Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC45_LEIBR

TriTrypDb:

LbrM.21.2120 , LBRM2903_080018100

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.756
CLV_NRD_NRD_1	263	265	PF00675	0.725
CLV_NRD_NRD_1	342	344	PF00675	0.709
CLV_NRD_NRD_1	80	82	PF00675	0.674
CLV_NRD_NRD_1	99	101	PF00675	0.479
CLV_PCSK_KEX2_1	263	265	PF00082	0.725
CLV_PCSK_KEX2_1	342	344	PF00082	0.709
CLV_PCSK_KEX2_1	80	82	PF00082	0.674
CLV_PCSK_KEX2_1	99	101	PF00082	0.479
CLV_PCSK_SKI1_1	104	108	PF00082	0.512
CLV_PCSK_SKI1_1	227	231	PF00082	0.655
CLV_PCSK_SKI1_1	330	334	PF00082	0.461
CLV_PCSK_SKI1_1	342	346	PF00082	0.445
CLV_PCSK_SKI1_1	80	84	PF00082	0.667
CLV_Separin_Metazoa	241	245	PF03568	0.437
DEG_APCC_DBOX_1	329	337	PF00400	0.453
DEG_SPOP_SBC_1	23	27	PF00917	0.608
DEG_SPOP_SBC_1	58	62	PF00917	0.532
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.478
DOC_MAPK_gen_1	80	88	PF00069	0.677
DOC_MAPK_gen_1	99	107	PF00069	0.462
DOC_MAPK_RevD_3	66	81	PF00069	0.484
DOC_PP2B_LxvP_1	190	193	PF13499	0.476
DOC_PP2B_LxvP_1	290	293	PF13499	0.606
DOC_PP2B_LxvP_1	56	59	PF13499	0.530
DOC_USP7_MATH_1	108	112	PF00917	0.517
DOC_USP7_MATH_1	176	180	PF00917	0.596
DOC_USP7_MATH_1	23	27	PF00917	0.733
DOC_USP7_MATH_1	234	238	PF00917	0.721
DOC_USP7_MATH_1	276	280	PF00917	0.569
DOC_USP7_MATH_1	296	300	PF00917	0.655
DOC_USP7_MATH_1	338	342	PF00917	0.439
DOC_USP7_MATH_1	4	8	PF00917	0.650
DOC_USP7_MATH_1	50	54	PF00917	0.650
DOC_USP7_MATH_1	57	61	PF00917	0.707
DOC_WW_Pin1_4	11	16	PF00397	0.746
DOC_WW_Pin1_4	133	138	PF00397	0.607
DOC_WW_Pin1_4	188	193	PF00397	0.486
DOC_WW_Pin1_4	249	254	PF00397	0.705
DOC_WW_Pin1_4	269	274	PF00397	0.406
DOC_WW_Pin1_4	288	293	PF00397	0.443
DOC_WW_Pin1_4	313	318	PF00397	0.721
DOC_WW_Pin1_4	39	44	PF00397	0.437
DOC_WW_Pin1_4	422	427	PF00397	0.732
DOC_WW_Pin1_4	88	93	PF00397	0.737
LIG_14-3-3_CanoR_1	342	350	PF00244	0.640
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BIR_III_2	354	358	PF00653	0.686
LIG_FHA_1	116	122	PF00498	0.736
LIG_FHA_1	147	153	PF00498	0.647
LIG_FHA_1	46	52	PF00498	0.687
LIG_GBD_Chelix_1	254	262	PF00786	0.656
LIG_LIR_Gen_1	30	37	PF02991	0.613
LIG_LIR_Gen_1	386	394	PF02991	0.653
LIG_LIR_Nem_3	136	142	PF02991	0.655
LIG_LIR_Nem_3	30	35	PF02991	0.553
LIG_LIR_Nem_3	386	392	PF02991	0.653
LIG_PCNA_yPIPBox_3	236	244	PF02747	0.658
LIG_PDZ_Class_2	432	437	PF00595	0.701
LIG_PDZ_Wminus1_1	435	437	PF00595	0.707
LIG_SH2_CRK	389	393	PF00017	0.642
LIG_SH2_PTP2	141	144	PF00017	0.607
LIG_SH2_PTP2	32	35	PF00017	0.620
LIG_SH2_SRC	32	35	PF00017	0.620
LIG_SH2_STAP1	323	327	PF00017	0.649
LIG_SH2_STAP1	45	49	PF00017	0.669
LIG_SH2_STAT5	141	144	PF00017	0.607
LIG_SH2_STAT5	287	290	PF00017	0.585
LIG_SH2_STAT5	32	35	PF00017	0.620
LIG_SH2_STAT5	411	414	PF00017	0.687
LIG_SH3_3	102	108	PF00018	0.519
LIG_SH3_3	141	147	PF00018	0.611
LIG_SH3_3	290	296	PF00018	0.543
LIG_SH3_3	314	320	PF00018	0.642
LIG_SUMO_SIM_anti_2	237	244	PF11976	0.446
LIG_SUMO_SIM_par_1	85	91	PF11976	0.706
LIG_TRAF2_1	299	302	PF00917	0.566
LIG_TRFH_1	288	292	PF08558	0.454
LIG_TYR_ITIM	387	392	PF00017	0.443
LIG_Vh1_VBS_1	107	125	PF01044	0.497
LIG_WW_1	137	140	PF00397	0.663
LIG_WW_3	398	402	PF00397	0.489
MOD_CDK_SPK_2	11	16	PF00069	0.524
MOD_CK1_1	111	117	PF00069	0.547
MOD_CK1_1	25	31	PF00069	0.564
MOD_CK1_1	272	278	PF00069	0.724
MOD_CK1_1	291	297	PF00069	0.476
MOD_CK1_1	313	319	PF00069	0.738
MOD_CK1_1	62	68	PF00069	0.671
MOD_CK2_1	235	241	PF00069	0.469
MOD_CK2_1	296	302	PF00069	0.559
MOD_GlcNHglycan	130	133	PF01048	0.424
MOD_GlcNHglycan	178	181	PF01048	0.532
MOD_GlcNHglycan	232	235	PF01048	0.655
MOD_GlcNHglycan	27	30	PF01048	0.669
MOD_GlcNHglycan	298	301	PF01048	0.682
MOD_GlcNHglycan	310	313	PF01048	0.801
MOD_GlcNHglycan	325	328	PF01048	0.486
MOD_GlcNHglycan	366	369	PF01048	0.698
MOD_GlcNHglycan	416	419	PF01048	0.507
MOD_GlcNHglycan	61	64	PF01048	0.684
MOD_GSK3_1	111	118	PF00069	0.662
MOD_GSK3_1	230	237	PF00069	0.645
MOD_GSK3_1	245	252	PF00069	0.606
MOD_GSK3_1	272	279	PF00069	0.742
MOD_GSK3_1	338	345	PF00069	0.451
MOD_GSK3_1	58	65	PF00069	0.679
MOD_GSK3_1	88	95	PF00069	0.724
MOD_NEK2_1	121	126	PF00069	0.712
MOD_NEK2_1	161	166	PF00069	0.633
MOD_NEK2_1	230	235	PF00069	0.650
MOD_NEK2_1	280	285	PF00069	0.617
MOD_NEK2_1	363	368	PF00069	0.570
MOD_NEK2_1	431	436	PF00069	0.607
MOD_NEK2_2	276	281	PF00069	0.477
MOD_PIKK_1	198	204	PF00454	0.680
MOD_PKA_1	342	348	PF00069	0.488
MOD_PKA_2	342	348	PF00069	0.488
MOD_Plk_1	115	121	PF00069	0.508
MOD_Plk_4	116	122	PF00069	0.509
MOD_Plk_4	161	167	PF00069	0.636
MOD_Plk_4	235	241	PF00069	0.502
MOD_Plk_4	257	263	PF00069	0.560
MOD_Plk_4	383	389	PF00069	0.476
MOD_ProDKin_1	11	17	PF00069	0.746
MOD_ProDKin_1	133	139	PF00069	0.606
MOD_ProDKin_1	188	194	PF00069	0.489
MOD_ProDKin_1	249	255	PF00069	0.696
MOD_ProDKin_1	269	275	PF00069	0.404
MOD_ProDKin_1	288	294	PF00069	0.453
MOD_ProDKin_1	313	319	PF00069	0.720
MOD_ProDKin_1	39	45	PF00069	0.433
MOD_ProDKin_1	422	428	PF00069	0.733
MOD_ProDKin_1	88	94	PF00069	0.741
TRG_DiLeu_BaEn_1	116	121	PF01217	0.509
TRG_DiLeu_BaEn_1	331	336	PF01217	0.663
TRG_DiLeu_BaEn_4	301	307	PF01217	0.563
TRG_DiLeu_LyEn_5	331	336	PF01217	0.663
TRG_ENDOCYTIC_2	139	142	PF00928	0.625
TRG_ENDOCYTIC_2	287	290	PF00928	0.585
TRG_ENDOCYTIC_2	32	35	PF00928	0.620
TRG_ENDOCYTIC_2	389	392	PF00928	0.643
TRG_ER_diArg_1	262	264	PF00400	0.583
TRG_ER_diArg_1	79	81	PF00400	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKQ2	Leptomonas seymouri	34%	100%
A0A3S5H698	Leishmania donovani	72%	100%
E9ACQ6	Leishmania major	72%	97%
E9AG91	Leishmania infantum	72%	100%
E9AMJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	80%