_LIR_Apic_2 737 743 PF02991 0.478
LIG_LIR_Gen_1 113 121 PF02991 0.381
LIG_LIR_Gen_1 171 180 PF02991 0.548
LIG_LIR_Gen_1 356 361 PF02991 0.673
LIG_LIR_Gen_1 42 51 PF02991 0.488
LIG_LIR_Gen_1 453 462 PF02991 0.728
LIG_LIR_Gen_1 581 592 PF02991 0.536
LIG_LIR_Gen_1 93 104 PF02991 0.270
LIG_LIR_Nem_3 113 117 PF02991 0.221
LIG_LIR_Nem_3 148 152 PF02991 0.681
LIG_LIR_Nem_3 171 175 PF02991 0.611
LIG_LIR_Nem_3 308 312 PF02991 0.629
LIG_LIR_Nem_3 356 360 PF02991 0.631
LIG_LIR_Nem_3 42 48 PF02991 0.488
LIG_LIR_Nem_3 431 437 PF02991 0.646
LIG_LIR_Nem_3 453 457 PF02991 0.730
LIG_LIR_Nem_3 534 539 PF02991 0.622
LIG_LIR_Nem_3 581 587 PF02991 0.536
LIG_LIR_Nem_3 70 75 PF02991 0.412
LIG_LIR_Nem_3 779 783 PF02991 0.529
LIG_LIR_Nem_3 93 99 PF02991 0.270
LIG_PCNA_TLS_4 802 809 PF02747 0.529
LIG_PDZ_Class_3 837 842 PF00595 0.718
LIG_Pex14_1 168 172 PF04695 0.607
LIG_Pex14_1 357 361 PF04695 0.678
LIG_Pex14_2 378 382 PF04695 0.661
LIG_SH2_CRK 96 100 PF00017 0.395
LIG_SH2_GRB2like 63 66 PF00017 0.473
LIG_SH2_PTP2 437 440 PF00017 0.655
LIG_SH2_PTP2 63 66 PF00017 0.473
LIG_SH2_SRC 63 66 PF00017 0.473
LIG_SH2_STAP1 349 353 PF00017 0.675
LIG_SH2_STAP1 548 552 PF00017 0.674
LIG_SH2_STAP1 773 777 PF00017 0.515
LIG_SH2_STAT5 393 396 PF00017 0.682
LIG_SH2_STAT5 434 437 PF00017 0.652
LIG_SH2_STAT5 63 66 PF00017 0.473
LIG_SH2_STAT5 639 642 PF00017 0.505
LIG_SH2_STAT5 781 784 PF00017 0.478
LIG_SH2_STAT5 830 833 PF00017 0.538
LIG_SH2_STAT5 96 99 PF00017 0.317
LIG_SH3_2 221 226 PF14604 0.628
LIG_SH3_3 218 224 PF00018 0.623
LIG_SH3_3 243 249 PF00018 0.626
LIG_SH3_3 541 547 PF00018 0.675
LIG_SH3_3 704 710 PF00018 0.478
LIG_SUMO_SIM_anti_2 100 105 PF11976 0.378
LIG_SUMO_SIM_anti_2 624 629 PF11976 0.536
LIG_SUMO_SIM_par_1 130 135 PF11976 0.653
LIG_SUMO_SIM_par_1 303 308 PF11976 0.771
LIG_SUMO_SIM_par_1 344 351 PF11976 0.665
LIG_SUMO_SIM_par_1 97 102 PF11976 0.221
LIG_TRAF2_1 28 31 PF00917 0.584
LIG_TYR_ITIM 310 315 PF00017 0.536
LIG_TYR_ITIM 61 66 PF00017 0.472
LIG_WRC_WIRS_1 172 177 PF05994 0.412
LIG_WRC_WIRS_1 306 311 PF05994 0.610
LIG_WRC_WIRS_1 548 553 PF05994 0.427
LIG_WRC_WIRS_1 639 644 PF05994 0.317
LIG_WRC_WIRS_1 66 71 PF05994 0.486
LIG_WRC_WIRS_1 756 761 PF05994 0.314
MOD_CDK_SPxxK_3 795 802 PF00069 0.385
MOD_CK1_1 173 179 PF00069 0.415
MOD_CK1_1 216 222 PF00069 0.684
MOD_CK1_1 253 259 PF00069 0.723
MOD_CK1_1 276 282 PF00069 0.648
MOD_CK1_1 308 314 PF00069 0.531
MOD_CK1_1 363 369 PF00069 0.419
MOD_CK1_1 37 43 PF00069 0.591
MOD_CK1_1 387 393 PF00069 0.627
MOD_CK1_1 450 456 PF00069 0.666
MOD_CK1_1 514 520 PF00069 0.639
MOD_CK1_1 531 537 PF00069 0.532
MOD_CK2_1 127 133 PF00069 0.549
MOD_CK2_1 171 177 PF00069 0.407
MOD_CK2_1 19 25 PF00069 0.567
MOD_CK2_1 308 314 PF00069 0.582
MOD_CK2_1 404 410 PF00069 0.548
MOD_CK2_1 473 479 PF00069 0.686
MOD_CK2_1 638 644 PF00069 0.347
MOD_CK2_1 668 674 PF00069 0.269
MOD_CK2_1 729 735 PF00069 0.385
MOD_CK2_1 743 749 PF00069 0.247
MOD_CK2_1 795 801 PF00069 0.221
MOD_GlcNHglycan 198 201 PF01048 0.669
MOD_GlcNHglycan 215 218 PF01048 0.525
MOD_GlcNHglycan 257 260 PF01048 0.840
MOD_GlcNHglycan 273 276 PF01048 0.790
MOD_GlcNHglycan 362 365 PF01048 0.613
MOD_GlcNHglycan 389 392 PF01048 0.532
MOD_GlcNHglycan 513 516 PF01048 0.682
MOD_GlcNHglycan 711 714 PF01048 0.314
MOD_GlcNHglycan 731 734 PF01048 0.187
MOD_GSK3_1 202 209 PF00069 0.760
MOD_GSK3_1 213 220 PF00069 0.644
MOD_GSK3_1 276 283 PF00069 0.634
MOD_GSK3_1 34 41 PF00069 0.502
MOD_GSK3_1 405 412 PF00069 0.506
MOD_GSK3_1 446 453 PF00069 0.662
MOD_GSK3_1 534 541 PF00069 0.568
MOD_GSK3_1 664 671 PF00069 0.225
MOD_GSK3_1 720 727 PF00069 0.314
MOD_GSK3_1 90 97 PF00069 0.492
MOD_N-GLC_2 335 337 PF02516 0.555
MOD_NEK2_1 110 115 PF00069 0.317
MOD_NEK2_1 140 145 PF00069 0.473
MOD_NEK2_1 293 298 PF00069 0.565
MOD_NEK2_1 305 310 PF00069 0.532
MOD_NEK2_1 452 457 PF00069 0.669
MOD_NEK2_1 473 478 PF00069 0.750
MOD_NEK2_1 51 56 PF00069 0.395
MOD_NEK2_1 566 571 PF00069 0.270
MOD_NEK2_1 664 669 PF00069 0.466
MOD_NEK2_1 720 725 PF00069 0.314
MOD_NEK2_1 809 814 PF00069 0.278
MOD_NEK2_1 99 104 PF00069 0.317
MOD_NEK2_2 19 24 PF00069 0.511
MOD_NEK2_2 547 552 PF00069 0.440
MOD_NEK2_2 773 778 PF00069 0.367
MOD_NEK2_2 84 89 PF00069 0.454
MOD_PIKK_1 286 292 PF00454 0.502
MOD_PIKK_1 664 670 PF00454 0.225
MOD_PIKK_1 781 787 PF00454 0.314
MOD_PIKK_1 809 815 PF00454 0.278
MOD_PK_1 278 284 PF00069 0.523
MOD_PKA_1 34 40 PF00069 0.450
MOD_PKA_1 474 480 PF00069 0.663
MOD_PKA_1 724 730 PF00069 0.314
MOD_PKA_1 73 79 PF00069 0.420
MOD_PKA_1 818 824 PF00069 0.385
MOD_PKA_2 161 167 PF00069 0.566
MOD_PKA_2 186 192 PF00069 0.566
MOD_PKA_2 196 202 PF00069 0.660
MOD_PKA_2 34 40 PF00069 0.612
MOD_PKA_2 473 479 PF00069 0.667
MOD_PKA_2 606 612 PF00069 0.271
MOD_PKA_2 631 637 PF00069 0.426
MOD_PKA_2 668 674 PF00069 0.225
MOD_PKA_2 724 730 PF00069 0.314
MOD_PKA_2 73 79 PF00069 0.420
MOD_PKA_2 818 824 PF00069 0.314
MOD_PKA_2 90 96 PF00069 0.510
MOD_Plk_1 132 138 PF00069 0.565
MOD_Plk_1 170 176 PF00069 0.406
MOD_Plk_1 284 290 PF00069 0.711
MOD_Plk_1 409 415 PF00069 0.545
MOD_Plk_1 464 470 PF00069 0.646
MOD_Plk_1 773 779 PF00069 0.367
MOD_Plk_1 84 90 PF00069 0.736
MOD_Plk_2-3 171 177 PF00069 0.407
MOD_Plk_4 127 133 PF00069 0.620
MOD_Plk_4 145 151 PF00069 0.527
MOD_Plk_4 305 311 PF00069 0.532
MOD_Plk_4 409 415 PF00069 0.545
MOD_Plk_4 418 424 PF00069 0.530
MOD_Plk_4 531 537 PF00069 0.480
MOD_Plk_4 547 553 PF00069 0.456
MOD_Plk_4 94 100 PF00069 0.342
MOD_ProDKin_1 202 208 PF00069 0.718
MOD_ProDKin_1 217 223 PF00069 0.545
MOD_ProDKin_1 238 244 PF00069 0.600
MOD_ProDKin_1 245 251 PF00069 0.674
MOD_ProDKin_1 384 390 PF00069 0.562
MOD_ProDKin_1 439 445 PF00069 0.566
MOD_ProDKin_1 447 453 PF00069 0.580
MOD_ProDKin_1 528 534 PF00069 0.525
MOD_ProDKin_1 734 740 PF00069 0.314
MOD_ProDKin_1 795 801 PF00069 0.314
MOD_SUMO_rev_2 562 571 PF00179 0.317
MOD_SUMO_rev_2 593 600 PF00179 0.395
TRG_DiLeu_BaEn_1 410 415 PF01217 0.660
TRG_DiLeu_BaEn_2 579 585 PF01217 0.395
TRG_DiLeu_BaEn_2 686 692 PF01217 0.314
TRG_ENDOCYTIC_2 121 124 PF00928 0.467
TRG_ENDOCYTIC_2 312 315 PF00928 0.534
TRG_ENDOCYTIC_2 437 440 PF00928 0.563
TRG_ENDOCYTIC_2 548 551 PF00928 0.502
TRG_ENDOCYTIC_2 63 66 PF00928 0.473
TRG_ENDOCYTIC_2 639 642 PF00928 0.317
TRG_ENDOCYTIC_2 780 783 PF00928 0.385
TRG_ENDOCYTIC_2 96 99 PF00928 0.317
TRG_ER_diArg_1 117 119 PF00400 0.559
TRG_ER_diArg_1 157 160 PF00400 0.390
TRG_ER_diArg_1 34 36 PF00400 0.469
TRG_ER_diArg_1 383 385 PF00400 0.589
TRG_ER_diArg_1 473 475 PF00400 0.692
TRG_ER_diArg_1 600 603 PF00400 0.317
TRG_ER_diArg_1 648 651 PF00400 0.225
TRG_ER_diArg_1 72 74 PF00400 0.408
TRG_ER_diArg_1 88 91 PF00400 0.404
TRG_ER_diArg_1 9 12 PF00400 0.523
TRG_NES_CRM1_1 128 139 PF08389 0.559

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5H9 Leptomonas seymouri 48% 96%
A0A3S5H699 Leishmania donovani 84% 85%
A0A3S7WQE5 Leishmania donovani 85% 99%
E9AG93 Leishmania infantum 85% 99%
E9AMJ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QI37 Leishmania major 84% 100%
Q4QI43 Leishmania major 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS